Research Explorer

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Researcher

Ludovicus Staelens

Awards & Distinctions

24 Results

2006

Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis

Ken CoppietersTorsten DreierKaren SilenceHans de HaardMarc LauwereysPeter CasteelsEls BeirnaertHeidi JonckheereChristophe Van De WieleLudovicus Staelens et al.

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Optimization by experimental design of precursor synthesis and radiolabeling of 2-iodo-L-phenylalanine, a novel amino acid for tumor imaging.

Veerle KersemansK KERSEMANSBart CornelissenLudovicus StaelensBart De SpiegeleerJ MERTENSGuido Slegers

A1 Journal Article in CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Valine-based biphenylsulphonamide matrix metalloproteinase inhibitors as tumor imaging agents

Ruth OltenfreiterLudovicus StaelensVeerle KersemansBart CornelissenF FRANKENNEJM FOIDARTChristophe Van De WieleGuido Slegers

A1 Journal Article in APPLIED RADIATION AND ISOTOPES

2005

Comparison between 1 T MRI and non-MRI based volumetry in inoculated tumours in mice

Bart CornelissenVeerle KersemansLennart JansLudovicus StaelensRuth OltenfreiterT ThonissenEric AchtenGuido Slegers

A1 Journal Article in BRITISH JOURNAL OF RADIOLOGY

In vitro and in vivo evaluation of [I-123]-VEGF(165) as a potential tumor marker

Bart CornelissenRuth OltenfreiterVeerle KersemansLudovicus StaelensF FRANKENNEJM FOIDARTG SLEGERS

A1 Journal Article in NUCLEAR MEDICINE AND BIOLOGY

In vivo evaluation of [I-123]-3-(4-iodobenzyl)-1,2,3,4-tetrahydro-8-hydroxychromeno [3,4-c]pyridin-5-one: a presumed dopamine D-4 receptor ligand for SPECT studies

Ludovicus StaelensRuth OltenfreiterPeter BlanckaertVeerle KersemansKATIA VANDENBULCKEChristophe Van De WieleGuido Slegers

A1 Journal Article in NUCLEAR MEDICINE AND BIOLOGY

In vivo evaluation of [I-123]-4-iodo-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-benzamide: a potential sigma receptor ligand for SPECT studies

Ludovicus StaelensRuth OltenfreiterFilip DumontRN WATERHOUSEK VANDENBULCKEPeter BlanckaertRudi DierckxGuido Slegers

A1 Journal Article in NUCLEAR MEDICINE AND BIOLOGY

Synthesis of [I-123]-3-(4-iodobenzyl)-1,2,3,4-tetrahydro-8-hydroxychromeno[3,4-c]pyri din-5-one, a potential dopamine D4 ligand for SPECT studies

Ludovicus StaelensRuth OltenfreiterBart CornelissenPeter BlanckaertFilip De VosDieter DeforceRudi DierckxGuido Slegers

A1 Journal Article in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis, quality control and in vivo evaluation of [I-123] rhTIMP-2, a potential tumour-imaging agent

Ruth OltenfreiterIngrid BurvenichLudovicus StaelensA LEJEUNEF FRANKENNEJM FOIDARTGuido Slegers

A1 Journal Article in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis, radiosynthesis, in vitro and preliminary in vivo evaluation of biphenyl carboxylic and hydroxamic matrix metalloproteinase (MMP) inhibitors as potential tumor imaging agents

Ruth OltenfreiterLudovicus StaelensUlrik HillaertA HEREMANSA NOELF FRANKENNEGuido Slegers

A1 Journal Article in APPLIED RADIATION AND ISOTOPES

Tryptophane-based biphenylsulfonamide matrix metalloproteinase inhibitors as tumor imaging agents

Ruth OltenfreiterLudovicus StaelensS LABIEDVeerle KersemansF FRANKENNEA NOELChristophe Van De WieleGuido Slegers

A1 Journal Article in CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

2004

New radioiodinated carboxylic and hydroxamic matrix metalloproteinase inhibitor tracers as potential tumor imaging agents

Ruth OltenfreiterLudovicus StaelensA LEJEUNEFilip DumontF FRANKENNEJM FOIDARTGuido Slegers

A1 Journal Article in NUCLEAR MEDICINE AND BIOLOGY

Precursor synthesis, radiosynthesis and in vivo evaluation in mice of [I-123]-(4-fluorophenyl) {1-[2-(2-iodophenyl)ethyl]piperidin-4-yl}-methanone and -methanol, as potential SPECT tracers for the 5-HT2A-receptor

Peter BlanckaertM VandecapelleIngrid BurvenichLudovicus StaelensGuido Slegers

Radiosynthesis and in vivo evaluation of 123I-rTIMP-2 as potential SPECT tumour imaging agent

Ruth OltenfreiterLudovicus StaelensIngrid BurvenichBart CornelissenF FrankenneJM FoidartGuido Slegers

Radiosynthesis and in vivo evaluation of a carboxylic MMP inhibitor as potential SPECT tumour imaging agent

Ruth OltenfreiterLudovicus StaelensIngrid BurvenichF FrankenneJM FoidartGuido Slegers

Synthesis, radiosynthesis and preliminary in vivo evaluation of [I-123](4-fluorophenyl) {1-[2-(2(2-iodophenyl)ethyl]piperidin-4-yl}methanone, a potential 5-HT2A-antagonist for SPECT brain imaging

Peter BlanckaertMarleen VandecapelleLudovicus StaelensIngrid BurvenichRudi DierckxGuido Slegers

A1 Journal Article in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

2003

Radiosynthesis and biological activity testing of a potent gelatinase inhibitor, a new potential SPECT tumour imaging agent

Ruth OltenfreiterLudovicus StaelensA LejeuneF OlivierF FrankenneA NoelGuido Slegers

Synthesis and in vivo evaluation in mice and rabbits of [123I]-3-(4-iodobenzyl)-8-methoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one as possible agent for imaging of the dopamine D4-receptor

Ludovicus StaelensRuth OltenfreiterFilip DumontVeerle KersemansBart CornelissenGuido Slegers

Synthesis and radiolabelling of [I-123]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-benzamide, a potential dopamine D-3 antagonist for SPECT studies

Ludovicus StaelensFilip DumontF DE VOSRuth OltenfreiterMarleen VandecapelleRudi DierckxGuido Slegers

A1 Journal Article in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis and radiolabelling of [I-123]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-benzamide, a potential dopamine D-3 antagonist for SPECT studies

Ludovicus StaelensFilip DumontF DE VOSRuth OltenfreiterMarleen VandecapelleRudi DierckxGuido Slegers

A1 Journal Article in JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

2002

Biological activity determination of I-BSP, a potent MMP 2 inhibitor, and its 123I tracer synthesis, World Journal of Nuclear Medicine, 2002, volume 1, supplement 2, S188

Ruth OltenfreiterLudovicus StaelensA LEJEUNEF FRANKENNERudi DierckxGuido Slegers

Synthesis and in vivo evaluation of [123I]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-benzamide, a potential sigma receptor ligand for SPECT studies

Ludovicus StaelensFilip DumontFilip De VosRuth OltenfreiterIngeborg GoethalsRudi DierckxGuido Slegers

2001

Optimization of the chiral separation of some 2-arylpropionic acids on an avidin column by modeling a combined response.

Els SmetLudovicus StaelensY VANDER HEYDENWilly BaeyensHY ABOUL-ENEING VAN DER WEKENAM GARCIA-CAMPANA

A1 Journal Article in CHIRALITY

Title: Synthesis, biodistribution and blocking studies in mice of a new 123I-labeled dopamine D3 antagonist Dierckx RA, Slegers G

Ludovicus StaelensFilip DumontF DEVOSRuth OltenfreiterM VANDECAPELLEIngeborg GoethalsRudi DierckxGuido Slegers