Research Explorer

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Researcher

Mathias Devreese

255 Results

2022

A piglet model of pediatric sepsis to investigate tissue penetration of antibiotics in children: a microdialysis study on piperacillin-tazobactam.

Eline HermansEvelyn DhontPeter De PaepeJohan Vande WallePieter De CockMathias Devreese

Development and validation of a reliable UHPLC-MS/MS method for simultaneous quantification of Macrocyclic lactones in bovine plasma

Siegrid De BaereMathias Devreese

A1 Journal Article in MOLECULES

Dose-dependent impact of enrofloxacin on broiler chicken gut resistome is mitigated by synbiotic application

Robin TemmermanGunther AntonissenLuc DuchateauFreddy HaesebrouckAn GarmynMathias Devreese

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Intestinal exposure to ceftiofur and cefquinome after intramuscular treatment and the impact of ceftiofur on the pig fecal microbiome and resistome

Sofie RutjensNick VereeckeWard De SpiegelaereSiska CroubelsMathias Devreese

A1 Journal Article in ANTIBIOTICS-BASEL

Pharmacokinetic and pharmacodynamic properties of orally administered torasemide in healthy cats

Marine Roche-CatholyDominique PaepeMathias DevreeseBart BroeckxArnaut HellemansPascale Smets

A1 Journal Article in JOURNAL OF VETERINARY INTERNAL MEDICINE

Pharmacokinetics of cannabidiol following intranasal, intrarectal, and oral administration in healthy dogs

Robin TemmermanMathias DevreeseMarios CharalambousLuc Van HamIne CornelisBart BroeckxSofie Bhatti

A1 Journal Article in FRONTIERS IN VETERINARY SCIENCE

The influence of sepsis on antibiotic tissue penetration in children: a microdialysis study in the juvenile pig

Eline HermansPieter De CockPeter De PaepeJohan Vande WalleMathias Devreese

The translation from in vitro experiments to in vivo microdialysis trials: a case study of piperacillin-tazobactam.

Eline HermansJohan Vande WalleEvelyn DhontPeter De PaepeMathias DevreesePieter De Cock

2021

Antibiotics in critically ill children : a focus on tissue penetration

Eline HermansMathias DevreesePeter De PaepeJohan Vande WallePieter De Cock

Determination of recovery and optimal calibration technique for piperacillin tazobactam and meropenem : an in vitro microdialysis study

Eline HermansPieter De CockMathias DevreesePeter De PaepeJohan Vande Walle

Determination of recovery and optimal calibration technique for piperacillin-tazobactam : an in vitro microdialysis study

Eline HermansMathias DevreesePeter De PaepeJohan Vande WallePieter De Cock

Development and validation of liquid chromatography-tandem mass spectrometry methods for the quantification of cefquinome, ceftiofur, and desfuroylceftiofuracetamide in porcine feces with emphasis on analyte stability

Sofie RutjensSiska CroubelsSiegrid De BaereMathias Devreese

A1 Journal Article in MOLECULES

Dietary exposure assessment and risk characterization of citrinin and ochratoxin A in Belgium

Celine MeerpoelArnau Vidal CorominasMarthe De BoevreMathias DevreeseSiska CroubelsSarah De Saeger

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Dose optimisation of antimicrobial agents in veterinary medicine using pharmacometrics to improve one health antimicrobial sustainability : the case of enrofloxacin and avian pathogenic Escherichia coli infections in broiler chickens

Robin TemmermanMathias DevreeseGunther AntonissenAn Garmyn

Enrofloxacin dose optimization for the treatment of colibacillosis in broiler chickens using a drinking behaviour pharmacokinetic model

Robin TemmermanWim SchelstraeteGunther AntonissenAn GarmynMathias Devreese

A1 Journal Article in ANTIBIOTICS-BASEL

In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation

Séan Mc CaffertyJoyca De TemmermanMathias DevreeseSiegrid De BaereFrancis CombesNiek Sanders

A1 Journal Article in MOLECULAR THERAPY

Microdialysis to study tissue penetration of drugs in the juvenile pig : an opportunity for pediatric drug research

Eline HermansPieter De CockPeter De PaepeJohan Vande WalleMathias Devreese

Population pharmacokinetics of intravenous amoxicillin combined with clavulanic acid in healthy and critically ill dogs

Marc CherletMathias Devreese

A1 Journal Article in FRONTIERS IN VETERINARY SCIENCE

The development of a juvenile porcine augmented renal clearance model through continuous infusion of lipopolysaccharides : an exploratory study

Laura DhondtSiska CroubelsRobin TemmermanPieter De CockEvelyne MeyerWim Van Den BroeckPeter De PaepeMathias Devreese

A1 Journal Article in FRONTIERS IN VETERINARY SCIENCE

Unraveling the contribution of fluid therapy to the development of augmented renal clearance in a piglet model

Laura DhondtSiska CroubelsPeter De PaepeKlara GoethalsPieter De CockMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Volumetric absorptive microsampling as alternative sampling technique for renal function assessment in the paediatric population using iohexol

Laura DhondtSiska CroubelsPieter De CockEvelyn DhontSiegrid De BaerePeter De PaepeMathias Devreese

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

2020

A study of carry-over and histopathological effects after chronic dietary intake of citrinin in pigs, broiler chickens and laying hens

Celine MeerpoelArnau Vidal CorominasLiesbeth CouckRiet De RyckeLobke De BelsSarah De SaegerWim Van Den BroeckMathias DevreeseSiska Croubels

A1 Journal Article in TOXINS

Age-related differences in toxicokinetics of modified fusarium mycotoxins in the juvenile pig as a human paediatric surrogate model

Amelie CatteuwSiska CroubelsMathias DevreeseSarah De Saeger

Agreement of quantitative and qualitative antimicrobial susceptibility testing methodologies : the case of enrofloxacin and avian pathogenic Escherichia coli

Robin TemmermanKlara GoethalsAn GarmynFreddy HaesebrouckGunther AntonissenMathias Devreese

Agreement of quantitative and qualitative antimicrobial susceptibility testing methodologies : the case of enrofloxacin and avian pathogenic escherichia coli

Robin TemmermanKlara GoethalsAn GarmynFreddy HaesebrouckGunther AntonissenMathias Devreese

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Calcination improves the in vivo efficacy of a montmorillonite clay to bind aflatoxin G1 in broiler chickens : a toxicokinetic approach

Roua RejebSiegrid De BaereMathias DevreeseRichard DucatelleSiska CroubelsGunther Antonissen

A1 Journal Article in TOXINS

Comparative pharmacokinetics of imepitoin after oral and rectal administration in healthy dogs

Valentine MartléMathias DevreeseLuc Van HamSiska CroubelsValérie VanhoorneChris VervaetSofie Bhatti

A1 Journal Article in VETERINARY JOURNAL

Comparative toxicokinetics of Fusarium mycotoxins in pigs and humans

Wim SchelstraeteMathias DevreeseSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Comprehensive toxicokinetic analysis reveals major interspecies differences in absorption, distribution and elimination of citrinin in pigs and broiler chickens

Celine MeerpoelArnau Vidal CorominasSarah De SaegerSiska CroubelsMathias Devreese

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Conventional pig as animal model for human renal drug excretion processes : unravelling the porcine renal function by use of a cocktail of exogenous markers

Laura DhondtSiska CroubelsPeter De PaepePieter De CockMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Evaluation of fluoroquinolone resistance in clinical avian pathogenic Escherichia coli isolates from Flanders (Belgium)

Robin TemmermanAn GarmynGunther AntonissenFreddy HaesebrouckMathias Devreese

A1 Journal Article in ANTIBIOTICS-BASEL

Fluoroquinolone resistance in clinical avian pathogenic Escherichia coli isolates from Flanders (Belgium)

Robin TemmermanAn GarmynGunther AntonissenFreddy HaesebrouckMathias Devreese

Gastrostomy tube placement via a laparotomic procedure in growing conventional piglets to perform multi-dose preclinical paediatric drug studies

Joske MillecamThomas van BergenMathias DevreeseStijn SchauvliegeAnn MartensKoen ChiersSiska CroubelsGunther Antonissen

A1 Journal Article in LABORATORY ANIMALS

Grasping the phenomenon of augmented renal clearance in the critically ill using the conventional pig as juvenile animal model

Laura DhondtMathias DevreeseSiska CroubelsPeter De PaepePieter De Cock

Investigation of age-related differences in toxicokinetic processes of deoxynivalenol and deoxynivalenol-3-glucoside in weaned piglets

Amelie CatteuwMathias DevreeseSiegrid De BaereGunther AntonissenAnn MartensSarah De SaegerMarthe De BoevreSiska Croubels

A1 Journal Article in ARCHIVES OF TOXICOLOGY

Pediatric pharmacology of desmopressin in children with enuresis : a comprehensive review

Elke GasthuysLien DosscheJens Peter NorgaardMathias DevreeseSiska CroubelsAn VermeulenJan Van BocxlaerJohan Vande Walle

A1 Journal Article in PEDIATRIC DRUGS

Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs

Lise VlerickMathias DevreeseKathelijne PeremansRobrecht DockxSiska CroubelsLuc DuchateauIngeborgh Polis

A1 Journal Article in PLOS ONE

Prophylactic use of meloxicam and paracetamol in peripartal sows suffering from postpartum dysgalactia syndrome

Alexandra SchoosIlias ChantziarasEvelien BiebautEvelyne MeyerAn CoolsMathias DevreeseDominiek Maes

A1 Journal Article in FRONTIERS IN VETERINARY SCIENCE

Stability, homogeneity and carry-over of amoxicillin, doxycycline, florfenicol and flubendazole in medicated feed and drinking water on 24 pig farms

Femke VandaelHelena Cardoso de Carvalho FerreiraMathias DevreeseJeroen DewulfMia EeckhoutSiska Croubels

A1 Journal Article in ANTIBIOTICS-BASEL

The impact of therapeutic-dose induced intestinal enrofloxacin concentrations in healthy pigs on fecal Escherichia coli populations

Joren De SmetFilip BoyenSiska CroubelsFreddy HaesebrouckRobin TemmermanSofie RutjensPatrick De BackerMathias Devreese

A1 Journal Article in BMC VETERINARY RESEARCH

The incidence of citrinin in the Belgian food and feed chain and the risk for human and animal health

Celine MeerpoelSarah De SaegerSiska CroubelsMathias Devreese

Toxicokinetic studies in piglets reveal age-related differences in systemic exposure to zearalenone, zearalenone-14-glucoside, and zearalenone-14-sulfate

Amelie CatteuwMathias DevreeseSiegrid De BaereGunther AntonissenAnn MartensSarah De SaegerMarthe De BoevreSiska Croubels

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Toxicokinetics of hydrolyzed fumonisin B1 after single oral or intravenous bolus to broiler chickens fed a control or a fumonisins-contaminated diet

Gunther AntonissenSiegrid De BaereDanica den HollanderMathias DevreeseSiska Croubels

A1 Journal Article in TOXINS

Weight-gain induced changes in renal perfusion assessed by contrast-enhanced ultrasound precede increases in urinary protein excretion suggestive of glomerular and tubular injury and normalize after weight-loss in dogs

Daisy LiuEmmelie StockBart BroeckxSylvie DaminetEvelyne MeyerJoris DelangheSiska CroubelsMathias DevreeseEvelien BogaertsMyriam HestaKatrien Vanderperren

A1 Journal Article in PLOS ONE

2019

Age-related differences in exposure to deoxynivalenol and deoxynivalenol-3-glucoside unravelled : toxicokinetic study in the weaned piglet as a human paediatric surrogate model

Amelie CatteuwGunther AntonissenAnn MartensSarah De SaegerMarthe De BoevreMathias DevreeseSiska Croubels

Alfaxalone total intravenous anaesthesia in dogs : pharmacokinetics, cardiovascular data and recovery characteristics

Virginie DehuisserTim BosmansMathias DevreeseSiska CroubelsLuc DuchateauIngeborgh Polis

A1 Journal Article in VETERINARY ANAESTHESIA AND ANALGESIA

Assessment of dried blood spots for multi-mycotoxin biomarker analysis in pigs and broiler chickens

Marianne LauwersSiska CroubelsSiegrid De BaereMathias Devreese

A1 Journal Article in TOXINS

Biomarkers for exposure as a tool for efficacy testing of a mycotoxin detoxifier in broiler chickens and pigs

Marianne LauwersSiska CroubelsMathias Devreese

A1 Journal Article in TOXINS

Biomarkers for mycotoxin exposure in livestock

Marianne LauwersMathias DevreeseSiska Croubels

Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective

Wim SchelstraeteLaura De ClerckElisabeth GovaertJoske MillecamMathias DevreeseDieter DeforceJan Van BocxlaerSiska Croubels

A1 Journal Article in SCIENTIFIC REPORTS

Citrinin : new occurrence, toxicokinetic and toxicity data to refine its risk assessment

Celine MeerpoelArnau Vidal CorominasSarah De SaegerSiska CroubelsMathias Devreese

Comparative physiology of glomerular filtration rate by plasma clearance of exogenous creatinine and exo-iohexol in six different avian species

Elke GasthuysNele CaekebekeMathias DevreeseSiegrid De BaereDominique PaepeSiska CroubelsGunther Antonissen

A1 Journal Article in SCIENTIFIC REPORTS

Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of iohexol, p-aminohippuric acid and creatinine in porcine and broiler chicken plasma

Laura DhondtSiska CroubelsPieter De CockPeter De PaepeSiegrid De BaereMathias Devreese

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Developmental pharmacokinetics and safety of ibuprofen and its enantiomers in the conventional pig as potential pediatric animal model

Joske MillecamThomas van BergenStijn SchauvliegeGunther AntonissenAnn MartensKoen ChiersElke GasthuysJohan Vande WalleSiska CroubelsMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Dosering en risico op bijwerkingen van trimethoprim-sulfamethoxazolepreparaten = Dosing and adverse event risks of trimethoprim-sulfamethoxazole

Sofie RutjensMathias Devreese

Impact of subacute exposure to T-2 toxin and zearalenone on the pharmacokinetics of midazolam as CYP3A probe drug in a porcine animal model : a pilot study

Wim SchelstraeteMathias DevreeseSiska Croubels

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

In vivo metabolism of ibuprofen in growing conventional pigs : a pharmacokinetic approach

Joske MillecamSiegrid De BaereSiska CroubelsMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Influence of administration route and dose on intestinal concentrations of selected antimicrobials in pigs

Joren De SmetMathias DevreeseSiska Croubels

Insights into in vivo absolute oral bioavailability, biotransformation, and toxicokinetics of zearalenone, α-zearalenol, β-zearalenol, zearalenone-14-glucoside, and zearalenone-14-sulfate in pigs

Amelie CatteuwNathan BroekaertSiegrid De BaereMarianne LauwersElke GasthuysMarthe De BoevreSarah De SaegerMathias DevreeseSiska Croubels

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Interactions between Fusarium mycotoxins and cytochrome P450 drug metabolizing enzymes in a porcine animal model

Wim SchelstraeteSiska CroubelsMathias Devreese

Multi LC-MS/MS and LC-HRMS methods for determination of 24 mycotoxins including major phase I and II biomarker metabolites in biological matrices from pigs and broiler chickens

Marianne LauwersSiegrid De BaereSiska CroubelsMathias Devreese

A1 Journal Article in TOXINS

Occurrence, oral bioavailability and toxicokinetics of citrinin in a porcine animal model

Celine MeerpoelArnau Vidal CorominasSarah De SaegerMathias DevreeseSiska Croubels

Occurrence, toxicokinetics and toxicity of citrinin and risk assessment

Celine MeerpoelArnau Vidal CorominasSarah De SaegerSiska CroubelsMathias Devreese

Oral group medication in pig production : characterising medicated feed and drinking water systems

Femke VandaelJeroen DewulfMia EeckhoutMathias DevreeseSiska Croubels

A1 Journal Article in VETERINARY RECORD

Pharmacokinetics and absolute oral bioavailability of meloxicam in guinea pigs (Cavia porcellus)

Ilse MoeremansMathias DevreeseSiegrid De BaereSiska CroubelsKatleen Hermans

A1 Journal Article in VETERINARY ANAESTHESIA AND ANALGESIA

Pharmacokinetics and muscle residue depletion of amoxicillin in cage cultured hybrid red tilapia (Oreochromis mossambicus × Oreochromis niloticus)

Mathias DevreeseSiska Croubels

A1 Journal Article in AQUACULTURE

Piglets as animal model to assess the contribution of fluid therapy to the development of augmented renal clearance in children

Laura DhondtSiska CroubelsPeter De PaepePieter De CockMathias Devreese

Population pharmacokinetics of mavacoxib after oral administration of a single dose to African grey parrots (Psittacus erithacus)

Siegrid De BaereMathias DevreeseGunther Antonissen

Quantitative risk model to estimate the level of antimicrobial residues that can be transferred to soil via manure, due to oral treatments of pigs

Mathias DevreeseJeroen Dewulf

A1 Journal Article in PREVENTIVE VETERINARY MEDICINE

Resistance assessment and safeguarding the efficacy : dose optimalization of enrofloxacin for the treatment of colibacillosis in broilers

Robin TemmermanWim SchelstraeteAn GarmynGunther AntonissenMathias Devreese

The conventional pig as juvenile animal model for preclinical paediatric pharmacokinetic studies : focus on hepatic metabolism using ibuprofen as model compound

Joske MillecamSiska CroubelsMathias Devreese

The juvenile pig as animal model for unraveling renal drug elimination processes in children

Laura DhondtSiska CroubelsPeter De PaepePieter De CockMathias Devreese

The role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves : from field observations to toxicokinetics

Bonnie ValgaerenSiska CroubelsMathias DevreeseSiegrid De BaereMarthe De BoevreSarah De SaegerArnau Vidal CorominasJosé Diana Di MavunguBart PardonPiet DeprezGunther Antonissen

A1 Journal Article in ARCHIVES OF TOXICOLOGY

Towards risk assessment of emerging Alternaria and Fusarium mycotoxins : comparative toxicity and toxicokinetics in broiler chickens and pigs

Sophie FraeymanSiska CroubelsMathias DevreeseGunther Antonissen

Use of non-steroidal anti-inflammatory drugs in porcine health management

Alexandra SchoosMathias DevreeseDominiek Maes

A1 Journal Article in VETERINARY RECORD

Validated multi-mycotoxin analysis using dried blood spots for pigs and broiler chickens applied in a screening and toxicokinetic study

Marianne LauwersSiska CroubelsMathias Devreese

2018

A novel approach in paediatric drug research : the development of a juvenile pig model for pharmacokinetic/pharmacodynamic studies, using desmopressin as case 1

Elke GasthuysJoske MillecamMathias DevreeseAn VermeulenPauline De BruyneJohan Vande WalleJoris DelangheSiska Croubels

A survey of citrinin and ochratoxin A in food and feed in Belgium

Celine MeerpoelArnau Vidal CorominasMathias DevreeseSiska CroubelsSarah De Saeger

Changes in renal perfusion precede increased urinary protein excretion caused by weight gain and normalize after weight-loss in dogs

Daisy LiuEmmelie StockEvelien BogaertsBart BroeckxSiska CroubelsMathias DevreeseSylvie DaminetMyriam HestaKatrien Vanderperren

Chronic dietary intake of enniatin B in broiler chickens has low impact on intestinal morphometry and hepatic histology, and shows limited transfer to liver tissue

Sophie FraeymanSiska CroubelsMathias DevreeseRichard DucatelleGunther Antonissen

A1 Journal Article in TOXINS

Comparative in vitro cytotoxicity of the emerging Fusarium mycotoxins beauvericin and enniatins to porcine intestinal epithelial cells

Sophie FraeymanEvelyne MeyerMathias DevreeseGunther AntonissenKristel DemeyereFreddy HaesebrouckSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Comparative toxicokinetics and plasma protein binding of ochratoxin A in four avian species

Mathias DevreeseSiska CroubelsSiegrid De BaereGunther Antonissen

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research : postnatal maturation of the glomerular filtration rate

Elke GasthuysJoske MillecamMathias DevreeseJoris DelangheJohan Vande WalleMarjolein HeyndrickxSiska Croubels

Development and validation of an LC-MS/MS method for the simultaneous determination of citrinin and ochratoxin a in a variety of feed and foodstuffs

Celine MeerpoelArnau Vidal CorominasJosé Diana Di MavunguMathias DevreeseSiska CroubelsSarah De Saeger

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Fluoroquinolone resistance in clinical avian pathogenic Escherichia coli (APEC) isolates from Flanders: Is the poultry industry at risk?

Robin TemmermanAn GarmynGunther AntonissenSiska CroubelsMathias Devreese

Impact of T-2 toxin and zearalenone on the pharmacokinetics of midazolam as CYP3A probe drug in an in vivo porcine animal model

Wim SchelstraeteMathias DevreeseSiska Croubels

In vitro model to assess the adsorption of oral veterinary drugs to mycotoxin binders in a feed- and aflatoxin B1-containing buffered matrix

Siegrid De BaereThomas De MilGunther AntonissenMathias DevreeseSiska Croubels

A1 Journal Article in FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT

Incidence of citrinin in the Belgian feed chain and its toxicokinetic profile in broiler chickens

Celine MeerpoelArnau Vidal CorominasSarah De SaegerMathias DevreeseSiska Croubels

Maturation of hepatic cytochrome P450 enzymes in conventional pigs : fact or fiction?

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceJan Van BocxlaerStanislas SysSiska Croubels

Maturation of hepatic cytochrome P450 enzymes in conventional pigs : the added value of proteomics

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas SysSiska Croubels

Maturation of hepatic cytochrome P450 enzymes in conventional pigs as model for preclinical paediatric drug research

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceJan Van BocxlaerStanislas SysSiska Croubels

Modelling the risks and consequences of residues of antimicrobial drugs in the gut and manure of pigs

Maria-Eleni FilippitziJeroen DewulfMathias Devreese

PK/PD studies in pigs leading to optimization of treatment dose in MNE?

Elke GasthuysLien DosscheSiska CroubelsPauline De BruyneMathias DevreeseAn VermeulenJohan Vande Walle

Pediatric drug development: towards maturity : desmopressin as a case

Elke GasthuysRobin MicheletLien DosschePauline De BruyneJohan Vande WalleAn VermeulenMathias DevreeseSiska Croubels

Pharmacokinetics and electrophysiological effects of sotalol hydrochloride in horses

Barbara BrouxDominique De ClercqAnnelies DecloedtLisse VeraMathias DevreeseSiska CroubelsGunther van Loon

A1 Journal Article in EQUINE VETERINARY JOURNAL

Pharmacokinetics of florfenicol in turkey plasma, lung tissue, and pulmonary epithelial lining fluid after single oral bolus or continuous administration in the drinking water

Anneleen WatteynSiska CroubelsSiegrid De BaerePatrick De BackerMathias Devreese

A1 Journal Article in POULTRY SCIENCE

Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population

Elke GasthuysAn VermeulenSiska CroubelsPauline De BruyneJoske MillecamJohan Vande WalleMathias Devreese

Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population

Elke GasthuysAn VermeulenSiska CroubelsJoske MillecamStijn SchauvliegeThomas van BergenPauline De BruyneJohan Vande WalleMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Prevention of mycotoxicosis using mycotoxin detoxifiers : in vivo efficacy testing of a mycotoxin detoxifier in broilers : toxicokinetic approach

Amelie CatteuwSiska CroubelsMathias Devreese

Probabilistic risk model to assess the potential for resistance selection following the use of anti-microbial medicated feed in pigs

Maria-Eleni FilippitziIlias ChantziarasMathias DevreeseJeroen Dewulf

A1 Journal Article in FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT

Similar gastro-intestinal exposure to florfenicol after oral or intramuscular administration in pigs, leading to resistance selection in commensal Escherichia coli

Joren De SmetFilip BoyenSiska CroubelsFreddy HaesebrouckPatrick De BackerMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Simultaneous determination of creatinine, iohexol and p-aminohippuric acid in animal plasma by ultra-high-performance liquid chromatography-tandem mass spectrometry

Laura DhondtSiska CroubelsPieter De CockPeter De PaepeMathias Devreese

Storage stability study of porcine hepatic and intestinal cytochrome P450 isoenzymes by use of a newly developed and fully validated highly sensitive HPLC-MS/MS method

Wim SchelstraeteMathias DevreeseSiska Croubels

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The composition of drinking water and feeding systems for oral group medication in 52 Belgian swine herds, in relation to homogeneity, stability and cross-contamination of veterinary medicinal products

Femke VandaelJeroen DewulfMia EeckhoutPatrick De BackerMathias DevreeseSiska Croubels

The development of a juvenile porcine augmented renal clearance model for paediatric drug research during sepsis : the effect of different continuously administered LPS doses on the renal function

Laura DhondtSiska CroubelsPieter De CockPeter De PaepeMathias Devreese

The ontogeny of cytochrome P450 enzyme activity and protein abundance in conventional pigs in support of preclinical pediatric drug research

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas SysSiska Croubels

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

2017

A new approach in pediatric drug design : the development of a pediatric pig model, part II : the maturation of hepatic cytochrome P450 enzymes using enzyme activity and proteomics

Joske MillecamElke GasthuysMathias DevreeseDieter DeforceJan Van BocxlaerSiska Croubels

A novel approach in paediatric drug design : the conventional pig as juvenile animal model

Joske MillecamElke GasthuysMathias DevreeseSiska Croubels

A novel approach in paediatric drug research : the development of a juvenile conventional pig model for pharmacokinetic/pharmacodynamic studies, using desmopressin as case

Elke GasthuysSiska CroubelsMathias Devreese

A survey of citrinin and ochratoxin A in food and feed on the Belgian market

Celine MeerpoelJosé Diana Di MavunguMathias DevreeseSiska CroubelsSarah De Saeger

Absorption and disposition of enniatin B1 in broiler chickens and pigs : comparative oral bioavailability and toxicokinetics

Sophie FraeymanMathias DevreeseGunther AntonissenSiegrid De BaereSiska Croubels

Biotransformation of the mycotoxin enniatin B1 in pigs : a comparative in vitro and in vivo approach

Mathias DevreeseSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Citririsk : incidence of citrinin in the Belgian food and feed chain & risk for human and animal health

Celine MeerpoelJosé Diana Di MavunguMathias DevreeseSiska CroubelsSarah De Saeger

Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus)

Laura DhondtMathias DevreeseSiska CroubelsSiegrid De BaereRoel HaesendonckTess GoessensPatrick De BackerGunther Antonissen

A1 Journal Article in SCIENTIFIC REPORTS

Comparative toxicokinetics of enniatins in broiler chickens and pigs

Sophie FraeymanMathias DevreeseGunther AntonissenSiegrid De BaereSiska Croubels

Effect of administration route and dose alteration on sulfadiazine-trimethoprim plasma and intestinal concentrations in pigs

Joren De SmetSiska CroubelsPatrick De BackerMathias Devreese

A1 Journal Article in INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Effect of weight gain in dogs on renal function and perfusion assessed by contrast-enhanced ultrasound

Daisy LiuMyriam HestaEmmelie StockSiska CroubelsMathias DevreeseBart BroeckxEvelien BogaertsSylvie DaminetKatrien Vanderperren

Emerging Fusarium and Alternaria mycotoxins : occurrence, toxicity and toxicokinetics

Sophie FraeymanSiska CroubelsMathias DevreeseGunther Antonissen

A1 Journal Article in TOXINS

Feed contamination with Fusarium mycotoxins induces a corticosterone stress response in broiler chickens

Gunther AntonissenSiegrid De BaereMathias DevreeseFilip Van ImmerseelAn MartelSiska Croubels

A1 Journal Article in POULTRY SCIENCE

Florfenicol concentrations in different gastro-intestinal segments of pigs, after oral and intramuscular treatments

Joren De SmetSiska CroubelsPatrick De BackerMathias Devreese

Het gebruik van (acetyl)salicylzuur bij varkens

Wim SchelstraeteMathias DevreeseDominiek Maes

Editorial material

Impact of Fusarium mycotoxins on hepatic and intestinal mRNA expression of cytochrome P450 enzymes and drug transporters, and on the pharmacokinetics of oral enrofloxacin in broiler chickens

Gunther AntonissenMathias DevreeseSiegrid De BaereAn MartelFilip Van ImmerseelSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Impact of Fusarium mycotoxins on in vitro activity of major hepatic cytochrome P450 biotransformation enzymes in pigs

Wim SchelstraeteMathias DevreeseSiska Croubels

In vivo contribution of deoxynivalenol-3-β-D-glucoside to deoxynivalenol exposure in broiler chickens and pigs: oral bioavailability, hydrolysis and toxicokinetics

Nathan BroekaertMathias DevreeseThomas van BergenStijn SchauvliegeMarthe De BoevreSarah De SaegerLynn VanhaeckeAn VermeulenSiska Croubels

A1 Journal Article in ARCHIVES OF TOXICOLOGY

Influence of mycotoxin binders on the oral bioavailability of tylosin, doxycycline, diclazuril, and salinomycin in fed broiler chickens

Thomas De MilMathias DevreeseAn MaesSarah De SaegerPatrick De BackerSiska Croubels

A1 Journal Article in POULTRY SCIENCE

Pharmacokinetic and urinary profiling reveals the prednisolone/cortisol ratio as a valid biomarker for prednisolone administration

Lieven Van MeulebroekNathalie De ClercqJulie Vanden BusscheMathias DevreeseSiska CroubelsLynn Vanhaecke

A1 Journal Article in BMC VETERINARY RESEARCH

Population pharmacokinetic modeling of the glomerular filtration rate in growing piglets using iohexol

Elke GasthuysJoske MillecamSiska CroubelsMathias Devreese

Postnatal maturation of the glomerular filtration rate in conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research

Elke GasthuysMathias DevreeseJoske MillecamStanislas SysKatrien VanderperrenJoris DelangheJohan Vande WalleMarjolein HeyndrickxSiska Croubels

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Repetitive urine and blood sampling in neonatal and weaned piglets for pharmacokinetic and pharmacodynamic modelling in drug discovery : a pilot study

Elke GasthuysStijn SchauvliegeThomas van BergenJoske MillecamAnn MartensFrank GasthuysTim VandecasteelePieter CornillieWim Van Den BroeckFilip BoyenSiska CroubelsMathias Devreese

A1 Journal Article in LABORATORY ANIMALS

Role of mycotoxins in herds with and without problems with tail necrosis in neonatal pigs

Tommy Van LimbergenMathias DevreeseSiska CroubelsNathan BroekaertAnnelies MichielsSarah De SaegerDominiek Maes

A1 Journal Article in VETERINARY RECORD

T-2 toxin-3α-glucoside in broiler chickens : toxicokinetics, absolute oral bioavailability, and in vivo hydrolysis

Nathan BroekaertMathias DevreeseMarthe De BoevreSarah De SaegerSiska Croubels

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The conventional pig as PK/PD/toxicity model for the pediatric subpopulation : development of urine and blood sampling strategies in growing piglets

Elke GasthuysThomas van BergenStijn SchauvliegeJoske MillecamSiska CroubelsMathias Devreese

The ontogeny of hepatic cytochrome P450 enzymes in conventional pigs using enzyme activity and proteomics

Joske MillecamElke GasthuysMathias DevreeseDieter DeforceJan Van BocxlaerSiska Croubels

The use of population pharmacokinetics for pharmacokinetic studies in small and exotic avian species : the case of celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus)

Laura DhondtMathias DevreeseSiska CroubelsSiegrid De BaereTess GoessensPatrick De BackerGunther Antonissen

The use of toxicokinetic modeling in mycotoxin research

Amelie CatteuwMarianne LauwersNathan BroekaertGunther AntonissenMathias DevreeseSiska Croubels

Validated LC-MS/MS multi-methods to detect 25 mycotoxins and phase I metabolites in biological fluids of pigs and broiler chickens and application to screening studies for mycotoxin exposure

Marianne LauwersSiegrid De BaereTommy Van LimbergenGunther AntonissenDominiek MaesMathias DevreeseSiska Croubels

2016

Biomarkers for exposure of mycotoxins in pigs and broiler chickens

Marianne LauwersSiegrid De BaereSarah De SaegerSiska CroubelsMathias Devreese

Comparative in vitro cytotoxicity of modified deoxynivalenol on porcine intestinal epithelial cells

Nathan BroekaertMathias DevreeseKristel DemeyereEvelyne MeyerSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Comparative oral bioavailability, toxicokinetics, and biotransformation of enniatin B1 and enniatin B in broiler chickens

Sophie FraeymanMathias DevreeseGunther AntonissenSiegrid De BaereSiska Croubels

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Deoxynivalenol-3-β-D-glucoside : in vitro cytotoxicity and in vivo oral bioavailability and hydrolysis in broiler chicken and pig

Nathan BroekaertMathias DevreeseThomas van BergenStijn SchauvliegeMarthe De BoevreSarah De SaegerLynn VanhaeckeAn VermeulenSiska Croubels

Disposition of enniatin B and B1 in broiler chickens : oral bioavailability and toxicokinetics

Sophie FraeymanMathias DevreeseGunther AntonissenSiegrid De BaereSiska Croubels

Efficacy of florfenicol and gamithromycin in an Ornithobacterium rhinotracheale infection model in turkeys : a pharmacokinetic/pharmacodynamic integration

Anneleen WatteynSiska CroubelsPatrick De BackerMathias Devreese

Efficacy of gamithromycin against Ornithobacterium rhinotracheale in turkey poults pre-infected with avian metapneumovirus

Anneleen WatteynMathias DevreeseElke PlessersHeidi WynsAn GarmynVishwanatha Reddy Avalakuppa Papi ReddyFrank PasmansAn MartelFreddy HaesebrouckPatrick De BackerSiska Croubels

A1 Journal Article in AVIAN PATHOLOGY

Farmacokinetiek van geneesmiddelen bij vogels en de toepassingen en beperkingen van dosisextrapolatie

Gunther AntonissenSiska CroubelsPatrick De BackerMathias Devreese

A1 Journal Article in VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT

GLP principles and their role in supporting pharmacokinetic and residue depletion studies for drug registration and licensing

Siska CroubelsPatrick De BackerMathias Devreese

A1 Journal Article in DRUG TESTING AND ANALYSIS

Influence of mycotoxin binders on the oral bioavailability of doxycycline in pigs

Thomas De MilMathias DevreeseSarah De SaegerMia EeckhoutPatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Influence of mycotoxin binders on the oral bioavailability of doxycycline in pigs

Thomas De MilMathias DevreeseSarah De SaegerMia EeckhoutPatrick De BackerSiska Croubels

Interaction between Fusarium mycotoxins and cytochrome P450 drug metabolizing enzymes/ABC drug transporters in a porcine animal model

Wim SchelstraeteMathias DevreeseJan Van BocxlaerSiska Croubels

Interactions between mycotoxins and the rumen, their possible toxicological effects on the gastrointestinal tract and their intestinal absorption in dairy cattle : an in vitro approach

Sandra DebevereMathias DevreeseSiegrid De BaereSarah De SaegerGeert HaesaertVeerle FievezSiska Croubels

Niet-steroïdale, anti-inflammatoire geneesmiddelen bij vogels: farmacokinetiek, farmacodynamiek en toxiciteit

Tess GoessensGunther AntonissenSiska CroubelsPatrick De BackerMathias Devreese

A1 Journal Article in VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT

Pharmacokinetics and electrophysiological effects of different dosages of oral sotalol in horses: preliminary results

Barbara BrouxDominique De ClercqLisse VeraGlenn Van SteenkisteAnnelies DecloedtAnneleen WatteynMathias DevreeseSiska CroubelsGunther van Loon

Pharmacokinetics of intravenously and orally administered sotalol hydrochloride in horses and effects on surface electrocardiogram and left ventricular systolic function

Barbara BrouxDominique De ClercqAnnelies DecloedtSiegrid De BaereMathias DevreeseNicky Van Der VekensSofie VenSiska CroubelsGunther van Loon

A1 Journal Article in VETERINARY JOURNAL

Plasma and intestinal concentrations of sulfadiazine-trimethoprim in pigs after (non)conventional oral and intramuscular treatment, in the context of antimicrobial resistance

Joren De SmetSiska CroubelsPatrick De BackerMathias Devreese

Quantitative determination of florfenicol in pig manure by LC-MS/MS to assess the exposure of the gut microbiota to florfenicol

Joren De SmetSiska CroubelsPatrick De BackerMathias Devreese

Residues of chlortetracycline, doxycycline and sulfadiazine-trimethoprim in intestinal content and feces of pigs due to cross-contamination of feed

Laura PeetersMathias DevreeseAnnemieke SmetJeroen DewulfMarc HeyndrickxFreddy HaesebrouckPatrick ButayeSiska Croubels

A1 Journal Article in BMC VETERINARY RESEARCH

Safety of mycotoxin binders regarding their use with veterinary medicinal products in poultry and pigs : an in vitro and pharmacokinetic approach

Thomas De MilSiska CroubelsMathias DevreesePatrick De Backer

The adsorption of veterinary drugs to mycotoxin binders in a feed-containing buffered matrix

Thomas De MilMathias DevreesePatrick De BackerSiska Croubels

The impact of deoxynivalenol on pigeon health : occurrence in feed, toxicokinetics and interaction with salmonellosis

Gunther AntonissenRoel HaesendonckMathias DevreeseNathan BroekaertElin VerbruggheSarah De SaegerKris AudenaertFreddy HaesebrouckFrank PasmansRichard DucatelleSiska CroubelsAn Martel

A1 Journal Article in PLOS ONE

The potential use of piglets as human pediatric surrogate for preclinical pharmacokinetic and pharmacodynamic drug testing

Elke GasthuysTim VandecasteelePauline De BruyneJohan Vande WallePatrick De BackerPieter CornillieMathias DevreeseSiska Croubels

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

2015

Assessment of mycotoxin occurrence in feed samples from the Belgian veal calf industry and the influence of roughage provision

Bonnie ValgaerenGunther AntonissenMathias DevreeseSiegrid De BaereEllen HeyndrickxSarah De SaegerBart PardonPiet DeprezSiska Croubels

Characterization of 27 mycotoxin binders and the relation with in vitro zearalenone adsorption at a single concentration

Thomas De MilMathias DevreeseSiegrid De BaereEric Van RanstMia EeckhoutPatrick De BackerSiska Croubels

A1 Journal Article in TOXINS

Chronic exposure to deoxynivalenol has no influence on the oral bioavailability of fumonisin B1 in broiler chickens

Gunther AntonissenMathias DevreeseFilip Van ImmerseelSiegrid De BaereAn MartelSiska Croubels

A1 Journal Article in TOXINS

Comparative pharmacokinetics and allometric scaling of carboplatin in different avian species

Gunther AntonissenMathias DevreeseSiegrid De BaereTom HellebuyckIsabel Van de MaeleLieze RouffaerPatrick De BackerAn MartelSiska Croubels

A1 Journal Article in PLOS ONE

Comparative pharmacokinetics and allometric scaling of carboplatin in different avian species

Mathias DevreeseGunther AntonissenSiegrid De BaereTom HellebuyckIsabel Van de MaeleLieze RouffaerPatrick De BackerAn MartelSiska Croubels

Comparative pharmacokinetics of celecoxib and mavacoxib in cockatiels (Nymphicus hollandicus)

Gunther AntonissenAn MartelTess GoessensMathias DevreeseRoel HaesendonckPatrick De BackerSiska Croubels

Comparative toxicokinetics, absolute oral bioavailability and biotransformation of zearalenone in different poultry species

Mathias DevreeseGunther AntonissenNathan BroekaertSiegrid De BaereLynn VanhaeckePatrick De BackerSiska Croubels

Comparative toxicokinetics, absolute oral bioavailability, and biotransformation of zearalenone in different poultry species

Mathias DevreeseGunther AntonissenNathan BroekaertSiegrid De BaereLynn VanhaeckePatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Comparison of iohexol and endogenous creatinine clearance as estimators of glomerular filtration rate in piglets at different age categories

Elke GasthuysMathias DevreeseJoske MillecamPatrick De BackerSiska Croubels

Concentrations of selected antimicrobials in caecum, colon and manure of pigs due to a 3% cross-contamination of the feed and their effect on resistance in Escherichia coli

Laura PeetersAnnemieke SmetMathias DevreeseJeroen DewulfMarc HeyndrickxFreddy HaesebrouckSiska CroubelsPatrick Butaye

Deoxynivalenol in turkey poults: toxicokinetic study, absolute oral bioavailability and biotransformation

Mathias DevreeseGunther AntonissenNathan BroekaertSiegrid De BaereLynn VanhaeckePatrick De BackerSiska Croubels

Deoxynivalenol in turkey poults: toxicokinetic study, absolute oral bioavailability and comparative biotransformation with broiler chickens

Mathias DevreeseGunther AntonissenNathan BroekaertThomas De MilSiegrid De BaereLynn VanhaeckePatrick De BackerSiska Croubels

Determination of selected veterinary antimicrobials in poultry excreta by UHPLC-MS/MS, for application in Salmonella control programs

Mathias DevreesePatrick De BackerSiska Croubels

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Development and validation of a liquid chromatography-tandem mass spectrometry method for the quantitative determination of gamithromycin in animal plasma, lung tissue and pulmonary epithelial lining fluid

Siegrid De BaereMathias DevreeseAnneleen WatteynHeidi WynsElke PlessersPatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Disposition of 3- and 15-acetyl-deoxynivalenol and deoxynivalenol-3-β-D-glucoside in broiler chickens and pigs

Nathan BroekaertSiska CroubelsMathias DevreeseSarah De Saeger

Efficacy of florfenicol and gamithromycin in an Ornithobacterium rhinotracheale infection model in turkeys: a pharmacokinetic-pharmacodynamic approach

Anneleen WatteynMathias DevreeseSiegrid De BaereElke PlessersHeidi WynsPatrick De BackerSiska Croubels

Fumonisins affect the intestinal microbial homeostasis in broiler chickens, predisposing to necrotic enteritis

Gunther AntonissenSiska CroubelsFrank PasmansRichard DucatelleVenessa EeckhautMathias DevreeseMarc VerlindenFreddy HaesebrouckMia EeckhoutSarah De SaegerAn MartelFilip Van Immerseel

A1 Journal Article in VETERINARY RESEARCH

In vitro adsorption and in vivo pharmacokinetic interaction between doxycycline and frequently used mycotoxin binders in broiler chickens

Thomas De MilMathias DevreeseNathan BroekaertSophie FraeymanPatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

In vivo hydrolysis and toxicokinetics of T-2 toxin and T2-glucoside in broiler chickens

Nathan BroekaertMathias DevreeseThomas De MilSophie FraeymanMarthe De BoevreSarah De SaegerPatrick De BackerSiska Croubels

Interactions of clay-based feed additives with orally administered veterinary drugs

Thomas De MilMathias DevreeseNathan BroekaertSophie FraeymanSiegrid De BaerePatrick De BackerSiska Croubels

Intestinal concentrations of sulfadiazine-trimethoprim in pigs after (non-)conventional oral and intramuscular treatment

Joren De SmetSiska CroubelsPatrick De BackerMathias Devreese

Modified Fusarium mycotoxins unmasked: from occurrence in cereals to animal and human excretion

Nathan BroekaertMathias DevreeseSiegrid De BaerePatrick De BackerSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Modulation by gamithromycin and ketoprofen of in vitro and in vivo porcine lipopolysaccharide-induced inflammation

Heidi WynsEvelyne MeyerElke PlessersAnneleen WatteynThomas van BergenStijn SchauvliegeSiegrid De BaereMathias DevreesePatrick De BackerSiska Croubels

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Mycotoxins deoxynivalenol and fumonisins alter the extrinsic component of intestinal barrier in broiler chickens

Gunther AntonissenFilip Van ImmerseelFrank PasmansRichard DucatelleGeert JanssensSiegrid De BaereBruno De MeulenaerMarc VerlindenMathias DevreeseFreddy HaesebrouckAn MartelSiska Croubels

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oral bioavailability, hydrolysis, and comparative toxicokinetics of 3-acetyldeoxynivalenol and 15-acetyldeoxynivalenol in broiler chickens and pigs

Nathan BroekaertMathias DevreeseThomas De MilSophie FraeymanGunther AntonissenSiegrid De BaerePatrick De BackerAn VermeulenSiska Croubels

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacokinetic and pharmacodynamic properties of gamithromycin in turkey poults with respect to Ornithobacterium rhinotracheale

Anneleen WatteynMathias DevreeseSiegrid De BaereHeidi WynsElke PlessersFilip BoyenFreddy HaesebrouckPatrick De BackerSiska Croubels

A1 Journal Article in POULTRY SCIENCE

Pharmacokinetics of the selective COX-2 inhibitors celecoxib and mavacoxib in cockatiels

Gunther AntonissenMathias DevreeseSiegrid De BaereAn MartelTess GoessensRoel HaesendonckPatrick De BackerSiska Croubels

Quantification of 8-α-hydroxy-mutilin as marker residue for tiamulin in rabbit tissues by high-performance liquid chromatography-mass spectrometry

Siegrid De BaereMathias DevreeseAn MaesPatrick De BackerSiska Croubels

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Quantification of ketamine and norketamine in bovine plasma by liquid chromatography–tandem mass spectrometry

Mathias DevreeseStijn SchauvliegeFrank GasthuysPatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF THE IRANIAN CHEMICAL SOCIETY

Quantitative determination of tenuazonic acid in broiler chicken plasma using a validated liquid chromatography-tandem mass spectrometry method

Sophie FraeymanMathias DevreeseNathan BroekaertThomas De MilSiegrid De BaerePatrick De BackerSiska Croubels

Quantitative determination of tenuazonic acid in pig and broiler chicken plasma by LC-MS/MS and its comparative toxicokinetics

Sophie FraeymanMathias DevreeseNathan BroekaertThomas De MilGunther AntonissenSiegrid De BaerePatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Safety of mycotoxin binders in broiler feed: interaction with the oral absorption of veterinary drugs and coccidiostats

Thomas De MilMathias DevreeseNathan BroekaertSophie FraeymanSiegrid De BaerePatrick De BackerSiska Croubels

The impact of deoxynivalenol on pigeon health: occurrence in feed, toxicokinetics and interaction with salmonellosis

Gunther AntonissenRoel HaesendonckMathias DevreeseNathan BroekaertElin VerbruggheFrank PasmansSarah De SaegerAn MartelSiska Croubels

The ontogeny of hepatic CYP3A, CYP2C and CYP2E enzyme activity in conventional pigs

Joske MillecamMathias DevreeseLies De BockJan Van BocxlaerElke GasthuysPatrick De BackerSiska Croubels

The use of chemotherapy in avian medicine: an international survey

Gunther AntonissenMathias DevreeseRichard DucatelleIsabel Van de MaeleSiska CroubelsAn Martel

Toxicokinetic study and oral bioavailability of deoxynivalenol in turkey poults, and comparative biotransformation between broilers and turkeys

Mathias DevreeseGunther AntonissenNathan BroekaertThomas De MilSiegrid De BaereLynn VanhaeckePatrick De BackerSiska Croubels

A1 Journal Article in WORLD MYCOTOXIN JOURNAL

Unravelling the role of ruminal development in the biotransformation of deoxynivalenol and its acetylated derivatives : a comparative toxicokinetic approach

Gunther AntonissenBonnie ValgaerenMathias DevreeseSiegrid De BaereEllen HeyndrickxSarah De SaegerPiet DeprezSiska Croubels

Use of LC–MS–MS as an alternative to currently available immunoassay methods to quantitate corticosterone in egg yolk and albumen

Siegrid De BaereTom Rosendahl LarsenMathias DevreesePatrick De BackerLiesbeth De NeveLuc LensSiska Croubels

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

2014

Characterization of 27 mycotoxin detoxifiers and the relation with in vitro zearalenone binding

Thomas De MilMathias DevreeseNathan BroekaertSophie FraeymanEric Van RanstSarah De SaegerMia EeckhoutGeert HaesaertPatrick De BackerSiska Croubels

Comparative method validation for closantel determination in cattle and sheep milk according to European Union Volume 8 and Veterinary International Conference on Harmonization guidelines

Mathias DevreeseAn MaesSiegrid De BaerePatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Comparative method validation for closantel in cattle and sheep milk according to EU Volume 8 and VICH GL 49 guidelines

Mathias DevreeseAn MaesSiegrid De BaerePatrick De BackerSiska Croubels

Concentrations of selected antimicrobials in caecum, colon and manure of pigs due to a 3% cross-contamination of the feed

Laura PeetersMathias DevreeseJeroen DewulfMarc HeyndrickxFreddy HaesebrouckPatrick ButayeSiska Croubels

Detection and quantification of selected veterinary antimicrobials in poultry excreta

Mathias DevreesePatrick De BackerSiska Croubels

Detection and quantification of the EU marker residue of tiamulin in animal tissues

Siegrid De BaereAn MaesMathias DevreesePatrick De BackerSiska Croubels

Determination of selected veterinary antimicrobials in poultry excreta

Mathias DevreesePatrick De BackerSiska Croubels

Determination of β-lactams, fluoroquinolones, sulfonamides/trimethoprim, tetracyclines and colistin in poultry excreta by UHPLC-MS/MS

Mathias DevreesePatrick De BackerSiska Croubels

Development and validation of an LC-MS/MS method for the toxicokinetic study of deoxynivalenol and its acetylated derivatives in chicken and pig plasma

Nathan BroekaertMathias DevreeseThomas De MilSophie FraeymanSiegrid De BaereSarah De SaegerPatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Effect of administration route and dose escalation on intestinal concentrations of enro- and ciprofloxacin in broiler chickens

Mathias DevreeseGunther AntonissenSiegrid De BaerePatrick De BackerSiska Croubels

Effect of administration route and dose escalation on plasma and intestinal concentrations of enrofloxacin and ciprofloxacin in broiler chickens

Mathias DevreeseGunther AntonissenSiegrid De BaerePatrick De BackerSiska Croubels

A1 Journal Article in BMC VETERINARY RESEARCH

Efficacy of active carbon towards the absorption of deoxynivalenol in pigs

Mathias DevreeseGunther AntonissenPatrick De BackerSiska Croubels

A1 Journal Article in TOXINS

Intestinal concentrations of enrofloxacin after different dosage regimens in broiler chickens

Mathias DevreeseSiegrid De BaerePatrick De BackerSiska Croubels

Is it safe to focus exclusively on non-conjugated toxins?: toxicokinetics, bioavailability and in vivo hydrolysis of 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol in chickens and pigs

Nathan BroekaertMathias DevreeseThomas De MilSophie FraeymanSarah De SaegerSiska Croubels

Is it safe to focus exclusively on non-conjugated toxins?: toxicokinetics, oral bioavailability and in vivo hydrolysis of 3ADON and 15ADON in broiler chickens

Nathan BroekaertMathias DevreeseThomas De MilSophie FraeymanSarah De SaegerSiska Croubels

Pharmacokinetics of florfenicol in turkey poults

Anneleen WatteynMathias DevreeseSiegrid De BaerePatrick De BackerSiska Croubels

Pharmacokinetics of gamithromycin in turkey plasma and lung tissue

Anneleen WatteynMathias DevreeseSiegrid De BaereElke PlessersHeidi WynsPatrick De BackerSiska Croubels

Pilot toxicokinetic study and absolute oral bioavailability of the Fusarium mycotoxin enniatin B1 in pigs

Mathias DevreeseNathan BroekaertThomas De MilSophie FraeymanPatrick De BackerSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Pilot toxicokinetic study and absolute oral bioavailability of the Fusarium mycotoxin enniatin B1 in pigs

Mathias DevreesePatrick De BackerSiska Croubels

The effects of feed-borne Fusarium mycotoxins and glucomannan in turkey poults based on specific and non-specific parameters

Mathias DevreeseSiegrid De BaerePatrick De BackerSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

The impact of deoxynivalenol and fumonisins on mRNA expression of intestinal and hepatic biotransformation enzymes and drug transporter systems in broiler chickens

Gunther AntonissenMathias DevreeseAn MartelFilip Van ImmerseelFrank PasmansRichard DucatelleFreddy HaesebrouckPatrick De BackerSiska Croubels

Underestimation of deoxynivalenol exposure: fate of 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol in pigs

Nathan BroekaertMathias DevreeseThomas De MilSophie FraeymanGunther AntonissenSiska Croubels

Unravelling the disposition of the Alternaria mycotoxin tenuazonic acid: a toxicokinetic study in piglets

Sophie FraeymanMathias DevreeseNathan BroekaertThomas De MilSiska Croubels

Unravelling the disposition of the Alternaria mycotoxin tenuazonic acid: a toxicokinetic study in pigs and broiler chickens

Sophie FraeymanMathias DevreeseNathan BroekaertThomas De MilSiegrid De BaerePatrick De BackerSiska Croubels

2013

An in vitro model using the IPEC-J2 cell line for efficacy and drug interaction testing of mycotoxin detoxifying agents

Mathias DevreeseFrank PasmansPatrick De BackerSiska Croubels

A1 Journal Article in TOXICOLOGY IN VITRO

Characterization of in vitro intestinal absorption of veterinary drugs and coccidiostats in the presence of mycotoxin detoxifiers using a porcine intestinal epithelial cell line: outline of the study

Thomas De MilMathias DevreeseAnn OsselaereElin VerbruggheFrank PasmansPatrick De BackerSiska Croubels

Chronic exposure to the mycotoxin T-2 promotes oral absorption of chlortetracycline in pigs

Joline GoossensMathias DevreeseFrank PasmansAnn OsselaereSiegrid De BaereElin VerbruggheFreddy HaesebrouckPatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Determination of the Alternaria mycotoxins alternariol, alternariol monomethyl ether and tenuazonic acid in animal plasma using LC-MS/MS: preliminary results

Sophie FraeymanSiegrid De BaereMathias DevreeseNathan BroekaertPatrick De BackerSiska Croubels

Development and validation of an LC-MS/MS method for the determination of DON, 3A-DON and 15A-DON in chicken plasma

Nathan BroekaertMathias DevreeseThomas De MilAnn OsselaereSophie FraeymanSarah De SaegerSiska Croubels

Development of in vitro and in vivo models for testing the efficacy of mycotoxin detoxifying agents and their possible interaction with oral absorption of veterinary drugs

Mathias DevreeseSiska CroubelsPatrick De Backer

Different methods to counteract mycotoxin production and its impact on animal health

Mathias DevreesePatrick De BackerSiska Croubels

A1 Journal Article in VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT

Efficacy testing of a glucomannan mycotoxin binder towards the effects of feed-borne Fusarium mycotoxins in turkey poults based on specific and unspecific parameters

Mathias DevreeseSiegrid De BaerePatrick De BackerSiska Croubels

Impact of deoxynivalenol on oral bioavailability of fumonisins in broilers

Gunther AntonissenFilip Van ImmerseelFrank PasmansRichard DucatelleMathias DevreeseSiegrid De BaereFreddy HaesebrouckMia EeckhoutSarah De SaegerAn MartelSiska Croubels

Overview of the most important mycotoxins for the pig and poultry husbandry

Mathias DevreesePatrick De BackerSiska Croubels

A1 Journal Article in VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT

Quantitative determination of the Fusarium mycotoxins beauvericin, enniatin A, A1, B and B1 in pig plasma using high performance liquid chromatography-tandem mass spectrometry

Mathias DevreeseSiegrid De BaereAnn OsselaereThomas De MilNathan BroekaertPatrick De BackerSiska Croubels

Quantitative determination of the Fusarium mycotoxins beauvericin, enniatin A, A1, B and B1 in pig plasma using high performance liquid chromatography–tandem mass spectrometry

Mathias DevreeseSiegrid De BaerePatrick De BackerSiska Croubels

A1 Journal Article in TALANTA

The mycotoxin T-2 inhibits hepatic cytochrome P4503A activity in pigs

Joline GoossensLies De BockAnn OsselaereElin VerbruggheMathias DevreeseKoen BousseryJan Van BocxlaerPatrick De BackerSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Toxic effects of dietary exposure to T-2 toxin on intestinal and hepatic biotransformation enzymes and drug transporter systems in broiler chickens

Ann OsselaereShaoji LiLies De BockMathias DevreeseJoline GoossensVirginie VandenbrouckeJan Van BocxlaerKoen BousseryFrank PasmansAn MartelPatrick De BackerSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Toxicokinetic study and absolute oral bioavailability of deoxynivalenol, T-2 toxin and zearalenone in broiler chickens

Ann OsselaereMathias DevreeseJoline GoossensVirginie VandenbrouckeSiegrid De BaerePatrick De BackerSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

2012

Development of a liquid-chromatography tandem mass spectrometry and ultra-high-performance liquid chromatography high-resolution mass spectrometry method for the quantitative determination of zearalenone and its major metabolites in chicken and pig plasma

Siegrid De BaereAnn OsselaereMathias DevreeseLynn VanhaeckePatrick De BackerSiska Croubels

A1 Journal Article in ANALYTICA CHIMICA ACTA

Effect of T-2 toxin and a yeast-extract feed additive on the oral bioavailability of chlortetracycline in pigs

Joline GoossensFrank PasmansVirginie VandenbrouckeElin VerbruggheMathias DevreeseAnn OsselaereSiegrid De BaereFreddy HaesebrouckPatrick De BackerSiska Croubels

Efficacy and safety testing of mycotocoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines

Ann OsselaereMathias DevreeseAnneleen WatteynVirginie VandenbrouckeJoline GoossensMia EeckhoutSarah De SaegerSiegrid De BaerePatrick De BackerSiska Croubels

A1 Journal Article in POULTRY SCIENCE

In vitro and in vivo safety testing of mycotoxin detoxifying agents

Mathias DevreeseJoline GoossensAnn OsselaereVirginie VandenbrouckeSiegrid De BaerePatrick De BackerSiska Croubels

Influence of mycotoxins and a mycotoxin adsorbing agent on the oral bioavailability of commonly used antibiotics in pigs

Joline GoossensVirginie VandenbrouckeFrank PasmansSiegrid De BaereMathias DevreeseAnn OsselaereElin VerbruggheFreddy HaesebrouckSarah De SaegerMia EeckhoutKris AudenaertGeert HaesaertPatrick De BackerSiska Croubels

A1 Journal Article in TOXINS

Interaction between tylosin and bentonite clay from a pharmacokinetic perspective

Mathias DevreeseAnn OsselaereJoline GoossensVirginie VandenbrouckeSiegrid De BaerePatrick De BackerSiska Croubels

A1 Journal Article in VETERINARY JOURNAL

Interaction between tylosin and bentonite clay from a pharmacokinetic perspective

Mathias DevreeseAnn OsselaereJoline GoossensSiegrid De BaerePatrick De BackerSiska Croubels

Myth and reality of antimicrobial selection for livestock

Patrick De BackerSiska CroubelsMathias Devreese

New bolus models for in vivo efficacy testing of mycotoxin detoxifying agents in relation to EFSA guidelines, assessed using deoxynivalenol in broiler chickens

Mathias DevreeseAnn OsselaereJoline GoossensVirginie VandenbrouckeSiegrid De BaereMia EeckhoutPatrick De BackerSiska Croubels

A1 Journal Article in FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT

Pharmacokinetics and oral bioavailability of a new developed florfenicol drinking water formulation in veal calves, pigs and broilers

Siska CroubelsMathias DevreesePatrick De Backer

Quantitative determination of several toxicological important mycotoxins in pig plasma using multi-mycotoxin and analyte-specific high performance liquid chromatography–tandem mass spectrometric methods

Mathias DevreeseSiegrid De BaerePatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Quantitative determination of zearalenone and its major metabolites in animal plasma using LC-MS/MS and (U)HPLC-HR-MS detection

Siegrid De BaereAnn OsselaereMathias DevreesePatrick De BackerSiska Croubels

Toxic effects of dietary exposure to T-2 toxin on intestinal and hepatic CYP450 in broilers

Ann OsselaereShaoji LiLies De BockMathias DevreeseJoline GoossensVirginie VandenbrouckeFrank PasmansAn MartelPatrick De BackerSiska Croubels

Toxicokinetic study of deoxynivalenol, T-2 toxin and zearalenone in broiler chickens

Ann OsselaereMathias DevreeseJoline GoossensVirginie VandenbrouckeSiegrid De BaerePatrick De BackerSiska Croubels

2011

Chiral inversion of R(-) to S(+) ketoprofen in pigs

Eva NeirinckxSiska CroubelsJean Paul RemonMathias DevreesePatrick De BackerChris Vervaet

A1 Journal Article in VETERINARY JOURNAL

In vivo efficacy testing of mycoxotoxin binders in poultry by means of a toxicokinetic study according to EFSA guidelines

Mathias DevreeseAnn OsselaereSiegrid De BaerePatrick De BackerSiska Croubels

Nieuwe Europese (EFSA) richtlijnen om de efficaciteit van mycotoxine binders en modifiers aan te tonen

Mathias DevreeseAnn OsselaereJoline GoossensSiegrid De BaerePatrick De BackerSiska Croubels

Quantitative determination of T-2 toxin, HT-2 toxin, deoxynivalenol and deepoxy-deoxynivalenol in animal body fluids using LC-MS/MS detection

Siegrid De BaereJoline GoossensAnn OsselaereMathias DevreeseVirginie VandenbrouckePatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

2010

Quantitative determination of deoxynivalenol and related compounds in animal plasma using LC-MS/MS as part of a toxicokinetic study

Siegrid De BaereAnn OsselaereMathias DevreeseJoline GoossensVirginie VandenbrouckePatrick De BackerSiska Croubels