Research Explorer

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Researcher

Lieven Verhoye

Publications & Research Data

Awards & Distinctions

52 Results

2026

In vivo determinants of hepatitis C virus adaptation and escape from neutralizing antibody AR5A

Rodrigo Velázquez-MoctezumaRani BurmLieven VerhoyeLaura CollignonKenn HolmbeckErick GiangMansun LawJens BukhPhilip MeulemanJannick Prentoe

A1 Journal Article in CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY

2025

A novel in vitro system for simultaneous infections with hepatitis B, C, D and E viruses

Roxanne FouilléEloi R. VerrierAmse De MeyerLieven VerhoyeMaud MicheletRomain BarnaultCaroline PonsOlivier DiazMichel RivoireGuillaume Passot et al.

A1 Journal Article in JHEP REPORTS

Broadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice

George SsebyatikaKatja DinkelborgLuisa J. StröhFlorian HinteLaura CorneillieLucas HueffnerElina M. GuzmanProssie L. NankyaNina PlückebaumLukas Fehlau et al.

A1 Journal Article in NATURE COMMUNICATIONS

2024

JFH1-based Core-NS2 genotype variants of HCV with genetic stability in vivo and in vitro : important tools in the evaluation of virus neutralization

Laura CollignonKenn HolmbeckAshley JustLieven VerhoyeRodrigo Velázquez-MoctezumaUlrik FahnøeThomas H R CarlsenMansun LawJannick PrentoeTroels K H Scheel et al.

A1 Journal Article in HEPATOLOGY

Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells

Cong Si TranJulia KerstenJingyi YanMarco BreinigThorben HuthTanja PothOmbretta ColasantiTobias RiedlSuzanne Faure-DupuyStefan Diehl et al.

A1 Journal Article in GASTROENTEROLOGY

2023

A human monoclonal antibody against HBsAg for the prevention and treatment of chronic HBV and HDV infection

Rani BurmFreya Van HoutteLieven VerhoyeAhmed Atef Ahmed Abouzeid MesalamS CiesekP RoingeardH WedemeyerGeert Leroux-RoelsPhilip Meuleman

A1 Journal Article in JHEP REPORTS

Novel prime-boost immune-based therapy inhibiting both hepatitis B and D virus infections

Rani BurmPanagiota MaraveliaGustaf AhlenSandra CiesekNoelia Caro PerezAnna PasettoStephan UrbanFreya Van HoutteLieven VerhoyeHeiner Wedemeyer et al.

A1 Journal Article in GUT

2022

A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function

TL MeisterY BrüggemannMK NockeRG UlrichJ SchuhennK SutterA GömerV BaderKF WinklhoferR Broering et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Study of hepatitis E virus-4 infection in human liver-chimeric, immunodeficient, and immunocompetent mice

Laura CollignonLieven VerhoyeRenate Hakze-Van der HoningWim H. M. Van der PoelPhilip Meuleman

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Viral interference of hepatitis C and E virus replication in novel experimental co-infection systems

T BurkardN ProskeK ResnerLaura CollignonL KnegendorfM FrieslandLieven VerhoyeIM SayedY BrüggemannMK Nocke et al.

A1 Journal Article in CELLS

2021

A role for B cells to transmit hepatitis C virus infection

Isabelle DesombereFreya Van HoutteAliasghar Farhoudi MoghadamLieven VerhoyeCaroline BuysschaertYvonne GijbelsSibyl CouventW SwinnenHans Van VlierbergheAndré Elewaut et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections

P MaraveliaL FrelinY NiNC PérezG AhlénN JagyaG VerchLieven VerhoyeL PaterM Johansson et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

2020

Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes

Eleftherios MichailidisKoen VercauterenLiliana Mancio-SilvaLinda AndrusCyprien JahanInna Ricardo-LaxChenhui ZouMohammad KabbaniPaul ParkCorrine Quirk et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation alters the secretome and immunomodulatory properties of human skin-derived precursor cells

Joery De KockRobim Marcelino RodriguesSteven BransonLieven VerhoyeHaaike Colemonts-VroninksMatthias RombautJoost BoeckmansJessie NeuckermansSien LequeueKarolien Buyl et al.

A1 Journal Article in CELLS

Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice

Richard J. P. BrownBirthe TegtmeyerJulie SheldonTanvi Khera[missing] AnggakusumaDaniel TodtGabrielle VieyresRomy WellerSebastian JoecksYudi Zhang et al.

A1 Journal Article in SCIENCE ADVANCES

Robust hepatitis E virus infection and transcriptional response in human hepatocytes

Daniel TodtMartina FrieslandNora MoellerDimas PradityaVolker KinastYannick BrüggemannLeonard KnegendorfThomas BurkardJoerg SteinmannRani Burm et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2019

Hepatitis E virus (HEV) open reading frame 2 antigen kinetics in human-liver chimeric mice and its impact on HEV diagnosis

Ibrahim Ibrahim Mahmoud SayedLieven VerhoyeClaire MontpellierFlorence AbravanelJacques IzopetLaurence CocquerelPhilip Meuleman

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Hepatitis E virus prevalence in Flemish blood donors

Ann-Sofie VercouterFreya Van HoutteLieven VerhoyeIsabel González FraileLydia BlancoVeerle CompernollePhilip Meuleman

A1 Journal Article in JOURNAL OF VIRAL HEPATITIS

2018

Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeJonathan BallJean DubuissonSteven KH FoungArvind H PatelMats AA Persson et al.

A1 Journal Article in VIROLOGY

The natural compound silvestrol inhibits hepatitis E virus (HEV) replication in vitro and in vivo

Daniel TodtNora MoellerDimas PradityaVolker KinastMartina FrieslandMichael EngelmannLieven VerhoyeIbrahim Ibrahim Mahmoud SayedPatrick BehrendtViet Loan Dao Thi et al.

A1 Journal Article in ANTIVIRAL RESEARCH

2017

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

Isabelle DesombereAhmed Atef Ahmed Abouzeid MesalamRichard A UrbanowiczFreya Van HoutteLieven VerhoyeZhen-Yong KeckAliasghar Farhoudi MoghadamKoen VercauterenKarin WeeningThomas F Baumert et al.

A1 Journal Article in ANTIVIRAL RESEARCH

Characterization of a novel monoclonal antibody targeting epitope II within hepatitis C virus E2 envelope glycoprotein

Philip MeulemanAhmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczFreya Van HoutteLieven VerhoyeZhen-Yong KeckAliasghar Farhoudi MoghadamKoen VercauterenKarin Weening et al.

Development and characterization of a human monoclonal antibody for prevention of HCV recurrence in liver transplant patients

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonKoen VercauterenAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan Ball et al.

Effect of hepatitis E virus infection on the human hepatic innate immune response in human liver chimeric mice

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLaurance CocquerelFlorence AbravanelLander FoquetClaire MontpellierYannick DebingAliasghar Farhoudi MoghadamCzeslaw WychowskiJean Dubuisson et al.

Impact of HEV infection on the human hepatic innate immune response in human liver chimeric mice

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLander FoquetFlorence AbravanelAliasghar Farhoudi MoghadamGeert Leroux-RoelsJacques IzopetPhilip Meuleman

Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLaurence CocquerelFlorence AbravanelLander FoquetClaire MontpellierYannick DebingAliasghar Farhoudi MoghadamCzeslaw WychowskiJean Dubuisson et al.

A1 Journal Article in GUT

Successful engraftment of human hepatocytes in uPA-SCID and FRG® KO mice

Lander FoquetElizabeth M WilsonLieven VerhoyeMarkus GrompeGeert Leroux-RoelsJohn BialPhilip Meuleman

Bookchapter in Hepatocyte transplantation : methods and protocols

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy

Tanvi KheraDaniel TodtKoen VercauterenC Patrick McClureLieven VerhoyeAliasghar Farhoudi MoghadamSabin BhujuRobert GeffersThomas F BaumertEike Steinmann et al.

A1 Journal Article in ANTIVIRAL RESEARCH

Transmission of hepatitis E virus infection to human-liver chimeric FRG mice using patient plasma

Ibrahim Mahmoud Sayed IbrahimLander FoquetLieven VerhoyeAliasghar Farhoudi MoghadamFloresence AbravanelGeert Leroux-RoelsJacques IzopetPhilip Meuleman

A1 Journal Article in ANTIVIRAL RESEARCH

2016

Characterization of a novel human monoclonal antibody targeting the hepatitis C virus envelope protein

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonKoen VercauterenAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan Ball et al.

Effect of hepatitis E virus infection on the human hepatic innate immune response in human liver chimeric mice

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLaurance CocquerelFlorence AbravanelLander FoquetClaire MontpellierYannick DebingAliasghar Farhoudi MoghadamCzeslaw WychowskiJean Dubuisson et al.

HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

Jannick PrentoeLieven VerhoyeRodrigo Velázquez MoctezumaCaroline BuysschaertAliasghar Farhoudi MoghadamRichard WangHarvey AlterPhilip MeulemanJens Bukh

A1 Journal Article in GUT

Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge

Isabelle DesombereSamira Fafi-KremerFreya Van HouttePatrick PessauxAliasghar Farhoudi MoghadamLaura HeydmannLieven VerhoyeSarah ColeJane A McKeatingGeert Leroux-Roels et al.

A1 Journal Article in HEPATOLOGY

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice

Koen VercauterenRichard JP BrownAhmed Atef Ahmed Abouzeid MesalamJuliane DoerrbeckerSabin BhujuRobert GeffersNaomi Van den EedeC Patrick McClureFulvia TroiseLieven Verhoye et al.

A1 Journal Article in GUT

2015

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonKoen VercauterenAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeKarin WeeningMats Persson et al.

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan BallGeert Leroux-Roels et al.

A broadly neutralizing monoclonal antibody targeting hepatitis C virus prevents viral infection in vitro and in uPA/SCID mice with humanized liver

Ahmed Atef Ahmed Abouzeid MesalamIsabelle DesombereRichard UrbanowiczDaniel X JohanssonAliasghar Farhoudi MoghadamFreya Van HoutteLieven VerhoyeMats PerssonJonathan BallGeert Leroux-Roels et al.

Anti-CD81 but not anti-SR-BI blocks Plasmodium falciparum liver infection in a humanized mouse model

Lander FoquetCornelus C HermsenLieven VerhoyeGeert-Jan van GemertRiccardo CorteseAlfredo NicosiaRobert W SauerweinGeert Leroux-RoelsPhilip Meuleman

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeLaurence CocquerelFlorence AbbravanelLander FoquetYannick DebingAliasghar Farhoudi MoghadamCzeslaw WychowskiJean DubuissonGeert Leroux-Roels et al.

Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeAliasghar Farhoudi MoghadamYannick DebingJohan NeytsGeert Leroux-RoelsRobert PurcellSuzanne EmersonPhilip Meuleman

Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeY DebingF AbbravanelAliasghar Farhoudi MoghadamGeert Leroux-RoelsJ NeytsJ IzopetR PurcellS Emerson et al.

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice

Koen VercauterenRichard JP BrownAhmed Atef Ahmed Abouzeid MesalamJuliane DoerrbeckerSabin BhujuRobert GeffersNaomi Van den EedeFulvia TroiseLieven VerhoyeThomas Baumert et al.

2014

Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses

Alicja M ChmielewskaMariarosaria NaddeoStefania CaponeVirginia AmmendolaKe HuLuke MeredithLieven VerhoyeMalgorzata RychlowskaRino RappuoliJeffrey B Ulmer et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Human liver chimeric mice as a novel model for the study of hepatitis E virus infections

Ibrahim Mahmoud Sayed IbrahimLieven VerhoyeAliasghar Farhoudi MoghadamYannick DebingJohan NeytsGeert Leroux-RoelsRobert PurcellSuzanne EmersonPhilip Meuleman

2013

99mTc-mebrofenin disposition in chimeric mice with a humanized liver

Sara NeytPhilip MeulemanLieven VerhoyeChristian VanhoveGeert MannensFilip De Vos

2012

A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo

Philip MeulemanMaria Teresa CataneseLieven VerhoyeIsabelle DesombereAliasghar Farhoudi MoghadamChristopher T JonesTimothy SheahanKatarzyna GrzybRiccardo CorteseCharles M Rice et al.

A1 Journal Article in HEPATOLOGY

Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice

Krzysztof LacekKoen VercauterenKatarzyna GrzybMariarosaria NaddeoLieven VerhoyeMarek Patryk SłowikowskiSamira Fafi-KremerArvind H PatelThomas F BaumertAntonella Folgori et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

2011

Griffithsin has antiviral activity against hepatitis C virus

Philip MeulemanAnna AlbeckaSandrine BelouzardKoen VercauterenLieven VerhoyeCzeslaw WychowskiGeert Leroux-RoelsKenneth E PalmerJean Dubuisson

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

Philip MeulemanJens BukhLieven VerhoyeAliasghar Farhoudi MoghadamTHOMAS VANWOLLEGHEMRichard Y WangIsabelle DesombereHarvey AlterRobert H PurcellGeert Leroux-Roels

A1 Journal Article in HEPATOLOGY

2010

Detection of mumps virus-specific memory B cells by transfer of peripheral blood mononuclear cells into immune-deficient mice

Corinne VandermeulenLieven VerhoyeSunil VaidyaFrédéric ClementKevin E BrownKarel HoppenbrouwersGeert Leroux-Roels

A1 Journal Article in IMMUNOLOGY

2007

Inhibition of replication of primary HIV-1 isolates in huPBL-NOD/Scid mice by antibodies from HIV-1 infected patients

Sophia SteyaertL HEYNDRICKXLieven VerhoyeT VERMOESENH DONNERSK FRANSENF VAN WANZEELEB VANDERGUCHTG VANHAMGeert Leroux-Roels et al.

A1 Journal Article in ANTIVIRAL RESEARCH

The intraspleen huPBL NOD/SCID model to study the human HIV-specific antibody response selected in the course of natural infection

Sophia SteyaertLieven VerhoyeE BEIRNAERTH DONNERSK FRANSENL HEYNDRICKXG VANHAMGeert Leroux-RoelsPeter Vanlandschoot

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS