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Researcher
Marijke De Bock
Profile
Projects
Publications
Activities
Awards & Distinctions
58
Results
2022
Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis
Marijke De Bock
Maarten De Smet
Stijn Verwaerde
Hanane Tahiri
Steffi Schumacher
Valérie Van Haver
Katja Witschas
Christian Steinhäuser
Nathalie Rouach
Roosmarijn Vandenbroucke
et al.
A1
Journal Article
in
JCI INSIGHT
2022
2020
Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells
Delphine Hoorelbeke
Elke Decrock
Maarten De Smet
Marijke De Bock
Benedicte Descamps
Valérie Van Haver
Tinneke Delvaeye
Dmitri Krysko
Christian Vanhove
Geert Bultynck
et al.
A1
Journal Article
in
CELL DEATH & DISEASE
2020
2019
Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke
Moises Freitas-Andrade
Nan Wang
John F Bechberger
Marijke De Bock
Paul D Lampe
Luc Leybaert
Christian C Naus
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2019
2018
Calcium, a pivotal player in photodynamic therapy?
Delphine Hoorelbeke
Elke Decrock
Valérie Van Haver
Marijke De Bock
Luc Leybaert
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
2018
2017
At the cross-point of connexins, calcium, and ATP : blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries
Mélissa Bol
Nan Wang
Marijke De Bock
Benjamin Wacquier
Elke Decrock
Ashish Kumar Gadicherla
Katrijn Decaluwe
Bert Vanheel
Harold Victor Maria van Rijen
Dmitri Krysko
et al.
A1
Journal Article
in
CARDIOVASCULAR RESEARCH
2017
Calcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?
Elke Decrock
Delphine Hoorelbeke
Raghda Ramadan
Tinneke Delvaeye
Marijke De Bock
Nan Wang
Dmitri Krysko
Sarah Baatout
Geert Bultynck
An Aerts
et al.
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
2017
Connexin channels at the glio-vascular interface : gatekeepers of the brain
Marijke De Bock
Luc Leybaert
Christian Giaume
A1
Journal Article
in
NEUROCHEMICAL RESEARCH
2017
Pannexin1 as mediator of inflammation and cell death
Sara Crespo Yanguas
Joost Willebrords
Scott R Johnstone
Michaël Maes
Elke Decrock
Marijke De Bock
Luc Leybaert
Bruno Cogliati
Mathieu Vinken
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
2017
2016
Electroporation loading and dye transfer : a safe and robust method to probe gap junctional coupling
Elke Decrock
Marijke De Bock
Diego De Baere
Delphine Hoorelbeke
Nan Wang
Luc Leybaert
Bookchapter
in
Gap junction protocols
2016
Into rather unexplored terrain : transcellular transport across the blood-brain barrier
Marijke De Bock
Valérie Van Haver
Roosmarijn Vandenbroucke
Elke Decrock
Nan Wang
Luc Leybaert
A1
Journal Article
in
GLIA
2016
2015
Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?
Elke Decrock
Marijke De Bock
Nan Wang
Geert Bultynck
Christian Giaume
Christian C Naus
Colin R Green
Luc Leybaert
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2015
Electroporation loading and flash photolysis to investigate intra- and intercellular Ca2+ signaling
Elke Decrock
Marijke De Bock
Nan Wang
Mélissa Bol
Ashish Kumar Gadicherla
Luc Leybaert
A2
Journal Article
in
COLD SPRING HARBOR PROTOCOLS
2015
Electroporation loading of membrane-impermeable molecules to investigate intra- and intercellular Ca2+ signaling
Elke Decrock
Marijke De Bock
Nan Wang
Mélissa Bol
Ashish Kumar Gadicherla
Luc Leybaert
A2
Journal Article
in
COLD SPRING HARBOR PROTOCOLS
2015
Flash photolysis of caged IP3 to trigger intercellular Ca2+ waves
Elke Decrock
Marijke De Bock
Nan Wang
Mélissa Bol
Ashish Kumar Gadicherla
Luc Leybaert
A2
Journal Article
in
COLD SPRING HARBOR PROTOCOLS
2015
Fluoxetine suppresses calcium signaling in human T lymphocytes through depletion of intracellular calcium stores
Veerle Gobin
Marijke De Bock
Bart Broeckx
Maja Kiselinova
Ward De Spiegelaere
Linos Vandekerckhove
Katleen Van Steendam
Luc Leybaert
Dieter Deforce
A1
Journal Article
in
CELL CALCIUM
2015
Intracellular cleavage of the Cx43 C-terminal domain by matrix-metalloproteases : a novel contributor to inflammation?
Marijke De Bock
Nan Wang
Elke Decrock
Geert Bultynck
Luc Leybaert
A1
Journal Article
in
MEDIATORS OF INFLAMMATION
2015
2014
A new angle on blood–CNS interfaces: a role for connexins?
Marijke De Bock
Roosmarijn Vandenbroucke
Elke Decrock
Maxime Culot
Romeo Cecchelli
Luc Leybaert
A1
Journal Article
in
FEBS LETTERS
2014
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes
Verónica Abudara
John Bechberger
Moises Freitas-Andrade
Marijke De Bock
Nan Wang
Geert Bultynck
Christian C Naus
Luc Leybaert
Christian Giaume
A1
Journal Article
in
FRONTIERS IN CELLULAR NEUROSCIENCE
2014
The dual face of connexin-based astroglial Ca2+ communication: a key player in brain physiology and a prime target in pathology
Marijke De Bock
Elke Decrock
Nan Wang
Mélissa Bol
Mathieu Vinken
Geert Bultynck
Luc Leybaert
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
2014
2013
Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening
Nan Wang
Marijke De Bock
Elke Decrock
Mélissa Bol
Ashish Kumar Gadicherla
Geert Bultynck
Luc Leybaert
A1
Journal Article
in
NEUROPHARMACOLOGY
2013
Endothelial calcium dynamics, connexin channels and blood-brain barrier function
Marijke De Bock
Nan Wang
Elke Decrock
Mélissa Bol
Ashish Kumar Gadicherla
Maxime Culot
Romeo Cecchelli
Geert Bultynck
Luc Leybaert
A1
Journal Article
in
PROGRESS IN NEUROBIOLOGY
2013
IP₃, a small molecule with a powerful message
Elke Decrock
Marijke De Bock
Nan Wang
Ashish Kumar Gadicherla
Mélissa Bol
Tinneke Delvaeye
Peter Vandenabeele
Mathieu Vinken
Geert Bultynck
Dmitri Krysko
et al.
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
2013
Inhibiting connexin channels protects against cryopreservation-induced cell death in human blood vessels
Mélissa Bol
Caroline Van Geyt
Saskia Baert
Elke Decrock
Nan Wang
Marijke De Bock
Ashish Kumar Gadicherla
Caren Randon
WH Evans
Hilde Beele
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
2013
Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system?
Marijke De Bock
Marianne Kerrebrouck
Nan Wang
Luc Leybaert
A1
Journal Article
in
FRONTIERS IN PHARMACOLOGY
2013
Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: gap junctions versus hemichannels
Jegan Iyyathurai
Catheleyne D'hondt
Nan Wang
Marijke De Bock
Bernard Himpens
Mauricio A Retamal
Jimmy Stehberg
Luc Leybaert
Geert Bultynck
A1
Journal Article
in
NEUROPHARMACOLOGY
2013
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury
Nan Wang
Elke De Vuyst
Raf Ponsaerts
Kerstin Boengler
Nicolás Palacios-Prado
Joris Wauman
Charles P Lai
Marijke De Bock
Elke Decrock
Mélissa Bol
et al.
A1
Journal Article
in
BASIC RESEARCH IN CARDIOLOGY
2013
2012
Connexin 43 hemichannels contribute to cytoplasmic Ca2+ oscillations by providing a bimodal Ca2+-dependent Ca2+ entry pathway
Marijke De Bock
Nan Wang
Mélissa Bol
Elke Decrock
Raf Ponsaerts
Geert Bultynck
Gnenviève Dupont
Luc Leybaert
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2012
Connexin channels provide a target to manipulate calcium dynamics and blood brain barrier permeability
Marijke De Bock
Luc Leybaert
Dissertation
2012
Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation
Nan Wang
Marijke De Bock
Gudrun Antoons
Ashish Kumar Gadicherla
Mélissa Bol
Elke Decrock
William Howard Evans
Karin R Sipido
Feliksas F Bukauskas
Luc Leybaert
A1
Journal Article
in
BASIC RESEARCH IN CARDIOLOGY
2012
Is chronic exposure of the blood-brain barrier to relatively low L-β-ODAP concentrations a possible entry point of L-β-ODAP into the central nervous system?
Marijke Van Moorhem
M Culot
M Kuntz
Elke Decrock
Marijke De Bock
Nan Wang
Katharina D'Herde
Fernand Lambein
Luc Leybaert
C3
Conference
2012
Low extracellular Ca2+ conditions induce an increase in brain endothelial permeability that involves intercellular Ca2+ waves
Marijke De Bock
Maxime Culot
Nan Wang
Anaelle da Costa
Elke Decrock
Mélissa Bol
Geert Bultynck
Romeo Cecchelli
Luc Leybaert
A1
Journal Article
in
BRAIN RESEARCH
2012
Paracrine signaling through plasma membrane hemichannels
Nan Wang
Marijke De Bock
Elke Decrock
Mélissa Bol
Ashish Kumar Gadicherla
Mathieu Vinken
Vera Rogiers
Feliksas F Bukauskas
Geert Bultynck
Luc Leybaert
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
2012
Transfer of IP3 through gap junctions is critical, but not sufficient, for the spread of apoptosis
Elke Decrock
Dmitri Krysko
Mathieu Vinken
Agnieszka Kaczmarek
Giulia Crispino
Mélissa Bol
Nan Wang
Marijke De Bock
Elke De Vuyst
Christian C Naus
et al.
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2012
2011
Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood brain barrier permeability
Marijke De Bock
Maxime Culot
Nan Wang
Mélissa Bol
Elke Decrock
Elke De Vuyst
Anaelle Da Costa
Ine Dauwe
Mathieu Vinken
Alexander Simon
et al.
A1
Journal Article
in
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
2011
L-β-N-oxalyl-α,β-diaminopropionic acid toxicity in motor neurons
Marijke Van Moorhem
Elke Decrock
Elke De Vuyst
Marijke De Bock
Nan Wang
Fernand Lambein
Ludo Van Den Bosch
Luc Leybaert
A1
Journal Article
in
NEUROREPORT
2011
Memichannels contribute to Ca2+ dynamics and contractility of smooth muscle cells in acutely isolated small mesenteric arteries
Mélissa Bol
Marijke De Bock
Nan Wang
Elke Decrock
Bert Vanheel
C3
Conference
2011
Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum
Catheleyne D'hondt
Raf Ponsaerts
Humbert De Smedt
Mathieu Vinken
Elke De Vuyst
Marijke De Bock
Nan Wang
Vera Rogiers
Luc Leybaert
Bernard Himpens
et al.
A1
Journal Article
in
CELLULAR SIGNALLING
2011
2010
Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death
Mathieu Vinken
Elke Decrock
Elke De Vuyst
Marijke De Bock
Roosmarijn Vandenbroucke
Bruno De Geest
Jo Demeester
Niek Sanders
Tamara Vanhaecke
Luc Leybaert
et al.
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2010
Hemichannel involvement in CA2+ dynamics and contractility of smooth muscle cells in acutely isolated small mesenteric arteries
Mélissa Bol
Marijke De Bock
Elke De Vuyst
Nan Wang
Elke Decrock
Jhon Jairo Monsalvo Castaño
Kelly Decaluwé
Bert Vanheel
Johan Van de Voorde
Luc Leybaert
C3
Conference
2010
L-β-ODAP alters mitochondrial Ca2+ handling as an early event in excitotoxicity
Marijke Van Moorhem
Elke Decrock
Evelyne Coussee
Liesbeth Faes
Elke De Vuyst
Katleen Vranckx
Marijke De Bock
Nan Wang
Katharina D'Herde
Fernand Lambein
et al.
A1
Journal Article
in
CELL CALCIUM
2010
2009
Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells
Elke De Vuyst
Nan Wang
Elke Decrock
Marijke De Bock
Mathieu Vinken
Marijke Van Moorhem
Charles Lai
Maxime Culot
Vera Rogiers
Romeo Cecchelli
et al.
A1
Journal Article
in
Cell Calcium
2009
Calcium regulation of connexin-43 hemichannel-mediated ATP release in glial cells
Elke De Vuyst
Marijke De Bock
Nan Wang
Elke Decrock
Mathieu Vinken
Marijke Van Moorhem
Vera Rogiers
Christian Naus
Howard Evans
Luc Leybaert
C3
Conference
2009
Cell death communication via connexin channels investigated in a C6 glioma cell model
Elke Decrock
Marijke Van Moorhem
Elke De Vuyst
Nan Wang
Marijke De Bock
Mathieu Vinken
Vera Rogiers
CC Naus
C Erneux
Luc Leybaert
C3
Conference
2009
Cell-cell communication of apoptosis via connexin channels in a C6 glioma cell model.
Elke Decrock
Marijke Van Moorhem
Elke De Vuyst
Nan Wang
Marijke De Bock
Mélissa Bol
Katharina D'Herde
C Erneux
Luc Leybaert
C3
Conference
2009
Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model.
Elke Decrock
Elke De Vuyst
Mathieu Vinken
Marijke Van Moorhem
Katleen Vranckx
Nan Wang
Laura Van Laeken
Marijke De Bock
Katharina D'Herde
Charles Lai
et al.
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2009
Hemichannels contribute to Ca2+ dynamics in smooth muscle cells in acutely isolated small mesenteric arteries
Mélissa Bol
Marijke De Bock
Elke De Vuyst
Nan Wang
Elke Decrock
Marijke Van Moorhem
Bert Vanheel
Luc Leybaert
C3
Conference
2009
Inhibition of connexin 43 hemichannel responses with high cytoplasmic calcium concentrations is mediated by mechanisms different from calcium activation of hemichannel responses
Nan Wang
Elke De Vuyst
Marijke De Bock
Elke Decrock
Marijke Van Moorhem
Luc Leybaert
C3
Conference
2009
Involvement of connexin hemichannels in dynamic calcium changes and permeability of blood-brain barrier endothelial cells
Marijke De Bock
Elke De Vuyst
Nan Wang
Elke Decrock
Marijke Van Moorhem
Maxime Culot
AM Simon
Romeo Cecchelli
Luc Leybaert
C3
Conference
2009
Neuro- and gliotoxicity of the excitatory amino acid beta-ODAP involves impaired free radical defence
Marijke Van Moorhem
Elke Decrock
Marijke De Bock
Nan Wang
Elke De Vuyst
Geert Callewaert
Ludo Van Den Bosch
Fernand Lambein
Luc Leybaert
C3
Conference
2009
Neuro- and gliotoxicity of the excitatory amino acid beta-ODAP involves impaired free radical difference
Marijke Van Moorhem
Elke Decrock
Marijke De Bock
Nan Wang
Elke De Vuyst
Geert Callewaert
Ludo Van den Bosch
Fernand Lambein
Luc Leybaert
C3
Conference
2009
2008
Cx43 hemichannel regulation by intracellular calcium: involvement of different signaling pathways
Elke De Vuyst
Marijke De Bock
Elke Decrock
Marijke Van Moorhem
Luc Leybaert
C3
Conference
2008
Gliotransmitter release via Connexin 43 hemichannels: role of cytoplasmic changes
Elke De Vuyst
Marijke De Bock
Nan Wang
Marijke Van Moorhem
Elke Decrock
C3
Conference
2008
In situ bipolar Electroporation for localized cell loading with reporter dyes and investigating gap junctional coupling
Elke De Vuyst
Marijke De Bock
Elke Decrock
Marijke Van Moorhem
C NAUS
Cyriel Mabilde
Luc Leybaert
A1
Journal Article
in
BIOPHYSICAL JOURNAL
2008
Inhibition of Cx43 hemichannel responses with High Ca2+i is mediated by mechanisms different from calcium activation of hemichannel responses
Nan Wang
Elke De Vuyst
Marijke De Bock
Elke Decrock
C3
Conference
2008
2007
Connexin channels mediate propagation of apoptosis in a C6 glioma cell model
Elke Decrock
Marijke Van Moorhem
Marijke De Bock
Elke De Vuyst
Katharina D'Herde
Luc Leybaert
C3
Conference
2007
Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor
Elke De Vuyst
Elke Decrock
Marijke De Bock
H YAMASAKI
CC NAUS
WH EVANS
Luc Leybaert
A1
Journal Article
in
MOLECULAR BIOLOGY OF THE CELL
2007
Neurobarrier coupling in the brain: Adjusting glucose entry with demand
Luc Leybaert
Marijke De Bock
Marijke Van Moorhem
Elke Decrock
Elke De Vuyst
A1
Journal Article
in
JOURNAL OF NEUROSCIENCE RESEARCH
2007
2006
Connexin channels, possible mediators in apoptosis spread in a glioma cell model
Elke Decrock
Marijke Van Moorhem
Marijke De Bock
Elke De Vuyst
Katharina D'Herde
Luc Leybaert
C3
Conference
2006