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Researcher
Ludwine Messiaen
Profile
Projects
Publications
Activities
Awards & Distinctions
74
Results
2006
Cafe-au-lait spots in neurofibromatosis type 1 and in healthy control individuals: hyperpigmentation of a different kind?
Sofie De Schepper
Joachim Boucneau
Yves Vander Haeghen
Ludwine Messiaen
Jean Naeyaert
Jo Lambert
A1
Journal Article
in
ARCHIVES OF DERMATOLOGICAL RESEARCH
2006
Neurofibromatosis type 1 protein and amyloid precursor protein interact in normal human melanocytes and colocalize with melanosomes
Sofie De Schepper
Joachim Boucneau
Wendy Westbroek
M MOMMAAS
J ONDERWATER
Ludwine Messiaen
Jean Naeyaert
Jo Lambert
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2006
2005
Deletions involving long-range conserved nongenic sequences upstream and downstream of FOXL2 as a novel disease-causing mechanism in Blepharophimosis syndrome
Diane Beysen
Jeroen Raes
Bart Leroy
A Lucassen
JRW Yates
J Clayton-Smith
H Ilyina
SS Brooks
S Christin-Maitre
Marc Fellous
et al.
A1
Journal Article
in
AMERICAN JOURNAL OF HUMAN GENETICS
2005
Familial pericentric inversion of chromosome 18: behavioral abnormalities in patients heterozygous for either the dup(18p)/del(18q) or dup(18q)/del(18p) recombinant chromosome
Stefan Vermeulen
Franki Speleman
L VANRANSBEECK
Jasmine Verspeet
Björn Menten
MR VERSCHRAEGEN-SPAE
Philippe De Wilde
Ludwine Messiaen
RC MICHAELIS
Juliaan Leroy
A1
Journal Article
in
EUROPEAN JOURNAL OF HUMAN GENETICS
2005
Pigment cell-related manifestations in neurofibromatosis type 1: an overview
Sofie De Schepper
Joachim Boucneau
Jo Lambert
Ludwine Messiaen
Jean Naeyaert
A1
Journal Article
in
PIGMENT CELL RESEARCH
2005
2004
A new type of autosomal recessive spondyloepiphyseal dysplasia tarda
Juliaan Leroy
Bart Leroy
LV Emmery
Ludwine Messiaen
JW Spranger
A1
Journal Article
in
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
2004
BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families
Kathleen Claes
Bruce Poppe
Ilse Coene
Anne De Paepe
Ludwine Messiaen
A1
Journal Article
in
BRITISH JOURNAL OF CANCER
2004
Mutations of VMD2 splicing regulators cause nanophthalmos and autosomal dominant vitreoretinochoroidopathy (ADVIRC)
Jill Yardley
Bart Leroy
Niki Hart-Holden
Bart Lafaut
Bart Loeys
Ludwine Messiaen
Rahat Perveen
M Ashwin Reddy
Shomi S Bhattacharya
Elias Traboulsi
et al.
A1
Journal Article
in
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
2004
Neurofibromin is actively transported to the nucleus
Ina Vandenbroucke
Patric Van Oostveldt
Elisabeth Coene
Anne De Paepe
Ludwine Messiaen
A1
Journal Article
in
FEBS LETTERS
2004
2003
BRCA1/2 mutation spectrum and frequencies in Belgian breast/ovarian cancer families
Kathleen Claes
Bruce Poppe
Ilse Coene
Anne De Paepe
Ludwine Messiaen
C3
Conference
2003
Differentiating pathogenic mutations from polymorphic alterations in the splice sites of BRCA1 and BRCA2
Kathleen Claes
Bruce Poppe
E MACHACKOVA
Ilse Coene
L FORETOVA
Anne De Paepe
Ludwine Messiaen
A1
Journal Article
in
GENES CHROMOSOMES & CANCER
2003
Evidence for involvement of a tumor suppressor gene on 1p in malignant peripheral nerve sheath tumors
Nadine Van Roy
M VAN GELE
Jo Vandesompele
Ludwine Messiaen
Simon Van Belle
R SCIOT
K MORTELE
J GYSELINCK
E MICHIELS
Ramses Forsyth
et al.
A1
Journal Article
in
CANCER GENETICS AND CYTOGENETICS
2003
FOXL2 and BPES: mutational hotspots, phenotypic variability, and revision of the genotype-phenotype correlation
Elfride De Baere
Diane Beysen
Christine Oley
Birgit Lorenz
Julie Cocquet
Petra De Sutter
Koen Devriendt
Michael Dixon
Marc Fellous
Jean-Pierre Fryns
et al.
A1
Journal Article
in
AMERICAN JOURNAL OF HUMAN GENETICS
2003
More than 125 FOXL2 mutations and variants in BPES and POF patients in the human FOXL2 allelic variant database
Diane Beysen
Jo Vandesompele
Filip Pattyn
Anne De Paepe
Ludwine Messiaen
Elfride De Baere
C3
Conference
2003
2002
A patient severely affected by spinal neurofibromas carries a recurrent splice site mutation in the NF1 gene.
K WIMMER
M MUHLBAUER
M ECKART
T CALLENS
H REHDER
T BIRKNER
Juliaan Leroy
C FONATSCH
Ludwine Messiaen
A1
Journal Article
in
EUROPEAN JOURNAL OF HUMAN GENETICS
2002
Aberrant splicing in several human tumors in the tumor suppressor genes neurofibromatosis type 1, neurofibromatosis type 2, and tuberous sclerosis 2.
D KAUFMANN
W LEISTNER
P KRUSE
O KENNER
S HOFFMEYER
C HEIN
W VOGEL
Ludwine Messiaen
B BARTELT
A1
Journal Article
in
CANCER RESEARCH
2002
BPES
Ludwine Messiaen
E DE BAERE
Bookchapter
in
National Organization for Rare Disorders (NORD) (eds). Guide to rare disorders Publisher Lippincott, Williams and Wilkins, Philadelphia, PA, 2002, p.641. -
2002
Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition
Ans Baeyens
Hubert Thierens
Kathleen Claes
Bruce Poppe
Ludwine Messiaen
Leo De Ridder
Anne Vral
A1
Journal Article
in
BRITISH JOURNAL OF CANCER
2002
Does monosymptomatic enuresis exist? A molecular genetic exploration of 32 families with enuresis/incontinence.
Bart Loeys
Piet Hoebeke
Ann Raes
Ludwine Messiaen
Anne De Paepe
Johan Vande Walle
A1
Journal Article
in
BJU INTERNATIONAL
2002
Evolution and expression of FOXL2
J COCQUET
E PAILHOUX
F JAUBERT
N SERVEL
X XIA
M PANNETIER
Elfride De Baere
Ludwine Messiaen
C COTINOT
M FELLOUS
et al.
A1
Journal Article
in
JOURNAL OF MEDICAL GENETICS
2002
Kallmann syndrome in a patient with congenital spherocytosis and an interstitial 8p11.2 deletion.
Stefan Vermeulen
Ludwine Messiaen
P SCHEIR
Sylvia De Bie
Franki Speleman
Anne De Paepe
A1
Journal Article
in
AMERICAN JOURNAL OF MEDICAL GENETICS
2002
Novel insights in genotype-phenotype correlations in BPES through in-depth FOXL2 mutation analysis
Elfride De Baere
Diane Beysen
C OLEY
Petra De Sutter
A GARZA
C JONSRUD
P KOIVISTO
Bart Leroy
B LORENZ
Françoise Meire
et al.
C3
Conference
2002
Pathological splice mutations outside the invariant AG/GT splice sites of BRCA1 exon 5 increase alternative transcript levels in the 5 ' end of the BRCA1 gene.
Kathleen Claes
Jo Vandesompele
Bruce Poppe
K DAHAN
I COENE
Anne De Paepe
Ludwine Messiaen
A1
Journal Article
in
ONCOGENE
2002
Quantification of NF1 transcripts reveals novel highly expressed splice variants.
Ina Vandenbroucke
Jo Vandesompele
Anne De Paepe
Ludwine Messiaen
A1
Journal Article
in
FEBS LETTERS
2002
Strategies for prenatal and preimplantation genetic diagnosis in Marfan syndrome (MFS).
Bart Loeys
Lieve Nuytinck
Petra Van Acker
SOPHIE WALRAEDT
M BONDUELLE
K SERMON
B HAMEL
A SANCHEZ
Ludwine Messiaen
Anne De Paepe
A1
Journal Article
in
PRENATAL DIAGNOSIS
2002
2001
Association between Cys282Tyr missense mutation and haptoglobin phenotype polymorphism in patients with chronic hepatitis C.
Hans Van Vlierberghe
JR DELANGHE
Sylvia De Bie
Marleen Praet
Anne De Paepe
Ludwine Messiaen
Martine De Vos
Geert Leroux-Roels
A1
Journal Article
in
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
2001
Carrier screening for cystic fibrosis in a prenatal setting.
Isabelle Delvaux
Ariane Van Tongerloo
Ludwine Messiaen
C VAN LOON
Sylvia De Bie
Geert Mortier
Anne De Paepe
A1
Journal Article
in
GENETIC TESTING
2001
Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis
C GROSS
Elfride De Baere
A LO
WH CHANG
Ludwine Messiaen
A1
Journal Article
in
DNA AND CELL BIOLOGY
2001
Diverse prevalence of large deletions within the OA1 gene in ocular albinism type 1 patients from Europe and North America.
MT BASSI
A BERGEN
P BITOUN
SJ CHARLES
M CLEMENTI
R GOSSELIN
J HURST
RA LEWIS
B LORENZ
T MEITINGER
et al.
A1
Journal Article
in
HUMAN GENETICS
2001
Quantification of splice variants using real-time PCR
Ina Vandenbroucke
Jo Vandesompele
Anne De Paepe
Ludwine Messiaen
A1
Journal Article
in
NUCLEIC ACIDS RESEARCH
2001
Spectrum and distribution of FOXL2 gene mutations and variants in BPES, POF and XX male patients: tentative genotype-phenotype correlation
Elfride De Baere
M DIXON
K SMALL
E JABS
Bart Leroy
K DEVRIENDT
Y GILLEROT
Geert Mortier
Françoise Meire
L VAN MALDERGEM
et al.
C3
Conference
2001
Spectrum of FOXL2 gene mutations in blepharophimosis-ptosis-epicanthus inversus (BPES) families demonstrates a genotype-phenotype correlation
Elfride De Baere
Michael J Dixon
Kent W Small
Ethylin W Jabs
Bart Leroy
Koenraad Devriendt
Yves Gillerot
Geert Mortier
Françoise Meire
Lioinel Van Maldergem
et al.
A1
Journal Article
in
HUMAN MOLECULAR GENETICS
2001
2000
Arg-Cys substitution at codon 1246 of the human myosin Va gene is not associated with Griscelli syndrome.
Jo Lambert
JM NAEYAERT
Anne De Paepe
Rudy Van Coster
A FERSTER
M SONG
Ludwine Messiaen
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2000
Association between the Cys282Tyr missense mutation and the haptoglobin phenotype polymorphism in patients with chronic hepatitis C
Hans Van Vlierberghe
Ludwine Messiaen
Anne De Paepe
Joris Delanghe
Marleen Praet
M De Vos
Geert Leroux-Roels
C3
Conference
2000
DNA-onderzoek in het begin van de 21ste eeuw: dromen en werkelijkheid.
Elfride De Baere
Ludwine Messiaen
A2
Journal Article
in
TIJDSCHRIFT VOOR GENEESKUNDE
2000
Exhaustive mutation analysis of the NF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects.
Ludwine Messiaen
T CALLENS
Geert Mortier
Diane Beysen
Ina Vandenbroucke
Nadine Van Roy
Franki Speleman
Anne De Paepe
A1
Journal Article
in
HUMAN MUTATION
2000
Identification and characterisation of a founder mutation in the Belgian breast/ovarian cancer population
Kathleen Claes
Bruce Poppe
PETRA SCHEIR
M De Vos
I Delveaux
Ilse Coene
Anne De Paepe
Ludwine Messiaen
C3
Conference
2000
Nieuwe inzichten in de moleculaire oorzaken van familiale borst- en ovariumkanker
Kathleen Claes
Anne De Paepe
Ludwine Messiaen
A2
Journal Article
in
TIJDSCHRIFT VOOR GENEESKUNDE
2000
Prevalence of the Cys282Tyr and His63Asp mutation in flemish patients with hereditary hemochromatosis.
Hans Van Vlierberghe
Ludwine Messiaen
Marc Hautekeete
Anne De Paepe
A1
Journal Article
in
ACTA GASTRO-ENTEROLOGICA BELGICA
2000
Transcript mapping of the BPES critical region at 3q23: identification of novel candidate genes
Elfride De Baere
Leen De Vuyst
Anne De Paepe
Ludwine Messiaen
C3
Conference
2000
1999
Closing in an the BPES gene on 3q23: Mapping of a de nova reciprocal translocation t(3;4)(q23;p15.2) breakpoint within a 45-kb cosmid and mapping of three candidate genes, RBP1, RBP2, and beta '-COP, distal to the breakpoint
Elfride De Baere
Nadine Van Roy
Franki Speleman
Y FUKUSHIMA
Anne De Paepe
Ludwine Messiaen
A1
Journal Article
in
GENOMICS
1999
Erfelijke hemochromatose: van Kelten en IJzeren Tijdperk tot genetische diagnose.
Hans Van Vlierberghe
Ludwine Messiaen
Marc Hautekeete
A ELEWAUT
Anne De Paepe
A2
Journal Article
in
TIJDSCHRIFT VOOR GENEESKUNDE
1999
Exclusion of the beta '-COP gene and identification of a novel candidate gene for the blepharophimosis syndrome (BPES)
Elfride De Baere
E ROMAN
Y FUKUSHIMA
K VERHOEVEN
G VAN CAMP
Anne De Paepe
Ludwine Messiaen
C3
Conference
1999
Exon 10b of the NF1 gene represents a mutational hotspot and harbors a recurrent missense mutation Y489C associated with aberrant splicing.
Ludwine Messiaen
T CALLENS
KJ ROUX
Geert Mortier
Anne De Paepe
M ABRAMOWICZ
MA PERICAK-VANCE
JM VANCE
MR WALLACE
A1
Journal Article
in
GENETICS IN MEDICINE
1999
Genetic counselling and testing for hereditary breast and ovarian cancer: the gent(le) approach
M De Vos
Bruce Poppe
Isabelle Delvaux
Geert Mortier
Kathleen Claes
Ludwine Messiaen
Anne De Paepe
A1
Journal Article
in
DISEASE MARKERS
1999
Mutation analysis of the BRCA1 and BRCA2 genes in the Belgian patient population and identification of a Belgian founder mutation BRCA1 IVS5+3A > G
Kathleen Claes
E Machackova
Martine De Vos
Bruce Poppe
Anne De Paepe
Ludwine Messiaen
A1
Journal Article
in
DISEASE MARKERS
1999
Mutation analysis of the BRCA1 and BRCA2 genes results in the identification of novel and recurrent mutations in 6/16 Flemish patients with breast and/or ovarian cancer but not in 12 sporadic patients with early-onset disease
Kathleen Claes
Eva Machackova
Michel De Vos
Geert Mortier
Anne De Paepe
Ludwine Messiaen
A2
Journal Article
in
HUMAN MUTATION
1999
Preimplantation genetic diagnosis of Marfan syndrome with the use of fluorescent polymerase chain reaction and the Automated Laser Fluorescence DNA sequencer
Karen Sermon
Willy Lissens
Ludwine Messiaen
Maryse Bonduelle
Mark Vandervorst
André Van Steirteghem
Inge Liebaers
A1
Journal Article
in
FERTILITY AND STERILITY
1999
The Czech Republic: Genetic counseling in high-risk breast/ovarian cancer families.
L FORETOVA
E MACHACKOVA
D VALIK
Ludwine Messiaen
A1
Journal Article
in
DISEASE MARKERS
1999
1998
APC resistance and associated F II variant or C677T homozygosity
Gaston Baele
Ludwine Messiaen
C3
Conference
1998
Application of fluorescence in situ hybridization to the identification of different marker chromosomes.
MR VERSCHRAEGEN-SPAE
B QUACK
S ROUSSEAUX
H PISON
Ludwine Messiaen
Anne De Paepe
J LESPINASSE
A1
Journal Article
in
ANNALES DE GENETIQUE
1998
Assignment of SHOX2 (alias OG12X and SHOT) to human chromosome bands 3q25 -> q26.1 by in situ hybridization.
Elfride De Baere
Franki Speleman
Nadine Van Roy
Anne De Paepe
Ludwine Messiaen
A1
Journal Article
in
CYTOGENETICS AND CELL GENETICS
1998
Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta ' subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization
Elfride De Baere
Franki Speleman
Nadine Van Roy
Anne De Paepe
Ludwine Messiaen
A1
Journal Article
in
CYTOGENETICS AND CELL GENETICS
1998
Assignment of the cellular retinol-binding protein 2 gene (RBP2) to human chromosome band 3q23 by in situ hybridization
Elfride De Baere
Franki Speleman
Nadine Van Roy
K MORTIER
Anne De Paepe
Ludwine Messiaen
A1
Journal Article
in
CYTOGENETICS AND CELL GENETICS
1998
Chondrodysplasia punctata with multiple congenital anomalies: a new syndrome?
Geert Mortier
Ludwine Messiaen
Marc Espeel
KJ SMETS
Bart Vanzieleghem
Frank Roels
Anne De Paepe
A1
Journal Article
in
PEDIATRIC RADIOLOGY
1998
Human myosin V gene produces different transcripts in a cell type-specific manner
Jo Lambert
Jean Naeyaert
TOM CALLENS
Anne De Paepe
Ludwine Messiaen
A1
Journal Article
in
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
1998
Molecular analysis of lp36 breakpoints in two Merkel cell carcinomas.
Mireille Van Gele
Nadine Van Roy
SG RONAN
Ludwine Messiaen
Jo Vandesompele
Marie Geerts
M NAEYAERT
E BLENNOW
I BAR-AM
TK DAS GUPTA
et al.
A1
Journal Article
in
GENES CHROMOSOMES & CANCER
1998
Molecular diagnostic evaluation of NF1 patients using the combined approach of karyotyping, fluorescent in situ hybridisation, the protein truncation assay and heteroduplex analysis
Ludwine Messiaen
Geert Mortier
T Callens
Nadine Van Roy
Franki Speleman
Anne De Paepe
C3
Conference
1998
Noonan-like phenotype in monozygotic twins with a duplication-deficiency of the long arm of chromosome 18 resulting from a maternal paracentric inversion.
W COURTENS
D GROSSMAN
Nadine Van Roy
Ludwine Messiaen
E VAMOS
V TOPPET
D HAUMONT
C STREYDIO
A JAUCH
JR VERMEESCH
et al.
A1
Journal Article
in
HUMAN GENETICS
1998
Prenatal diagnosis of a constitutional interstitial deletion of chromosome 5 (q15q31.1) presenting with features of congenital contractural arachnodactyly.
W COURTENS
W TJALMA
Ludwine Messiaen
E VAMOS
JJ MARTIN
E VAN BOGAERT
G KEERSMAEKERS
P MEULYZER
J WAUTERS
A1
Journal Article
in
AMERICAN JOURNAL OF MEDICAL GENETICS
1998
1997
Analysis of 22 cystic fibrosis mutations in 62 patients from the Flanders, Belgium, reveals a high prevalence of Nordic mutation 394delTT.
Ludwine Messiaen
Conny VAN LOON
Rudi ROSSAU
Ilse DE CANCK
Frans De Baets
Eddy ROBBRECHT
Anne De Paepe
A1
Journal Article
in
HUMAN MUTATION
1997
Characterisation of two different nonsense mutations, C6792A and C6792G, causing skipping of exon 37 in the NF1 gene.
Ludwine Messiaen
T CALLENS
A DEPAEPE
Margarita Craen
Geert Mortier
A1
Journal Article
in
HUMAN GENETICS
1997
Experience with the APC resistance test without and with factor V deficient plasma
J Van Acker
Ludwine Messiaen
Gaston Baele
C3
Conference
1997
Identification of two different mutations causing protein S deficiency in two unrelated Belgian families using a nonisotopic scanning and sequencing method
Ludwine Messiaen
T Callens
Gaston Baele
A1
Journal Article
in
HAEMOSTASIS
1997
Identification of two novel mutations in the protein S active gene using a non-isotopic scanning and sequencing method
Ludwine Messiaen
T Callens
Bart Vanbrabandt
Gaston Baele
C3
Conference
1997
Interstitial deletion 2q33.3-q34 in a boy with a phenotype resembling the Seckel syndrome.
W COURTENS
Franki Speleman
Ludwine Messiaen
J BORMANS
Nadine Van Roy
E VAMOS
A1
Journal Article
in
AMERICAN JOURNAL OF MEDICAL GENETICS
1997
Resistentie tegen geactiveerd proteïne C: Casuïstiek en overzicht van de literatuur.
M REMERY
Ludwine Messiaen
Gaston Baele
A2
Journal Article
in
TIJDSCHRIFT VOOR GENEESKUNDE
1997
1996
Novel frameshift mutation in a heterozygous woman with Fabry disease and end-stage renal failure.
A VANLOO
Raymond Vanholder
K MADSEN
Marleen Praet
Jozef Kint
A DEPAEPE
Ludwine Messiaen
Norbert Lameire
L HASHOLT
SA SORENSEN
et al.
A1
Journal Article
in
AMERICAN JOURNAL OF NEPHROLOGY
1996
Refined genetic and physical mapping of BPES type II
Ludwine Messiaen
Bart Leroy
Sylvia De Bie
K De Pauw
Nadine Van Roy
Franki Speleman
G Van Camp
Anne De Paepe
A1
Journal Article
in
EUROPEAN JOURNAL OF HUMAN GENETICS
1996
Report of the sixth international workshop on human chromosome 3 mapping 1995
SL Naylor
B Carritt
C Boileau
C Beroud
C Alexander
P Allderdice
A Alimov
T Ashworth
J Bonifas
P Bugert
et al.
Editorial material
1996
1995
An in vitro model for chick embryonic notochords
E Ghanem
Ludwine Messiaen
Leo De Ridder
A1
Journal Article
in
CYTOTECHNOLOGY
1995
Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES): clinical subtypes and their genotype
Bart Leroy
Ludwine Messiaen
Nadine Van Roy
Franki Speleman
Anne De Paepe
C3
Conference
1995
1993
Identificatie en karakterisatie van het gen voor neurofibromatose type 1 (NF1): recente ontwikkelingen
Ludwine Messiaen
Juliaan Leroy
A2
Journal Article
in
TIJDSCHRIFT VOOR GENEESKUNDE
1993
LACK OF INDEPENDENCE BETWEEN 5 DNA POLYMORPHISMS IN THE NF1 GENE.
Ludwine Messiaen
S DEBIE
T MOENS
A VANDENENDEN
Juliaan Leroy
A1
Journal Article
in
HUMAN MOLECULAR GENETICS
1993