Research Explorer

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Researcher

Marion Pardons

Awards & Distinctions

23 Results

2025

Blood and tissue HIV-1 reservoirs display plasticity and lack of compartmentalization in virally suppressed people

Marion PardonsLaurens LambrechtsYtse NoppeLiesbet TermoteSofie De BraekeleerJerel VegaEllen Van GulckSarah GerloLinos Vandekerckhove

A1 Journal Article in NATURE COMMUNICATIONS

2024

A truncated HIV Tat demonstrates potent and specific latency reversal activity( vol 67 , e00417-23 , 2023)

Ellen Van GulckMarion PardonsErik NijsNick VerheyenKoen DockxChristel van den EyndeEmilie BattivelliJerel VegaEric FlorenceBrigitte Autran et al.

Longitudinal analysis in early treated individuals reveals alteration in the HIV-1 integration site landscape and composition of the inducible reservoir

Tine StruyveMarion PardonsJozefien De ClercqLiesbet TermoteLaurens LambrechtsYtse NoppeM. LichterfeldSofie RutsaertLinos Vandekerckhove

2023

A truncated HIV Tat demonstrates potent and specific latency reversal activity

Ellen Van GulckMarion PardonsErik NijsNick VerheyenKoen DockxChristel van den EyndeEmilie BattivelliJerel VegaEric FlorenceBrigitte Autran et al.

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HIV-PULSE : a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization

Laurens LambrechtsNoah BonineRita VerstraetenMarion PardonsYtse NoppeSofie RutsaertFilip Van NieuwerburghWim Van CriekingeBasiel ColeLinos Vandekerckhove

A1 Journal Article in NUCLEIC ACIDS RESEARCH

HIV-PULSE : a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization

Laurens LambrechtsNoah BonineRita VerstraetenMarion PardonsYtse NoppeSofie RutsaertFilip Van NieuwerburghWim Van CriekingeBasiel ColeLinos Vandekerckhove

In-depth assessment of the HIV-1 viral reservoir in early treated individuals

Tine StruyveMarion PardonsLiesbet TermoteJozefien De ClercqLaurens LambrechtsJerel VegaDaniel BodenMathias LichterfeldSofie RutsaertLinos Vandekerckhove

Linking inducible HIV-1 reservoir to rebound after treatment interruption

Laurens LambrechtsYtse NoppeMarion PardonsBasiel ColeSofie RutsaertStéphane De WitGuido VanhamEric FlorenceLinos Vandekerckhove

Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir

Marion PardonsBasiel ColeLaurens LambrechtsWillem van SnippenbergSofie RutsaertYtse NoppeNele De LangheAnnemieke DhondtJerel VegaFilmon Eyassu et al.

A1 Journal Article in NATURE COMMUNICATIONS

The Rainbow 5-plex digital PCR assay improves quantification of the viral reservoir resulting in a better understanding of the HIV-1 proviral landscape

Mareva DelporteLaurens LambrechtsMarion PardonsSofie De BraekeleerEvy BlommeSofie RutsaertWim TrypsteenLinos Vandekerckhove

2022

Characterization of the HIV-1 viral reservoir in subtype B early treated individuals

Tine StruyveMarion PardonsLiesbet TermoteJozefien De ClercqLaurens LambrechtsJerel VegaDaniel BodenMathias LichterfeldSofie RutsaertLinos Vandekerckhove

First-in-human immunoPET imaging of HIV-1 infection using 89 Zr-labeled VRC01 broadly neutralizing antibody

DR Beckford-VeraRR FlavellY SeoE Martinez-OrtizM AslamC ThanhE FehrmanMarion PardonsS KumarAN Deitchman et al.

A1 Journal Article in NATURE COMMUNICATIONS

Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

Laurens LambrechtsRita VerstraetenNoah BonineYtse NoppeSofie RutsaertMarion PardonsBasiel ColeLinos Vandekerckhove

Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

Laurens LambrechtsRita VerstraetenNoah BonineYtse NoppeSofie RutsaertMarion PardonsBasiel ColeLinos Vandekerckhove

Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

Laurens LambrechtsRita VerstraetenNoah BonineYtse NoppeMarion PardonsBasiel ColeLinos Vandekerckhove

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

Cedric BosteelsKarel Van DammeElisabeth De LeeuwJozefien DeclercqBastiaan MaesVictor BosteelsLevi HosteLeslie NaesensNincy DebeufJulie Deckers et al.

A1 Journal Article in CELL REPORTS MEDICINE

The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription

AA OkoyeR FromentinH TakataJH BrehmY FukazawaB RandallMarion PardonsV TaiJ TangJ Smedley et al.

A1 Journal Article in PLOS PATHOGENS

2021

Development of novel assays to characterize the size and dynamics of the HIV-1 viral reservoir

Basiel ColeLinos VandekerckhoveMarion Pardons

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

Basiel ColeLaurens LambrechtsPierre GantnerYtse NoppeNoah BonineWojciech WitkowskiLennie ChenSarah PalmerJames I. MullinsNicolas Chomont et al.

A1 Journal Article in NATURE COMMUNICATIONS

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of residual viremia and rebound viruses

Basiel ColeLaurens LambrechtsPierre GantnerYtse NoppeNoah BonineLennie ChenSarah PalmerJames MullinsNicolas ChomontMarion Pardons et al.

2020

Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART

P GantnerA PagliuzzaMarion PardonsM RamgopalJP RoutyR FromentinN Chomont

A1 Journal Article in NATURE COMMUNICATIONS

2019

Latency-reversing agents induce differential responses in distinct memory CD4 T cell subsets in individuals on antiretroviral therapy

Marion PardonsR FromentinA PagliuzzaJP RoutyN Chomont

A1 Journal Article in CELL REPORTS

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection

Marion PardonsAE BaxterM MassanellaA PagliuzzaR FromentinC DufourL LeyreJP RoutyDE KaufmannN Chomont

A1 Journal Article in PLOS PATHOGENS