Research Explorer

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Researcher

Margot Fonteyne

Awards & Distinctions

18 Results

2017

Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process

Ana Tavares da SilvaMC SarraguçaMargot FonteyneJurgen VercruysseFien De LeersnyderValérie VanhoorneNils BostijnMaxim VerstraetenChris VervaetJean Paul Remon et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2015

Impact of screw configuration on the particle size distribution of granules produced by twin screw granulation

Jurgen VercruysseAnneleen BurggraeveMargot FonteyneP CappuynsU DelaetI Van AsscheThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Process analytical technology for continuous manufacturing of solid-dosage forms

Margot FonteyneJurgen VercruysseFien De LeersnyderBernd Van SnickChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Use of a continuous twin screw granulation and drying system during formulation development and process optimization

Jurgen VercruysseElisabeth PeetersMargot FonteyneP CappuynsU DelaetI Van AsscheThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2014

Development and validation of process analytical methods for a continuous pharmaceutical manufacturing process of tablets based on wet granulation

Margot FonteyneThomas De BeerJean Paul Remon

Distribution of binder in granules produced by means of twin screw granulation

Margot FonteyneAndrew Luke FussellJurgen VercruysseChris VervaetJean Paul RemonClare StrachanThomas RadesThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Influence of raw material properties upon critical quality attributes of continuously produced granules and tablets

Margot FonteyneHenrika WickströmElisabeth PeetersJurgen VercruysseHenrik EhlersBjörn-Hendrik PetersJean Paul RemonChris VervaetJarkko KetolainenNiklas Sandler et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Moisture and drug solid-state monitoring during a continuous drying process using empirical and mass balance models

Margot FonteyneDelphine GildemynElisabeth PeetersSéverine MortierJurgen VercruysseKrist V GernaeyChris VervaetJean Paul RemonIngmar NopensThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

NIR spectroscopic method for the in-line moisture assessment during drying in a six-segmented fluid bed dryer of a continuous tablet production line : validation of quantifying abilities and uncertainty assessment

Margot FonteyneJulen ArruabarrenaJacques de BeerMario HellingsTom Van Den KerkhofAnneleen BurggraeveChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Visualization and understanding of the granulation liquid mixing and distribution during continuous twin screw granulation using NIR chemical imaging

Jurgen VercruysseMaunu ToiviainenMargot FonteyneNiko HelkimoJarkko KetolainenMikko JuutiUrbain DelaetIvo Van AsscheJean Paul RemonChris Vervaet et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2013

Real-time assessment of critical quality attributes of a continuous granulation process

Margot FonteyneJurgen VercruysseDamián Córdoba DíazDelphine GildemynChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

2012

Continuous twin screw granulation: influence of process variables on granule and tablet quality

Jurgen VercruysseD Córdoba DíazElisabeth PeetersMargot FonteyneU DelaetI Van AsscheThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Mechanistic modelling of the drying behaviour of single pharmaceutical granules

Séverine MortierThomas De BeerKrist GernaeyJurgen VercruysseMargot FonteyneJean Paul RemonChris VervaetIngmar Nopens

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Prediction of quality attributes of continuously produced granules using complementary pat tools

Margot FonteyneSandra Liliana De Oliveira SoaresJurgen VercruysseElisabeth PeetersAnneleen BurggraeveChris VervaetJean Paul RemonNiklas SandlerThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2011

Modelling of drying processes of pharmaceutical granules

Séverine MortierSreepriya VedantamThomas De BeerKV GernaeyMargot FonteyneJurgen VercruysseJean Paul RemonChris VervaetIngmar Nopens

Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes

Thomas De BeerAnneleen BurggraeveMargot FonteyneLien SaerensJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2010

Classification of lyophilised mixtures using multivariate analysis of NIR spectra

Holger GrohganzMargot FonteyneErik SkibstedThomas FalckBent PalmqvistJukka Rantanen

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2009

Role of excipients in the quantification of water in lyophilised mixtures using NIR spectroscopy

Holger GrohganzMargot FonteyneErik SkibstedThomas FalckBent PalmqvistJukka Rantanen

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS