Research Explorer

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Researcher

Lien Lippens

Awards & Distinctions

30 Results

2024

Associations of the gut microbiome with outcomes in cervical and endometrial cancer patients treated with pembrolizumab : insights from the phase II PRIMMO trial

Emiel De JaeghereHannelore HamerlinckSandra TuyaertsLien LippensAn M.T. Van NuffelRegina Baiden-AmissahPeter VuylstekeStéphanie HenryXuan Bich TrinhPeter A. van Dam et al.

A1 Journal Article in GYNECOLOGIC ONCOLOGY

Identification and validation of extracellular vesicle reference genes for the normalization of RT‐qPCR data

Cláudio PinheiroNiké GuilbertLien LippensQuentin RouxRobin BoiySuzanne FischerSofie Van DorpeBram De CraeneGeert BerxTom Boterberg et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Minimal information for studies of extracellular vesicles (MISEV2023) : from basic to advanced approaches

Joshua A. WelshDeborah C. I. GoberdhanLorraine O'DriscollEdit I. BuzasCherie BlenkironBenedetta BussolatiHoujian CaiDolores Di VizioTom A. P. DriedonksUta Erdbrügger et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma : results of the phase II PRIMMO study (vol 72, pg 475, 2022)

Emiel De JaeghereSandra TuyaertsAn M. T. Van NufelAnn BelmansKris BogaertsRegina Baiden-AmissahLien LippensPeter VuylstekeStéphanie HenryXuan Bich Trinh et al.

2023

Extracellular vesicle analysis

An HendrixLien LippensCláudio PinheiroClotilde ThéryLorena Martin-JaularJan LötvallCecilia LässerAndrew F. HillKenneth W. Witwer

A2 Journal Article in NATURE REVIEWS METHODS PRIMERS

Integrating automated liquid handling in the separation workflow of extracellular vesicles enhances specificity and reproducibility

Sofie Van DorpeLien LippensRobin BoiyCláudio PinheiroGlenn VergauwenPekka RappuIlkka MiinalainenPhilippe TummersHannelore DenysOlivier De Wever et al.

A1 Journal Article in JOURNAL OF NANOBIOTECHNOLOGY

Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma : results of the phase II PRIMMO study

Emiel De JaeghereSandra TuyaertsAn M. T. Van NuffelAnn BelmansKris BogaertsRegina Baiden-AmissahLien LippensPeter VuylstekeStéphanie HenryXuan Bich Trinh et al.

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

2022

Association of cell death markers with tumor immune cell infiltrates after chemo-radiation in cervical cancer

Teodora-Eugenia OlteanLien LippensKelly LemeireCaroline De TenderMarnik VuylstekeHannelore DenysKatrien VandecasteelePeter VandenabeeleSandy Adjemian Catani

A1 Journal Article in FRONTIERS IN ONCOLOGY

Biomarkers in gynecological cancer : the potential of tumor infiltrating immune cells and circulating extracellular vesicles

Lien LippensHannelore DenysAn HendrixKatrien Vandecasteele

2021

Automated liquid handling for highly specific and reproducible density‐based separation of extracellular vesicles from human body fluids

Sofie Van DorpeLien LippensRobin BoiyHannelore DenysOlivier De WeverAn Hendrix

Pembrolizumab, SBRT, and immunomodulation for recurrent and/or refractory cervical or endometrial carcinoma

Emiel De JaeghereSandra TuyaertsAnn M.T. Van NuffelLien LippensAn HendrixP. VuylstekeS. HenryX.B. TrinhP.A. Van DamS. Aspeslagh et al.

Recombinant extracellular vesicles as biological reference material for method development, data normalization and assessment of (pre-)analytical variables

Edward GeeurickxLien LippensPekka RappuBruno De GeestOlivier De WeverAn Hendrix

A1 Journal Article in NATURE PROTOCOLS

2020

Immunologic impact of chemoradiation in cervical cancer and how immune cell infiltration could lead towards personalized treatment

Lien LippensMieke Van BockstalEmiel De JaegherePhilippe TummersAmin MakarSofie De GeyterKoen Van de VijverAn HendrixKatrien VandecasteeleHannelore Denys

A1 Journal Article in International Journal of Cancer

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

Joeri TulkensGlenn VergauwenJan Van DeunEdward GeeurickxBert DhondtLien LippensMarie-Angélique De ScheerderIlkka MiinalainenPekka RappuBruno De Geest et al.

A1 Journal Article in GUT

Splenic 18F-FDG uptake on baseline PET/CT is associated with oncological outcomes and tumor immune state in uterine cervical cancer

Emiel De JaeghereFrederiek LalooLien LippensMieke Van BockstalKathia De ManEline NaertJo Van DorpeKoen Van de VijverPhilippe TummersAmin Makar et al.

A1 Journal Article in GYNECOLOGIC ONCOLOGY

Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine

Bert DhondtEdward GeeurickxJoeri TulkensJan Van DeunGlenn VergauwenLien LippensIlkka MiinalainenPekka RappuJyrki HeinoPiet Ost et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

2019

Exploration of the urinary proteome in the search for new biomarkers for prostate cancer : a promising role for extracellular vesicles

Bert DhondtGlenn VergauwenJan Van DeunEdward GeeurickxLien LippensJoeri Tulkenslkka MiinalainenPekka RappuJyrki Heino Oulu, FinlandPiet Ost et al.

Immunologic impact of chemoradiation in cervical cancer and how immune cell infiltration could lead towards personalized treatment

Lien LippensMieke Van BockstalEmiel De JaegherePhilippe TummersAmin MakarSofie De GeyterKoen Van de VijverAn HendrixKatrien VandecasteeleHannelore Denys

PRIMMO study protocol : a phase II study combining PD-1 blockade, radiation and immunomodulation to tackle cervical and uterine cancer

Sandra TuyaertsAn MT Van NuffelEline NaertPeter A Van DamPeter VuylstekeAlex De CaluwéSandrine AspeslaghPiet DirixLien LippensEmiel De Jaeghere et al.

A1 Journal Article in BMC CANCER

Splenic metabolic activity as biomarker in cervical cancer

Emiel De JaeghereFrederiek LalooLien LippensKathia De ManMieke Van BockstalKoen Van de VijverPhilippe TummersAmin MakarPieter De VisschereOlivier De Wever et al.

The generation and use of recombinant extracellular vesicles as biological reference material

Edward GeeurickxJoeri TulkensBert DhondtJan Van DeunLien LippensGlenn VergauwenElisa HeyrmanDelphine De SutterKris GevaertFrancis Impens et al.

A1 Journal Article in NATURE COMMUNICATIONS

2018

Recombinant extracellular vesicles : biological reference material to standardize extracellular vesicle research

Edward GeeurickxElisa HeyrmanJan Van DeunLien LippensJoeri TulkensBert DhondtGlenn VergauwenKris GevaertFrancis ImpensIlkka Miinalainen et al.

Recombinant extracellular vesicles : biological reference material to standardize extracellular vesicle research

Edward GeeurickxElisa HeyrmanJan Van DeunLien LippensJoeri TulkensBert DhondtGlenn VergauwenKris GevaertFrancis ImpensIlkka Miinalainen et al.

Repeatable, high-purity isolation of urinary extracellular vesicles for uro-oncological biomarker studies

Bert DhondtGlenn VergauwenJan Van DeunEdward GeeurickxJoeri TulkensLien LippensIlkka MiinalainenPekka RappuJyrki HeinoNicolaas Lumen et al.

Reproduceerbare isolatie van hoog-zuivere urinaire extracellulaire vesikels voor uro-oncologische biomerkerstudies

Bert DhondtGlenn VergauwenJan Van DeunEdward GeeurickxJoeri TulkensLien LippensSarah BuelensElise De BleserFilip PoelaertTom Claeys et al.

Reproducible high-purity isolation of urinary extracellular vesicles for uro-oncological biomarker studies

Bert DhondtGlenn VergauwenJan Van DeunEdward GeeurickxJoeri TulkensLien LippensSarah BuelensElise De BleserIlkka MiinalainenPekka Rappu et al.

Reproducible isolation of high-purity urinary extracellular vesicles for uro-oncological biomarker studies

Bert DhondtGlenn VergauwenJan Van DeunEdward GeeurickxJoeri TulkensLien LippensSarah BuelensElise De BleserFilip PoelaertTom Claeys et al.

The small GTPase Rab27B stimulates secretion of a subpopulation of ARRDC1-positive small extracellular vesicles (SEV)

Lien LippensRobin BoiyBert DhondtBruno De GeestKatrien VandecasteeleHannelore DenysOlivier De WeverAn Hendrix

2017

EV-TRACK : transparent reporting and centralizing knowledge in extracellular vesicle research

Jan Van DeunPieter MestdaghPatrizia AgostinisÖzden AkaySushma AnandJasper AnckaertZoraida Andreu MartinezTine BaetensEls BegheinLaurence Bertier et al.

A1 Journal Article in NATURE METHODS

Extracellular vesicles to diagnose and treat cancer

Joeri TulkensLien LippensGlenn VergauwenSarah JeurissenBert DhondtHannelore DenysAn Hendrix

A2 Journal Article in BELGIAN JOURNAL OF MEDICAL ONCOLOGY