Research Explorer

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Researcher

Magdalena Radwanska

Awards & Distinctions

58 Results

2024

Effect of Leishmania infantum infection on B cell lymphopoiesis and memory in the bone marrow and spleen

Laura DirkxMarlotte LoyensSara I. Van AckerDimitri BultéMathieu ClaesMagdalena RadwanskaStefan MagezGuy Caljon

A1 Journal Article in FASEB JOURNAL

2023

Chronic pathology of experimental Trypanosoma evansi infection is the combined result of an extra-medullary erythropoiesis abrogation, a failing host B cell response, and the induction of a unique Th1 cell population

Thi Thu Hang NguyenMagdalena RadwanskaStefan Magez

From helping to regulating : a transcriptomic profile of Ifng+ Il10+ Il21+ Cd4+ Th1 cells indicates their role in regulating inflammation during experimental trypanosomosis

Thi Thu Hang NguyenStefan MagezMagdalena Radwanska

A2 Journal Article in FRONTIERS IN TROPICAL DISEASES

Mosaic RBD nanoparticles induce intergenus cross-reactive antibodies and protect against SARS-CoV-2 challenge

Dan Bi LeeHyojin KimJu Hwan JeongUi Soon JangYuyeon JangSeokbeom RohHyunbum JeonEun Jeong KimSu Yeon HanJin Young Maeng et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanobody technology and new molecular biology methods to advance rapid diagnostic test for neglected tropical diseases

Andrés Álvarez RodríguezMagdalena RadwanskaStefan MagezSteven Odongo

Bookchapter in Rapid antigen testing

Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis

Hien Thi Thu PhamStefan MagezBoyoon ChoiBolortsetseg BaatarJoohee JungMagdalena Radwanska

A1 Journal Article in NATURE COMMUNICATIONS

The pathogenesis of African trypanosomiasis

Etienne PaysMagdalena RadwanskaStefan Magez

A1 Journal Article in ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE

2022

African trypanosomiasis

Stefan MagezThi Thu Hang NguyenJoar Esteban Pinto TorresMagdalena Radwanska

Bookchapter in Textbook of parasitic zoonoses

Assessing impacts of experimental trypanosome infections on B cell memory

Moon SangphilMagdalena RadwanskaStefan Magez

Detrimental effect of Trypanosoma brucei brucei infection on memory B cells and host ability to recall protective B-cell responses

Sangphil MoonIbo JanssensKyung Hyun KimBenoit StijlemansStefan MagezMagdalena Radwanska

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Recent progress in diagnosis and treatment of Human African Trypanosomiasis has made the elimination of this disease a realistic target by 2030

Andrés Álvarez RodríguezBo-kyung JinMagdalena RadwanskaStefan Magez

A1 Journal Article in FRONTIERS IN MEDICINE

Retrospective in silico mutation profiling of SARS-CoV-2 structural proteins circulating in Uganda by July 2021 : towards refinement of COVID-19 disease vaccines, diagnostics, and therapeutics

Steven OdongoHedmon OkellaChristian NdekeziMoses OkeeMonica NamayanjaBrian MujuniYann G. J. SterckxDennison KizitoMagdalena RadwanskaStefan Magez et al.

A1 Journal Article in PLOS ONE

Tipping the balance between erythroid cell differentiation and induction of anemia in response to the inflammatory pathology associated with chronic trypanosome infections

Thi Thu Hang NguyenMagdalena RadwanskaStefan Magez

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2021

African trypanosomosis obliterates DTPa vaccine-induced functional memory so that post-treatment Bordetella pertussis challenge fails to trigger a protective recall response

Magdalena RadwanskaThi Thu Hang NguyenStefan Magez

A1 Journal Article in VACCINES

Comprehensive genomic analysis reveals virulence factors and antibiotic resistance genes in Pantoea agglomerans KM1, a potential opportunistic pathogen

Robin GuevarraStefan MagezEveline PeetersMi Sook ChungKyung Hyun KimMagdalena Radwanska

A1 Journal Article in PLOS ONE

Salivarian trypanosomes have adopted intricate host-pathogen interaction mechanisms that ensure survival in plain sight of the adaptive immune system

Stefan MagezJoar Esteban Pinto TorresSeoyeon OhMagdalena Radwanska

A1 Journal Article in PATHOGENS

Single-cell transcriptome profiling and the use of AID deficient mice reveal that B cell activation combined with antibody class switch recombination and somatic hypermutation do not benefit the control of experimental trypanosomosis

Thi Thu Hang NguyenRobin GuevarraStefan MagezMagdalena Radwanska

A1 Journal Article in PLOS PATHOGENS

The history of anti-trypanosome vaccine development shows that highly immunogenic and exposed pathogen-derived antigens are not necessarily good target candidates : enolase and ISG75 as examples

Stefan MagezZeng LiThi Thu Hang NguyenJoar Esteban Pinto TorresPieter Van WielendaeleMagdalena RadwanskaJakub BeganSebastian ZollYann G. -J. Sterckx

A1 Journal Article in PATHOGENS

2020

Establishment of a standardized vaccine protocol for the analysis of protective immune responses during experimental Trypanosome infections in mice

Magdalena RadwanskaThi Thu Hang NguyenSangphil MoonEmmanuel Tumininu ObishakinStefan Magez

Bookchapter in Trypanosomatids

Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system

Stefan MagezJoar Esteban Pinto TorresEmmanuel Tumininu ObishakinMagdalena Radwanska

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Isolation of Trypanosoma brucei brucei infection-derived splenic marginal zone B cells based on CD1dHigh/B220High surface expression in a two-step MACS-FACS approach

Magdalena RadwanskaNick VereeckeStefan Magez

Bookchapter in Trypanosomatids

2019

Trypanosoma brucei brucei causes a rapid and persistent influx of neutrophils in the spleen of infected mice

Violette DeleeuwHien Thi Thu PhạmIsabel De PoorterIbo JanssensCarl De TrezMagdalena RadwanskaStefan Magez

A1 Journal Article in PARASITE IMMUNOLOGY

2018

DNA detection of Trypanosoma evansi : diagnostic validity of a new assay based on loop-mediated isothermal amplification (LAMP)

Qunbo TongRui ChenQingming KongJulie GoossensMagdalena RadwanskaDi LouJianzu DingBin ZhengYixiu FuTianping Wang et al.

A1 Journal Article in VETERINARY PARASITOLOGY

Salivarian trypanosomosis : a review of parasites involved, their global distribution and their interaction with the innate and adaptive mammalian host immune system

Magdalena RadwanskaNick VereeckeViolette DeleeuwJoar PintoStefan Magez

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2017

African Trypanosomes undermine humoral responses and vaccine development : link with inflammatory responses?

Benoit StijlemansMagdalena RadwanskaCarl De TrezStefan Magez

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells

Nathan De BeuleEline MenuMathieu BertrandMérédis FavreauElke De BruyneKen MaesKim De VeirmanMagdalena RadwanskaAfshin SamaliStefan Magez et al.

A1 Journal Article in ONCOTARGET

Functionalization of gold nanoparticles with nanobodies through physical adsorption

Julie GoossensHla SeinShaohong LuMagdalena RadwanskaSerge MuyldermansYann G-J SterckxStefan Magez

A1 Journal Article in ANALYTICAL METHODS

2016

Evaluation of antigens for development of a serological test for human African trypanosomiasis

Sylvain BiélerHarald WaltenbergerMichael P BarrettRichard McCullochJeremy C MottramMark CarringtonWilhelm SchwaebleJames McKerrowMargaret A PhillipsPaul A Michels et al.

A1 Journal Article in PLOS ONE

Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection

J CnopsF KauffmannC De TrezT BaltzJ KeirsseMagdalena RadwanskaE MurailleStefan Magez

A1 Journal Article in PARASITE IMMUNOLOGY

Trypanosoma brucei co-opts NK cells to kill splenic B2 B cells

Deborah FrenkelFengqiu ZhangPatrick GuirnaldaCarole HaynesViki BockstalMagdalena RadwanskaStefan MagezSamuel J Black

A1 Journal Article in PLOS PATHOGENS

2015

Curative drug treatment of trypanosomosis leads to the restoration of B-cell lymphopoiesis and splenic B-cell compartments

J CnopsV BockstalC De TrezMC MiquelMagdalena RadwanskaStefan Magez

A1 Journal Article in PARASITE IMMUNOLOGY

IFN-γ mediates early B-cell loss in experimental African trypanosomosis

J CnopsC De TrezD BulteMagdalena RadwanskaB RyffelStefan Magez

A1 Journal Article in PARASITE IMMUNOLOGY

2014

Relationship between genome and epigenome : challenges and requirements for future research

Geneviève AlmouzniLucia AltucciBruno AmatiNeil AshleyDavid BaulcombeNathalie BeaujeanChristoph BockErik Bongcam-RudloffJean BousquetSigurd Braun et al.

A1 Journal Article in BMC GENOMICS

2011

T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis

Viki BockstalPatrick GuirnaldaGuy CaljonRadhika GoenkaJanice C TelferDeborah FrenkelMagdalena RadwanskaStefan MagezSamuel J Black

A1 Journal Article in PLOS PATHOGENS

2010

Current status of vaccination against African trypanosomiasis

Stefan MagezGuy CalhonThao TranBenoit StijlemansMagdalena Radwanska

A1 Journal Article in PARASITOLOGY

Emerging trends in the diagnosis of human African trypanosomiasis

Magdalena Radwanska

A1 Journal Article in PARASITOLOGY

Parasite-induced B-cell apoptosis results in loss of specific protective anti-trypanosome antibody responses, and abolishment of vaccine induced protective memory responses.

Stefan MagezV BockstalF BrombacherS BlackMagdalena Radwanska

2009

African trypanosomiasis and antibodies : implications for vaccination, therapy and diagnosis

Stefan MagezMagdalena Radwanska

A1 Journal Article in FUTURE MICROBIOLOGY

2008

Trypanosomiasis-induced B cell apoptosis results in loss of protective anti-parasite antibody responses and abolishment of vaccine-induced memory responses

Magdalena RadwanskaPatrick GuirnaldaCarl De TrezBernard RyffelSamuel BlackStefan Magez

A1 Journal Article in PLOS PATHOGENS

2007

Deletion of IL-4Rα on CD4 T cells renders BALB/c mice resistant to Leishmania major infection

Magdalena RadwanskaAntony J CutlerJ Claire HovingStefan MagezChristoph HolscherAndreas BohmsBerenice ArendseRichard KirschThomas HunigJames Alexander et al.

A1 Journal Article in PLOS PATHOGENS

Optimizing gene suppression in schistosomes using RNA interference

Greice Krautz-PetersonMagdalena RadwanskaDavid NdegwaCharles B ShoemakerPatrick J Skelly

A1 Journal Article in MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage‐derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing

Stefan MagezMagdalena RadwanskaMichael DrennanLizette FickToya Nath BaralNasiema AllieMuazzam JacobsSergei NedospasovFrank BrombacherBernard Ryffel et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

2006

Interferon‐γ and nitric oxide in combination with antibodies are key protective host immune factors during Trypanosoma congolense Tc13 Infections

Stefan MagezMagdalena RadwanskaMichael DrennanLizette FickToya Nath BaralFrank BrombacherPatrick De Baetselier

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

2004

Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology

De'Broski R HerbertChristoph HölscherMarkus MohrsBerenice ArendseAnita SchwegmannMagdalena RadwanskaMosiuoa LeetoRichard KirschPauline HallHorst Mossmann et al.

A1 Journal Article in IMMUNITY

P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis

Stefan MagezCarine TruyensMakram MerimiMagdalena RadwanskaBenoît StijlemansPeter BrouckaertFrank BrombacherEtienne PaysPatrick De Baetselier

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Variable surface glycoprotein RoTat 1.2 PCR as a specific diagnostic tool for the detection of Trypanosoma evansi infections

Filip ClaesMagdalena RadwanskaToyo UrakawaPhelix AO MajiwaBruno GoddeerisPhilip Büscher

A2 Journal Article in KINETOPLASTID BIOLOGY AND DISEASE

2003

Antibodies raised against the flagellar pocket fraction of Trypanosoma brucei preferentially recognize HSP60 in cDNA expression library

Magdalena RadwanskaStefan MagezNathalie DumontAnnette PaysDerek NolanEtienne Pays

A1 Journal Article in PARASITE IMMUNOLOGY

How does Trypanosoma equiperdum fit into the Trypanozoon group? : a cluster analysis by RAPD and multiplex-endonuclease genotyping approach

F ClaesEC AgboMagdalena RadwanskaMFW Te PasT BaltzDT De WaalBruno GoddeerisE ClassenP Buscher

A1 Journal Article in PARASITOLOGY

2002

A transcript encoding a proteasome beta-subunit and a zinc finger protein in Trypanosoma brucei brucei

Magdalena RadwanskaBernard CouvreurNathalie DumontAnnette PaysLuc VanhammeEtienne Pays

A1 Journal Article in GENE

Comparative analysis of antibody responses against HSP60, invariant surface glycoprotein 70, and variant surface glycoprotein reveals a complex antigen-specific pattern of immunoglobulin isotype switching during infection by Trypanosoma brucei

Magdalena RadwanskaStefan MagezA MichelB StijlemansM GeuskensE Pays

A1 Journal Article in INFECTION AND IMMUNITY

Direct detection and identification of African trypanosomes by fluorescence in situ hybridization with peptide nucleic acid probes

Magdalena RadwanskaStefan MagezH Perry-O'KeefeH StenderJ CoullJM SternbergP BuscherJJ Hyldig-Nielsen

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

Novel primer sequences for polymerase chain reaction-based detection of Trypanosoma brucei gambiense.

Magdalena RadwanskaFilip ClaesStefan MagezEddy MagnusDavid Perez-MorgaEtienne PaysPhilippe Büscher

A1 Journal Article in AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense

Magdalena RadwanskaMustapha ChamekhLuc VanhammeFilip ClaesStefan MagezEddy MagnusPatrick de BaetselierPhilippe BüscherEtienne Pays

A1 Journal Article in AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

2001

A conserved flagellar pocket exposed high mannose moiety is used by African trypanosomes as a host cytokine binding molecule

Stefan MagezMagdalena RadwanskaBenoı̂t StijlemansHoang Van XongEtienne PaysPatrick De Baetselier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1999

Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections

Stefan MagezMagdalena RadwanskaA BeschinK SekikawaP De Baetselier

A1 Journal Article in INFECTION AND IMMUNITY

1998

TNF-alpha plays a key role in the regulation of the experimental infection with Trypanosoma brucei

Stefan MagezA BeschinMagdalena RadwanskaP De Baetselier

The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factors

Stefan MagezB StijlemansMagdalena RadwanskaE PaysMAJ FergusonP De Baetselier

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Trypanosoma brucei infection elicits nitric oxide-dependent and nitric oxide-independent suppressive mechanisms

A BeschinL BrysStefan MagezMagdalena RadwanskaP De Baetselier

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY