Research Explorer

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Researcher

Liesbet De Bus

Awards & Distinctions

42 Results

2025

Impact of reporting rapid susceptibility results in Gram negative bloodstream infections : a real world prospective study

Anne-Sophie MessiaenStien VandendriesscheEmilie De MuynckGregory StrubbeLiesbet De BusPetra SchelstraeteKristen DecommerSanne De SmetAlexander SoetensLeslie Naesens et al.

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Unraveling mitochondrial pyruvate dysfunction to mitigate hyperlactatemia and lethality in sepsis.

Louise NuyttensMarah HeyerickGeike HeremansElise MoensMaxime RoesCéline Van DenderLiesbet De BusJohan DecruyenaereJan DewaeleJolien Vandewalle et al.

U Journal Article in Cell reports

2024

Antibiotic de-escalation : finally, some action and not only words

Alexis TabahLiesbet De BusMarc Leone

Editorial material

Clinical outcomes in combination versus mono antibiotic therapy in ICU admitted patients with a suspected infection : a substudy of the DIANA study

Nima TanhaIlja Areskog LejbmanLiesbet De BusGennaro De PascaleJose Garnacho-MonteroMarc LeoneShigeki FujitanJan De WaeleGustav TorissonFredrik Sjovall

A1 Journal Article in JOURNAL OF CRITICAL CARE

D-PRISM : a global survey-based study to assess diagnostic and treatment approaches in pneumonia managed in intensive care

Luis Felipe ReyesCristian C. Serrano-MayorgaZhongheng ZhangIsabela TsujiGennaro De PascaleValeria Enciso PrietoMervyn MerElyce SheehanPrashant NasaGoran Zangana et al.

A1 Journal Article in CRITICAL CARE

Empirical antimicrobials in the intensive care unit

Liesbet De BusKostoula ArvanitiFredrik Sjoevall

Editorial material

Empirical carbapenems or piperacillin/tazobactam for infections in intensive care : an international retrospective cohort study

Nick MeierMarie Warrer MunchAnders GranholmAnders PernerFrederik Boetius HertzBalasubramanian VenkateshNaomi E. HammondQiang LiLiesbet De BusJan De Waele et al.

A1 Journal Article in ACTA ANAESTHESIOLOGICA SCANDINAVICA

Hospital-acquired bloodstream infections in critically ill cirrhotic patients : a post-hoc analysis of the EUROBACT-2 international cohort study

Hannah WozniakAlexis TabahFrancois BarbierStephane RucklyAmbre LoiodiceMurat AkovaMarc LeoneAndrew Conway MorrisMatteo BassettiKostoula Arvaniti et al.

A1 Journal Article in ANNALS OF INTENSIVE CARE

No improvement in mortality among critically ill patients with carbapenems as initial empirical therapy and more detection of multi-drug resistant pathogens associated with longer use : a post hoc analysis of a prospective cohort study

Junki IshiiMitsuaki NishikimiLiesbet De BusJan De WaeleAkihiro TakabaAkira KuriyamaAtsuko KobayashiChie TanakaHideki HashiHideki Hashimoto et al.

A1 Journal Article in MICROBIOLOGY SPECTRUM

The role of centre and country factors on process and outcome indicators in critically ill patients with hospital-acquired bloodstream infections

Niccolo BuettiAlexis TabahNour SettiStephane RucklyFrancois BarbierMurat AkovaAbdullah Tarik AslanMarc LeoneMatteo BassettiAndrew Conway Morris et al.

A1 Journal Article in INTENSIVE CARE MEDICINE

Variability in forgoing life-sustaining treatment practices in critically Ill patients with hospital-acquired bloodstream infections : a secondary analysis of the EUROBACT-2 international cohort

Hannah WozniakAlexis TabahJan De WaeleJean-Francois TimsitNiccolo BuettiLiesbet De Bus[missing] EUROBACT-2 Study Grp[missing] European Soc Intensive Care Med ESICM[missing] European Soc Clinical Microbiology[missing] Infect Dis ESCMID Study Grp Infections Critically Ill Patients ESGCIP et al.

A1 Journal Article in CRITICAL CARE

2023

Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients : the EUROBACT-2 international cohort study

Alexis TabahNiccolo BuettiQuentin StaiqulyStephane RucklyMurat AkovaAbdullah Tarik AslanMarc LeoneAndrew Conway MorrisMatteo BassettiKostoula Arvaniti et al.

A1 Journal Article in INTENSIVE CARE MEDICINE

Pathogen-based target attainment of optimized continuous infusion dosing regimens of piperacillin-tazobactam and meropenem in surgical ICU patients : a prospective single center observational study

Thomas De CorteJarne VerhaegheSofie DhaeseSarah Van VoorenJerina BoelensAlain VerstraeteVeronique StoveFemke OngenaeLiesbet De BusPieter Depuydt et al.

A1 Journal Article in ANNALS OF INTENSIVE CARE

When fear takes control : the multidrug resistance story during pandemics

Marc LeoneLiesbet De BusAndrew Conway Morris

Editorial material

2022

Antimicrobial prescription in severe COVID-19 and CAP : a matched case-control study

Jan FierensLiesbet De BusKirsten ColpaertJerina BoelensBram GadeyneJohan DecruyenaereEva Van BraeckelPieter Depuydt

A1 Journal Article in ACTA CLINICA BELGICA

Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients : a descriptive analysis of the Eurobact II study

Niccolo BuettiAlexis TabahAmbre LoiodiceStephane RucklyAbdullah Tarik AslanGiorgia MontrucchioAndrea CortegianiNese SaltogluBircan KayaaslanFirdevs Aksoy et al.

A1 Journal Article in CRITICAL CARE

Effect of antiplatelet therapy on survival and organ support-free days in critically ill patients with COVID-19 : a randomized clinical trial

Charlotte A. BradburyPatrick R. LawlerSimon J. StanworthBryan J. McVerryZoe McQuiltenAlisa M. HigginsPaul R. MounceyFarah Al-BeidhKathryn M. RowanLindsay R. Berry et al.

A1 Journal Article in JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Empirical antimicrobial use in ICU and outcome before and after abandoning the concept of healthcare-associated pneumonia : a single center retrospective analysis

Thomas CouckJan FierensJerina BoelensLiesbet De BusDiana Huis in 't VeldEva Van BraeckelPieter Depuydt

Sensitivity and specificity of 14 SARS-CoV-2 serological assays and their diagnostic potential in RT-PCR negative COVID-19 infections

Eveline Van HonackerLiselotte CoorevitsJerina BoelensBruno VerhasseltEva Van BraeckelFre BautersLiesbet De BusPetra SchelstraeteJef WillemsStien Vandendriessche et al.

A1 Journal Article in ACTA CLINICA BELGICA

Use of broad-spectrum antimicrobials for more than 72 h and the detection of multidrug-resistant bacteria in Japanese intensive care units : a multicenter retrospective cohort study

H YoshidaT MotohashiLiesbet De BusJan De WaeleA TakabaA KuriyamaA KobayashiC TanakaH HashiH Hashimoto et al.

A1 Journal Article in ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL

2021

Attributable mortality of ventilator-associated pneumonia : replicating findings, revisiting methods

Johan SteenStijn VansteelandtLiesbet De BusPieter DepuydtBram GadeyneDominique BenoitJohan Decruyenaere

A1 Journal Article in ANNALS OF THE AMERICAN THORACIC SOCIETY

Characteristics of Sepsis-2 septic shock patients failing to satisfy the Sepsis-3 septic shock definition : an analysis of real-time collected data

Joris VermassenJohan DecruyenaereLiesbet De BusPieter DepuydtKirsten Colpaert

A1 Journal Article in ANNALS OF INTENSIVE CARE

2020

Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure : the DIANA study

Liesbet De BusPieter DepuydtJohan SteenSofie DhaeseKen De SmetAlexis TabahMurat AkovaMenino Osbert CottaGennaro De PascaleGeorge Dimopoulos et al.

A1 Journal Article in INTENSIVE CARE MEDICINE

Automated screening of natural language in electronic health records for the diagnosis septic shock is feasible and outperforms an approach based on explicit administrative codes

Joris VermassenKirsten ColpaertLiesbet De BusPieter DepuydtJohan Decruyenaere

A1 Journal Article in JOURNAL OF CRITICAL CARE

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Lise Van WyngeneTineke VanderhaeghenSteven TimmermansJolien VandewalleKelly Van LooverenJolien SouffriauCharlotte WallaeysMelanie EggermontSam ErnstEvelien Van Hamme et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

Overexpression of Gilz protects mice against lethal septic peritonitis

Marlies BallegeerJolien VandewalleMelanie EggermontGert Van IsterdaelLien DejagerLiesbet De BusJohan DecruyenaereRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in SHOCK

2018

A complete and multifaceted overview of antibiotic use and infection diagnosis in the intensive care unit : results from a prospective four-year registration

Liesbet De BusBram GadeyneJohan SteenJerina BoelensGeert ClaeysDominique BenoitJan De WaeleJohan DecruyenaerePieter Depuydt

A1 Journal Article in CRITICAL CARE

Emergence of antimicrobial resistance to piperacillin/tazobactam or meropenem in the ICU : intermittent versus continuous infusion : a retrospective cohort study

Sofie DhaeseMagalie De KezelMaxime CallantJerina BoelensLiesbet De BusPieter DepuydtJan De Waele

A1 Journal Article in JOURNAL OF CRITICAL CARE

Impact of AST meetings on antimicrobial therapy decisions in the ICU

Sofie DhaeseLiesbet De BusJerina BoelensLiselotte CoorevitsBruno VerhasseltPieter DepuydtJan De Waele

Simultaneous inhibition of tumor necrosis factor receptor 1 and matrix metalloproteinase 8 completely protects against acute inflammation and sepsis

Sophie SteelandSara Van RyckeghemJolien VandewalleMarlies BallegeerElien Van WonterghemMelanie EggermontJohan DecruyenaereLiesbet De BusClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in CRITICAL CARE MEDICINE

Use of a computer-assisted registration program to investigate antibiotic prescription and antibiotic resistance in the intensive care unit

Liesbet De BusPieter DepuydtJohan Decruyenaere

2017

P. aeruginosa colonization at ICU admission as a risk factor for developing P. aeruginosa ICU pneumonia

Fleur P PalingMartin WolkewitzPieter DepuydtLiesbet De BusFrangiscos SifakisMarc JM BontenJan AJW Kluytmans

A1 Journal Article in ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL

Staphylococcus aureus colonization at ICU admission as a risk factor for developing S. aureus ICU pneumonia

FP PalingM WolkewitzLGM BodePMC Klein KlouwenbergDSY OngPieter DepuydtLiesbet De BusF SifakisMJM BontenJAJW Kluytmans

A1 Journal Article in CLINICAL MICROBIOLOGY AND INFECTION

2016

Antibiotic stewardship : do not rely on de-escalation alone

Liesbet De BusPieter Depuydt

A1 Journal Article in INTENSIVE CARE MEDICINE

Impact of de-escalation of beta-lactam antibiotics on the emergence of antibiotic resistance in ICU patients : a retrospective observational study

Liesbet De BusWOUTER DENYSJULIE CATTEEUWBram GadeyneKarel VermeulenJerina BoelensGeert ClaeysJan De WaeleJohan DecruyenaerePieter Depuydt

A1 Journal Article in INTENSIVE CARE MEDICINE

Reducing antibiotic use in the ICU : a time-based approach to rational antimicrobial use

Pieter DepuydtLiesbet De BusJan De Waele

Bookchapter in Annual update in intensive care and emergency medicine 2016

2014

Development of antibiotic treatment algorithms based on local ecology and respiratory surveillance cultures to restrict the use of broad-spectrum antimicrobial drugs in the treatment of hospital-acquired pneumonia in the intensive care unit : a retrospective analysis

Liesbet De BusLIES SAERENSBram GadeyneJerina BoelensGeert ClaeysJan De WaeleDominique BenoitJohan DecruyenaerePieter Depuydt

A1 Journal Article in CRITICAL CARE

How to treat infections in a surgical intensive care unit

Jan De WaeleLiesbet De Bus

A2 Journal Article in BMC INFECTIOUS DISEASES

Validity analysis of a unique infection surveillance system in the intensive care unit by analysis of a data warehouse built through a workflow-integrated software application

Liesbet De BusGUNTER DIETBram GadeyneIsabel Leroux-RoelsGeert ClaeysKristof SteurbautDominique BenoitFilip De TurckJohan DecruyenaerePieter Depuydt

A1 Journal Article in JOURNAL OF HOSPITAL INFECTION

2013

Microbial etiology and antimicrobial resistance in healthcare-associated versus community-acquired and hospital-acquired bloodstream infection in a tertiary care hospital

Liesbet De BusGwen CoessensJerina BoelensGeert ClaeysJohan DecruyenaerePieter Depuydt

A1 Journal Article in DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

2012

Assessment of microbial diversity in biofilms recovered from endotracheal tubes using culture dependent and independent approaches

Ilse VandecandelaereNele MatthijsFilip Van NieuwerburghDieter DeforcePETER VOSTERSLiesbet De BusHans NelisPieter DepuydtTom Coenye

A1 Journal Article in PLOS ONE

2010

Severe drug-induced liver injury associated with prolonged use of Linezolid

Liesbet De BusPieter DepuydtLouis LibbrechtLinos VandekerckhoveJOKE NOLLETDominique BenoitDirk VogelaersHans Van Vlierberghe

A2 Journal Article in JOURNAL OF MEDICAL TOXICOLOGY