Research Explorer

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Researcher

Lisa Opsomer

Publications & Research Data

Awards & Distinctions

10 Results

2026

Freeze-drying in sucrose followed by cryomilling enables the formulation of sa-mRNA–LNP powders for inhalation

E. M. JansenM. J. R. RuigrokM. S. SuhP. M. RuppelXiaole CuiLisa OpsomerNiek SandersH. W. FrijlinkW. L. J. Hinrichs

A1 Journal Article in PHARMACEUTICS

2025

Advancing self-amplifying RNA delivery : evaluating novel polyethylenimine-inspired polymers as non-viral carriers

Lisa OpsomerNiek SandersRichard Hoogenboom

Overcoming cold chain challenges : cryoprotection of self-amplifying mRNA polyplexes for long-term storage at ambient temperature

Lisa OpsomerSomdeb JanaRichard HoogenboomNiek Sanders

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2024

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Emily De LombaerdeXiaole CuiYong ChenZifu ZhongJulie DeckersGiulia MencarelliLisa OpsomerHaixiu WangJamie De BaereStefan Lienenklaus et al.

A1 Journal Article in ACS NANO

Efficient in vitro and in vivo transfection of self-amplifying mRNA with linear poly(propylenimine) and poly(ethylenimine-propylenimine) random copolymers as non-viral carriers

Lisa OpsomerSomdeb JanaIne MertensXiaole CuiRichard HoogenboomNiek Sanders

A1 Journal Article in JOURNAL OF MATERIALS CHEMISTRY B

2023

Novel polymers as promising non-viral carriers for self-amplifying mRNA-based applications

Lisa OpsomerSomdeb JanaIne MertensRichard HoogenboomNiek Sanders

Stability study of self-amplifying mRNA-based polyplexes

Lisa OpsomerSomdeb JanaRichard HoogenboomNiek Sanders

2022

Linear (PEI-)PPI-based (co-)polymers as promising alternative carrier platform for RNA-based vaccines and therapeutics

Novel promising PPI and PEI-PPI based polymeric carriers for sa-mRNA vaccines

2021

Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs

Zifu ZhongSéan Mc CaffertyLisa OpsomerHaixiu WangHanne HuysmansJoyca De TemmermanStefan LienenklausJoão Portela CataniFrancis CombesNiek Sanders

A1 Journal Article in MOLECULAR THERAPY