Research Explorer

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Researcher

Lieven Haenebalcke

Awards & Distinctions

17 Results

2024

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids

Helene LasolleAndrea SchiavoAdrien TourneurPierre GillotayBarbara de Faria da FonsecaLucieli CeolinOlivier MonestierBenilda AganahiLaura ChometteMarina Malta Letro Kizys et al.

A1 Journal Article in ONCOGENE

2019

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Tim PietersSara T'SasLisa DemoenAndré Pedro Pinto De AlmeidaLieven HaenebalckeFilip MatthijssensKelly LemeireJinke D'HontFrédérique VanrockeghemTino Hochepied et al.

A1 Journal Article in SCIENTIFIC REPORTS

2017

Structure-function studies in mouse embryonic stem cells using recombinase-mediated cassette exchange

Tim PietersLieven HaenebalckeKenneth BruneelNiels VandammeTino HochepiedJolanda van HengelDagmar WirthGeert BerxJody J HaighFrans Van Roy et al.

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

2016

Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL

Tim PietersSteven GoossensSara T'SasLieven HaenebalckeTino HochepiedBéatrice LintermansSofie PeirsFilip MatthijssensJ HaighGeert Berx et al.

p120 Catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification

Tim PietersSteven GoossensLieven HaenebalckeVanessa AndriesAgata StryjewskaRiet De RyckeKelly LemeireTino HochepiedDanny HuylebroeckGeert Berx et al.

A1 Journal Article in PLOS GENETICS

2015

Strategies to rescue the consequences of inducible arginase-1 deficiency in mice

Laurel L BallantyneYuan Yan SinTim St AmandJoshua SiSteven GoossensLieven HaenebalckeJody HaighLianna KyriakopoulouAndrea SchulzeColin D Funk

A1 Journal Article in PLOS ONE

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven GoossensEnrico RadaelliOdile BlanchetKaat DurinckJoni Van der MeulenSofie PeirsTom TaghonCedric S TremblayMagdaline CostaMorvarid Farhang Ghahremani et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

Loss of autocrine endothelial-derived VEGF significantly reduces hemangiosarcoma development in conditional p53-deficient mice

Morvarid Farhang GhahremaniEnrico RadaelliKatharina HaighSona BartunkovaLieven HaenebalckeJean-Christophe MarineSteven GoossensJody Haigh

A1 Journal Article in CELL CYCLE

2013

Cre/loxP-transgenics

Lieven HaenebalckeJody Haigh

Bookchapter in Brenner’s encyclopedia of genetics, vol. 2

Efficient ROSA26-based conditional and/or inducible transgenesis using RMCE-compatible F1 hybrid mouse embryonic stem cells

Lieven HaenebalckeSteven GoossensMichaël NaessensNatascha KruseMorvarid Farhang GhahremaniSona BartunkovaKatharina HaighTim PietersPieterjan DierickxBenjamin Drogat et al.

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

The ROSA26-iPSC mouse : a conditional, inducible, and exchangeable resource for studying cellular (de)differentiation

Lieven HaenebalckeSteven GoossensPieterjan DierickxSona BartunkovaJinke D'HontKatharina HaighTino HochepiedDagmar WirthAndras NagyJody Haigh

A1 Journal Article in CELL REPORTS

p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway

Morvarid Farhang GhahremaniSteven GoossensD NittnerX BisteauSona BartunkovaA ZwolinskaPaco HulpiauKatharina HaighLieven HaenebalckeBenjamin Drogat et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2012

Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells

Tim PietersLieven HaenebalckeTino HochepiedJinke D'HontJody HaighFrans Van RoyJolanda van Hengel

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

Generation and use of novel ROSA26-based ESC/iPSC technologies to study cellular reprogramming and gene function during lineage-directed differentiation

Lieven HaenebalckeJody HaighAnne De Paepe

2011

The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization

Steven GoossensViktor JanzenSona BartunkovaTomomasa YokomizoBenjamin DrogatMihaela CrisanKatharina HaighEve SeuntjensLieve UmansTamara Riedt et al.

A1 Journal Article in BLOOD

2010

Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones

Christa MaesSteven GoossensSona BartunkovaBenjamin DrogatLieven CoenegrachtsIngrid StockmansKaren MoermansOmar NyabiKatharina HaighMichaël Naessens et al.

A1 Journal Article in EMBO JOURNAL

2009

Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells

Omar NyabiMichaël NaessensKatharina HaighAgnieszka GembarskaSteven GoossensMarion MaetensSarah De ClercqBenjamin DrogatLieven HaenebalckeSona Bartunkova et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH