Research Explorer

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Researcher

Liesbet Martens

Publications & Research Data

Awards & Distinctions

46 Results

2025

Epigenomic preconditioning of peripheral monocytes determines their transcriptional response to the tumor microenvironment.

Máté KissLaszlo HalaszEva HadadiWilhelm K. BergerPetros TzerposSzilard PoliskaDaliya KanchevaAurélie GabrielRomina Mora BarthelmessAyla Debraekeleer et al.

A1 Journal Article in GENOME MEDICINE

Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair

Federico Francesco De PontiAnna BujkoZhuangzhuang LiuPaul CollinsSara SchuermansChristian MaueröderSeraja AmstelveenTinne ThonéLiesbet MartensJohn McKendrick et al.

A1 Journal Article in IMMUNITY

2024

A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver

Andrew S. PerryNiran HadadEmeli ChatterjeeMaria Jimenez-RamosEric Farber-EgerRashedeh RoshaniLindsey K. StolzeMichael J. BettiShilin ZhaoShi Huang et al.

A1 Journal Article in CELL REPORTS MEDICINE

Pattern or artifact? Interactively exploring embedding quality with TRACE

Edith HeiterLiesbet MartensRuth SeurinckMartin GuilliamsTijl De BieYvan SaeysJefrey Lijffijt

SPArrOW : a flexible, interactive and scalable pipeline for spatial transcriptomics analysis

Lotte PollarisBavo VannesteBenjamin RombautArne DefauwFrank VernaillenJulien MortierWout VanhendenLiesbet MartensTinne ThonéJean-François Hastir et al.

The unfolded protein sensor IRE1a is essential for homeostatic dendritic cell maturation

Sophie JanssensVictor BosteelsSandra MaréchalEva ClootsLaurien Van HeddegemSimon TavernierSofie RennenClint De NolfSeraja AmstelveenJonathan Maelfait et al.

2023

A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Karel Van DammeLevi HosteJozefien DeclercqElisabeth De LeeuwBastiaan MaesLiesbet MartensRoos ColmanRobin BrowaeysCedric BosteelsStijn Verwaerde et al.

A complement atlas identifies interleukin-6-dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Karel Van DammeLevi HosteJozefien DeclercqElisabeth De LeeuwBastiaan MaesLiesbet MartensRoos ColmanRobin BrowaeysCedric BosteelsStijn Verwaerde et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

LXR signaling controls homeostatic dendritic cell maturation

Victor BosteelsSandra MaréchalClint De NolfSofie RennenJonathan MaelfaitSimon TavernierJessica VettersEvelien Van De VeldeFarzaneh FayazpourKim Deswarte et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

2022

Innovative mouse models for the tumor suppressor activity of protocadherin-10 isoforms

Irene KleinbergerEllen SandersKatrien StaesMarleen Van TroysShinji HiranoTino HochepiedKelly LemeireLiesbet MartensChristophe AmpeFrans Van Roy

A1 Journal Article in BMC CANCER

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

Cedric BosteelsKarel Van DammeElisabeth De LeeuwJozefien DeclercqBastiaan MaesVictor BosteelsLevi HosteLeslie NaesensNincy DebeufJulie Deckers et al.

A1 Journal Article in CELL REPORTS MEDICINE

Single-cell RNA and protein profiling of immune cells from the mouse brain and its border tissues

Isabelle ScheyltjensHannah Van HoveKaren De VlaminckDaliya KanchevaJonathan BastosMonica Vara-PerezAna Rita Pombo AntunesLiesbet MartensCharlotte ScottJo Van Ginderachter et al.

A1 Journal Article in NATURE PROTOCOLS

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

Martin GuilliamsJohnny BonnardelBirthe HaestBart VanderborghtCamille WagnerAnneleen RemmerieAnna BujkoLiesbet MartensTinne ThonéRobin Browaeys et al.

A1 Journal Article in CELL

2021

A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism

Leen CatrysseBastiaan MaesParul MehrotraArne MartensEsther HosteLiesbet MartensChristian MaueröderAnneleen RemmerieAnna BujkoKarolina Slowicka et al.

A1 Journal Article in CELL REPORTS

Macrophages are metabolically heterogeneous within the tumor microenvironment

Xenia GeeraertsJuan Fernandez-GarciaFelix J. HartmannKyra E. de GoedeLiesbet MartensYvon ElkrimAyla DebraekeleerBenoit StijlemansAnke VandekeereGianmarco Rinaldi et al.

A1 Journal Article in CELL REPORTS

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization

Ana Rita Pombo AntunesIsabelle ScheyltjensFrancesca LodiJulie MessiaenAsier AntoranzJohnny DuerinckDaliya KanchevaLiesbet MartensKaren De VlaminckHannah Van Hove et al.

A1 Journal Article in NATURE NEUROSCIENCE

Therapeutic depletion of CCR8(+) tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

Helena Van DammeBruno DombrechtMate KissHeleen RooseElizabeth AllenEva Van OvermeireDaliya KanchevaLiesbet MartensAleksandar MurgaskiPauline Madeleine Rachel Bardet et al.

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

2020

Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection

Cedric BosteelsKatrijn NeytManon VanheerswynghelsMary van HeldenDorine SichienNincy DebeufSofie De PrijckVictor BosteelsNiels VandammeLiesbet Martens et al.

A1 Journal Article in IMMUNITY

Macrophage subsets in obesity, aligning the liver and adipose tissue

Anneleen RemmerieLiesbet MartensCharlotte Scott

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver

Anneleen RemmerieLiesbet MartensTinne ThonéAngela CastoldiRuth SeurinckBenjamin PavieJoris RoelsBavo VannesteSofie De PrijckMathias Vanhockerhout et al.

A1 Journal Article in IMMUNITY

Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury

Elke YdensLukas AmannBob AsselberghCharlotte ScottLiesbet MartensDorine SichienOmar MossadThomas BlankSofie De PrijckDonovan Low et al.

A1 Journal Article in NATURE NEUROSCIENCE

TAO-kinase 3 governs the terminal differentiation of conventional dendritic cells

Matthias VanderkerkenBastiaan MaesLana VandersarrenWendy ToussaintKim DeswarteManon VanheerswynghelsPhilippe PouliotLiesbet MartensSofie Van GassenConnie M. Arthur et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2019

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Hannah Van HoveLiesbet MartensIsabelle ScheyltjensKaren De VlaminckAna Rita Pombo AntunesSofie De PrijckNiels VandammeSebastiaan De SchepperGert Van IsterdaelCharlotte Scott et al.

A1 Journal Article in NATURE NEUROSCIENCE

Epithelial HMGB1 delays skin wound healing and drives tumor initiation by priming neutrophils for NET formation

Esther HosteChristian MaueröderLisette Van HoveLeen CatrysseHanna-Kaisa VikkulaMozes SzeBastiaan MaesDyah KarjosukarsoLiesbet MartensAmanda Gonçalves et al.

A1 Journal Article in CELL REPORTS

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

Hanne DuboisFrederic SorgeloosSoroush T. SarvestaniLiesbet MartensYvan SaeysJason M. MackenzieMohamed LamkanfiGeert van LooIan GoodfellowAndy Wullaert

A1 Journal Article in PLOS PATHOGENS

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Koen VenkenPeggy JacquesCéline MortierMark E. LabadiaTine DecruyJulie CoudenysKathleen HoytAnita L. WayneRobert HughesMichael Turner et al.

A1 Journal Article in NATURE COMMUNICATIONS

Single-cell RNA sequencing of the T helper cell response to house dust mites defines a distinct gene expression signature in airway Th2 cells

Christopher Andrew TibbittJulian Mario StarkLiesbet MartensJunjie MaJeff Eron MoldKim DeswarteGanna OliynykXiaogang FengBart LambrechtPieter De Bleser et al.

A1 Journal Article in IMMUNITY

Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche

Johnny BonnardelWouter T'JonckDjoere GaublommeRobin BrowaeysCharlotte ScottLiesbet MartensBavo VannesteSofie De PrijckSergei A NedospasovAnna Kremer et al.

A1 Journal Article in IMMUNITY

2018

Myocarditis elicits dendritic cell and monocyte infiltration in the heart and self-antigen presentation by conventional type 2 dendritic cells

Katrien Van Der BorghtCharlotte ScottLiesbet MartensDorine SichienGert Van IsterdaelVeronika NindlYvan SaeysLouis BoonBurkhard LudewigThierry Gillebert et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Some news from the unknown soldier, the Peyer's patch macrophage

Camille WagnerJohnny BonnardelClement Da SilvaLiesbet MartensJean-Pierre GorvelHugues Lelouard

A1 Journal Article in CELLULAR IMMUNOLOGY

The TLX1 oncogene modules the enhancer RNA landscape in T-ALL

Karen VerboomWouter Van LoockeJo VandesompeleNiels VandammeGeert BerxYvan SaeysLiesbet MartensPieter Van VlierbergheFranki SpelemanKaat Durinck

The transcription factor ZEB2 is required to maintain the tissue-specific identities of macrophages

Charlotte ScottWouter T'JonckLiesbet MartensHelena TodorovDorine SichienBieke SoenJohnny BonnardelSofie De PrijckNiels VandammeRobrecht Cannoodt et al.

A1 Journal Article in IMMUNITY

TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia

Karen VerboomWouter Van LoockeJo VandesompeleNiels VandammeGeert BerxLiesbet MartensYvan SaeysPieter Van VlierbergheFranki SpelemanKaat Durinck

2017

A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties

Aline Van AckerKonrad GronkeAindrila BiswasLiesbet MartensYvan SaeysJessica FiltjensSylvie TaveirneEls Van AmmelTessa KerrePatrick Matthys et al.

A1 Journal Article in CELL REPORTS

Myocardial infarction primes autoreactive T cells through activation of dendritic cells

Katrien Van Der BorghtCharlotte ScottVeronika NindlAnn BouchéLiesbet MartensDorine SichienJustine Van MoorleghemManon VanheerswynghelsSofie De PrijckYvan Saeys et al.

A1 Journal Article in CELL REPORTS

Nlrp6-and ASC-dependent inflammasomes do not shape the commensal gut microbiota composition

Michail MamantopoulosFrancesca RonchiFilip Van HauwermeirenSara Vieira-SilvaBahtiyar YilmazLiesbet MartensYvan SaeysStefan K DrexlerAmir S YazdiJeroen Raes et al.

A1 Journal Article in IMMUNITY

TGFβR signalling controls CD103⁺CD11b⁺ dendritic cell development in the intestine

CC BainJ MontgomeryCharlotte ScottJM KelMJH Girard-MadouxLiesbet MartensTFP Zangerle-MurrayJ Ober-BlobaumD Lindenbergh-KortleveJN Samsom et al.

A1 Journal Article in NATURE COMMUNICATIONS

The checkpoint for agonist selection precedes conventional selection in human thymus

Greet VerstichelDavid VermijlenLiesbet MartensGlenn GoetgelukMargreet BrouwerNicolas ThiaultYasmine Van CaeneghemStijn De MunterKarin WeeningSarah Bonte et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

2016

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Charlotte ScottFang ZhengPatrick De BaetselierLiesbet MartensYvan SaeysSofie De PrijckSaskia LippensChloé AbelsSteve SchoonoogheGeert Raes et al.

A1 Journal Article in NATURE COMMUNICATIONS

Early TCRA rearrangements favor development of agonist selected CD8ααhi T cells in human

Greet VerstichelGlenn GoetgelukLiesbet MartensYvan SaeysTessa KerreHilde CheroutreDavid VermijlenBart Vandekerckhove

IRF8 transcription factor controls survival and function of terminally differentiated conventional and plasmacytoid dendritic cells, respectively

Dorine SichienCharlotte ScottLiesbet MartensMatthias VanderkerkenSofie Van GassenMaud PlantingaThorsten JoerisSofie De PrijckLeen VanhoutteManon Vanheerswynghels et al.

A1 Journal Article in IMMUNITY

The checkpoint for agonist selection precedes conventional selection in human thymus

Greet VerstichelDavid VermijlenLiesbet MartensGlenn GoetgelukYvan SaeysHilde CheroutreBart Vandekerckhove

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2

Charlotte ScottBieke SoenLiesbet MartensNicolas SkrypekWouter SaelensJoachim TaminauGillian BlanckeGert Van IsterdaelDanny HuylebroeckJody Haigh et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Yolk sac macrophages, fetal liver, and adult monocytes can colonize an empty niche and develop into functional tissue-resident macrophages

Lianne van de LaarWouter SaelensSofie De PrijckLiesbet MartensCharlotte ScottGert Van IsterdaelEik HoffmannRudi BeyaertYvan SaeysBart Lambrecht et al.

A1 Journal Article in IMMUNITY

2015

Passenger mutations confound interpretation of all genetically modified congenic mice

Tom Vanden BerghePaco HulpiauLiesbet MartensRoosmarijn VandenbrouckeElien Van WonterghemSeth W PerryInge BruggemanTatyana DivertSze Men ChoiMarnik Vuylsteke et al.

A1 Journal Article in IMMUNITY

2014

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α⁺ dendritic cells

Fabiola OsorioSimon TavernierEik HoffmannYvan SaeysLiesbet MartensJessica VettersIris DelrueRiet De RyckeEef ParthoensPhilippe Pouliot et al.

A1 Journal Article in NATURE IMMUNOLOGY