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Researcher
Lothar Steidler
Profile
Projects
Publications
Activities
Awards & Distinctions
33
Results
2008
Paracellular entry of interleukin-10 producing Lactococcus lactis in inflamed intestinal mucosa in mice
Anouk Waeytens
Liesbeth Ferdinande
Sabine Neirynck
Pieter Rottiers
Martine De Vos
Lothar Steidler
Claude Cuvelier
A1
Journal Article
in
INFLAMMATORY BOWEL DISEASES
2008
2006
A phase I trial with Transgenic bacteria expressing interleukin-10 in Crohn's disease
H BRAAT
Pieter Rottiers
DW HOMMES
Nathalie Huyghebaert
Erik Remaut
Jean Paul Remon
SJH VAN DEVENTER
S NEIRYNCK
MP PEPPELENBOSCH
Lothar Steidler
A1
Journal Article
in
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
2006
Altered gut transcriptome in spondyloarthropathy
Debby Laukens
Harald Peeters
Bert Vander Cruyssen
Tom Boonefaes
Dirk Elewaut
Filip De Keyser
Herman Mielants
Claude Cuvelier
Eric Veys
Kenny Knecht
et al.
A1
Journal Article
in
ANNALS OF THE RHEUMATIC DISEASES
2006
Clinical potential of Lactococcus lactis mediated delivery of human Interleukin-10 and Trefoil Factors
Erik Remaut
H BRAAT
Klaas Vandenbroucke
Pieter Rottiers
Lothar Steidler
A2
Journal Article
in
Bioscience and microflora
2006
Genetically modified Lactococcus lactis: novel tools for drug delivery
Lothar Steidler
Klaas Vandenbroucke
A1
Journal Article
in
INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY
2006
Intracellular accumulation of trehalose protects Lactococcus lactis from freeze-drying damage and bile toxicity and increases gastric acid resistance
Sofie Termont
Klaas Vandenbroucke
Dirk Iserentant
Sabine Neirynck
Lothar Steidler
Erik Remaut
Pieter Rottiers
A1
Journal Article
in
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
2006
Therapeutic drug delivery by genetically modified Lactococcus lactis
Lothar Steidler
Pieter Rottiers
A1
Journal Article
in
INFLAMMATORY BOWEL DISEASE: GENETICS, BARRIER FUNCTION, IMMUNOLOGIC MECHANISMS, AND MICROBIAL PATHWAYS
2006
2005
CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease
Debby Laukens
Harald Peeters
DENIS MARICHAL
Bert Vander Cruyssen
Herman Mielants
Dirk Elewaut
Pieter Demetter
Claude Cuvelier
M VAN DEN BERGHE
Pieter Rottiers
et al.
A1
Journal Article
in
ANNALS OF THE RHEUMATIC DISEASES
2005
Development of an enteric-coated formulation containing freeze-dried, viable recombinant Lactococcus lactis for the ileal mucosal delivery of human interleukin-10
Nathalie Huyghebaert
A VERMEIRE
S NEIRYNCK
Lothar Steidler
Erik Remaut
Jean Paul Remon
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2005
Evaluation of extrusion/spheronisation, layering and compaction for the preparation of an oral, multi-particulate formulation of viable, hIL-10 producing Lactococcus lactis
Nathalie Huyghebaert
A VERMEIRE
S NEIRYNCK
Lothar Steidler
Erik Remaut
Jean Paul Remon
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2005
2004
Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice
Klaas Vandenbroucke
Wolfgang Hans
Jacques Van Huysse
Sabine Neirynck
Pieter Demetter
Erik Remaut
Pieter Rottiers
Lothar Steidler
A1
Journal Article
in
GASTROENTEROLOGY
2004
2003
Biological containment of genetically modified Lactococcus lactis for intestinal delivery of human interleukin 10
Lothar Steidler
Sabine Neirynck
Nathalie Huyghebaert
Veerle Snoeck
An Vermeire
Bruno Goddeeris
Eric Cox
Jean Paul Remon
Erik Remaut
A1
Journal Article
in
NATURE BIOTECHNOLOGY
2003
CARD15 mutations in patients with spondyloarthropathy are linked with disease progression and evolution to Crohn's disease
Martine De Vos
Debby Laukens
DENIS MARICHAL
M VAN DEN BERGHE
Harald Peeters
Dirk Elewaut
Herman Mielants
Filip De Keyser
Claude Cuvelier
Eric Veys
et al.
C3
Conference
2003
Crohn's disease patients with CARD15 variants have higher risk of developing axial joint involvement
Martine De Vos
Harald Peeters
Bert Vander Cruyssen
Debby Laukens
Denis Marichal
Marthe Vandenberghe
T Van Oostveldt
Dirk Elewaut
Filip De Keyser
Claude Cuvelier
et al.
C3
Conference
2003
Cytokines, chemokines and growth factors in the pathogenesis and treatment of inflammatory bowel disease
D O'NEIL
Lothar Steidler
A1
Journal Article
in
CYTOKINES AND CHEMOKINES IN AUTOIMMUNE DISEASE
2003
2002
In situ delivery of cytokines by genetically engineered Lactococcus lactis.
Lothar Steidler
A1
Journal Article
in
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
2002
Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis.
Tino Hochepied
Andy Wullaert
FG BERGER
H BAUMANN
Peter Brouckaert
Lothar Steidler
Claude Libert
A1
Journal Article
in
GUT
2002
2001
In situ delivery of cytokines at mucosal surfaces by genetically engineered Lactococcus lactis
Lothar Steidler
P1
Conference
2001
In situ delivery of cytokines at mucosal surfaces by genetically engineered Lactococcus lactis.
Lothar Steidler
[0-9]{2}
2001
Lactococcus lactis, a tool for the delivery of therapeutic proteins. Treatment of IBD.
Lothar Steidler
[0-9]{2}
2001
Microbiological and immunological strategies for treatment of inflammatory bowel disease.
Lothar Steidler
A1
Journal Article
in
MICROBES AND INFECTION
2001
2000
Secretion of biologically active murine interleukin-10 by Lactococcus lactis.
Lieven Schotte
Lothar Steidler
Joël Vandekerckhove
Erik Remaut
A1
Journal Article
in
ENZYME AND MICROBIAL TECHNOLOGY
2000
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.
Lothar Steidler
Wolfgang Hans
Lieven Schotte
Sabine Neirynck
F OBERMEIER
W FALK
Walther Fiers
Erik Remaut
A1
Journal Article
in
SCIENCE
2000
1998
Functional display of a heterologous protein on the surface of Lactococcus lactis by means of the cell wall anchor of Staphylococcus aureus protein A
Lothar Steidler
Jasmine Viaene
Walther Fiers
Erik Remaut
A1
Journal Article
in
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
1998
Mucosal delivery of murine interleukin-2 (IL-2) and IL-6 by recombinant strains of Lactococcus lactis coexpressing antigen and cytokine.
Lothar Steidler
K ROBINSON
L CHAMBERLAIN
KM SCHOFIELD
Erik Remaut
RWF LE PAGE
JM WELLS
A1
Journal Article
in
INFECTION AND IMMUNITY
1998
1996
Expression of human and murine interleukins in Lactococcus lactis
Lothar Steidler
Walther Fiers
Erik Remaut
Bookchapter
in
Lactic Acid Bacteria: Current Advances in Metabolism, Genetics and Applications
1996
The expression of the Photinus pyralis luciferase gene in Staphylococcus aureus Cowan I allows the development of a live amplifiable tool for immunodetection.
Lothar Steidler
W YU
Walther Fiers
Erik Remaut
A1
Journal Article
in
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
1996
1995
PRODUCTION OF SOLUBLE AND ACTIVE RECOMBINANT MURINE INTERLEUKIN-2 IN ESCHERICHIA-COLI - HIGH-LEVEL EXPRESSION, KIL-INDUCED RELEASE, AND PURIFICATION.
J ROBBENS
A RAEYMAEKERS
Lothar Steidler
Walther Fiers
Erik Remaut
A1
Journal Article
in
PROTEIN EXPRESSION AND PURIFICATION
1995
SECRETION OF BIOLOGICALLY-ACTIVE MURINE INTERLEUKIN-2 BY LACTOCOCCUS-LACTIS SUBSP LACTIS.
Lothar Steidler
JM WELLS
A RAEYMAEKERS
Joël Vandekerckhove
Walther Fiers
Erik Remaut
A1
Journal Article
in
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
1995
SIMULTANEOUS LIGHT-EMISSION FROM CLONED VIBRIO-FISCHERI LUX GENES AND EXPRESSION OF LAMB OR LAMB PROTEIN-A FUSION PROTEINS IN ESCHERICHIA-COLI DEPENDS ON USING A SINGLE CHIMERIC OPERON.
Lothar Steidler
Walther Fiers
Erik Remaut
A1
Journal Article
in
BIOTECHNOLOGY AND BIOENGINEERING
1995
1994
Efficient specific release of periplasmic proteins from Escherichia coli using temperature induction of cloned kil gene of pMB9.
Lothar Steidler
Walther Fiers
Erik Remaut
A1
Journal Article
in
BIOTECHNOLOGY AND BIOENGINEERING
1994
1993
LamB as a carrier molecule for the functional exposition of IgG-binding domains of the Staphylococcus aureus protein A at the surface of Escherichia coli K12.
Lothar Steidler
Erik Remaut
Walther Fiers
A1
Journal Article
in
MOLECULAR AND GENERAL GENETICS
1993
Pap pili as a vector system for surface exposition of an immunoglobulin G-binding domain of protein-A of Staphylococcus-aureus in Escherichia-coli.
Lothar Steidler
Erik Remaut
Walther Fiers
A1
Journal Article
in
JOURNAL OF BACTERIOLOGY
1993