Research Explorer

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Researcher

Lutz Nuhn

Publications & Research Data

Awards & Distinctions

31 Results

2025

A fentanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Zifu ZhongMarie DeventerYong ChenStijn VanheeInés LammensKim DeswarteYi HuangTingting YeHaixiu WangLutz Nuhn et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhancing anti-tumor immunity through intratumoral combination therapy with amphiphilic conjugates of oxaliplatin and imidazoquinoline TLR7/8 agonist

Hanne VerschuereSabah KasmiLutz NuhnSènan Mickaël D'AlmeidaQiwen ZhuZifu ZhongSandy Adjemian CataniBenoit LouageJana De VriezeHaijun Yu et al.

A1 Journal Article in RSC ADVANCES

2020

Design of pH-degradable polymer-lipid amphiphiles using a ketal-functionalized RAFT chain transfer agent

Jana De VriezeSimon Van HerckLutz NuhnBruno De Geest

A1 Journal Article in MACROMOLECULAR RAPID COMMUNICATIONS

Sterilizing immunity against SARS-CoV-2 infection in mice by a single-shot and modified imidazoquinoline TLR7/8 agonist-adjuvanted recombinant spike protein vaccine

Sonia JangraJana De VriezeAngela ChoiRaveen RathnasingheGabriel LaghlaliAnnemiek UvynSimon Van HerckLutz NuhnKim DeswarteZifu Zhong et al.

2019

A synthetic, transiently thermoresponsive homopolymer with UCST behaviour within a physiologically relevant window

Zhiyue ZhangHui LiSabah KasmiSimon Van HerckKim DeswarteBart LambrechtRichard HoogenboomLutz NuhnBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2018

FRET monitoring of intracellular ketal hydrolysis in synthetic nanoparticles

Lutz NuhnSimon Van HerckAndreas BestKim DeswarteMaria KokkinopoulouIngo LieberwirthKaloian KoynovBart LambrechtBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lymph-node-targeted immune activation by engineered block copolymer amphiphiles-TLR7/8 agonist conjugates

Simon Van HerckKim DeswarteLutz NuhnZifu ZhongJoão Portela CataniYupeng LiNiek SandersStefan LienenklausStefaan De KokerBart Lambrecht et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses

Lutz NuhnStefaan De KokerSandra Van LintZifu ZhongJoão Portela CataniFrancis CombesKim DeswarteYupeng LiBart LambrechtStefan Lienenklaus et al.

A1 Journal Article in ADVANCED MATERIALS

pH-Sensitive hydrazone-linked doxorubicin nanogels via polymeric-activated ester scaffolds : synthesis, assembly, and in vitro and in vivo evaluation in tumor-bearing zebrafish

Alexandra Van DriesscheAgnese KocereHannelien EveraertLutz NuhnSimon Van HerckGareth GriffithsFederico FenaroliBruno De Geest

A1 Journal Article in CHEMISTRY OF MATERIALS

Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist

Lutz NuhnLien Van HoeckeKim DeswarteBert SchepensYupeng LiBart LambrechtStefaan De KokerSunil A DavidXavier SaelensBruno De Geest

A1 Journal Article in BIOMATERIALS

Targeting protumoral tumor-associated macrophages with nanobody-functionalized nanogels through strain promoted azide alkyne cycloaddition ligation

Lutz NuhnEvangelia BolliSam MassaIsabel VandenbergheKiavash MovahediBart DevreeseJo A Van GinderachterBruno De Geest

A1 Journal Article in BIOCONJUGATE CHEMISTRY

2017

Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization

Sabah KasmiBenoit LouageLutz NuhnGlenn VerstraeteSimon Van HerckMies J van SteenbergenChris VervaetWim E HenninkBruno De Geest

A1 Journal Article in POLYMER CHEMISTRY

Cancer cell lysate entrapment in CaCO3 engineered with polymeric TLR-agonists : immune-modulating microparticles in view of personalized antitumor vaccination

Lien LybaertKeun Ah RyuLutz NuhnRiet De RyckeOlivier De WeverAlfred C ChonAaron P Esser-KahnBruno De Geest

A1 Journal Article in CHEMISTRY OF MATERIALS

Downstream processing from hot-melt extrusion towards tablets : a quality by design approach

Wouter GrymonpréNils BostijnSimon Van HerckGlenn VerstraeteValérie VanhoorneLutz NuhnPieter RomboutsThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Micellar paclitaxel-initiated RAFT polymer conjugates with acid-sensitive behavior

Benoit LouageMies J. van SteenbergenLutz NuhnMartijn RisseeuwIzet KaralicJohan WinneSerge Van CalenberghWim E HenninkBruno De Geest

A1 Journal Article in ACS MACRO LETTERS

SiRNA-mediated in vivo gene knockdown by acid-degradable cationic nanohydrogel particles

Nadine LeberLeonard KapsMisbah AslamJonathan SchuppAlexander BroseDavid SchäffelKarl FischerMustafa DikenDennis StrandKaloian Koynov et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Thermoplastic polyurethane-based intravaginal rings for prophylaxis and treatment of (recurrent) bacterial vaginosis

Glenn VerstraeteL. VandenbusscheSabah KasmiLutz NuhnD. BrouckaertJeroen Van RenterghemW. GrymonpreValérie VanhoorneTom CoenyeBruno De Geest et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Transiently thermoresponsive polymers and their applications in biomedicine

Nane VanparijsLutz NuhnBruno De Geest

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

2016

A generic polymer-protein ligation strategy for vaccine delivery

Lien LybaertNane VanparijsKaat FierensMartijn SchuijsLutz NuhnBart LambrechtBruno De Geest

A1 Journal Article in BIOMACROMOLECULES

Core/shell protein-reactive nanogels via a combination of RAFT polymerization and vinyl sulfone postmodification

Nane VanparijsLutz NuhnSamantha J PaluckMaria KokkinopoulouIngo LieberwirthHeather D MaynardBruno De Geest

A1 Journal Article in NANOMEDICINE

Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

Zhiyue ZhangBert SchepensLutz NuhnXavier SaelensMichael SchotsaertNico CallewaertRiet De RyckeQilu ZhangSébastien MoinsSamira Benali et al.

A1 Journal Article in CHEMICAL COMMUNICATIONS

pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation

Lutz NuhnNane VanparijsAns De BeuckelaerLien LybaertGlenn VerstraeteKim DeswarteStefan LienenklausNikunj M ShuklaAlex CD SalyerBart Lambrecht et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pH-Degradable mannosylated nanogels for dendritic cell targeting

Ruben De CoenNane VanparijsMartijn RisseeuwLien LybaertBenoit LouageStefaan De KokerVimal Kumar UdhayakumarJohan GrootenLeeanne TaylorNeil Ayres et al.

A1 Journal Article in BIOMACROMOLECULES

Reductive decationizable block copolymers for stimuli-responsive mRNA delivery

Lutz NuhnLeonard KapsMustafa DikenDetlef SchuppanRudolf Zentel

A1 Journal Article in MACROMOLECULAR RAPID COMMUNICATIONS

Squaric ester amides as hydrolysis-resistant functional groups for protein-conjugation of RAFT-derived polymers

Zhiyue ZhangNane VanparijsStef VandewalleFilip Du PrezLutz NuhnBruno De Geest

A1 Journal Article in POLYMER CHEMISTRY

Transiently responsive block copolymer micelles based on N-(2-hydroxypropyl)methacrylamide engineered with hydrolyzable ethylcarbonate side chains

Sabah KasmiBenoit LouageLutz NuhnAlexandra Van DriesscheJan Van DeunIzet KaralicMartijn RisseeuwSerge Van CalenberghRichard HoogenboomRiet De Rycke et al.

A1 Journal Article in BIOMACROMOLECULES

Tunable dynamic hydrophobic attachment of guest molecules in amphiphilic core–shell polymers

Jörg ReichenwallnerAnja ThomasLutz NuhnTobias JohannAnnette MeisterHolger FreyDariush Hinderberger

A1 Journal Article in POLYMER CHEMISTRY

Well-defined polymer-paclitaxel prodrugs by a grafting-from-drug approach

Benoit LouageLutz NuhnMartijn RisseeuwNane VanparijsRuben De CoenIzet KaralicSerge Van CalenberghBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Wohldefinierte polymere Paclitaxel-Prodrugs über eine Grafting-From-Methode ausgehend vom Arzneistoff

Benoit LouageLutz NuhnMartijn RisseeuwNane VanparijsRuben De CoenIzet KaralicSerge Van CalenberghBRUNO DE GEEST

A2 Journal Article in ANGEWANDTE CHEMIE

2015

In vivo gene-silencing in fibrotic liver by siRNA-loaded cationic nanohydrogel particles

Leonard KapsLutz NuhnMisbah AslamAlexander BroseFriedrich FoersterSebastian RosigkeitPatricia RenzRosario HeckYong Ook KimIngo Lieberwirth et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Not just for tumor targeting : unmet medical needs and opportunities for nanomedicine

Elise Anne LepeltierLutz NuhnClaus-Michael LehrRudolf Zentel

Editorial material