Research Explorer

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Researcher

Martine Neckebroek

Publications & Research Data

Awards & Distinctions

45 Results

2026

Pharmacokinetic modelling during long-term anesthesia : minimizing the gap

Amani Rayene YninebErhan YumukDana CopotGhada Ben OthmanHamed FarbakhshIsabela Roxana BirsRobain De KeyserSamir LadaciCristina MuresanMartine Neckebroek et al.

A1 Journal Article in JOURNAL OF ADVANCED RESEARCH

2025

Online and personalised control of the Depth of hypnosis during induction using fractional order PID

Marcian MihaiIsabela Roxana BirsErwin HegedusAmani Rayene YninebDana CopotRobain De KeyserClara IonescuSamir LadaciCristina I. MuresanMartine Neckebroek

A1 Journal Article in JOURNAL OF ADVANCED RESEARCH

2024

A compact fractional-order model for hypnosis in general anesthesia

Marcian MihaiIsabela Roxana BirsErwin HegedusDana CopotRobain De KeyserClara-Mihaela IonescuCristina MuresanMartine Neckebroek

A compartmental modelling framework for drug distribution in lean and obese patients in long-term general anesthesia

Amani Rayene YninebErhan YumukHamed FarbakhshGhada Ben OthmanDana CopotIsabela Roxana BirsCristina MuresanRobain De KeyserSamir LadaciClara-Mihaela Ionescu et al.

A fractional order impedance model for heterogeneous drug distribution in obese patients during general anesthesia

Amani Rayene YninebErhan YumukHamed FarbakhshGhada Ben OthmanDana CopotIsabela Roxana BirsCristina MuresanRobain De KeyserSamir LadaciClara-Mihaela Ionescu et al.

An adaptive control structure to mitigate lack of feasibility in systems with poor identifiability : case study on general anesthesia

Clara-Mihaela IonescuRobain De KeyserErhan YumukDana CopotMartine Neckebroek

Comparative analysis of pharmacokinetic-pharmacodynamic models for Propofol and Remifentanil using model predictive control

Amani Rayene YninebHamed FarbakhshGhada Ben OthmanYlva WahlquistIsabela Roxana BirsErhan YumukCristina MuresanRobain De KeyserDana CopotClara-Mihaela Ionescu et al.

Data-driven identification and comparison of full multivariable models for propofol-remifentanil induced general anesthesia

Erhan YumukDana CopotClara-Mihaela IonescuMartine Neckebroek

A1 Journal Article in JOURNAL OF PROCESS CONTROL

Development, validation, and comparison of a novel nociception/anti-nociception monitor against two commercial monitors in general anesthesia

Clara-Mihaela IonescuDana CopotErhan YumukRobain De KeyserCristina MuresanIsabela Roxana BirsGhada Ben OthmanHamed FarbakhshAmani Rayene YninebMartine Neckebroek

A1 Journal Article in SENSORS

Enhancing pain level assessment in post-surgery patients using artificial intelligence algorithms

Ghada Ben OthmanErhan YumukDana CopotAmani Rayene YninebHamed FarbakhshIsabela Roxana BirsCristina MuresanRobain De KeyserInes ChihiClara-Mihaela Ionescu et al.

First-hand design of a fractional order PID for controlling the depth of hypnosis during induction

Marcian MihaiIsabela Roxana BirsErwin HegedusDana CopotMartine NeckebroekRobain De KeyserClara-Mihaela IonescuCristina Muresan

Fractional-order modeling of the depth of analgesia as reference model for control purposes

Cristina MuresanErwin T. HegedüsMarcian D. MihaiGhada Ben OthmanIsabela Roxana BirsDana CopotEva Henrietta DulfRobain De KeyserClara-Mihaela IonescuMartine Neckebroek

A1 Journal Article in FRACTAL AND FRACTIONAL

Minimizing epistemic uncertainty for predictive control of general anesthesia

Clara-Mihaela IonescuRobain De KeyserDana CopotErhan YumukIsabela Roxana BirsErwin HegedusCristina MuresanMartine Neckebroek

Model extraction from clinical data subject to large uncertainties and poor identifiability

Clara-Mihaela IonescuRobain De KeyserDana CopotErhan YumukAmani Rayene YninebGhada Ben OthmanMartine Neckebroek

A2 Journal Article in IEEE CONTROL SYSTEMS LETTERS

PID control of data-driven patient response with fixed ratio co-administration of drugs for depth of hypnosis

Clara-Mihaela IonescuHamed FarbakhshCristina MuresanRobain De KeyserErhan YumukGhada Ben OthmanAmani Rayene YninebIsabela Roxana BirsDana CopotMartine Neckebroek

Selecting optimal Long Short-Term Memory (LSTM) architectures for online estimation of mean arterial pressure (MAP) in patients undergoing general anesthesia

Ghada Ben OthmanDana CopotErhan YumukMartine NeckebroekClara-Mihaela Ionescu

A1 Journal Article in APPLIED SCIENCES-BASEL

2023

Modeling and clinical investigation of bioimpedance for nociception and pain monitoring

Mihaela GhitaClara-Mihaela IonescuDana CopotMartine Neckebroek

Modelling of blood loss influence on propofol concentrations and anesthetic states in critical responses

Mihaela GhitaDana CopotIsabela Roxana BirsCristina MuresanMartine NeckebroekClara Ionescu

Parametric modeling and deep learning for enhancing pain assessment in postanesthesia

Mihaela GhitaIsabela Roxana BirsDana CopotCristina MuresanMartine NeckebroekClara-Mihaela Ionescu

A1 Journal Article in IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

2022

Artificial intelligence for pain classification with the non-invasive pain monitor Anspec-Pro

Tim De GrauweMihaela GhitaDana CopotClara IonescuMartine Neckebroek

A2 Journal Article in ACTA ANAESTHESIOLOGICA BELGICA

Uncertainty minimization and feasibility study for managing the complex and interacting anesthesia-hemodynamic system

Mihaela GhitaDana CopotIsabela Roxana BirsCristina MuresanRobain De KeyserMartine NeckebroekMichel StruysClara-Mihaela Ionescu

2021

An open source patient simulator for design and evaluation of computer based multiple drug dosing control for anesthetic and hemodynamic variables

Clara-Mihaela IonescuMartine NeckebroekMihaela GhitaDana Copot

A1 Journal Article in IEEE ACCESS

Modeling and analysis of monitored vs. self-reported postsurgical acute pain in a clinical trial

Mihaela GhitaNegin JalilianDana CopotClara-Mihaela IonescuMartine Neckebroek

Perspectives on hybrid control of the anesthesia-hemodynamic system in the pandemic context

Mihaela GhitaMartine NeckebroekDana CopotMaria GhitaAntonio VisioliClara-Mihaela Ionescu

Study of Bayesian-based closed-loop drug administration for propofol in anesthesia and sedation

Martine NeckebroekMichel StruysClara-Mihaela Ionescu

2020

Bioimpedance sensor and methodology for acute pain monitoring

Mihaela GhitaMartine NeckebroekJasper JuchemDana CopotChristina I. MuresanClara-Mihaela Ionescu

A1 Journal Article in SENSORS

Closed-loop control of anesthesia : survey on actual trends, challenges and perspectives

Mihaela GhitaMartine NeckebroekCristina MuresanDana Copot

A1 Journal Article in IEEE ACCESS

Influence of remifentanil on the control performance of the bispectral index controlled Bayesian-based closed-loop system for propofol administration

Martine NeckebroekJan-Willem H. L. BoldinghTom De SmetMichel Struys

A1 Journal Article in ANESTHESIA AND ANALGESIA

Pain detection with bioimpedance methodology from 3-dimensional exploration of nociception in a postoperative observational trial

Martine NeckebroekMihaela GhitaMaria GhitaDana CopotClara-Mihaela Ionescu

A1 Journal Article in JOURNAL OF CLINICAL MEDICINE

2019

A comparison of propofol-to-BIS post-operative intensive care sedation by means of target controlled infusion, Bayesian-based and predictive control methods : an observational, open-label pilot study

Martine NeckebroekClara-Mihaela IonescuK van AmsterdamT De SmetPATRICK DE BAETSJohan DecruyenaereRobain De KeyserMichel Struys

A1 Journal Article in JOURNAL OF CLINICAL MONITORING AND COMPUTING

Distributed model predictive control for hypnosis-hemodynamic maintenance during anesthesia

Dana CopotFrederik KusséMaria GhitaMihaela GhitaMartine NeckebroekAnca Maxim

Experimental measurement of pain stimulus effects in skin impedance

Maria GhitaMihaela GhitaDana CopotMartine NeckebroekClara-Mihaela Ionescu

Prospective observational cohort study on grading the severity of postoperative complications in global surgery research

T. E. F. AbbottK. E. GreavesAshok PatelT. AhmadJ. HaddowE. FutierM. BiaisK. SlimR. M. PearseJacques Abeloos et al.

A1 Journal Article in BRITISH JOURNAL OF SURGERY

2018

Anesthesia regulation : towards completing the picture

Clara-Mihaela IonescuDana CopotMartine NeckebroekCristina I Muresan

Hypnosis regulation in presence of saturation, surgical stimulation and additional bolus infusion

Dana CopotMartine NeckebroekClara-Mihaela Ionescu

The surgical safety checklist and patient outcomes after surgery : a prospective observational cohort study, systematic review and meta-analysis

TEF AbbottT AhmadMK PhullAJ FowlerR HewsonBM BiccardMS ChewM GilliesRM Pearsefor the International Surgical Outcomes Study (ISOS) group et al.

A1 Journal Article in BRITISH JOURNAL OF ANAESTHESIA

2017

Critical care admission following elective surgery was not associated with survival benefit : prospective analysis of data from 27 countries

Brennan C KahanDesponia KoulentiKostoula ArvanitiVanessa BeavisDouglas CampbellMatthew ChanRui MorenoRupert M Pearsethe International Surgical Outcomes Study (ISOS) groupPatrick Wouters et al.

A1 Journal Article in INTENSIVE CARE MEDICINE

In-hospital clinical outcomes after upper gastrointestinal surgery : data from an international observational study

T. AhmadR. A. BouwmanI. GrigorasC. AldecoaC. HoferA. HoeftP. HoltL. A. FleisherW. BuhreR. M. Pearse et al.

A1 Journal Article in EJSO

Incidence of severe critical events in paediatric anaesthesia (APRICOT) : a prospective multicentre observational study in 261 hospitals in Europe

Walid HabreNicola DismaKatalin ViragMartin JoehrBrigitte LevaNeil S MortonPetronella M VermeulenMarzena ZielinskaKrisztina BodaWalter Klimscha et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Use of failure-to-rescue to identify international variation in postoperative care in low-, middle- and high-income countries : a 7-day cohort study of elective surgery

T. AhmadR. A. BouwmanI. GrigorasC. AldecoaC. HoferA. HoeftP. HoltL. A. FleisherW. BuhreR. M. Pearse et al.

A1 Journal Article in BRITISH JOURNAL OF ANAESTHESIA

2016

Global patient outcomes after elective surgery : prospective cohort study in 27 low-, middle- and high-income countries : the International Surgical Outcomes Study group

T AhmadRA BouwmanI GrigorasC AldecoaC HoferA HoeftP HoltLA FleisherW BuhreRM Pearse et al.

A1 Journal Article in BRITISH JOURNAL OF ANAESTHESIA

2013

Automated drug delivery in anesthesia

Martine NeckebroekTom De SmetMichel Struys

A2 Journal Article in CURRENT ANESTHESIOLOGY REPORTS

2008

Accuracy and clinical feasibility of a new Bayesian-based closed-loop control system for propofol administration using the BIS as a controlled variable

Bjorn HeyseTom De SmetMartine NeckebroekKRISTOF VAN DEN HAUWESJOERT BONTEEric MortierMichel Struys

The accuracy and clinical feasibility of a new Bayesian-based closed-loop control system for propofol administration using the bispectral index as a controlled variable

Tom De SmetMichel StruysMartine NeckebroekKRISTOF VAN DEN HAUWESJOERT BONTEEric Mortier

A1 Journal Article in ANESTHESIA AND ANALGESIA

1998

Isolation of colonie mucosal lamina propria and intra-epithelial lymphocytes : mechanical versus enzymatic isolation

Nancy Van DammeDominique BaetenFilip De KeyserPieter DemetterDirk ElewautMartine NeckebroekHans Van VlierbergheHerman MielantsG. VerbruggenC. Cuvelier et al.

A2 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS