Research Explorer

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Researcher

Lindsey Devisscher

108 Results

2022

Glycomics-based serum markers as reliable tool for assessment of viral response after treatment with direct-acting antiviral drugs in hepatitis C virus infection

Nicky SomersElisabeth VandekerckhoveAnja GeertsHelena DegrooteSander LefereLindsey DevisscherLeander MeurisNico CallewaertHans Van VlierbergheXavier Verhelst

U Journal Article in ACTA CLINICA BELGICA

Intensive lifestyle management improves steatosis and fibrosis in pediatric non-alcoholic fatty liver disease

Sander LefereEllen DupontAnn De GuchtenaereStephanie Van BiervlietSaskia Vande VeldeXavier VerhelstLindsey DevisscherHans Van VlierbergheAnja GeertsRuth De Bruyne

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Intensive lifestyle management improves steatosis and fibrosis in pediatric nonalcoholic fatty liver disease

Sander LefereEllen DupontAnn De GuchtenaereStephanie Van BiervlietSaskia Vande VeldeXavier VerhelstLindsey DevisscherHans Van VlierbergheANJA GEERTSRuth De Bruyne

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Maternal and perinatal risk factors for pediatric nonalcoholic fatty liver disease : a systematic review

Ilya QuerterNele PauwelsRuth De BruyneEllen DupontXavier VerhelstLindsey DevisscherHans Van VlierbergheAnja GeertsSander Lefere

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Metallothioneins alter macrophage phenotype and represent novel therapeutic targets for acetaminophen-induced liver injury

Lindsey DevisscherSanne Van CampenhoutSander LefereSarah RaevensLaurentijn TillemanFilip Van NieuwerburghHannelore P. Van EeckhoutteAnne HoorensMichael A. LynesAnja GeertsDebby LaukensHans Van Vlierberghe

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Martin GuilliamsJohnny BonnardelBirthe HaestBart VanderborghtCamille WagnerAnneleen RemmerieAnna BujkoLiesbet MartensTinne ThonéRobin BrowaeysFederico Francesco De PontiBavo VannesteChristian ZwickerFreya SvedbergTineke VanhalewynAmanda GonçalvesSaskia LippensBert DevriendtEric CoxGiuliano FerreroValerie WittamerAndy WillaertSuzanne J.F. KapteinJohan NeytsKai DallmeierPeter GeldhofStijn CasaertBart DeplanckePeter ten DijkeAnne HoorensAude VanlanderFrederik BerrevoetYves Van NieuwenhoveYvan SaeysWouter SaelensHans Van VlierbergheLindsey DevisscherCharlotte Scott

A1 Journal Article in CELL

2021

Bariatric surgery and the liver : mechanisms, benefits, and risks

Sander LefereLouis OnghenaAude VanlanderYves Van NieuwenhoveLindsey DevisscherAnja Geerts

A1 Journal Article in OBESITY REVIEWS

Characterization of the inflammatory microenvironment and hepatic macrophage subsets in experimental hepatocellular carcinoma models

Helena DegrooteSander LefereAstrid VandierendonckBart VanderborghtTim MeeseFilip Van NieuwerburghXavier VerhelstAnja GeertsHans Van VlierbergheLindsey Devisscher

A2 Journal Article in ONCOTARGET

Dataset on transcriptomic profiling of cholestatic liver injury induced by food additives and a cosmetic ingredient

Eva GijbelsLindsey DevisscherMathieu Vinken

A2 Journal Article in DATA IN BRIEF

In vivo and in vitro models of hepatocellular carcinoma : current strategies for translational modeling

Guilherme Ribeiro RomualdoKaat LeroyCícero Júlio Silva CostaGabriel Bacil PrataBart VanderborghtTereza Cristina da SilvaLuís Fernando BarbisanWellington AndrausLindsey DevisscherNiels Olsen Saraiva CâmaraMathieu VinkenBruno Cogliati

A1 Journal Article in CANCERS

Modelling and prediction of chemical-induced human cholestatic liver injury : a mechanistic approach

Eva GijbelsMathieu VinkenLindsey DevisscherTamara Vanhaecke

NOX1 inhibition attenuates the development of a pro‐tumorigenic environment in experimental hepatocellular carcinoma

Aster VandierendonckHelena DegrooteBart VanderborghtXavier VerhelstAnja GeertsLindsey DevisscherHans Van Vlierberghe

A1 Journal Article in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Recent advances in the approach to hepatopulmonary syndrome and portopulmonary hypertension

Sarah RaevensAlbert GeertsLindsey DevisscherHans Van VlierbergheChristophe Van SteenkisteIsabelle Colle

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

Rodent models of cholestatic liver disease : a practical guide for translational research

Eva GijbelsAlanah PietersKevin De MuynckMathieu VinkenLindsey Devisscher

A1 Journal Article in LIVER INTERNATIONAL

The gut–liver axis in chronic liver disease : a macrophage perspective

Kevin De MuynckBart VanderborghtHans Van VlierbergheLindsey Devisscher

A1 Journal Article in CELLS

The neurogliovascular unit in hepatic encephalopathy

Wouter ClaeysLien Van HoeckeSander LefereAnja GeertsXavier VerhelstHans Van VlierbergheHelena DegrooteLindsey DevisscherRoosmarijn VandenbrouckeChristophe Van Steenkiste

A1 Journal Article in JHEP REPORTS

2020

Angiogenesis in the progression of non-alcoholic fatty liver disease

Sander LefereLindsey DevisscherAnja Geerts

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

Combination of sivelestat and N-acetylcysteine alleviates the inflammatory response and exceeds standard treatment for acetaminophen-induced liver injury

Sarah RaevensSanne Van CampenhoutPieter-Jan DebackerSander LefereXavier VerhelstAnja GeertsHans Van VlierbergheIsabelle ColleLindsey Devisscher

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Dataset on transcriptomic profiling of cholestatic liver injury in an in vitro and in vivo animal model

Eva GijbelsLindsey DevisscherMathieu Vinken

A2 Journal Article in DATA IN BRIEF

Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages

Sander LefereTobias PuengelJana HundertmarkChristian PennersAnna Katharina FrankAdrien GuillotKevin De MuynckFelix HeymannVanessa AdarbesEvelyne DefreneCeline EstivaletAnja GeertsLindsey DevisscherGuillaume WettsteinFrank Tacke

A1 Journal Article in JOURNAL OF HEPATOLOGY

Effect of isoform-specific HIF-1α and HIF-2α antisense oligonucleotides on tumorigenesis, inflammation and fibrosis in a hepatocellular carcinoma mouse model

Bart VanderborghtKevin De MuynckSander LefereAnja GeertsHelena DegrooteXavier VerhelstHans Van VlierbergheLindsey Devisscher

A2 Journal Article in ONCOTARGET

Hepatocellular carcinoma : refining selection criteria for liver transplantation and search for new therapeutic options

Helena DegrooteHans Van VlierbergheLindsey Devisscher

Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease

Sanne Van CampenhoutAgustina Ari Murti Budi HastutiSander LefereHans Van VlierbergheFrank VanhaeckeMarta Costas RodriguezLindsey Devisscher

A2 Journal Article in BMC RESEARCH NOTES

Myeloid-specific IRE1alpha deletion reduces tumour development in a diabetic, non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model

Sanne Van CampenhoutLaurentijn TillemanSander LefereAstrid VandierendonckSarah RaevensXavier VerhelstAnja GeertsFilip Van NieuwerburghHans Van VlierbergheLindsey Devisscher

A1 Journal Article in METABOLISM-CLINICAL AND EXPERIMENTAL

Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver

Anneleen RemmerieLiesbet MartensTinne ThonéAngela CastoldiRuth SeurinckBenjamin PavieJoris RoelsBavo VannesteSofie De PrijckMathias VanhockerhoutMushida Binte Abdul LatibLindsey DevisscherAnne HoorensJohnny BonnardelNiels VandammeAnna KremerPeter BorghgraefHans Van VlierbergheSaskia LippensEdward PearceYvan SaeysCharlotte Scott

A1 Journal Article in IMMUNITY

Relevance and application of mouse models to study non-viral chronic liver disease

Sanne Van CampenhoutHans Van VlierbergheLindsey DevisscherFrank Vanhaecke

Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury

Eva GijbelsVânia Vilas‐BoasPieter AnnaertTamara VanhaeckeLindsey DevisscherMathieu Vinken

A1 Journal Article in ARCHIVES OF TOXICOLOGY

Targeting CCR2/5 in the treatment of nonalcoholic steatohepatitis (NASH) and fibrosis : opportunities and challenges

Sander LefereLindsey DevisscherFrank Tacke

Editorial material

The angiopoietin/tie2 pathway in hepatocellular carcinoma

Bart VanderborghtSander LefereHans Van VlierbergheLindsey Devisscher

A1 Journal Article in CELLS

2019

Angiogenesis and macrophages as diagnostic and therapeutic targets in non-alcoholic fatty liver disease

Sander LefereAnja GeertsLindsey DevisscherChristophe Van Steenkiste

Angiopoietin-2 promotes pathological angiogenesis and is a therapeutic target in murine nonalcoholic fatty liver disease

Sander LefereFrederique Van de VeldeAnne HoorensSarah RaevensSanne Van CampenhoutAster VandierendonckSara NeytBert VandeghinsteChristian VanhoveCharlotte DebbautXavier VerhelstJo Van DorpeChristophe Van SteenkisteChristophe CasteleynBruno LapauwHans Van VlierbergheAnja GeertsLindsey Devisscher

A1 Journal Article in HEPATOLOGY

Body distribution of stable copper isotopes during the progression of cholestatic liver disease induced by common bile duct ligation in mice

Marta Costas RodriguezSanne Van CampenhoutAgustina Ari Murti Budi HastutiLindsey DevisscherHans Van VlierbergheFrank Vanhaecke

A1 Journal Article in METALLOMICS

Common bile duct ligation as model for secondary biliary cirrhosis

Sanne Van CampenhoutHans Van VlierbergheLindsey Devisscher

Bookchapter in Experimental cholestasis research

Myeloid-specific IRE1 alpha deletion reduces tumour development in a non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model

Sanne Van CampenhoutSander LefereAstrid VandierendonckXavier VerhelstAnja GeertsHans Van VlierbergheLindsey Devisscher

Unveiling the depletion of Kupffer cells in experimental hepatocarcinogenesis through liver macrophage subtype-specific markers

Sander LefereHelena DegrooteHans Van VlierbergheLindsey Devisscher

A1 Journal Article in JOURNAL OF HEPATOLOGY

Validation of hepatobiliary transport PET imaging in liver function assessment : evaluation of 3β-[18F]FCA in mouse models of liver disease

Stef De LombaerdeLindsey DevisscherJeroen VerhoevenSara NeytHans Van VlierbergheChristian VanhoveFilip De Vos

A1 Journal Article in NUCLEAR MEDICINE AND BIOLOGY

2018

Angiopoietin-2 as therapeutic target for pathological angiogenesis and inflammation in non-alcoholic steatohepatitis

Sander LefereFrederique Van de VeldeSarah RaevensSanne Van CampenhoutAstrid VandierendonckS NeytChristian VanhoveAnne HoorensChristophe CasteleynXavier VerhelstHans Van VlierbergheBruno LapauwAnja GeertsLindsey Devisscher

Angiopoietin-2 as therapeutic target for pathological angiogenesis and inflammation in non-alcoholic steatohepatitis

Sander LefereF Van de VeldeSarah RaevensSanne Van CampenhoutAstrid VandierendonckSara NeytChristian VanhoveAnne HoorensCHRISTINE CASTELEYNXavier VerhelstHans Van VlierbergheBruno LapauwAnja GeertsLindsey Devisscher

Angiopoietin-2 promotes pathological angiogenesis and is a novel therapeutic target in non-alcoholic fatty liver disease

Sander LefereFrederique Van de VeldeAnne HoorensSarah RaevensSanne Van CampenhoutAster VandierendonckSara NeytBert VandeghinsteChristian VanhoveCharlotte DebbautXavier VerhelstJo Van DorpeChristophe Van SteenkisteChristophe CasteleynBruno LapauwHans Van VlierbergheAnja GeertsLindsey Devisscher

Cu isotope ratio shifts in common bile duct ligated mice and correlates with the degree of cholestatic-induced liver disease

Sanne Van CampenhoutMarta Costas RodriguezAgustina Ari Murti Budi HastutiSarah RaevensAnja GeertsXavier VerhelstFrank VanhaeckeHans Van VlierbergheLindsey Devisscher

Evaluation of 3b-[18F]Fluorocholic acid in hepatocellular carcinoma bearing mice

Stef De LombaerdeLindsey DevisscherJeroen VerhoevenSara NeytChristian VanhoveFilip De Vos

Placental growth factor inhibition targets pulmonary angiogenesis and represents a therapy for hepatopulmonary syndrome in mice

Sarah RaevensAnja GeertsAnnelies ParidaensSander LefereXavier VerhelstAnne HoorensJo Van DorpeTania MaesKen BrackeChristophe CasteleynBart JonckxThomas HorvatitsValentin FuhrmannHans Van VlierbergheChristophe Van SteenkisteLindsey DevisscherIsabelle Colle

A1 Journal Article in HEPATOLOGY

Preclinical and clinical therapeutic strategies affecting tumor-associated macrophages in hepatocellular carcinoma

Helena DegrooteAlex van DierendonckAnja GeertsHans Van VlierbergheLindsey Devisscher

A1 Journal Article in JOURNAL OF IMMUNOLOGY RESEARCH

The combination of N-acetylcysteine and anti-MT antibodies as novel therapy for acetaminophen-induced liver injury

Lindsey DevisscherDebby LaukensHannelore Van EeckhoutteSarah RaevensSander LefereAnne HoorensXavier VerhelstM LynesAnja GeertsHans Van Vlierberghe

2017

Anti-placental growth factor therapy attenuates experimental hepatopulmonary syndrome

Sarah RaevensAnnelies ParidaensSander LefereChristophe CasteleynB JonckxXavier VerhelstHans Van VlierbergheChristophe Van SteenkisteAnja GeertsLindsey DevisscherIsabelle Colle

Combination of tauroursodeoxycholic acid and N-acetylcysteine exceeds standard treatment for acetaminophen intoxication

Annelies ParidaensSarah RaevensIsabelle ColleEliene BogaertsYves-Paul VandewynckelXavier VerhelstAnne HoorensLeo A van GrunsvenHans Van VlierbergheAnja GeertsLindsey Devisscher

A1 Journal Article in LIVER INTERNATIONAL

Detection and manipulation of the stress response protein metallothionein

Sadikshya BhandariClare MelchiorreKristen DostieDebby LaukensLindsey DevisscherAriel LouwrierAmy TheesMichael A Lynes

A2 Journal Article in CURRENT PROTOCOLS IN TOXICOLOGY

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis

Sophie Van WeldenMartine De VosBen WielockxSimon TavernierMelissa DullaersSara NeytBenedicte DescampsLindsey DevisscherSarah DevrieseLien Van den BosscheTom HolvoetAnn BaeyensCarmen CorrealeSilvia D'AlessioChristian VanhoveFilip De VosBruno VerhasseltGeorg BreierBart LambrechtSophie JanssensPeter CarmelietSilvio DaneseDirk ElewautDebby LaukensPieter Hindryckx

A1 Journal Article in JOURNAL OF PATHOLOGY

Kupffer cell pool is maintained by local proliferation and the differentiation of bone marrow monocytes into short-lived monocyte-derived Kupffer cells during non-alcoholic steatohepatitis and recovery

Lindsey DevisscherCharlotte ScottSander LefereSarah RaevensEliene BogaertsAnnelies ParidaensXavier VerhelstAnja GeertsMartin GuilliamsHans Van Vlierberghe

Laser ablation-inductively coupled plasma-mass spectrometry for quantitative mapping of the copper distribution in liver tissue sections from mice with liver disease induced by common bile duct ligation

Marta Costas RodriguezThibaut Van AckerAgustina Ari Murti Budi HastutiLindsey DevisscherSanne Van CampenhoutHans Van VlierbergheFrank Vanhaecke

A1 Journal Article in JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Modulation of the unfolded protein response by tauroursodeoxycholic acid counteracts apoptotic cell death and fibrosis in a mouse model for secondary biliary liver fibrosis

Annelies ParidaensSarah RaevensLindsey DevisscherEliene BogaertsXavier VerhelstAnne HoorensHans Van VlierbergheLeo van GrunsvenAnja GeertsIsabelle Colle

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool

Lindsey DevisscherCharlotte ScottSander LefereSarah RaevensEliene BogaertsAnnelies ParidaensXavier VerhelstAnja GeertsMartin GuilliamsHans Van Vlierberghe

A1 Journal Article in CELLULAR IMMUNOLOGY

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in non-alcoholic fatty liver disease

Sander LefereFrederique Van de VeldeLindsey DevisscherMarlies BekaertSarah RaevensXavier VerhelstYves Van NieuwenhoveMarleen PraetAnne HoorensChristophe Van SteenkisteHans Van VlierbergheBruno LapauwAnja Geerts

A1 Journal Article in INTERNATIONAL JOURNAL OF OBESITY

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in obese patients with non-alcoholic fatty liver disease

Sander LefereFrederique Van de VeldeLindsey DevisscherMarlies BekaertSarah RaevensXavier VerhelstYves Van NieuwenhoveMarleen PraetAnne HoorensChristophe Van SteenkisteHans Van VlierbergheBruno LapauwAnja Geerts

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in obese patients with non-alcoholic fatty liver disease

Sander LefereFrederique Van de VeldeLindsey DevisscherMarlies BekaertSarah RaevensXavier VerhelstYves Van NieuwenhoveMarleen PraetAnne HoorensChristophe Van SteenkisteHans Van VlierbergheBruno LapauwAnja Geerts

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice

Stef De LombaerdeSara NeytKen KersemansJeroen VerhoevenLindsey DevisscherHans Van VlierbergheChristian VanhoveFilip De Vos

A1 Journal Article in PLOS ONE

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid, a radiolabeled bile acid to detect drug-induced cholestasis in preclinical drug development.

Stef De LombaerdeSara NeytKen KersemansJeroen VerhoevenLindsey DevisscherHans Van VlierbergheChristian VanhoveFilip De Vos

Tauroursodeoxycholic acid protects bile acid homeostasis under inflammatory conditions and dampens Crohn’s disease-like ileitis

Lien Van den BosscheDaniel BorsboomSarah DevrieseSophie Van WeldenTom HolvoetLindsey DevisscherPieter HindryckxMartine De VosDebby Laukens

A1 Journal Article in LABORATORY INVESTIGATION

The role of hypoxia and NOTCH signalling on the expression of liver progenitor cell characteristics in primary liver cancer

Eliene BogaertsHans Van VlierbergheLeo A van GrunsvenLindsey Devisscher

Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho kinase inhibitor

Tom HolvoetSarah DevrieseKarolien CastermansSandro BolandDirk LeysenYves-Paul VandewynckelLindsey DevisscherLien Van den BosscheSophie Van WeldenMelissa DullaersRoosmarijn VandenbrouckeRiet De RyckeKarel GeboesArnaud BourinOlivier DefertPieter HindryckxMartine De VosDebby Laukens

A1 Journal Article in GASTROENTEROLOGY

Ursodeoxycholic acid and its taurine/glycine conjugated species reduce colitogenic dysbiosis and equally suppress experimantal colitis in mice

Lien Van den BosschePieter HindryckxLindsey DevisscherSarah DevrieseSophie Van WeldenTom HolvoetRamiro Vilchez VargasMarius VitalDietmar PieperJulie Vanden BusscheLynn VanhaeckeTom Van de WieleMartine De VosDebby Laukens

Ursodeoxycholic acid and its taurine/glycine conjugated species reduce colitogenic dysbiosis and equally suppress experimental colitis in mice

Lien Van den BosschePieter HindryckxLindsey DevisscherSarah DevrieseSophie Van WeldenTom HolvoetRamiro Vilchez VargasMarius VitalDietmar H PieperJulie VandenbusscheLynn VanhaeckeTom Van de WieleMartine De VosDebby Laukens

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Ursodeoxycholic acid and its taurine/glycine conjugated species reduce colitogenic dysbiosis and equally suppress experimental colitis in mice

Lien Van den BosschePieter HindryckxLindsey DevisscherSarah DevrieseSophie Van WeldenTom HolvoetRamiro Vilchez VargasMarius VitalDietmar H PieperJulie VandenbusscheLynn VanhaeckeTom Van de WieleMartine De VosDebby Laukens

2016

Effect of prolyl hydroxylase domain 2 haplodeficiency on liver progenitor cell characteristics in early mouse hepatocarcinogenesis

Eliene BogaertsAnnelies ParidaensXavier VerhelstPeter CarmelietAnja GeertsHans Van VlierbergheLindsey Devisscher

A1 Journal Article in EXCLI JOURNAL

Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease

Sander LefereChristophe Van SteenkisteXavier VerhelstHans Van VlierbergheLindsey DevisscherAnja Geerts

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Kinetics of pulmonary angiogenesis in mouse common bile duct ligation-induced liver fibrosis

Sarah RaevensLindsey DevisscherAnnelies ParidaensEliene BogaertsSander LefereYves-Paul VandewynckelCHRISTINE CASTELEYNKen BrackeTania MaesXavier VerhelstHans Van VlierbergheChristophe Van SteenkisteAnja GeertsIsabelle Colle

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma

Yves-Paul VandewynckelCéline CouckeDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsAstrid VandierendonckSarah RaevensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtAnja GeertsHans Van Vlierberghe

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma

Yves-Paul VandewynckelCéline CouckeDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsAster VandierendonckSarah RaevensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtAnja GeertsHans Van Vlierberghe

A1 Journal Article in ONCOTARGET

Placental growth factor inhibition alleviates hepatopulmonary syndrome in mice

Sarah RaevensAnnelies ParidaensSander LefereBart JonckxXavier VerhelstHans Van VlierbergheChristophe Van SteenkisteAnja GeertsLindsey DevisscherIsabelle Colle

Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherEliene BogaertsAnnelies ParidaensAnja Van den BusscheSarah RaevensXavier VerhelstChristophe Van SteenkisteBart JonckxLouis LibbrechtAnja GeertsPeter CarmelietHans Van Vlierberghe

A1 Journal Article in BMC CANCER

Targeting the angio-proteostasis network : combining the forces against cancer

Lindsey DevisscherMargherita VieriSusan E. LogueJens PanseAnja GeertsHans van VlierbergheEric ChevetAdrienne M. GormanAfshin SamaliBehzad Kharabi Masouleh

A1 Journal Article in PHARMACOLOGY & THERAPEUTICS

The bile acid tauroursodeoxycholic acid cooperates with N-acetylcysteine in the treatment of experimental acetaminophen-induced hepatotoxicity

Annelies ParidaensLindsey DevisscherSarah RaevensEliene BogaertsYves-Paul VandewynckelXavier VerhelstI MannaertsL Van GrunsvenHans Van VlierbergheIsabelle ColleAnja Geerts

The role of macrophages in obesity-driven chronic liver disease

Lindsey DevisscherXavier VerhelstIsabelle ColleHans Van VlierbergheAnja Geerts

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

The unfolded protein response underlies microenvironmental stress-induced phenotype switching leading to stemness and chemoresistance in human hepatocellular carcinoma

Yves-Paul VandewynckelO GovaereAstrid VandierendonckDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsSarah RaevensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtChristophe AmpeMarleen Van TroysAnja GeertsT RoskamsHans Van Vlierberghe

2015

Folates from metabolically engineered rice: a long-term study in rats

Filip KiekensDieter BlancquaertLindsey DevisscherJeroen Van DaeleVeronique StoveJoris DelangheDominique Van Der StraetenWilly LambertChristophe Stove

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

Placental growth factor inhibition modulates the interplay between hypoxia and the unfolded protein response in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsXavier VerhelstAnja Van den BusscheSarah RaevensChristophe Van SteenkisteB JonckxLouis LibbrechtAnja GeertsP CarmelietHans Van Vlierberghe

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsXavier VerhelstAnja Van den BusscheSarah RaevensChristophe Van SteenkisteMarleen Van TroysChristophe AmpeBenedicte DescampsChristian VanhoveOlivier GovaereAnja GeertsHans Van Vlierberghe

A1 Journal Article in ONCOTARGET

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsXavier VerhelstA Van den BusscheSarah RaevensChristophe Van SteenkisteMarleen Van TroysChristophe AmpeBenedicte DescampsChristian VanhoveO GovaereLouis LibbrechtAnja GeertsHans Van Vlierberghe

Time-dependent effect of hypoxia on tumor progression and liver progenitor cell markers in primary liver tumors

Eliene BogaertsFemke HeindryckxLindsey DevisscherAnnelies ParidaensYves-Paul VandewynckelAnja Van den BusscheXavier VerhelstLouis LibbrechtLeo A van GrunsvenAnja GeertsHans Van Vlierberghe

A1 Journal Article in PLOS ONE

2014

Ly49E Expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases

Aline Van AckerJessica FiltjensSophie Van WeldenSylvie TaveirneEls Van AmmelMandy VanheesLindsey DevisscherTessa KerreTom TaghonBart VandekerckhoveJean PlumGeorges Leclercq

A1 Journal Article in PLOS ONE

Metallothionein and stress combine to affect multiple organ systems

Michael A LynesJuan HidalgoYasmina MansoLindsey DevisscherDebby LaukensDavid A Lawrence

A1 Journal Article in CELL STRESS & CHAPERONES

Metallothioneins as modulators of intestinal inflammation and potential therapeutic targets for inflammatory bowel diseases

Lindsey DevisscherMARTINE DE VOSDebby Laukens

Role of metallothioneins as danger signals in the pathogenesis of colitis

Lindsey DevisscherPieter HindryckxMichael A LynesAnouk WaeytensClaude CuvelierFilip De VosChristian VanhoveMartine De VosDebby Laukens

A1 Journal Article in JOURNAL OF PATHOLOGY

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

Debby LaukensLindsey DevisscherLien Van den BosschePieter HindryckxRoosmarijn VandenbrouckeYves-Paul VandewynckelClaude CuvelierBrigitta BrinkmanClaude LibertPeter VandenabeeleMartine De Vos

A1 Journal Article in LABORATORY INVESTIGATION

Therapeutic effects of artesunate in hepatocellular carcinoma : repurposing an ancient antimalarial agent

Yves-Paul VandewynckelDebby LaukensAnja GeertsChristian VanhoveBenedicte DescampsLindsey DevisscherEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtBart LambrechtS JanssensHans Van Vlierberghe

Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent

Yves-Paul VandewynckelDebby LaukensAnja GeertsChristian VanhoveBenedicte DescampsIsabelle ColleLindsey DevisscherEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtBart LambrechtSophie JanssensHans Van Vlierberghe

A1 Journal Article in EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

2013

Metallothionein, an emerging danger signal during experimental colitis

Lindsey DevisscherPieter HindryckxKim OlievierHarald PeetersMichael LynesClaude CuvelierMartine De VosDebby Laukens

The therapeutic potential of artesunate in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensAnja GeertsIsabelle ColleLouis LibbrechtEliene BogaertsLindsey DevisscherAnnelies ParidaensXavier VerhelstChristian VanhoveBenedicte DescampsSophie JanssensBart LambrechtChristophe Van SteenkisteHans Van Vlierberghe

2012

TUDCA alleviates DSS-induced colitis by forcing IRE1 activity and reducing colonocyte apoptosis

Debby LaukensLindsey DevisscherPieter HindryckxHarald PeetersMartine De Vos

Targeting metallothionein in DSS-colitis points to new therapeutic strategies for IBD patients

Lindsey DevisscherPieter HindryckxKim OlievierHarald PeetersMichael LynesClaude CuvelierMartine De Vos

Targeting metallothionein in dextran sulfate sodium-induced colitis points to new therapeutic strategies for patients suffering from inflammatory bowel diseases

Lindsey DevisscherPieter HindryckxKim OlievierHarald PeetersMichael LynesClaude CuvelierMartine De VosDebby Laukens

Tauroursodeoxycholic acid forces epithelial IRE1 activation and alleviates DSS-induced colitis

Debby LaukensLindsey DevisscherPieter HindryckxHarald PeetersMartine De Vos

2011

Effects of a constant rate infusion of detomidine on cardiovascular function, isoflurane requirements and recovery quality in horses

Stijn SchauvliegeMiguel Gozalo MarcillaKirsten VerrykenLuc DuchateauLindsey DevisscherFrank Gasthuys

A1 Journal Article in VETERINARY ANAESTHESIA AND ANALGESIA

Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia

Pieter HindryckxLindsey DevisscherDebby LaukensKoen VenkenHarald PeetersMartine De Vos

A1 Journal Article in LABORATORY INVESTIGATION

Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia

Pieter HindryckxLindsey DevisscherDebby LaukensHarald PeetersMartine De Vos

Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis

Lindsey DevisscherPieter HindryckxHarald PeetersMartine De VosDebby Laukens

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Longitudinal quantification of inflammation in the murine DSS-induced colitis model using μPET/CT

Pieter HindryckxSteven StaelensLindsey DevisscherSteven DeleyeFilip De VosLouke DelrueHarald PeetersDebby LaukensMartine De Vos

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

The hypoxia adaptive response regulates metallothionein expression in intestinal epithelial cells

Lindsey DevisscherPieter HindryckxHarald PeetersMartine De VosDebby Laukens

2010

Romifidine as a constant rate infusion in isoflurane anaesthetized horses: a clinical study

Lindsey DevisscherStijn SchauvliegeJeroen DewulfFrank Gasthuys

A1 Journal Article in VETERINARY ANAESTHESIA AND ANALGESIA

2009

Abomasal end-to-end anastomosis as treatment for abomasal fistulation and herniation.

Geert VertentenJeroen DeclercqFrank GasthuysLindsey DevisscherSara TorfsGunther van LoonAnn Martens

A1 Journal Article in VETERINARY RECORD

Distal limb cast sores in horses : risk factors and early detection using thermography

Tamara LevetAnn MartensLindsey DevisscherLuc DuchateauLies BogaertLieven Vlaminck

A1 Journal Article in EQUINE VETERINARY JOURNAL

Influence of two different ventilation modes on the function of an anaesthetic conserving device in sevoflurane anaesthetized piglets

Stijn SchauvliegeStefaan BouchezLindsey DevisscherTim ReynsSandra De BoeverFrank Gasthuys

A1 Journal Article in VETERINARY ANAESTHESIA AND ANALGESIA

Risk factors for equine postoperative ileus and effectiveness of prophylactic lidocaine

Sara TorfsCatherine DelesalleJeroen DewulfLindsey DevisscherPiet Deprez

A1 Journal Article in JOURNAL OF VETERINARY INTERNAL MEDICINE

2008

Abomasal end-to-end Anastomosis as a Treatment for an Extensive Abomasal Hernia and Fistula in a Cow

Geert VertentenJeroen DeclercqAnn MartensLindsey DevisscherSara TorfsGunther van LoonFrank Gasthuys

Bilateral Surgical Fracture Repair in an Alpaca

Jeroen DeclercqGeert VertentenLindsey DevisscherVirginie BarberetFrank GasthuysPieter VerleyenAnn Martens

Cardiovascular function in anaesthetized horses during transvenous electrical cardioversion as therapy for atrial fibrillation

Stijn SchauvliegeDominique De ClercqLindsey DevisscherPiet DeprezFrank GasthuysGunther van Loon

2007

Influence of two different ventilation modes on the function of an anaesthetic conserving device (AnaConDa®) in sevoflurane anaesthetized pigs

Stijn SchauvliegeLindsey DevisscherTim ReynsSandra De BoeverSiska CroubelsFrank Gasthuys

Pre- and intraoperative parameters related to hypotension and hypoxaemia during anaesthesia in colic horses: a retrospective study

Lindsey DevisscherCatherine DelesalleJeroen DewulfPiet DeprezSara TorfsStijn SchauvliegeAnn MartensFrank Gasthuys