Research Explorer

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Researcher

Lieselotte Vande Walle

Awards & Distinctions

41 Results

2023

Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets

Lieselotte Vande WalleMohamed Lamkanfi

U Journal Article in Nature Reviews Drug Discovery

Effective <i>ex vivo</i> inhibition of cryopyrin-associated periodic syndrome (CAPS)-associated mutant NLRP3 inflammasome by MCC950/CRID3

Lieselotte Vande WalleMohamed Lamkanfi

U Journal Article in RHEUMATOLOGY

2022

GSDMD drives canonical inflammasome-induced neutrophil pyroptosis and is dispensable for NETosis

Dhruv ChauhanDieter DemonLieselotte Vande WalleOonagh PaerewijckAnnalisa ZecchinLeslie BosselerKarin SantoniRemi PlanesSilvia Ribó GenéAmelie Fossoul et al.

A1 Journal Article in EMBO REPORTS

Nonredundancy of IL-1 alpha and IL-1 beta is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection

Kevin EislmayrAnnika BestehornLuisa MorelliMartina BorroniLieselotte Vande WalleMohamed LamkanfiPavel Kovarik

A1 Journal Article in SCIENCE ADVANCES

2021

IL1 beta promotes immune suppression in the tumor microenvironment independent of the inflammasome and gasdermin D

Mate KissLieselotte Vande WallePedro Henrique Viana SaavedraEls LebeggeHelena Van DammeAleksandar MurgaskiJunbin QianManuel EhlingSamantha PrettoEvangelia Bolli et al.

A1 Journal Article in CANCER IMMUNOLOGY RESEARCH

2020

Snapshot of a deadly embrace : the caspase-1-GSDMD interface

Lieselotte Vande WalleMohamed Lamkanfi

Editorial material

Therapeutic modulation of inflammasome pathways

Dhruv ChauhanLieselotte Vande WalleMohamed Lamkanfi

A1 Journal Article in IMMUNOLOGICAL REVIEWS

2019

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

Lieselotte Vande WalleIrma B StowePavel SachaBettina L LeeDieter DemonAmelie FossoulFilip Van HauwermeirenPedro Henrique Viana SaavedraPetr SimonVladimir Subrt et al.

A1 Journal Article in PLOS BIOLOGY

2018

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Sofie VoetConor Mc GuireNora HagemeyerArne MartensAnna SchroederPeter WieghoferCarmen DaemsOri StaszewskiLieselotte Vande WalleMarta Joana Costa Jordao et al.

A1 Journal Article in NATURE COMMUNICATIONS

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

Apurva KannegantiRK Subbarao MalireddiPedro Henrique Viana SaavedraLieselotte Vande WalleHanne Van GorpHiroto KambaraHeather TillmanPeter VogelHongbo R LuoRamnik J Xavier et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2017

Carboxylate isosteres for caspase inhibitors : the acylsulfonamide case revisited

Y AdriaenssensDaniel Jiménez FernandezLieselotte Vande WalleF ElvasJ JoossensA LambeirK AugustynsMohamed LamkanfiP Van der Veken

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4

Nina Van OpdenboschHanne Van GorpMaarten VerdoncktPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosAmanda GonçalvesLieselotte Vande WalleDieter DemonMagdalena MatusiakFilip Van Hauwermeiren et al.

A1 Journal Article in CELL REPORTS

2016

Does caspase-12 suppress inflammasome activation?

Lieselotte Vande WalleDaniel Jiménez FernandezDieter DemonNaomi Van LaethemFilip Van HauwermeirenHanne Van GorpNina Van OpdenboschNobuhiko KayagakiMohamed Lamkanfi

A1 Journal Article in NATURE

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakGiusi PrencipeAntonella InsalacoFilip Van HauwermeirenDieter Demon et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasomes in inflammatory disease

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakFilip Van HauwermeirenG. PrencipeDelfien BogaertMelissa Dullaers et al.

Lieselotte Vande WalleMohamed Lamkanfi

Editorial material

2015

Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5

Magdalena MatusiakNina Van OpdenboschLieselotte Vande WalleJean-Claude SirardThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2014

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

Nina Van OpdenboschPrajwal GurungLieselotte Vande WalleAmelie FossoulThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in NATURE COMMUNICATIONS

Airway structural cells regulate TLR5-mediated mucosal adjuvant activity

L Van MaeleD FougeronL JanotA DidierlaurentD CayetJ TabareauM RumboS Corvo-ChamaillardS BoulenouarS Jeffs et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Dietary modulation of the microbiome affects autoinflammatory disease

John R LukensPrajwal GurungPeter VogelGordon R JohnsonRobert A CarterDaniel J McGoldrickSrinivasa Rao BandiChristopher R CalabreseLieselotte Vande WalleMohamed Lamkanfi et al.

A1 Journal Article in NATURE

FADD and Caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes

Prajwal GurungParas K AnandRK Subbarao MalireddiLieselotte Vande WalleNina Van OpdenboschChristopher P DillonRicardo WeinlichDouglas R GreenMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Lieselotte Vande WalleNina Van OpdenboschPeggy JacquesAmelie FossoulEveline VerheugenPeter VogelRudi BeyaertDirk ElewautThirumala-Devi KannegantiGeert van Loo et al.

A1 Journal Article in NATURE

Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria

Dieter DemonLieselotte Vande WalleMohamed Lamkanfi

Editorial material

The small GTPase Arf6 is essential for the Tram/Trif pathway in RLR4 signaling

Tim Van AckerSven EyckermanLieselotte Vande WalleSarah GerloMarc GoethalsMohamed LamkanfiCelia BovijnJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2012

Defective Dock2 expression in a subset of ASC-deficient mouse lines

Sirish K IppaguntaRK Subbarao MalireddiPatrick J ShawGeoffrey A NealeLieselotte Vande WalleYoshinori FukuiDouglas R GreenMohamed LamkanfiThirumala-Devi Kanneganti

Editorial material

Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens

Prajwal GurungRK Subbarao MalireddiParas K AnandDieter DemonLieselotte Vande WalleZhiPing LiuPeter VogelMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2011

Deregulated inflammasome signaling in disease

Mohamed LamkanfiLieselotte Vande WalleThirumala-Devi Kanneganti

A1 Journal Article in IMMUNOLOGICAL REVIEWS

HMGB1 release by inflammasomes

Lieselotte Vande WalleThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in VIRULENCE

Inflammasomes: caspase-1-activating platforms with critical roles in host defense

Lieselotte Vande WalleMohamed Lamkanfi

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Non-canonical inflammasome activation targets caspase-11

Nobuhiko KayagakiSoren WarmingMohamed LamkanfiLieselotte Vande WalleSalina LouieJennifer DongKim NewtonYan QuJinFeng LiuSherry Heldens et al.

A1 Journal Article in NATURE

The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization

Sirish K IppaguntaRK Subbarao MalireddiPatrick J ShawGeoffrey A NealeLieselotte Vande WalleDouglas R GreenYoshinori FukuiMohamed LamkanfiThirumala-Devi Kanneganti

A1 Journal Article in NATURE IMMUNOLOGY

2010

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

Ellen WirawanLieselotte Vande WalleKristof KersseSigrid CornelisS ClaerhoutIsabel VanoverbergheRia RoelandtRiet De RyckeJelle VerspurtenWim Declercq et al.

A1 Journal Article in CELL DEATH & DISEASE

Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia

Mohamed LamkanfiAnasuya SarkarLieselotte Vande WalleAlberto C Vitarimal AO AmerMark D WewersKevin J TraceyThirumala-Devi KannegantiVishva M Dixit

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal

Lieselotte Vande WalleEllen WirawanMohamed LamkanfiNele FestjensJelle VerspurtenXavier SaelensTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL RESEARCH

2008

The mitochondrial serine protease HtrA2/Omi: an overview

Lieselotte Vande WalleMohamed LamkanfiPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2007

Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis

G SCHILDERSR RAIJMAKERSKCR MALMEGRIMLieselotte Vande WalleXavier SaelensWV EGBERTSWJ VAN VENROOIJPeter VandenabeeleGJM PRUIJN

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Proteome-wide identification of HtrA2/Omi substrates

Lieselotte Vande WallePetra Van DammeMohamed LamkanfiXavier SaelensJoël VandekerckhoveKris GevaertPeter Vandenabeele

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

2006

Role of mitochondrial proteins in apoptosis.

Xavier SaelensNele FestjensLieselotte Vande WallePeter Vandenabeele

Bookchapter in Apoptosis and cancer therapy

2005

A novel caspase-2 complex containing TRAF2 and RIP1

Mohamed LamkanfiKathleen D'HondtLieselotte Vande WalleMarjan Van GurpGeertrui DeneckerJill DemeulemeesterMichaël KalaiWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria: Breathe or die

Lieselotte Vande WalleNele FestjensXavier SaelensPeter Vandenabeele

Bookchapter in Apoptosis

2004

Toxic proteins released from mitochondria in cell death

Xavier SaelensNele FestjensLieselotte Vande WalleMarjan Van GurpGeert van LooPeter Vandenabeele

A1 Journal Article in ONCOGENE