Research Explorer

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Researcher

Lien Van Hoecke

Publications & Research Data

Awards & Distinctions

59 Results

2026

Base barrier cells provide compartmentalization of choroid plexus, brain and CSF

Daan VerhaegeClint De NolfLore Van AckerWouter ClaeysJonas CasteleinElien Van WonterghemGriet Van ImschootPieter DujardinWard De SpiegelaereEsther Hoste et al.

A1 Journal Article in NATURE NEUROSCIENCE

Decoding brain border immunity to enable future therapeutic avenues

Lien Van HoeckeLore Van AckerRoosmarijn Vandenbroucke

A1 Journal Article in TRENDS IN IMMUNOLOGY

2025

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors

Xiuming LiangDhanu GuptaJunhua XieElien Van WonterghemLien Van HoeckeJustin HeanZheyu NiuMarziyeh GhaeidaminiOscar P. B. WiklanderWenyi Zheng et al.

A1 Journal Article in NATURE COMMUNICATIONS

Gut microbiota modulates CNS barrier function in murine model for multiple sclerosis

Junhua XieMarlies BurgelmanPieter DujardinJonas CasteleinGriet Van ImschootElien Van WonterghemHannah LernoutSjoerd SchettersCharysse VandendriesscheLien Van Hoecke et al.

A1 Journal Article in FLUIDS AND BARRIERS OF THE CNS

Mesenchymal stromal cell extracellular vesicles as immune modulators and drug carriers in neurodegenerative disorders

Lien Van HoeckeCristiano LucciRoosmarijn Vandenbroucke

A1 Journal Article in TRENDS IN NEUROSCIENCES

Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease : lessons from animal studies

Wouter ClaeysAnja GeertsLien Van HoeckeChristophe Van SteenkisteRoosmarijn Vandenbroucke

A1 Journal Article in NEURAL REGENERATION RESEARCH

The gut-brain axis in Alzheimer's disease is shaped by commensal gut microbiota derived extracellular vesicles

Junhua XieLien Van HoeckeElien Van WonterghemGriet Van ImschootVanessa AndriesLars VereeckeRoosmarijn Vandenbroucke

A1 Journal Article in GUT MICROBES

2024

A new MVA ancestor-derived oncolytic vaccinia virus induces immunogenic tumor cell death and robust antitumor immune responses

Juan J. RojasLien Van HoeckeMiquel ConesaCarmen Bueno-MerinoAna del CanizoStephanie RiedererMaria BarciaKatrin BrosinskiMichael H. LehmannAsisa Volz et al.

A1 Journal Article in MOLECULAR THERAPY

An immunological puzzle : the adaptive immune system fuels Alzheimer’s disease pathology

Lien Van HoeckeJonas CasteleinJunhua XieLore Van AckerGriet Van ImschootElien Van WonterghemIne VlaeminckDaan VerhaegeWouter ClaeysKeimpe Wierda et al.

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

Beyond genetics: including the environmental dimension in amyloidosis mouse models for Alzheimer's disease

Lien Van HoeckeRoosmarijn Vandenbroucke

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS

Challenging the conventional wisdom : re-evaluating smpd3's role in extracellular vesicle biogenesis

Marlies BurgelmanPieter DujardinAnthony WillemsTino HochepiedGriet Van ImschootElien Van WonterghemLien Van HoeckeCharysse VandendriesscheRoosmarijn Vandenbroucke

A2 Journal Article in JOURNAL OF EXTRACELLULAR BIOLOGY

The spreading and effects of human recombinant α-synuclein preformed fibrils in the cerebrospinal fluid of mice

Charysse VandendriesscheArnout BruggemanJoyce ForoozandehLien Van HoeckePieter DujardinJunhua XieGriet Van ImschootElien Van WonterghemJonas CasteleinCristiano Lucci et al.

A1 Journal Article in ENEURO

2023

Bacterial extracellular vesicles : an emerging avenue to tackle diseases

Junhua XieFreddy HaesebrouckLien Van HoeckeRoosmarijn Vandenbroucke

A1 Journal Article in TRENDS IN MICROBIOLOGY

Choroid plexus base barrier cells : the key to understand compartmentalization and immune surveillance at the blood-CFS barrier

Daan VerhaegeRoosmarijn VandenbrouckeLien Van Hoecke

Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes

Wouter ClaeysLien Van HoeckeHannah LernoutClint De NolfGriet Van ImschootElien Van WonterghemDaan VerhaegeJonas CasteleinAnja GeertsChristophe Van Steenkiste et al.

A1 Journal Article in JOURNAL OF NEUROINFLAMMATION

Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling

Junhua XieLien CoolsGriet Van ImschootElien Van WonterghemMarie PauwelsIne VlaeminckChloë De WitteSamir EL AndaloussiKeimpe WierdaLies De Groef et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Limitations of PLX3397 as a microglial investigational tool : peripheral and off-target effects dictate the response to inflammation

Wouter ClaeysDaan VerhaegeGriet Van ImschootElien Van WonterghemLore Van AckerLaura AmelinckFederico Francesco De PontiCharlotte ScottAnja GeertsChristophe Van Steenkiste et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

A mouse model of hepatic encephalopathy : bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation.

Wouter ClaeysLien Van HoeckeAnja GeertsHans Van VlierbergheSander LefereGriet Van ImschootElien Van WonterghemBart GhesquièreRoosmarijn VandenbrouckeChristophe Van Steenkiste

A1 Journal Article in SCIENTIFIC REPORTS

Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics

Marie PauwelsJunhua XieAdam CeroiSriram BalusuJonas CasteleinElien Van WonterghemGriet Van ImschootAndrew WardTrevelyan R. MenheniottOskar Gustafsson et al.

A1 Journal Article in BIOMATERIALS

Exploration of blood-cerebrospinal fluid barrier targeted extracellular vesicles as brain delivery strategy

Marie PauwelsRoosmarijn VandenbrouckeLien Van Hoecke

Fighting fire with fire : the immune system might be key in our fight against Alzheimer’s disease

Pieter DujardinRoosmarijn VandenbrouckeLien Van Hoecke

A1 Journal Article in DRUG DISCOVERY TODAY

Microdissection and whole mount scanning electron microscopy visualization of mouse choroid plexus

Elien Van WonterghemLien Van HoeckeGriet Van ImschootDaan VerhaegeMarlies BurgelmanRoosmarijn Vandenbroucke

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Neurometabolic and gliovascular changes in murine hepatic encephalopathy

Wouter ClaeysLien Van HoeckeAnja GeertsHans Van VlierbergheXavier VerhelstSander LefereHelena DegrooteGriet Van ImschootElien Van WonterghemRoosmarijn Vandenbroucke et al.

Recent insights into viral infections as a trigger and accelerator in Alzheimer's disease

Lize De VliegerRoosmarijn VandenbrouckeLien Van Hoecke

A1 Journal Article in DRUG DISCOVERY TODAY

Studying the impact of the gastrointestinal bacteria on the brain, focusing on the blood-cerebrospinal fluid barrier and Alzheimer's disease

Junhua XieRoosmarijn VandenbrouckeFreddy HaesebrouckLien Van Hoecke

The impact of systemic inflammation on Alzheimer's disease pathology

Junhua XieLien Van HoeckeRoosmarijn Vandenbroucke

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The tremendous biomedical potential of bacterial extracellular vesicles

Junhua XieQiqiong LiFreddy HaesebrouckLien Van HoeckeRoosmarijn Vandenbroucke

A1 Journal Article in TRENDS IN BIOTECHNOLOGY

2021

Anti-inflammatory mesenchymal stromal cell-derived extracellular vesicles improve pathology in Niemann-Pick type C disease

Lien Van HoeckeCaroline Van CauwenbergheVerena BoergerArnout BruggemanJonas CasteleinGriet Van ImschootElien Van WonterghemRobin DittrichWouter ClaeysJunhua Xie et al.

A1 Journal Article in BIOMEDICINES

In vivo therapy with M2e-specific IgG selects for an influenza A virus mutant with delayed matrix protein 2 expression

Silvie Van den HoeckeMarlies BallegeerBram VranckenLei DengEmma JobKenny RooseBert SchepensLien Van HoeckePhilippe LemeyXavier Saelens

A1 Journal Article in MBIO

Involvement of the choroid plexus in the pathogenesis of Niemann-Pick disease type C

Lien Van HoeckeCaroline Van CauwenbergheKristina DominkoGriet Van ImschootElien Van WonterghemJonas CasteleinJunhua XieWouter ClaeysCharysse VandendriesscheAnna Kremer et al.

A1 Journal Article in FRONTIERS IN CELLULAR NEUROSCIENCE

Low-grade peripheral inflammation affects brain pathology in the App(NL-G-F)mouse model of Alzheimer's disease

Junhua XieNina GorléCharysse VandendriesscheGriet Van ImschootElien Van WonterghemCaroline Van CauwenbergheEef ParthoensEvelien Van HammeSaskia LippensLien Van Hoecke et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA COMMUNICATIONS

mRNA in cancer immunotherapy : beyond a source of antigen

Lien Van HoeckeRein VerbekeHeleen DewitteIne LentackerKarim VermaelenKarine BreckpotSandra Van Lint

A1 Journal Article in MOLECULAR CANCER

The neurogliovascular unit in hepatic encephalopathy

Wouter ClaeysLien Van HoeckeSander LefereAnja GeertsXavier VerhelstHans Van VlierbergheHelena DegrooteLindsey DevisscherRoosmarijn VandenbrouckeChristophe Van Steenkiste

A1 Journal Article in JHEP REPORTS

2020

Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation

Laurens RaesStephan StremerschJuan FraireToon BransGlenn GoetgelukStijn De MunterLien Van HoeckeRein VerbekeJelter Van HoeckRanhua Xiong et al.

A1 Journal Article in NANO-MICRO LETTERS

mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice

Lien Van HoeckeRein VerbekeDorien De VliegerHeleen DewitteKenny RooseSharon Van NevelOlga KryskoClaus BachertBert SchepensIne Lentacker et al.

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

mRNA-based therapeutics to induce immunity against cancer and infectious diseases

Lien Van HoeckeXavier SaelensSandra Van LintKenny Roose

Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice

Lien Van HoeckeStephanie RiedererXavier SaelensGerd SutterJuan Jose Rojas

A1 Journal Article in ONCOIMMUNOLOGY

Selected IL-1 activity on CD8+ T cells allows for safe enhancement of cellular immune responses

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanNiko KleyGilles UzéXavier SaelensJan TavernierSarah Gerlo

Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanNiko KleyGilles UzéXavier SaelensJan TavernierSarah Gerlo

A1 Journal Article in NPJ VACCINES

The opposing effect of type I IFN on the T cell response by non-modified mRNA-lipoplex vaccines Is determined by the route of administration

Lien Van HoeckeKenny RooseMarlies BallegeerZifu ZhongNiek SandersStefaan De KokerXavier SaelensSandra Van Lint

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

2019

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells

Lien Van HoeckeLaurens RaesStephan StremerschToon BransJuan FraireRia RoelandtWim DeclercqPeter VandenabeeleKoen RaemdonckKevin Braeckmans et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice

Patrick Tjok JoeIoanna ChristopoulouLien Van HoeckeBert SchepensTine YsenbaertCarlo HeirmanKris ThielemansXavier SaelensJoeri Aerts

A1 Journal Article in JOURNAL OF TRANSLATIONAL MEDICINE

Mx1 in hematopoietic cells protects against Thogoto virus infection

Jan SpitaelsLien Van HoeckeKenny RooseGeorg KochsXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

Selective engagement of FcγRIV by a M2e-specific single domain antibody construct protects against influenza A virus infection

Dorien De VliegerKatja HoffmannInge Van MolleWim NerinckxLien Van HoeckeMarlies BallegeerSarah CreytensHan RemautHartmut HengelBert Schepens et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Towards the use of interleukin-1β as vaccine adjuvant

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanXavier SaelensJan TavernierSarah Gerlo

2018

Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist

Lutz NuhnLien Van HoeckeKim DeswarteBert SchepensYupeng LiBart LambrechtStefaan De KokerSunil A DavidXavier SaelensBruno De Geest

A1 Journal Article in BIOMATERIALS

Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy

Pieterjan MerckxLynn De BackerLien Van HoeckeRoberta GuagliardoMercedes EchaidePieter BaatsenBárbara OlmedaXavier SaelensJésus Pérez-GilStefaan De Smedt et al.

A1 Journal Article in ACTA BIOMATERIALIA

Therapeutic anti-tumor immunity directed against neo-epitopes by intratumor delivery of mRNA encoding MLKL

Lien Van HoeckeXavier Saelens

A2 Journal Article in CELL STRESS

Transiently thermoresponsive acetal polymers for safe and effective administration of Amphotericin B as a vaccine adjuvant

Simon Van HerckLien Van HoeckeBenoit LouageLien LybaertRuben De CoenSabah KasmiAaron P Esser-KahnSunil A DavidLutz NuhnBert Schepens et al.

A1 Journal Article in BIOCONJUGATE CHEMISTRY

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

Lien Van HoeckeSandra Van LintKenny RooseAlexander Van ParysPeter VandenabeeleJohan GrootenJan TavernierStefaan De KokerXavier Saelens

A1 Journal Article in NATURE COMMUNICATIONS

2017

Arginine-rich peptide-based mRNA nanocomplexes efficiently instigate cytotoxic T cell immunity dependent on the amphipathic organization of the peptide

Vimal Kumar UdhayakumarAns De BeuckelaerJoanne McCaffreyCian M McCruddenJonathan L KirschmanDaryll VanoverLien Van HoeckeKenny RooseKim DeswarteBruno De Geest et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Bronchoalveolar lavage of murine lungs to analyze inflammatory cell infiltration

Lien Van HoeckeEmma JobXavier SaelensKenny Roose

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Chemical-controlled activation of antiviral myxovirus resistance protein 1

Judith VerhelstLien Van HoeckeJan SpitaelsDorien De VliegerAnnasaheb KolpeXavier Saelens

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Stefaan De KokerLien Van HoeckeAns De BeuckelaerKenny RooseKim DeswarteMonique WillartPieter BogaertThomas NaessensBruno De GeestXavier Saelens et al.

A1 Journal Article in SCIENTIFIC REPORTS

2016

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice

Muriel SmetLien Van HoeckeAns De BeuckelaerSeppe Vander BekenThomas NaessensKarl VergoteMonique WillartBart LambrechtJan-Ake GustafssonKnut R Steffensen et al.

A2 Journal Article in IMMUNITY INFLAMMATION AND DISEASE

Coadministration of a plasmid encoding HIV-1 Gag enhances the efficacy of cancer DNA vaccines

Laure LambrichtKevin VanvarenbergAns De BeuckelaerLien Van HoeckeJohan GrootenBernard UcakarPascale LipnikNiek SandersStefan LienenklausVéronique Préat et al.

A1 Journal Article in MOLECULAR THERAPY

GM-CSF treatment prevents respiratory syncytial virus– induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation

Thomas NaessensBert SchepensMuriel SmetCharlotte PollardLien Van HoeckeAns De BeuckelaerMonique WillartBart LambrechtStefaan De KokerXavier Saelens et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mycobacterium tuberculosis-associated synthetic mycolates differentially exert immune stimulatory adjuvant activity

Muriel SmetCharlotte PollardAns De BeuckelaerLien Van HoeckeSeppe Vander BekenStefaan De KokerJuma'a R Al DulayymiKris HuygenJan VerschoorMark S Baird et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Type I interferons interfere with the capacity of mRNA lipoplex vaccines to elicit cytolytic T cell responses

Ans De BeuckelaerCharlotte PollardSandra Van LintKenny RooseLien Van HoeckeTom NaessensVimal Kumar UdhayakumarMuriel SmetNiek SandersStefan Lienenklaus et al.

A1 Journal Article in MOLECULAR THERAPY