Research Explorer

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Researcher

Lies De Bock

Awards & Distinctions

20 Results

2018

Maturation of hepatic cytochrome P450 enzymes in conventional pigs : the added value of proteomics

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

The ontogeny of cytochrome P450 enzyme activity and protein abundance in conventional pigs in support of preclinical pediatric drug research

Joske MillecamLaura De ClerckElisabeth GovaertMathias DevreeseElke GasthuysWim SchelstraeteDieter DeforceLies De BockJan Van BocxlaerStanislas Sys et al.

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

2017

Strategies for determining correct cytochrome P450 contributions in hepatic clearance predictions : in vitro-in vivo extrapolation as modelling approach and tramadol as proof-of concept compound

Huybrecht T'jollynJan SnoeysJan Van BocxlaerLies De BockPieter AnnaertAchiel Van PeerKarel AllegaertGeert MannensAn VermeulenKoen Boussery

A1 Journal Article in EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

2015

Age-related differences in CYP3A abundance and activity in the liver of the Gottingen Minipig

Els Van PeerLies De BockKoen BousseryJan Van BocxlaerChristophe CasteleynChris Van GinnekenSteven Van Cruchten

A1 Journal Article in BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The ontogeny of hepatic CYP3A, CYP2C and CYP2E enzyme activity in conventional pigs

Joske MillecamMathias DevreeseLies De BockJan Van BocxlaerElke GasthuysPatrick De BackerSiska Croubels

2014

Enzymatic tumour tissue digestion coupled to SPE-UPLC–tandem mass spectrometry as a tool to explore paclitaxel tumour penetration

Pieter ColinLieselotte De SmetLies De BockWim GoeteynKoen BousseryChris VervaetJan Van Bocxlaer

A1 Journal Article in TALANTA

Microsomal protein per gram of liver (MPPGL) in paediatric biliary atresia patients

Lies De BockKoen BousseryRuth De BruyneMyriam Van WinckelXavier StephenneEtienne SokalJan Van Bocxlaer

A1 Journal Article in BIOPHARMACEUTICS & DRUG DISPOSITION

Pharmacokinetics in children with liver disease : can ex vivo obtained population-specific CYP450 characteristics bridge the knowledge gap?

Lies De BockJan Van BocxlaerKoen Boussery

Quantification of cytochrome 2E1 in human liver microsomes using a validated indirect ELISA

Lies De BockPieter ColinKoen BousseryJan Van Bocxlaer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

2013

Development and validation of a fast and uniform approach to quantify β-lactam antibiotics in human plasma by solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry

Pieter ColinLies De BockHuybrecht T'jollynKoen BousseryJan Van Bocxlaer

A1 Journal Article in TALANTA

Hepatic and intestinal CYP3A expression and activity in broilers

Ann OsselaereLies De BockVenessa EeckhautPatrick De BackerJan Van BocxlaerKoen BousserySiska Croubels

A1 Journal Article in JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

In vitro cytochrome P450 activity decreases in children with high paediatric end-stage liver disease scores

Lies De BockKoen BousseryMyriam Van WinckelPeter De PaepeXavier RogiersXavier StephenneEtienne SokalJan Van Bocxlaer

A1 Journal Article in DRUG METABOLISM AND DISPOSITION

Metabolism of hop-derived bitter acids

Ko CattoorMichael DreselLies De BockKoen BousseryJan Van BocxlaerJean Paul RemonDenis De KeukeleireDieter DeforceThomas HofmannArne Heyerick

A1 Journal Article in JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The mycotoxin T-2 inhibits hepatic cytochrome P4503A activity in pigs

Joline GoossensLies De BockAnn OsselaereElin VerbruggheMathias DevreeseKoen BousseryJan Van BocxlaerPatrick De BackerSiska Croubels

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

Toxic effects of dietary exposure to T-2 toxin on intestinal and hepatic biotransformation enzymes and drug transporter systems in broiler chickens

Ann OsselaereShaoji LiLies De BockMathias DevreeseJoline GoossensVirginie VandenbrouckeJan Van BocxlaerKoen BousseryFrank PasmansAn Martel et al.

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

2012

Development and validation of a fast and sensitive UPLC-MS/MS method for the quantification of six probe metabolites for the in vitro determination of cytochrome P450 activity

Lies De BockKoen BousseryPieter ColinJulie De SmetHuybrecht T'jollynJan Van Bocxlaer

A1 Journal Article in TALANTA

Development and validation of an enzyme-linked immunosorbent assay for the quantification of cytochrome 3A4 in human liver microsomes

Lies De BockPieter ColinKoen BousseryJan Van Bocxlaer

A1 Journal Article in TALANTA

Hypervariable cytochrome P450 activity in children with severe hepatic dysfunction

Lies De BockKoen BousseryMyriam Van WinckelPeter De PaepeXavier StephenneEtienne SokalJan Van Bocxlaer

Toxic effects of dietary exposure to T-2 toxin on intestinal and hepatic CYP450 in broilers

Ann OsselaereShaoji LiLies De BockMathias DevreeseJoline GoossensVirginie VandenbrouckeFrank PasmansAn MartelPatrick De BackerSiska Croubels

2011

In vitro cytochrome P450 activity: development and validation of a sensitive high performance liquid chromatography–tandem mass spectrometry method for the quantification of six probe metabolites after derivatization with pyridine-3-sulfonyl chloride in an aqueous environment

Lies De BockSofie Vande CasteeleSYLVIE MULLIEZKoen BousseryJan Van Bocxlaer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A