Research Explorer

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Researcher

Manon Vanheerswynghels

Awards & Distinctions

22 Results

2025

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base

Sieglinde De CaeInge Van MolleLoes van SchieSophie R. ShoemakerJulie DeckersNincy DebeufSahine LameireWim NerinckxKenny RooseDaria Fijalkowska et al.

A1 Journal Article in NATURE COMMUNICATIONS

2024

Interleukin-33-activated basophils promote asthma by regulating Th2 cell entry into lung tissue

Martijn SchuijsClaudia Mariela Brenis GómezFabian BickJustine Van MoorleghemManon VanheerswynghelsGeert van LooRudi BeyaertDavid VoehringerRichard M. LocksleyHamida Hammad et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Modélisation de l’asthme sévère par la technologie des cellules humaines souches pluripotentes induites (hiPSC)

Engi AhmedS AssouF FoissetC BourdaisManon VanheerswynghelsA PetitA S GamezD GrasP ChanezJ de Vos et al.

A1 Journal Article in REVUE DES MALADIES RESPIRATOIRES

TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders

Nincy DebeufSahine LameireManon VanheerswynghelsJulie DeckersCaroline De WolfWendy ToussaintRein VerbekeKevin VerstaenHamida HammadStijn Vanhee et al.

A2 Journal Article in ELIFE

2023

Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection

Jessica VettersMary van HeldenClint De NolfSofie RennenEva ClootsEvelien Van De VeldeFarzaneh FayazpourJustine Van MoorleghemManon VanheerswynghelsKarl Vergote et al.

A1 Journal Article in ISCIENCE

STE20 kinase TAOK3 regulates type 2 immunity and metabolism in obesity

Bastiaan MaesFarzaneh FayazpourLeen CatrysseGuillaume LornetEvelien Van De VeldeCaroline De WolfSofie De PrijckJustine Van MoorleghemManon VanheerswynghelsKim Deswarte et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2022

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Levi HosteLisa RoelsLeslie NaesensVictor BosteelsStijn VanheeSam DupontCedric BosteelsRobin BrowaeysNiels VandammeKevin Verstaen et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice

Bastiaan MaesUrsula SmoleMatthias VanderkerkenKim DeswarteJustine Van MoorleghemKarl VergoteManon VanheerswynghelsCaroline De WolfSofie De PrijckNincy Debeuf et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2021

CCR2-and Flt3-dependent inflammatory conventional type 2 dendritic cells are necessary for the induction of adaptive immunity by the human vaccine adjuvant system AS01

Cedric BosteelsKaat FierensSofie De PrijckJustine Van MoorleghemManon VanheerswynghelsCaroline De WolfAurelie ChalonCatherine CollignonHamida HammadArnaud M. Didierlaurent et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

IRE1 beta does not affect mucus secretion during allergic asthma development in a house dust mite murine model

Eva ClootsNincy DebeufKim DeswarteFarzaneh FayazpourManon VanheerswynghelsCaroline De WolfEvelien Van de VeldeHamida HammadBart LambrechtSven Eyckerman et al.

A1 Journal Article in ALLERGY

2020

Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection

Cedric BosteelsKatrijn NeytManon VanheerswynghelsMary van HeldenDorine SichienNincy DebeufSofie De PrijckVictor BosteelsNiels VandammeLiesbet Martens et al.

A1 Journal Article in IMMUNITY

TAO-kinase 3 governs the terminal differentiation of conventional dendritic cells

Matthias VanderkerkenBastiaan MaesLana VandersarrenWendy ToussaintKim DeswarteManon VanheerswynghelsPhilippe PouliotLiesbet MartensSofie Van GassenConnie M. Arthur et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2019

Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF

Eline HaspeslaghManon VanheerswynghelsKim DeswarteJustine Van MoorleghemAlain JacquetBart LambrechtHamida Hammad

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van Moorleghem et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2018

Co-activation of glucocorticoid receptor and peroxisome proliferator-activated receptor-γ in murine skin prevents worsening of atopic march

Julie DeckersNadia BougarneViacheslav MylkaSofie DesmetAstrid LuypaertMichael DevosGiel TangheJustine Van MoorleghemManon VanheerswynghelsLode De Cauwer et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

The generation and use of allergen-specific TCR transgenic animals

Manon VanheerswynghelsWendy ToussaintMartijn SchuijsLeen VanhoutteNigel KilleenHamida HammadBart Lambrecht

Bookchapter in Type 2 immunity : methods and protocols

2017

Epicutaneous sensitization to house dust mite allergen requires interferon regulatory factor 4-dependent dermal dendritic cells

Julie DeckersDorine SichienMaud PlantingaJustine Van MoorleghemManon VanheerswynghelsEsther HosteBernard MalissenDavid DombrowiczMartin GuilliamsKarolien De Bosscher et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epitope mapping and kinetics of CD4 T cell immunity to pneumonia virus of mice in the C57BL/6 strain

Lana VandersarrenCedric BosteelsManon VanheerswynghelsJames J MoonAndrew J EastonGert Van IsterdaelSophie JanssensBart LambrechtMary van Helden

A1 Journal Article in SCIENTIFIC REPORTS

Myocardial infarction primes autoreactive T cells through activation of dendritic cells

Katrien Van Der BorghtCharlotte ScottVeronika NindlAnn BouchéLiesbet MartensDorine SichienJustine Van MoorleghemManon VanheerswynghelsSofie De PrijckYvan Saeys et al.

A1 Journal Article in CELL REPORTS

The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome

Lotte PyfferoenElisabeth BrabantsCeline EveraertNancy De CabooterKelly HeynsKim DeswarteManon VanheerswynghelsSofie De PrijckGlenn WaegemansMelissa Dullaers et al.

A1 Journal Article in ONCOIMMUNOLOGY

2016

IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively

Dorine SichienCharlotte ScottLiesbet MartensMatthias VanderkerkenSofie Van GassenMaud PlantingaThorsten JoerisSofie De PrijckLeen VanhoutteManon Vanheerswynghels et al.

A1 Journal Article in IMMUNITY

2013

Conventional and monocyte-derived CD11b⁺ dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen

Maud PlantingaMartin GuilliamsManon VanheerswynghelsKim DeswarteFilipe Branco MadeiraWendy ToussaintLeen VanhoutteKatrijn NeytNigel KilleenBernard Malissen et al.

A1 Journal Article in IMMUNITY