Research Explorer

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Researcher

Martijn Risseeuw

72 Results

2023

Targeted AURKA degradation : towards new therapeutic agents for neuroblastoma

Muhammad RishfiSimon KrolsFien MartensSarah-Lee BekaertEllen SandersAline EggermontFanny De VloedJoshua Robert GouldingMartijn RisseeuwJan Molenaar et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2022

Enrichment of a purine nucleoside analog library towards activity against Leishmania and Trypanosoma cruzi species

Cai LinSerge Van CalenberghMartijn Risseeuw

2021

2-((3,5-Dinitrobenzyl)thio)quinazolinones : potent antimycobacterial agents activated by deazaflavin (F420)-dependent nitroreductase (Ddn)

Yanlin JianHe Eun ForbesFabian HulpiaMartijn RisseeuwGuy CaljonHélène Munier-LehmannHelena I. M. BoshoffSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Analytical characterization of 'etonitazepyne', a new pyrrolidinyl‐containing 2‐benzylbenzimidazole opioid sold online

Peter BlanckaertMargot BalcaenCéline VanheeMartijn RisseeuwMichaël CanfynBart DesmedtSerge Van CalenberghEric Deconinck

A1 Journal Article in DRUG TESTING AND ANALYSIS

Discovery of a true bivalent dopamine D2 receptor agonist

Mingcheng QianAdrián RicarteElise WoutersJames A.R. DaltonMartijn RisseeuwJesús GiraldoSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

Filip MatthijssensNitesh D. SharmaMonique NysusChristian K. NicklHuining KangDominique R. PerezBéatrice LintermansWouter Van LoockeJuliette RoelsSofie Peirs et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Report on a new opioid NPS : chemical and in vitro functional characterization of a structural isomer of the MT-45 derivative diphenpipenol

Annelies CannaertFabian HulpiaMartijn RisseeuwKatleen Van UytfangheEric DeconinckSerge Van CalenberghPeter BlanckaertChristophe Stove

A1 Journal Article in JOURNAL OF ANALYTICAL TOXICOLOGY

Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors

Lijun SongRomain MerceronFabian HulpiaAinhoa LuciaBegona GraciaYanlin JianMartijn RisseeuwToon VerstraelenPaul CosJose A. Ainsa et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2020

1-(1-Arylethylpiperidin-4-yl)thymine analogs as antimycobacterial TMPK inhibitors

Yanlin JianFabian HulpiaMartijn RisseeuwHe Eun ForbesGuy CaljonHélène Munier-LehmannHelena I. M. BoshoffSerge Van Calenbergh

A1 Journal Article in MOLECULES

Design and synthesis of M. tuberculosis thymidylate kinase inhibitors towards active whole-cell antimycobacterial agents

Yanlin JianSerge Van CalenberghMartijn Risseeuw

Design, synthesis and characterization of a new series of fluorescent metabotropic glutamate receptor type 5 negative allosteric modulators

Víctor Fernández-DueñasMingcheng QianJosep ArgerichCarolina AmaralMartijn RisseeuwSerge Van CalenberghFrancisco Ciruela

A1 Journal Article in MOLECULES

Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents

Yanlin JianRomain MerceronSteven De MunckHe Eun ForbesFabian HulpiaMartijn RisseeuwKristof Van HeckeSavvas SavvidesHélène Munier-LehmannHelena I. M. Boshoff et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents

Yanlin JianFabian HulpiaMartijn RisseeuwHe Eun ForbesHélène Munier-LehmannGuy CaljonHelena I. M. BoshoffSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthetic rhamnose glycopolymer cell-surface receptor for endogenous antibody recruitment

Ruben De CoenLutz NuhnChamani PereraMaria Arista-RomeroMartijn RisseeuwAlec FreynRaffael NachbagauerLorenzo AlbertazziSerge Van CalenberghDavid A. Spiegel et al.

A1 Journal Article in BIOMACROMOLECULES

2019

Amino acid based prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents

Charlotte CourtensMartijn RisseeuwGuy CaljonLouis MaesAnandi MartinSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Double prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents

Charlotte CourtensMartijn RisseeuwGuy CaljonLouis MaesPaul CosAnandi MartinSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics

Aurélie CrabbéLisa OstynSorien StaelensCharlotte RigautsMartijn RisseeuwMaarten DhaenensSimon DaledHeleen Van AckerDieter DeforceSerge Van Calenbergh et al.

A1 Journal Article in PLOS PATHOGENS

Phosphonodiamidate prodrugs of N-alkoxy analogs of a fosmidomycin surrogate as antimalarial and antitubercular agents

Charlotte CourtensMartijn RisseeuwGuy CaljonPaul CosAnandi MartinSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents

Charlotte CourtensSerge Van CalenberghMartijn Risseeuw

2018

Acyloxybenzyl and alkoxyalkyl prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents

Charlotte CourtensMartijn RisseeuwGuy CaljonPaul CosSerge Van Calenbergh

A1 Journal Article in ACS MEDICINAL CHEMISTRY LETTERS

Design, synthesis, and biological evaluation of bivalent ligands targeting dopamine D2-like receptors and the μ-opioid receptor

Mingcheng QianLakshmi VasudevanJelle HuysentruytMartijn RisseeuwChristophe StovePatrick ML VanderheydenKathleen Van CraenenbroeckSerge Van Calenbergh

A1 Journal Article in CHEMMEDCHEM

Identification and characterization of 4-chloromethamphetamine (4-CMA) in seized ecstacy : a risk to public health

Peter BlanckaertStijn VanquekelbergheVera CoopmanMartijn RisseeuwSerge Van CalenberghJan Cordonnier

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL

Regioselective ring opening of 1,3-dioxane-type acetals in carbohydrates

Jonas JanssensMartijn RisseeuwJohan Van der EyckenSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Structure guided lead generation toward nonchiral M. tuberculosis thymidylate kinase inhibitors

Lijun SongRomain MerceronBegoña GraciaAinhoa Lucía QuintanaMartijn RisseeuwFabian HulpiaPaul CosJosé A AínsaHélène Munier-LehmannSavvas Savvides et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis toward bivalent ligands for the dopamine D2 and metabotropic glutamate 5 receptors

Mingcheng QianElise WoutersJames AR DaltonMartijn RisseeuwRené CransChristophe StoveJesús GiraldoKathleen Van CraenenbroeckSerge Van Calenbergh

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2017

Galactosylsphingamides : new α-GalCer analogues to probe the F’-pocket of CD1d

Joren GuillaumeJing WangJonas JanssensSoumya G RemeshMartijn RisseeuwTine DecruyMathy FroeyenDirk ElewautDirk M ZajoncSerge Van Calenbergh

A1 Journal Article in SCIENTIFIC REPORTS

Identification of a new tert -leucinate class synthetic cannabinoid in powder and 'spice-like' herbal incenses : methyl 2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethyl-butanoate (5F-MDMB-PICA)

Martijn RisseeuwPeter BlanckaertVera CoopmanStijn Van QuekelbergheSerge Van CalenberghJan Cordonnier

A1 Journal Article in FORENSIC SCIENCE INTERNATIONAL

Micellar paclitaxel-initiated RAFT polymer conjugates with acid-sensitive behavior

Benoit LouageMies J. van SteenbergenLutz NuhnMartijn RisseeuwIzet KaralicJohan WinneSerge Van CalenberghWim E HenninkBruno De Geest

A1 Journal Article in ACS MACRO LETTERS

Novel hamamelitannin analogues for the treatment of biofilm related MRSA infections : a scaffold hopping approach

Arno VermoteGilles BrackmanMartijn RisseeuwTom CoenyeSerge Van Calenbergh

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel potentiators for vancomycin in the treatment of biofilm-related MRSA infections via a mix and match approach

Arno VermoteGilles BrackmanMartijn RisseeuwDavie CappoenPaul CosTom CoenyeSerge Van Calenbergh

A1 Journal Article in ACS MEDICINAL CHEMISTRY LETTERS

2016

Design, synthesis and biological evaluation of novel hamamelitannin analogues as potentiators for vancomycin in the treatment of biofilm related Staphylococcus aureus infections

Arno VermoteGilles BrackmanMartijn RisseeuwTom CoenyeSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Don’t let the 'bad bugs' bite: hamamelitannin analogues as adjuvants for vancomycin in the treatment of MRSA biofilm infections

Arno VermoteGilles BrackmanMartijn RisseeuwKoen BreyneEvelyne MeyerP CosTom CoenyeSerge Van Calenbergh

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents

Lijun SongMartijn RisseeuwMatheus FroeyenIzet KaralicJan GoemanDavie CappoenJohan Van der EyckenPaul CosHélène Munier-LehmannSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Getting fosmidomycin inside mycobacterial cells : a prodrug approach

Charlotte CourtensMartijn RisseeuwSerge Van Calenbergh

Hamamelitannin analogues potentiate antibiotics in the fight against biofilm-related Staphylococcus aureus infections

Arno VermoteGilles BrackmanMartijn RisseeuwKristof Van HeckePaul CosEvelyne MeyerTom CoenyeSerge Van Calenbergh

Hamamelitannin analogues that modulate quorum sensing as potentiators of antibiotics against Staphylococcus aureus

Arno VermoteGilles BrackmanMartijn RisseeuwBieke VanhouttePaul CosKristof Van HeckeKoen BreyneEvelyne MeyerTom CoenyeSerge Van Calenbergh

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mucosal and blood-brain barrier transport kinetics of the plant N-alkylamide spilanthol using in vitro and in vivo models

Lieselotte VeryserLien TaevernierTanmayee JoshiPratima TatkeEvelien WynendaeleNathalie BrackeSofie StalmansKathelijne PeremansChristian BurvenichMartijn Risseeuw et al.

A1 Journal Article in BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE

Targeting an aromatic hotspot in Plasmodium falciparum 1-deoxy-d-xylulose-5-phosphate reductoisomerase with β-arylpropyl analogues of fosmidomycin

Sanjeewani SooriyaarachchiRené ChoforMartijn RisseeuwTerese BergforsJenny PouyezCynthia S DowdLouis MaesJohan WoutersT Alwyn JonesSerge Van Calenbergh et al.

A1 Journal Article in CHEMMEDCHEM

The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK)

Lijun SongMartijn RisseeuwFabian HulpiaHélène Munier-LehmannSerge Van Calenbergh

The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK)

Lijun SongMartijn RisseeuwFabian HulpiaRomain MerceronSavvas SavvidesHélène Munier-LehmannSerge Van Calenbergh

Transiently responsive block copolymer micelles based on N-(2-hydroxypropyl)methacrylamide engineered with hydrolyzable ethylcarbonate side chains

Sabah KasmiBenoit LouageLutz NuhnAlexandra Van DriesscheJan Van DeunIzet KaralicMartijn RisseeuwSerge Van CalenberghRichard HoogenboomRiet De Rycke et al.

A1 Journal Article in BIOMACROMOLECULES

Well-defined polymer-paclitaxel prodrugs by a grafting-from-drug approach

Benoit LouageLutz NuhnMartijn RisseeuwNane VanparijsRuben De CoenIzet KaralicSerge Van CalenberghBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Wohldefinierte polymere Paclitaxel-Prodrugs über eine Grafting-From-Methode ausgehend vom Arzneistoff

Benoit LouageLutz NuhnMartijn RisseeuwNane VanparijsRuben De CoenIzet KaralicSerge Van CalenberghBRUNO DE GEEST

A2 Journal Article in ANGEWANDTE CHEMIE

pH-Degradable mannosylated nanogels for dendritic cell targeting

Ruben De CoenNane VanparijsMartijn RisseeuwLien LybaertBenoit LouageStefaan De KokerVimal Kumar UdhayakumarJohan GrootenLeeanne TaylorNeil Ayres et al.

A1 Journal Article in BIOMACROMOLECULES

2015

Alternative reagents for methotrexate as immobilizing anchor moieties in the optimization of MASPIT: synthesis and biological evaluation

Dries De ClercqMartijn RisseeuwIzet KaralicAnne-Sophie De SmetDieter DefeverJan TavernierSam LievensSerge Van Calenbergh

A1 Journal Article in CHEMBIOCHEM

Hamametitannin based adjuvants in the Vancomycin treatment of Staphylococcus Aureus infections: from a natural product towards a more druglike lead compound

Martijn RisseeuwSerge Van Calenbergh

Small molecule fusion compounds for the optimization of MASPIT, a high throughput three-hybrid target deconvolution assay

Dries De ClercqSam LievensMartijn RisseeuwJan TavernierSerge Van Calenbergh

Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase

René ChoforSanjeewani SooriyaarachchiMartijn RisseeuwTerese BergforsJenny PouyezChinchu JohnyAmanda HaymondAnnelien EveraertCynthia S DowdLouis Maes et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of small-molecule fusion compounds for the optimization of MASPIT, a three-hybrid target deconvolution assay

Dries De ClercqSam LievensMartijn RisseeuwJan TavernierSerge Van Calenbergh

Synthesis and evaluation of β-substituted fosmidomycin analogues as inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase

René ChoforSanjeewani SooriyaarachchiMartijn RisseeuwTerese BergforsT Alwyn JonesSherry L MowbraySerge Van Calenbergh

The design and synthesis of inhibitors of Mycobacterium tuberculosis thymidylate kinase (MtTMPK)

Lijun SongMartijn RisseeuwFabian HulpiaHélène Munier-LehmannSerge Van Calenbergh

The influence of the acyl chain on the transdermal penetration-enhancing effect of synthetic phytoceramides

Lieselotte VeryserJente BoonenLien TaevernierJoren GuillaumeMartijn RisseeuwSyed Nisar Hussain ShahNathalie RocheSerge Van CalenberghBart De Spiegeleer

A1 Journal Article in SKIN PHARMACOLOGY AND PHYSIOLOGY

2014

An immunogen synthesis strategy for the development of specific anti-deoxynivalenol monoclonal antibodies

Melanie SandersYirong GuoAbhishek IyerYara Ruiz GarciaAnastasia GalvitaArne HeyerickDieter DeforceMartijn RisseeuwSerge Van CalenberghMarc Bracke et al.

A1 Journal Article in FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT

C5/C6-fused or C5/C6-separated uridine phosphonates

Lijun SongMartijn RisseeuwSerge Van Calenbergh

Design, synthesis and biological evaluation of tamoxifen-fusion compounds for the optimization of MASPIT, a three-hybrid target deconvolution assay

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Kinase Substrate Sensor (KISS), a mammalian in situ protein interaction sensor

Sam LievensSarah GerloIrma LemmensDries De ClercqMartijn RisseeuwNele VanderroostAnne-Sophie De SmetElien RuyssinckEric ChevetSerge Van Calenbergh et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Synthesis and biological evaluation of tamoxifen fusion compounds for the optimization of MASPIT, a three-hybrid target deconvolution assay

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Synthesis of extended uridine phosphonates derived from an allosteric P2Y2 receptor ligand

Lijun SongMartijn RisseeuwIzet KaralicMatthew O BarrettKyle A BrownT Kendall HardenSerge Van Calenbergh

A1 Journal Article in MOLECULES

Synthetic fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-D-xylulose 5-phosphate reductoisomerase or Plasmodium falciparum growth in vitro

René ChoforMartijn RisseeuwJenny PouyezChinchu JohnyJohan WoutersCynthia S DowdRobin D CouchSerge Van Calenbergh

A1 Journal Article in MOLECULES

2013

A 'clickable' MTX-reagent as a practical tool for profiling small molecule-intracellular target interactions via MASPIT

Martijn RisseeuwDries De ClercqSam LievensUlrik HillaertDavy SinnaeveFreya Van den BroeckJosé MartinsJan TavernierSerge Van Calenbergh

A1 Journal Article in CHEMMEDCHEM

Development of nanomedicines for the treatment of pulmonary biofilm infections: Insights from advanced fluorescence microscopy studies

Katrien ForierAnne-Sophie MessiaenMartijn RisseeuwSerge Van CalenberghHendrik DeschoutKoen RaemdonckHans NelisFabienne DanhierVéronique PréatFrans De Baets et al.

Syntheses of MTX-fusion compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors

Kiran TotiFrederick VerbekeMartijn RisseeuwVladimir FrecerHélène Munier-LehmannSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

2012

5,5'-Bis-substituted 2'-deoxyuridines as possible M. tuberculosis thymidylate kinase inhibitors

Kiran TotiFrederick VerbekeMartijn RisseeuwHélène Munier-LehmannSerge Van Calenbergh

Dancing on coke: smuggling cocaine dispersed in polyvinyl alcohol

Alexander LN van NuijsKristof E MaudensWilly LambertSerge Van CalenberghMartijn RisseeuwPaul Van HeeAdrian CovaciHugo Neels

A1 Journal Article in JOURNAL OF FORENSIC SCIENCES

MASPIT: a high throughput assay for the identification of cytosolic targets of small molecules : proof of principle

Martijn RisseeuwSam LievensDries De ClercqUlrik HillaertJan TavernierSerge Van Calenbergh

Penetration enhancing effect of phytoceramides

Lieselotte VeryserJente BoonenJoren GuillaumeMartijn RisseeuwSerge Van CalenberghBart De Spiegeleer

Syntheses of methotrexate-hybrid compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Syntheses of methotrexate-hybrid compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Syntheses of methotrexate-hybrid compounds for target profiling of small molecules with MASPIT

Dries De ClercqMartijn RisseeuwSam LievensJan TavernierSerge Van Calenbergh

Synthesis and evaluation of the quorum sensing inhibitory effect of substituted triazolyldihydrofuranones

Gilles BrackmanMartijn RisseeuwShari CelenPaul CosLouis MaesHans NelisSerge Van CalenberghTom Coenye

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of β-analogues of FR900098 as antimalarials

René ChoforMartijn RisseeuwThomas VerbrugghenSerge Van Calenbergh