Research Explorer

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Researcher

Marleen Van Troys

Awards & Distinctions

78 Results

2024

Exploiting the covalent triazolinedione and furan chemistry toolbox for labelling, crosslinking and degradation of proteins

Laure TackAnnemieke MadderJan GettemansMarleen Van TroysLaia Miret Casals

2023

Multisite assessment of reproducibility in high‐content cell migration imaging data

Jianjiang HuXavier Serra‐PicamalGert‐Jan BakkerMarleen Van TroysSabina Winograd‐KatzNil EgeXiaowei GongYuliia DidanInna GroshevaOmer Polansky et al.

A1 Journal Article in MOLECULAR SYSTEMS BIOLOGY

Proximity-induced ligation and one-pot macrocyclization of 1,4-diketone-tagged peptides derived from 2,5-disubstituted furans upon release from the solid support

Alex ManicardiAtiruj TheppawongMarleen Van TroysAnnemieke Madder

A1 Journal Article in ORGANIC LETTERS

2022

Innovative mouse models for the tumor suppressor activity of protocadherin-10 isoforms

Irene KleinbergerEllen SandersKatrien StaesMarleen Van TroysShinji HiranoTino HochepiedKelly LemeireLiesbet MartensChristophe AmpeFrans Van Roy

A1 Journal Article in BMC CANCER

2021

Cancer type-specific alterations in actin genes : worth a closer look?

Christophe AmpeLaura WitjesMarleen Van Troys

Bookchapter in Actin cytoskeleton in cancer progression and metastasis : part C

Furan warheads for covalent trapping of weak protein-protein interactions : cross-linking of thymosin β4 to actin

Laia Miret CasalsWillem VanneckeKurt HoogewijsGianluca Arauz-GarofaloMarina GayMireia Diaz-LoboMarta VilasecaChristophe AmpeMarleen Van TroysAnnemieke Madder

A1 Journal Article in CHEMICAL COMMUNICATIONS

Pseudomonas cyclic lipopeptides as cytotoxic agents for cancer cells : structure-function analysis

Yentl VerleysenJosé MartinsAnnemieke MadderMarleen Van Troys

2020

Dry heat induced whey protein-lactose conjugates largely improve the heat stability of O/W emulsions

Qurrotul A'yunPaolo DemicheliLorenz De NeveJianfeng WuMathieu BalcaenArima Diah SetiowatiJosé MartinsMarleen Van TroysPaul Van der Meeren

A1 Journal Article in INTERNATIONAL DAIRY JOURNAL

Heat stable whey protein stabilised O/W emulsions : optimisation of the whey protein concentrate dry heat incubation conditions

Qurrotul A'yunIstna Nafi AzzahraniArne HuystLorenz De NeveJosé MartinsMarleen Van TroysChusnul HidayatPaul Van der Meeren

A1 Journal Article in COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Maillard conjugation of whey protein isolate with water-soluble fraction of almond gum or flaxseed mucilage by dry heat treatment

Ali Sedaghat DoostMaryam Nikbakht NasrabadiSayed Amir Hossein GoliMarleen Van TroysPeter DubruelNympha De NevePaul Van der Meeren

A1 Journal Article in FOOD RESEARCH INTERNATIONAL

Prevalence of cytoplasmic actin mutations in diffuse large B-cell lymphoma and multiple myeloma : a functional assessment based on actin three-dimensional structures

Laura WitjesMarleen Van TroysBruno VerhasseltChristophe Ampe

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2019

A new evolutionary model for the vertebrate actin family including two novel groups

Laura WitjesMarleen Van TroysJoël VandekerckhoveKlaas VandepoeleChristophe Ampe

A1 Journal Article in MOLECULAR PHYLOGENETICS AND EVOLUTION

DoRes within CellMissy : dose-response analysis on cell migration and related data

Gwendolien SergeantLennart MartensMarleen Van TroysPaola Masuzzo

A1 Journal Article in BIOINFORMATICS

2018

Analysis of invasion dynamics of matrix-embedded cells in a multisample format

Marleen Van TroysPaola MasuzzoLynn HuyckKarima BakkaliDAVY WATERSCHOOTLennart MartensChristophe Ampe

Bookchapter in Cell migration : methods and protocols

Combination of EGFR inhibitor lapatinib and MET inhibitor foretinib inhibits migration of triple negative breast cancer cell lines

Aleksandra SimiczyjewEwelina DratkiewiczMarleen Van TroysChristophe AmpeIlona StyczeńDorota Nowak

A1 Journal Article in CANCERS

Concerted biophysical and biological evaluation of Pseudomonas lipopeptides as a premise to unlock their application potential

José MartinsYentl VerleysenBenjámin KovácsVic De RooChristophe AmpeAnnemieke MadderMarleen Van TroysNiels Geudens

Exploration of CLP antitumor potential

Yentl VerleysenMatthias De VleeschouwerNiels GeudensMarleen Van TroysChristophe AmpeAnnemieke MadderJosé Martins

Influence of CLP structure on antitumor potential

Yentl VerleysenMatthias De VleeschouwerNiels GeudensTim Van KersavondArend MandelingsMarleen Van TroysChristophe AmpeAnnemieke MadderJosé Martins

Surveillance of myelodysplastic syndrome via migration analyses of blood neutrophils : a potential prognostic tool

Marc SchusterMischa MoellerLea BornemannClara BessenCharlyn SobczakSaskia SchmitzLaura WitjesKatja KruithoffChristina KohnOlga Just et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2017

An end-to-end software solution for the analysis of high-throughput single-cell migration data

Paola MasuzzoLynn HuyckAleksandra SimiczyjewChristophe AmpeLennart MartensMarleen Van Troys

A1 Journal Article in SCIENTIFIC REPORTS

Cross-linking furan-modified kisspeptin-10 to the KISS receptor

Willem VanneckeChristophe AmpeMarleen Van TroysMassimiliano BeltramoAnnemieke Madder

A1 Journal Article in ACS CHEMICAL BIOLOGY

Expanding the interactome of TES by exploiting TES modules with different subcellular localizations

Stefano SalaMarleen Van TroysSandrine MedvesMarie CatillonEvy TimmermanAn StaesElisabeth Schaffner-ReckingerKris GevaertChristophe Ampe

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Inhibitory cortactin nanobodies delineate the role of NTA- and SH3-domain-specific functions during invadopodium formation and cancer cell invasion

Laurence BertierCiska BoucherieOlivier ZwaenepoelBerlinda VanlooMarleen Van TroysIsabel Van AudenhoveJan Gettemans

A1 Journal Article in FASEB JOURNAL

Structure-function study of the focal adhesion protein and tumour suppressor testin : determination of module-specific interactomes and expansion of its conformational repertoire

Stefano SalaChristophe AmpeMarleen Van Troys

The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions

Stefano SalaMarie CatillonErmin HadzicElisabeth Schaffner-ReckingerMarleen Van TroysChristophe Ampe

A1 Journal Article in PLOS ONE

2016

An actomyosin-like cytoskeleton in the cyanobiont (Nosctoc sp.) of Peltigera canina

Eva-María DiazChristophe AmpeMarleen Van TroysMiguel Vicente-ManzanaresMaría-Estrella LegazCarlos Vicente

A1 Journal Article in PHYTOCHEMISTRY LETTERS

Furan-based crosslinking in situ : seizing ligand-receptor complexes in the act

Willem VanneckeChristophe AmpeMarleen Van TroysAnnemieke Madder

Mammalian actins : isoform-specific functions and diseases

Christophe AmpeMarleen Van Troys

Bookchapter in The actin cytoskeleton

Quantitative evaluation of single cell spread on collagen matrices

Elly De VlieghereGlenn WagemansS De BackerZuzanna DrebertJoke TommeleinQuentin RousseauB WeynMarleen Van TroysMarc BrackeOlivier De Wever

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

Taking aim at moving targets in computational cell migration

Paola MasuzzoMarleen Van TroysChristophe AmpeLennart Martens

A1 Journal Article in TRENDS IN CELL BIOLOGY

The unfolded protein response underlies microenvironmental stress-induced phenotype switching leading to stemness and chemoresistance in human hepatocellular carcinoma

Yves-Paul VandewynckelO GovaereAster VandierendonckDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsSarah RaevensXavier VerhelstChristophe Van Steenkiste et al.

Towards an open data exchange ecosystem : forging a new path for cell migration data analysis and mining

Paola MasuzzoChristophe AmpeLennart MartensMarleen Van Troys

2015

Active invadopodia of mesenchymally migrating cancer cells contain both β and γ cytoplasmic actin isoforms

Aleksandra SimiczyjewAntonina Joanna MazurChristophe AmpeMaria Malicka-BłaszkiewiczMarleen Van TroysDorota Nowak

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

An open data ecosystem for cell migration research

Paola MasuzzoLennart Martensthe 2014 Cell Migration workshop participantsChristophe AmpeOlivier De WeverMarleen Van Troys

Editorial material

Delineating the Tes interaction site in zyxin and studying cellular effects of its disruption

Ermin HadzicMarle CatillonAllaksandr HalavatyiSandrine MedvesMarleen Van TroysMichèle MoesMichelle A BairdMichael W DavidsonElisabeth Schaffner-ReckingerChristophe Ampe et al.

A1 Journal Article in PLOS ONE

Pseudorabies virus US3 triggers RhoA phosphorylation to reorganize the actin cytoskeleton

Thary JacobCeline Van den BroekeCliff Van WaesbergheMarleen Van TroysHerman Favoreel

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsXavier VerhelstAnja Van den BusscheSarah RaevensChristophe Van SteenkisteMarleen Van Troys et al.

A1 Journal Article in ONCOTARGET

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsXavier VerhelstA Van den BusscheSarah RaevensChristophe Van SteenkisteMarleen Van Troys et al.

2014

β-Agonists selectively modulate proinflammatory gene expression in skeletal muscle cells via non-canonical nuclear crosstalk mechanisms

Krzysztof KolmusMarleen Van TroysKarlien Van WesemaelChristophe AmpeGuy HaegemanJan TavernierSarah Gerlo

A1 Journal Article in PLOS ONE

2013

A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis

Katrien Van ImpeJonas BethuyneSteven CoolFrancis ImpensDavid Ruano-GallegoOlivier De WeverBerlinda VanlooMarleen Van TroysKathleen LambeinCiska Boucherie et al.

A1 Journal Article in BREAST CANCER RESEARCH

Alphaherpesviral US3 kinase induces cofilin dephosphorylation to reorganize the actin cytoskeleton

Thary JacobCeline Van den BroekeMarleen Van TroysDAVY WATERSCHOOTChristophe AmpeHerman Favoreel

A1 Journal Article in JOURNAL OF VIROLOGY

CellMissy: a tool for management, storage and analysis of cell migration data produced in wound healing-like assays

Paola MasuzzoNiels HulstaertLynn HuyckChristophe AmpeMarleen Van TroysLennart Martens

A1 Journal Article in BIOINFORMATICS

p210bcr-abl induces amoeboid motility by recruiting ADF/destrin through RhoA/ROCK1

Tristan RochelleThomas DaubonMarleen Van TroysThomas HarnoisDAVY WATERSCHOOTChristophe AmpeLydia RoyNicolas BourmeysterBruno Constantin

A1 Journal Article in FASEB JOURNAL

β-actin knock-out mouse embryonic fibroblasts show increased expression of LIM-, CH-, EFh-domain containing proteins with predicted common upstream regulators

Christophe AmpeJelle LibbrechtMarleen Van Troys

A1 Journal Article in CYTOSKELETON

2012

Phosphosite conservation in single domain orthologs versus paralogs: a way to combine differential regulation with redundant core functions

Lynn HuyckMarleen Van TroysChristophe Ampe

A1 Journal Article in FEBS LETTERS

The US3 kinase of pseudorabies virus leads to activation of the actin regulator cofilin to induce actin cytoskeleton changes

Thary JacobCeline Van den BroekeMarleen Van TroysDAVY WATERSCHOOTChristophe AmpeHerman Favoreel

The XTT cell proliferation assay applied to cell layers embedded in three-dimensional matrix

Lynn HuyckChristophe AmpeMarleen Van Troys

A1 Journal Article in ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

2011

A QUICK screen for Lrrk2 interaction partners: leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics

Andrea MeixnerKarsten BoldtMarleen Van TroysManor AskenaziChrsitian J GloecknerMatthias BauerJarrod A MartoChristophe AmpeNorbert KinklMarius Ueffing

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

2009

An integrative simulation model linking major biochemical reactions of actin-polymerization to structural properties of actin filaments

Aliaksandr A. HalavatyiPetr V. NazarovSandrine MedvesMarleen Van TroysChristophe AmpeMikalai YatskouEvelyne Friederich

A1 Journal Article in BIOPHYSICAL CHEMISTRY

The Mouse Thymosin Beta15 Gene Family Displays Unique Complexity and Encodes A Functional Thymosin Repeat

Stien DhaeseKlaas VandepoeleDAVY WATERSCHOOTBerlinda VanlooJoël VandekerckhoveChristophe AmpeMarleen Van Troys

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering

Shirley LeymanMazen SidaniLaila RitsmaDAVY WATERSCHOOTRobert EddyDaisy DewitteOlivier DebeirChristine DecaesteckerJoël VandekerckhoveJacco van Rheenen et al.

A1 Journal Article in MOLECULAR BIOLOGY OF THE CELL

2008

Ins and outs of ADF/cofilin activity and regulation

Marleen Van TroysLynn HuyckShirley LeymanStien DhaeseJoël VandekerckhoveChristophe Ampe

A1 Journal Article in EUROPEAN JOURNAL OF CELL BIOLOGY

Listeria comet tails: the actin-based motility machinery at work

Anja LambrechtsKris GevaertP COSSARTJoël VandekerckhoveMarleen Van Troys

A1 Journal Article in TRENDS IN CELL BIOLOGY

Predicting the effect of a point mutation on a protein fold: The villin and advillin headpieces and their Pro62Ala mutants

S PIANAA LAIOF MARINELLIMarleen Van TroysDavid BourryChristophe AmpeJosé Martins

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

The actin propulsive machinery: The proteome of Listeria monocytogenes tails

Marleen Van TroysAnja LambrechtsVERA DAVIDHans DemolMagda PuypeJ PIZARRO-CERDAKris GevaertP COSSARTJoël Vandekerckhove

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

2007

Atomistic Prediction of the structure of the Advillin headpiece and its Pro62Ala mutant

José MartinsA LAIOF MARINELLIMarleen Van TroysChristophe AmpeDavid BourryS PIANO

Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta 15

Stien DhaeseVeronique JonckheereMarc GoethalsD WALTREGNYJoël VandekerckhoveChristophe AmpeMarleen Van Troys

A1 Journal Article in FEBS LETTERS

Structural and Functional Implicationof the PXWK-motif in HeadPiece Domains

David BourryW VERMEULENMarleen Van TroysJoël VandekerckhoveChristophe AmpeJosé Martins

Structural and Functional Implications of the PXWK-motif in HeadPiece Domains

David BourryW VERMEULENMarleen Van TroysJoël VandekerckhoveChristophe AmpeJosé Martins

Structure-function relationship of actin binding modules studied by NMR

David BourryMarleen Van TroysM DUMOULINA MATAGNEChristophe AmpeJosé Martins

The LIM domains of WLIM1 define a new class of actin bundling modules

C THOMASF MOREAUM DIETERLEC HOFFMANNS GATTIC HOFMANNMarleen Van TroysChristophe AmpeA STEINMETZ

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2006

Identification of the PXW sequence as a structural gatekeeper of the headpiece C-terminal subdomain fold

Wim VermeulenMarleen Van TroysDavid BourryDaisy DewitteStefaan RossenuMarc GoethalsFrans BorremansJoël VandekerckhoveJosé MartinsChristophe Ampe

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Multirepeat beta-thymosins

Marleen Van TroysStien DhaeseJoël VandekerckhoveChristophe Ampe

Bookchapter in Actin-Monomer-Binding Proteins

THE ROLE OF PRO62 AND TRP64 FOR HEADPIECE STABILITY

David BourryW VERMEULENMarleen Van TroysD DEWITTES ROSSENUMarc GoethalsFrans BorremansJoël VandekerckhoveJosé MartinsChristophe Ampe

The Role of Pro62 and Trp64 for HeadPiece Stability

David BourryW VERMEULENMarleen Van TroysMarc GoethalsFrans BorremansJoël VandekerckhoveChristophe AmpeJosé Martins

Tobacco WLIM1 is a novel F-actin binding protein involved in actin cytoskeleton remodeling

Clément ThomasCéline HoffmannMonika DieterleMarleen Van TroysChristophe AmpeAndré Steinmetz

A1 Journal Article in PLANT CELL

2005

Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement

A GIGANTIJ PLASTINOB JANJIMarleen Van TroysD LENTZChristophe AmpeC SYKESE FRIEDERICH

A1 Journal Article in JOURNAL OF CELL SCIENCE

2004

Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements

Wim VermeulenPeter VanhaesebrouckMarleen Van TroysM VERSCHUERENFranky FantMarc GoethalsChristophe AmpeJosé MartinsFrans Borremans

A1 Journal Article in PROTEIN SCIENCE

TetraThymosin beta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats

Marleen Van TroysK ONODaisy DewitteVeronique JonckheereNatalie De RuyckJoël VandekerckhoveS ONOChristophe Ampe

A1 Journal Article in MOLECULAR BIOLOGY OF THE CELL

The actin cytoskeleton in normal and pathological cell motility

Anja LambrechtsMarleen Van TroysChristophe Ampe

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

2003

A phage display-based method for determination of relative affinities of mutants - Application to the actin-binding motifs in thymosin beta 4 and the villin headpiece

S ROSSENUShirley LeymanDaisy DewitteDanny PeelaersVeronique JonckheereMarleen Van TroysJoël VandekerckhoveChristophe Ampe

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2000

Structural requirements for thymosin beta 4 in its contact with actin - An NMR-analysis of thymosin beta 4 mutants in solution and correlation with their biological activity.

C SIMENELMarleen Van TroysJoël VandekerckhoveChristophe AmpeM DELEPIERRE

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

The competitive interaction of actin and PIP2 with actophorin is based on overlapping target sites : design of a gain-of-function mutant

Marleen Van TroysDaisy DewitteJean-Luc VerscheldeMarc GoethalsJoël VandekerckhoveChristophe Ampe

A1 Journal Article in BIOCHEMISTRY

1999

Structural modules in actin binding proteins: towards a new classification.

Marleen Van TroysJoël VandekerckhoveChristophe Ampe

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

1998

Structuur-functie analyse van thymosine ßb4, cofiline en gelsoline, drie actinebindende eiwitten met een sleutelrol in microfilamentendynamica

Marleen Van TroysJ. VandekerckhoveC. Ampe

1997

Analogous F-actin binding by cofilin and gelsolin segment 2 substantiates their structural relationship

Marleen Van TroysDaisy DewitteJean-Luc VerscheldeMark GoethalsJoël VandekerckhoveChristophe Ampe

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1996

Evidence for an actin binding helix in gelsolin segment 2; Have homologous sequences in segments 1 and 2 of gelsolin evolved to divergent actin binding functions?

Marleen Van TroysD DEWITTEM GOETHALSJoël VandekerckhoveChristophe Ampe

A1 Journal Article in FEBS LETTERS

T beta(4) is not a simple G-actin sequestering protein and interacts with F-actin at high concentration

MF CarlierD DidryI ErkJ LepaultMarleen Van TroysJoël VandekerckhoveI PerelroizenH YinYK DoiD Pantaloni

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY