Research Explorer

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Researcher

Lynn De Backer

Awards & Distinctions

13 Results

2023

The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments

Thijs Van de VyverCristina MunteanIuliia EfimovaDmitri KryskoLynn De BackerStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2020

Cationic amphiphilic drugs boost the lysosomal escape of small nucleic acid therapeutics in a nanocarrier-dependent manner

Thijs Van de VyverBram BogaertLynn De BackerFreya JorisRoberta GuagliardoJelter Van HoeckPieterjan MerckxSerge Van CalenberghSrinivas RamishettiDan Peer et al.

A1 Journal Article in ACS NANO

2019

Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA

Roberta GuagliardoPieterjan MerckxAgata ZamborlinLynn De BackerMercedes EchaideJesus Pérez-GilStefaan De SmedtKoen Raemdonck

A1 Journal Article in PHARMACEUTICS

2018

Repurposing cationic amphiphilic drugs as adjuvants to induce lysosomal siRNA escape in nanogel transfected cells

Freya JorisLynn De BackerThijs Van de VyverChiara BastiancichStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy

Pieterjan MerckxLynn De BackerLien Van HoeckeRoberta GuagliardoMercedes EchaidePieter BaatsenBárbara OlmedaXavier SaelensJésus Pérez-GilStefaan De Smedt et al.

A1 Journal Article in ACTA BIOMATERIALIA

2016

Hitchhiking nanoparticles: reversible coupling of lipid-based nanoparticles to cytotoxic T lymphocytes

Laura WayteckHeleen DewitteLynn De BackerKarine BreckpotJo DemeesterStefaan De SmedtKoen Raemdonck

A1 Journal Article in BIOMATERIALS

2015

Bio-inspired materials in drug delivery : exploring the role of pulmonary surfactant in siRNA inhalation therapy

Lynn De BackerAlejandro CerradaJesús Pérez-GilStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Bio-inspired pulmonary surfactant-modified nanogels : a promising siRNA delivery system

Lynn De BackerKevin BraeckmansMarc CA StuartJo DemeesterStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Exploring bio-inspired nanocomposites of nanogels and pulmonary surfactant for small interfering RNA delivery

Lynn De BackerStefaan De SmedtKoen Raemdonck

Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages

Lynn De BackerThomas NaessensStefaan De KokerElisa ZagatoJo DemeesterJohan GrootenStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2014

Unraveling the effects of siRNA carrier systems on cell physiology: a multiparametric approach demonstrated on dextran nanogels

Stefaan SoenenLynn De BackerBella ManshianShareen DoakKoen RaemdonckJo DemeesterKevin BraeckmansStefaan De Smedt

A1 Journal Article in NANOMEDICINE

2013

The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels

Lynn De BackerKevin BraeckmansJo DemeesterStefaan De SmedtKoen Raemdonck

A1 Journal Article in NANOMEDICINE

2012

Bio-inspired surfactant-modified dextran nanogels mediate enhanced intracellular siRNA delivery

Lynn De BackerJo DemeesterStefaan De SmedtKoen Raemdonck