Research Explorer

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Researcher

Margot Van der Jeught

Publications & Research Data

Awards & Distinctions

60 Results

2021

Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells

Swati MishraJasin TaelmanMina PopovicLaurentijn TillemanEvi DuthooMargot Van der JeughtDieter DeforceFilip Van NieuwerburghBjörn MentenPetra De Sutter et al.

A1 Journal Article in STEM CELLS

2020

Germline nuclear transfer in mice may rescue poor embryo development associated with advanced maternal age and early embryo arrest

Maoxing TangMina PopovicPanagiotis StamatiadisMargot Van der JeughtRudy Van CosterDieter DeforcePetra De SutterPaul CouckeBjörn MentenDominic Stoop et al.

A1 Journal Article in HUMAN REPRODUCTION

2019

Comparative analysis of different nuclear transfer techniques to prevent the transmission of mitochondrial DNA variants

Maoxing TangRamesh Reddy GuggillaYannick GansemansMargot Van der JeughtAnnekatrien BoelMina PopovicPanagiotis StamatiadisMinerva Ferrer BuitragoVanessa ThysRudy Van Coster et al.

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Comparative analysis of different nuclear transfer techniques to prevent the transmission of mitochondrial DNA variants

Maoxing TangR ReddyYannick GansemansMargot Van der JeughtAnnekatrien BoelPanagiotis StamatiadisRudy Van CosterDieter DeforceFilip Van NieuwerburghPetra De Sutter et al.

Genome editing by CRISPR-Cas9 reveals that pre-implantation development in the mouse is compromised in Pou5f1-null embryos

Panagiotis StamatiadisAnnekatrien BoelMargot Van der JeughtBieke BekaertRamesh Reddy GuggillaMaoxing TangPetra De SutterPaul CouckeBjörn Heindryckx

Human blastocyst outgrowths recapitulate primordial germ cell specification events

Mina PopovicMonika BialeckaMaria Gomes FernandesJasin TaelmanMargot Van der JeughtPetra De SutterBjörn HeindryckxSusana Marina Chuva de Sousa Lopes

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Increased primordial germ cell (PGC) specification from human embryonic stem cells (hESC) derived in Activin A

Swati MishraMargot Van der JeughtMina PopovicJasin TaelmanEvi DuthooKatarzyna Szymańska-VandendriesschePetra De SutterLaurentijn TillemanFilip Van NieuwerburghAnnekatrien Boel et al.

The use of pronuclear transfer to overcome infertility disorders in mice

Björn HeindryckxAnnekatrien BoelPanagiotis StamatiadisMargot Van der JeughtRamesh Reddy GuggillaDieter DeforceRudy Van CosterPetra De Sutter

Untargeted histone profiling during naive conversion uncovers conserved modification markers between mouse and human

Laura De ClerckJasin TaelmanMina PopovicSander WillemsMargot Van der JeughtBjörn HeindryckxPetra De SutterHendrik MarksDieter DeforceMaarten Dhaenens

A1 Journal Article in SCIENTIFIC REPORTS

WNT inhibition and increased fibroblast growth factor signaling promotes derivation of less heterogeneous primed human embryonic stem cells, compatible with differentiation

Jasin TaelmanMina PopovicMonika BialeckaLaurentijn TillemanSharat WarrierMargot Van der JeughtBjörn MentenDieter DeforcePetra De SutterFilip Van Nieuwerburgh et al.

A1 Journal Article in STEM CELLS AND DEVELOPMENT

2018

Comparative analysis of naive, primed and ground state pluripotency in mouse embryonic stem cells originating from the same genetic background

Sabitri GhimireMargot Van der JeughtJitesh NeupaneMatthias S RoostJasper AnckaertMina PopovicFilip Van NieuwerburghPieter MestdaghJo VandesompeleDieter Deforce et al.

A1 Journal Article in SCIENTIFIC REPORTS

CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells

Eva JacobsSharat WarrierPieter-Jan VoldersEva D'haeneEva VanlombergenLies VantommeMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells

Eva JacobsSharat WarrierPieter-Jan VoldersEva D'haeneEva VanlombergenLies VantommeMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

Culture conditions affect Ca2+ release in artificially activated mouse and human oocytes

Yuechao LuDavina BonteMinerva Ferrer BuitragoMina PopovicJitesh NeupaneMargot Van der JeughtLuc LeybaertPetra De SutterBjörn Heindryckx

A1 Journal Article in REPRODUCTION FERTILITY AND DEVELOPMENT

Impact of pluripotency state and Activin A supplementation on derivation of primordial germ cell-like cells from human

Swati MishraMargot Van der JeughtJasin TaelmanMina PopovicKatarzyna Szymańska-VandendriesscheDieter DeforcePetra De SutterSusana Marina Chuva de Sousa LopesBjörn Heindryckx

Patients with a high proportion of immature and meiotically resistant oocytes experience defective nuclear oocyte maturation patterns and impaired pregnancy outcomes

Yuechao LuMinerva Ferrer BuitragoMina PopovicJitesh NeupaneWinnok De VosSylvie LiermanEtienne Van den AbbeelMargot Van der JeughtDimitra NikiforakiPetra De Sutter et al.

A1 Journal Article in REPRODUCTIVE BIOMEDICINE ONLINE

Polar body transfer in a mouse model to overcome transmission of mitochondrial diseases

Maoxing TangRamesh Reddy GuggillaPanagiotis StamatiadisMinerva Ferrer BuitragoVanessa ThysMargot Van der JeughtPetra De SutterBjörn Heindryckx

Stem cell-derived spermatozoa

Jasin TaelmanSwati MishraMargot Van der JeughtBjörn Heindryckx

Bookchapter in Reproductomics : the -omics revolution and its impact on human reproductive medicine

Strontium fails to induce Ca2+ release and activation in human oocytes despite the presence of functional TRPV3 channels

Y LuR ReddyMinerva Ferrer BuitragoMargot Van der JeughtJitesh NeupaneWinnok De VosEtienne Van den AbbeelSylvie LiermanPetra De SutterBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION OPEN

The role of the reprogramming method and pluripotency state in gamete differentiation from patient-specific human pluripotent stem cells

Swati MishraE KacinPanagiotis StamatiadisS FranckMargot Van der JeughtHeidi MertesGuido PenningsPetra De SutterK SermonBjörn Heindryckx et al.

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Transcriptional landscape changes during human embryonic stem cell derivation

Sharat WarrierJasin TaelmanLaurentijn TillemanMargot Van der JeughtGalbha DuggalSylvie LiermanMina PopovicAnn Van SoomLuc PeelmanFilip Van Nieuwerburgh et al.

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Unravelling the molecular pathways responsible for sex determination in humans

Jasin TaelmanMina PopovicLaurentijn TillemanMargot Van der JeughtDieter DeforcePetra De SutterFilip Van NieuwerburghBjörn HeindryckxS Chuva De Sousa Lopes

2017

Comprehensive comparison of inner cell mass and trophectoderm reveals the complex nature of chromosomal mosaicism in human embryos

Mina PopovicAnnelies DheedeneCHRISTODOULOS CHRISTODOULOUMargot Van der JeughtFilip Van NieuwerburghDieter DeforcePetra De SutterEtienne Van den AbbeelBjörn MentenBjörn Heindryckx

CRISPR/Cas9-mediated genome editing in naive human embryonic stem cells followed by neural differentiation : an optimized workflow

Eva JacobsSharrat WarrierEva D'haeneMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells

Eva JacobsSharat WarrierPieter-Jan VoldersEva D'haeneEva Van LombergenLies VantommeMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

A1 Journal Article in SCIENTIFIC REPORTS

Direct comparison of distinct naive pluripotent states in human embryonic stem cells

Sharat WarrierMargot Van der JeughtGalbha DuggalLaurentijn TillemanElla SutherlandJasin TaelmanMina PopovicSylvie LiermanSusana Marina Chuva de Sousa LopesAnn Van Soom et al.

A1 Journal Article in NATURE COMMUNICATIONS

Wnt inhibition during hESC culture provides an improved pluripotent state starting point for directed differentiation

Jasin TaelmanLaurentijn TillemanFilip Van NieuwerburghSharat WarrierMina PopovicMargot Van der JeughtDieter DeforcePetra De SutterBjörn HeindryckxSusana Marina Chuva de Sousa Lopes

2016

Can Wnt inhibition induce more favorable characteristics in primed hESCs for future clinical applications?

J. TaelmanMargot Van der JeughtSylvie LiermanBjörn HeindryckxSusana Marina Chuva de Sousa LopesPetra De Sutter

CRISPR/Cas9-mediated genome editing in naive human embryonic stem cells : an optimized workflow

Eva JacobsSharrat WarrierEva D'haeneMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

Elucidating the role of coding and noncoding genes in neuronal development using human embryonic stem cells and the CRISPR/Cas9 system

Eva JacobsSharat WarrierEva Van LombergenEva D'haeneMargot Van der JeughtBjörn HeindryckxSarah VergultBjörn Menten

Establishment and characterization of naïve pluripotency in human embryonic stem cells

Sharat WarrierMina PopovicMargot Van der JeughtBjörn Heindryckx

Bookchapter in Stem cell heterogeneity : methods and protocols

Inhibition of Rho-associated protein kinase (ROCK) in mouse embryos affects trophectoderm formation and blastocyst development, but still allows subsequent stem cell derivation

Sabitri GhimireMargot Van der JeughtJitesh NeupanePetra De SutterBjörn Heindryckx

Massive parallel sequencing uncovers chromosomal mosaicism in human embryonic stem cells in both primed and naive culture conditions

Mina PopovicMargot Van der JeughtFranki SpelemanFilip Van NieuwerburghPetra De SutterBjörn MentenBjörn Heindryckx

Predictive value of human calcium pattern analysis on the benefit of assisted oocyte activation in cases of failed fertilization after ICSI

Minerva Ferrer BuitragoYuechao LuSylvie LiermanEtienne Van den AbbeelMargot Van der JeughtDieter DeforceLuc LeybaertPetra De SutterBjörn Heindryckx

Uncovering the novel role of mTORC2 subunit of the PI3K/AKT/mTORC pathway in establishing naive pluripotency in human embryonic stem cells

Sharat WarrierMargot Van der JeughtGalbha DuggalJasin TaelmanSylvie LiermanSusana Marina Chuva de Sousa LopesAnn Van SoomLuc PeelmanFilip Van NieuwerburghDieter De Coninck et al.

Zinc chelation promotes oocyte activation in human oocytes

Davina BonteMinerva Ferrer BuitragoEtienne Van den AbbeelMargot Van der JeughtDieter DeforceLuc LeybaertPetra De SutterBjörn Heindryckx

2015

Alternative routes to induce naive pluripotency in human embryonic stem cells

Galbha DuggalSharat WarrierSabitri GhimireDorien BroekaertMargot Van der JeughtSylvie LiermanTom DerooLuc PeelmanAnn Van SoomMaria Cornelissen et al.

A1 Journal Article in STEM CELLS

Application of small molecules favoring naive pluripotency during human embryonic stem cell derivation

Margot Van der JeughtJasin TaelmanGalbha DuggalSabitri GhimireSylvie LiermanSusana Marina Chuva de Sousa LopesDieter DeforceTom DerooPetra De SutterBjörn Heindryckx

A1 Journal Article in CELLULAR REPROGRAMMING

Are TrpV3 channels present in human oocytes to mediate strontium-induced artificial activation?

Yuechao LuMinerva Ferrer BuitragoJitesh NeupaneW. H. De VosEtienne Van den AbbeelMargot Van der JeughtPetra De SutterBjörn Heindryckx

Comparative analysis of different culture conditions inducing naive pluripotency in human embryonic stem cells

Sharat WarrierGalbha DuggalJasin TaelmanSylvie LiermanS Chuva de Sousa LopesAnn Van SoomLuc PeelmanFilip Van NieuwerburghDieter De ConinckBjörn Menten et al.

Comparison of attachment layers for the priming human embryonic stem cells towards epiblast-like cells

J. TaelmanMargot Van der JeughtSylvie LiermanBjörn HeindryckxSusana Marina Chuva de Sousa LopesPetra De Sutter

CRISPR/Cas9-mediated genome editing in primed versus naïve human embryonic stem cells

Eva JacobsSharat WarrierEva D'haeneFilip MatthijssensMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

Derivation conditions affect pluripotency and differentiation propensity of mouse embryonic stem cells

Sabitri GhimireMargot Van der JeughtJitesh NeupaneFilip Van NieuwerburghDieter DeforceSusana Marina Chuva de Sousa LopesPetra De SutterBjörn Heindryckx

Exogenous supplementation of Activin A enhances germ cell differentiation of human embryonic stem cells

Galbha DuggalBjörn HeindryckxSharat WarrierJasin TaelmanMargot Van der JeughtDieter DeforceSusana Marina Chuva de Sousa LopesPetra De Sutter

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Human oocyte calcium analysis (HOCA) : a novel test for sperm oocyte-activation potential

Minerva Ferrer BuitragoSylvie LiermanFrauke Vanden MeerschautDimitra NikiforakiEtienne Van den AbbeelMargot Van der JeughtPetra De SutterBjörn Heindryckx

Inhibition of transforming growth factor β signaling promotes epiblast formation in mouse embryos

Sabitri GhimireBjörn HeindryckxMargot Van der JeughtJitesh NeupaneThomas O'LearySylvie LiermanWinnok De VosSusana Marina Chuva de Sousa LopesTom DerooPetra De Sutter

A1 Journal Article in STEM CELLS AND DEVELOPMENT

The post-inner cell mass intermediate : implications for stem cell biology and assisted reproductive technology

Margot Van der JeughtThomas O'LearyGalbha DuggalPetra De SutterSusana Marina Chuva de Sousa LopesBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION UPDATE

2014

Small molecules, big effects? : the use of small molecules during human embryo development and human embryonic stem cell derivation

Margot Van der JeughtPetra De SutterDieter Deforce

Treatment of human embryos with the TGFβ inhibitor SB431542 increases epiblast proliferation and permits successful human embryonic stem cell derivation

Margot Van der JeughtBjörn HeindryckxThomas O'LearyGalbha DuggalSabitri GhimireSylvie LiermanNadine Van RoySusana Marina Chuva de Sousa LopesTom DerooDieter Deforce et al.

A1 Journal Article in HUMAN REPRODUCTION

2013

Derivation of human embryonic stem cells using a post-inner cell mass intermediate

Thomas O'LearyBjörn HeindryckxSylvie LiermanMargot Van der JeughtGalbha DuggalPetra De SutterSusana M Chuva de Sousa Lopes

A1 Journal Article in NATURE PROTOCOLS

Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential

Galbha DuggalBjörn HeindryckxSharat WarrierThomas O'LearyMargot Van der JeughtSylvie LiermanLiesbeth VossaertTom DerooDieter DeforceSusana Marina Chuva de Sousa Lopes et al.

A1 Journal Article in STEM CELLS AND DEVELOPMENT

The combination of inhibitors of FGF/MEK/Erk and GSK3β signaling increases the number of OCT3/4-and NANOG-positive cells in the human inner cell mass, but does not improve stem cell derivation

Margot Van der JeughtThomas O'LearySabitri GhimireSylvie LiermanGalbha DuggalKaren VersierenDieter DeforceSusana Chuva de Sousa LopesBjörn HeindryckxPetra De Sutter

A1 Journal Article in STEM CELLS AND DEVELOPMENT

2012

Challenges and possible clinical applications of human embryonic stem cell research

Björn HeindryckxThomas O'LearyMargot Van der JeughtPetra De Sutter

A2 Journal Article in PROCEEDINGS OF THE BELGIAN ROYAL ACADEMIES OF MEDICINE

Dose-dependent effect of inhibition of the transforming growth factor beta pathway during early mouse lineage segregation

Sabitri GhimireMargot Van der JeughtJitesh NeupaneSylvie LiermanThomas O'LearySusana Chuva de Sousa LopesBjörn HeindryckxPetra De Sutter

Effect of small molecule supplements during in vitro culture of mouse zygotes and parthenogenetic embryos on hypoblast formation and stem cell derivation

Karen VersierenMargot Van der JeughtThomas O'LearyGalbha DuggalJan GerrisS Chuva de Sousa LopesBjörn HeindryckxPetra De Sutter

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

The TGFβ pathway plays a pivotal role in early embryo lineage segregation

Margot Van der JeughtSabitri GhimireThomas O'LearySylvie LiermanDieter DeforceSusana Chuva de Sousa LopesBjörn HeindryckxPetra De Sutter

The TGFβ pathway plays a pivotal role in early embryo lineage segregation in both mouse and human

Margot Van der JeughtSabitri GhimireThomas O'LearySylvie LiermanDieter DeforceSusana Marina Chuva de Sousa LopesBjörn HeindryckxPetra De Sutter

Tracking the progression of X-chromosome inactivation and reactivation during female human embryonic stem cell derivation

Thomas O'LearyBjörn HeindryckxMargot Van der JeughtGalbha DuggalSusana Chuva de Sousa LopesPetra De Sutter

Treatment of human embryos with the TGFβ inhibitor SB431542 increases epiblast proliferation and permits successful human embryonic stem cell derivation

Margot Van der JeughtThomas O'LearySylvie LiermanDieter DeforceSusana Chuva de Sousa LopesBjörn HeindryckxPetra De Sutter

2011

The influence of early embryo traits on human embryonic stem cell derivation efficiency

Thomas O'LearyBjörn HeindryckxSylvie LiermanMargot Van der JeughtBjörn MentenDieter DeforceMaria CornelissenSusana Chuva de Sousa LopesPetra De Sutter

A1 Journal Article in STEM CELLS AND DEVELOPMENT