Research Explorer

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Researcher

Lotte Vermeulen

Awards & Distinctions

8 Results

2020

Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis

Juan FraireGaëlle HouthaeveJing LiuLaurens RaesLotte VermeulenStephan StremerschToon BransGerardo Garcia-Diaz BarrigaSarah De KeulenaerFilip Van Nieuwerburgh et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2018

Endosomal size and membrane leakiness influence proton sponge-based rupture of endosomal vesicles

Lotte VermeulenToon BransSangram Keshari SamalPeter DubruelJo DemeesterStefaan De SmedtKatrien RemautKevin Braeckmans

A1 Journal Article in ACS NANO

Investigating the intracellular delivery of non-viral gene therapeutics : a focus on the endosomal barrier

Lotte VermeulenKevin BraeckmansKatrien Remaut

Methodologies to investigate intracellular barriers for nucleic acid delivery in non-viral gene therapy

Lotte VermeulenToon BransStefaan De SmedtKatrien RemautKevin Braeckmans

A1 Journal Article in NANO TODAY

Photothermally triggered endosomal escape and its influence on transfection efficiency of gold-functionalized JetPEI/pDNA nanoparticles

Lotte VermeulenJuan FraireLaurens RaesEllen De MeesterSarah De KeulenaerFilip Van NieuwerburghStefaan De SmedtKatrien RemautKevin Braeckmans

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quantifying the average number of nucleic acid therapeutics per nanocarrier by single particle tracking microscopy

Elisa ZagatoLotte VermeulenHeleen DewitteGriet Van ImschootRoosmarijn VandenbrouckeJo DemeesterStefaan De SmedtKristiaan NeytsKatrien RemautKevin Braeckmans

A1 Journal Article in MOLECULAR PHARMACEUTICS

The proton sponge hypothesis : fable or fact?

Lotte VermeulenStefaan De SmedtKatrien RemautKevin Braeckmans

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2016

Design of smart GE11-PLGA/PEG-PLGA blend nanoparticulate platforms for parenteral administration of hydrophilic macromolecular drugs : synthesis, preparation and in vitro/ex vivo characterization

Barbara ColzaniGiovanna SperanzaRossella DoratiBice ContiTiziana ModenaGiovanna BruniElisa ZagatoLotte VermeulenGeorge DakwarKevin Braeckmans et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS