Research Explorer

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Researcher

Magda De Smedt

Publications & Research Data

Awards & Distinctions

45 Results

2016

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

Inge Van de WalleAnne-Catherine DolensKaat DurinckKatrien De MulderWouter Van LoockeSagar DamleEls WaegemansJelle De MedtsImke VelgheMagda De Smedt et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

Notch3 activation is sufficient but not required for inducing human T-lineage specification

Els WaegemansInge Van de WalleJelle De MedtsMagda De SmedtTessa KerreBart VandekerckhoveGeorges LeclercqTao WangJean PlumTom Taghon

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2013

Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength

Inge Van de WalleEls WaegemansJelle De MedtsGreet De SmetMagda De SmedtSYLVIA SNAUWAERTBart VandekerckhoveTessa KerreGeorges LeclercqJean Plum et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2012

Notch ligands control the human alpha beta/gamma delta lineage choice through receptor-specific induction of differential Notch signal strength

Tom TaghonInge Van de WalleEls WaegemansJelle De MedtsGreet De SmetMagda De SmedtBart VandekerckhoveTessa KerreGeorges LeclercqTao Wang et al.

2011

CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation

Veerle De ColvenaerSylvie TaveirneMaarten DelforcheMagda De SmedtBart VandekerckhoveTom TaghonLouis BoonJean PlumGeorges Leclercq

A1 Journal Article in IMMUNOLOGY AND CELL BIOLOGY

Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions

Inge Van de WalleGreet De SmetMartina GärtnerMagda De SmedtEls WaegemansBart VandekerckhoveGeorges LeclercqJean PlumJon C AsterIrwin D Bernstein et al.

A1 Journal Article in BLOOD

T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells

Magda De SmedtGeorges LeclercqBart VandekerckhoveTessa KerreTom TaghonJean Plum

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

2010

Continuous CD27 triggering in vivo strongly reduces NK cell numbers

Veerle De ColvenaerSylvie TaveirneJörg HamannAlex M de BruinMagda De SmedtTom TaghonBart VandekerckhoveJean PlumRené van LierGeorges Leclercq

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

2009

An early decrease in Notch activation is required for human TCR-αβ lineage differentiation at the expense of TCR-γδ T cells

Inge Van de WalleGreet De SmetMagda De SmedtBart VandekerckhoveGeorges LeclercqJean PlumTom Taghon

A1 Journal Article in BLOOD

Functionally mature CD4 and CD8 TCRαβ cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells

Stefanie Van CoppernolleGreet VerstichelFrank TimmermansImke VelgheDavid VermijlenMagda De SmedtGeorges LeclercqJean PlumTom TaghonBart Vandekerckhove et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Generation of T cells from human embryonic stem cell-derived hematopoietic zones

Frank TimmermansImke VelgheLieve VanwalleghemMagda De SmedtStefanie Van CoppernolleTom TaghonHarry MooreGeorges LeclercqAnton LangerakTessa Kerre et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Notch signaling is required for proliferation but not for differentiation at a well-defined β-selection checkpoint during human T-cell development

Tom TaghonInge Van de WalleGreet De SmetMagda De SmedtGeorges LeclercqBart VandekerckhoveJean Plum

A1 Journal Article in BLOOD

2008

Human intrathymic development: a selective approach

Jean PlumMagda De SmedtGeorges LeclercqTom TaghonTessa KerreBart Vandekerckhove

A1 Journal Article in SEMINARS IN IMMUNOPATHOLOGY

Stage-dependent molecular changes in Notch signaling are critical for normal human T cell development

Tom TaghonInge Van de WalleGreet De SmetMagda De SmedtJean Plum

2007

Endothelial outgrowth cells are not derived from CD133(+) cells or CD45(+) hematopoietic precursors

Frank TimmermansFilip Van HauwermeirenMagda De SmedtRobrecht RaedtFRANK PLASSCHAERTMarc De BuyzereThierry GillebertJean PlumBart Vandekerckhove

A1 Journal Article in ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

In vitro expanded cells contributing to rapid severe combined Immunodeficient repopulation activity are CD34(+)38(-)33(+)90(+)45RA(-)

Katrien VanheusdenStefanie Van CoppernolleMagda De SmedtJean PlumBart Vandekerckhove

A1 Journal Article in STEM CELLS

Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells

Magda De SmedtTom TaghonInge Van de WalleGreet De SmetGeorges LeclercqJean Plum

A1 Journal Article in BLOOD

T-, B- and NK-lymphoid, but not myeloid cells arise from human CD34+CD38-CD7+ common lymphoid progenitors expressing lymphoid-specific genes

Inge HoebekeMagda De SmedtFrank StolzK Pike-OverzetFJT StaalJean PlumGeorges Leclercq

A1 Journal Article in LEUKEMIA

Tumor necrosis factor promotes T-cell at the expense of B-cell lymphoid development from cultured human CD34(+) cord blood cells

K SMITSMagda De SmedtEvelien NaessensGreet De SmetVeronique StoveTom TaghonJean PlumBruno Verhasselt

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

2006

Endothelial cells are not derived from hematopoietic precursor cells

Frank TimmermansMagda De SmedtRobrecht RaedtJean PlumBart Vandekerckhove

Ex vivo characterization of allo-MHC-restricted T cells specific for a single MHC-peptide complex

MJ PITTETA GATIFA LE GALG BIOLEYP GUILLAUMEMagda De SmedtJean PlumDE SPEISERJC CEROTTINIPY DIETRICH et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Overexpression of HES-1 is not sufficient to impose T-cell differentiation on human hernatopoietic stem cells

Inge HoebekeMagda De SmedtInge Van de WalleKatia ReynvoetGreet De SmetJean PlumGeorges Leclercq

A1 Journal Article in BLOOD

2005

Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment

Magda De SmedtInge HoebekeKatia ReynvoetGeorges LeclercqJean Plum

A1 Journal Article in BLOOD

Negative thymocyte selection to HERV-K18 superantigens in humans

F MEYLANMagda De SmedtGeorges LeclercqJean PlumO LEUPINS MARGUERATB CONRAD

A1 Journal Article in BLOOD

2004

Human bone marrow CD34+ progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment

Magda De SmedtInge HoebekeJean Plum

A1 Journal Article in BLOOD CELLS MOLECULES AND DISEASES

Human thymus exports naive CD8 T cells that can home to nonlymphoid tissues

A ZIPPELIUSG BIOLEYFA LE GALN RUFERM BRANDESP BATARDMagda De SmedtJean PlumDE SPEISERJC CEROTTINI et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Notch receptor signaling and human T cell development.

Magda De SmedtKatia ReynvoetGeorges LeclercqJean Plum

2003

Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development

Tom TaghonK THYSMagda De SmedtF WEERKAMPFJT STAALJean PlumGeorges Leclercq

A1 Journal Article in LEUKEMIA

2002

Active form of notch imposes T cell fate in human progenitor cells

Magda De SmedtKatia ReynvoetTessa KerreTom TaghonBruno VerhasseltBart VandekerckhoveGeorges LeclercqJean Plum

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Enforced expression of HOX-A10 drives human hematopoietic precursor cells toward the monocytic lineage

Tom TaghonF StolzMagda De SmedtM CnockaertBruno VerhasseltJean PlumGeorges Leclercq

HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor

Tom TaghonFrank StolzMagda De SmedtM CNOCKAERTBruno VerhasseltJean PlumGeorges Leclercq

A1 Journal Article in BLOOD

2001

Enforced expression of GATA-3 severely reduces human thymic cellularity

Tom TaghonMagda De SmedtFrank StolzM CNOCKAERTJean PlumGeorges Leclercq

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2000

Both human CD34(+)38(+) and CD34(+)38(-) cells home specifically to the bone marrow, but show different kinetics in take and proliferation

Tessa KerreG DE SMETMagda De SmedtFritz OffnerJean PlumBart Vandekerckhove

1999

Bone marrow CD34+ cells generate fewer T cells in vitro with increasing age and following chemotherapy

Fritz OffnerTessa KerreMagda De SmedtJean Plum

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Human immunodeficiency virus nef gene expression affects generation and function of human T cells, but not dendritic cells

Bruno VerhasseltEvelien NaessensChris VerhofstedeMagda De SmedtSigrid SchollenTessa KerreDominique VanheckeJean Plum

A1 Journal Article in BLOOD

In vitro intrathymic differentiation kinetics of human fetal liver CD34(+)CD38(-) progenitors reveals a phenotypically defined dendritic/T-NK precursor split

Jean PlumMagda De SmedtBruno VerhasseltFritz OffnerTessa KerreD VANHECKEGeorges LeclercqBart Vandekerckhove

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Positive selection of fetal nuclear red blood cells from maternal circulation using magnetic beads and flow cytometry

Anuradha GoudMagda De SmedtHeleen LavergePravin GoudJean PlumPetra De SutterJosiane Van der ElstMarc Dhont

Thymic repopulation by CD34+ human cord blood cells after expansion in stroma-free culture

Bruno VerhasseltTessa KerreEvelien NaessensDominique VanheckeMagda De SmedtBart VandekerckhoveJean Plum

A1 Journal Article in BLOOD

1994

Human fetal liver cells differentiate into thymocytes in chimeric mouse fetal thymus organ culture

Magda De SmedtGeorges LeclercqBart VandekerckhoveJean Plum

Stem cell differentiation into mature lymphocytes using the SCID mouse thymus chimera model

Magda De SmedtGeorges LeclercqBart VandekerckhoveJean Plum

Bookchapter in Hematopoietic stem cells : the Mulhouse manual

1991

INTERLEUKIN-4 INDUCES CD8-ALPHA EXPRESSION ON T-CELL RECEPTOR V-GAMMA-5 THYMOCYTES

Georges LeclercqMagda De SmedtJean Plum

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

1990

Direct evidence for partial target specificity in lymphokine-activated killer thymocytes

Georges LeclercqMagda De SmedtJean Plum

A1 Journal Article in SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Expansion of large granular lymphocytes in IL-2-driven 14-day-old fetal thymocytes in organ culture

Jean PlumFrits KoningGeorges LeclercqBernard TisonMagda De Smedt

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Inhibitory effect of murine recombinant IL-4 on thymocyte development in fetal thymus organ cultures

Jean PlumMagda De SmedtGeorges LeclercqBernard Tison

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Preferential proliferation of T cell receptor Vγ3-positive cells in IL-2-stimulated fetal thymocytes

Georges LeclercqMagda De SmedtBernard TisonJean Plum

A1 Journal Article in JOURNAL OF IMMUNOLOGY