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Researcher
Lien Dejager
Profile
Projects
Publications
Activities
Awards & Distinctions
41
Results
2019
Overexpression of Gilz protects mice against lethal septic peritonitis
Marlies Ballegeer
Jolien Vandewalle
Melanie Eggermont
Gert Van Isterdael
Lien Dejager
Liesbet De Bus
Johan Decruyenaere
Roosmarijn Vandenbroucke
Claude Libert
A1
Journal Article
in
SHOCK
2019
2017
Airway epithelial cells are crucial targets of glucocorticoids in a mouse model of allergic asthma
Carina Klassen
Anna Karabinskaya
Lien Dejager
Sabine Vettorazzi
Justine Van Moorleghem
Fred Luehder
Sebastiaan H Meijsing
Jan P Tuckermann
Hanibal Bohnenberger
Claude Libert
et al.
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2017
Dual-specificity phosphatase 3 deletion protects female, but not male, mice from endotoxemia-induced and polymicrobial-induced septic shock
Maud M Vandereyken
Pratibha Singh
Caroline P Wathieu
Sophie Jacques
Tinatin Zurashvilli
Lien Dejager
Mathieu Amand
Lucia Musumeci
Maneesh Singh
Michel P Moutschen
et al.
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2017
Glucocorticoid receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor
Ioanna Petta
Nadia Bougarne
Jolien Vandewalle
Lien Dejager
Sofie Vandevyver
Marlies Ballegeer
Sofie Desmet
Jonathan Thommis
Lode De Cauwer
Sam Lievens
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
2016
The interactome of the glucocorticoid receptor and its influence on the actions of glucocorticoids in combatting inflammatory and infectious diseases
Ioanna Petta
Lien Dejager
Marlies Ballegeer
Sam Lievens
Jan Tavernier
Karolien De Bosscher
Claude Libert
A2
Journal Article
in
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
2016
2015
An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17
Lynda Grine
Lien Dejager
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
CYTOKINE & GROWTH FACTOR REVIEWS
2015
DUSP3 genetic deletion confers M2-like macrophage-dependent tolerance to septic shock
Pratibha Singh
Lien Dejager
Mathieu Amand
Emilie Theatre
Maud Vandereyken
Tinatin Zurashvili
Maneesh Singh
Matthias Mack
Steven Timmermans
Lucia Musumeci
et al.
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2015
Determining differentially expressed miRNAs and validating miRNA-target relationships using the SPRET/Ei mouse strain
Steven Timmermans
Filip Van Hauwermeiren
Leen Puimège
Lien Dejager
Elien Van Wonterghem
Valerie Vanhooren
Pieter Mestdagh
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
MAMMALIAN GENOME
2015
Dual inhibition of TNFR1 and IFNAR1 in imiquimod-induced psoriasiform skin inflammation in mice
Lynda Grine
Lien Dejager
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2015
Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1
Leen Puimège
Filip Van Hauwermeiren
Sophie Steeland
Sara Van Ryckeghem
Jolien Vandewalle
Sofie Lodens
Lien Dejager
Sofie Vandevyver
Jan Staelens
Steven Timmermans
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2015
Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1
Sabine Vettorazzi
Constantin Bode
Lien Dejager
Lucien Frappart
Ekaterina Shelest
Carina Klaßen
Alpaslan Tasdogan
Holger M Reichardt
Claude Libert
Marion Schneider
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2015
Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation
Lien Dejager
Karen Dendoncker
Melanie Eggermont
Jolien Souffriau
Filip Van Hauwermeiren
Monique Willart
Elien Van Wonterghem
Thomas Naessens
Marlies Ballegeer
Sofie Vandevyver
et al.
A1
Journal Article
in
MUCOSAL IMMUNOLOGY
2015
The glucocorticoid receptor in inflammatory processes : transrepression is not enough
Sabine Hübner
Lien Dejager
Claude Libert
Jan P Tuckermann
A1
Journal Article
in
BIOLOGICAL CHEMISTRY
2015
2014
An acute phase protein ready to go therapeutic for sepsis
Sofie Vandevyver
Lien Dejager
Roosmarijn Vandenbroucke
Claude Libert
Editorial material
2014
Cofactor profiling of the glucocorticoid receptor from a cellular environment
Sofie Desmet
Lien Dejager
Dorien Clarisse
Jonathan Thommis
Diana Melchers
Niek Bastiaensen
Rob Ruijtenbeek
Ilse Beck
Claude Libert
Renée Houtman
et al.
Bookchapter
in
Steroid receptors : methods and protocols
2014
Comprehensive overview of the structure and regulation of the glucocorticoid receptor
Sofie Vandevyver
Lien Dejager
Claude Libert
A1
Journal Article
in
ENDOCRINE REVIEWS
2014
Dominance of the strongest: inflammatory cytokines versus glucocorticoids
Lien Dejager
Sofie Vandevyver
Ioanna Petta
Claude Libert
A1
Journal Article
in
CYTOKINE & GROWTH FACTOR REVIEWS
2014
How steroids steer T cells
Claude Libert
Lien Dejager
A1
Journal Article
in
CELL REPORTS
2014
Pharmacological inhibition of type I interferon signaling protects mice against lethal sepsis
Lien Dejager
Sofie Vandevyver
Marlies Ballegeer
Elien Van Wonterghem
Ling-Ling An
Jeffrey Riggs
Roland Kolbeck
Claude Libert
A1
Journal Article
in
JOURNAL OF INFECTIOUS DISEASES
2014
Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1
Karolien De Bosscher
Ilse Beck
Lien Dejager
Nadia Bougarne
Anthoula Gaigneaux
Sebastien Chateauvieux
Dariusz Ratman
Marc Bracke
Jan Tavernier
Wim Vanden Berghe
et al.
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2014
2013
Direct effect of dsRNA mimetics on cancer cells induces endogenous IFN-beta production capable of improving dendritic cell function
Gerardo Gatti
Nicolás Gonzalo Nuñez
David Andrés Nocera
Lien Dejager
Claude Libert
Constancio Giraudo
Mariana Maccioni
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
2013
How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering
Dariusz Ratman
Wim Vanden Berghe
Lien Dejager
Claude Libert
Jan Tavernier
Ilse Beck
Karolien De Bosscher
A1
Journal Article
in
MOLECULAR AND CELLULAR ENDOCRINOLOGY
2013
LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome
Iris Pinheiro
Lien Dejager
Ioanna Petta
Sofie Vandevyver
Leen Puimège
Tina Mahieu
Marlies Ballegeer
Filip Van Hauwermeiren
Carlo Riccardi
Marnik Vuylsteke
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2013
New insights into the anti-inflammatory mechanisms of glucocorticoids : an emerging role for glucocorticoid-receptor-mediated transactivation
Sofie Vandevyver
Lien Dejager
Jan Tuckermann
Claude Libert
A1
Journal Article
in
ENDOCRINOLOGY
2013
2012
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation
Sofie Vandevyver
Lien Dejager
Tom Van Bogaert
Anna Kleyman
Yusen Liu
Jan Tuckermann
Claude Libert
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2012
IFNβ produced by TLR4-activated tumor cells is involved in improving the antitumoral immune response
Nicolás Gonzalo Núñez
Virginia Andreani
María Inés Crespo
David Andrés Nocera
María Laura Breser
Gabriel Morón
Lien Dejager
Claude Libert
Virginia Rivero
Mariana Maccioni
A1
Journal Article
in
CANCER RESEARCH
2012
On the trail of the glucocorticoid receptor: into the nucleus and back
Sofie Vandevyver
Lien Dejager
Claude Libert
A1
Journal Article
in
TRAFFIC
2012
2011
Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?
Lien Dejager
Iris Pinheiro
Eline Dejonckheere
Claude Libert
A1
Journal Article
in
TRENDS IN MICROBIOLOGY
2011
Strategies to inhibit the toxicity of systemic TNF treatment
Filip Van Hauwermeiren
Leen Puimège
Sofie Vandevyver
Tom Van Bogaert
Ineke Vanlaere
Liesbeth Huys
Lien Dejager
Claude Libert
A1
Journal Article
in
Advances in Experimental Medicine and Biology
2011
The first MMP in sepsis
Roosmarijn Vandenbroucke
Lien Dejager
Claude Libert
Editorial material
2011
Tumor necrosis factor Inhibits glucocorticoid receptor function in mice a strong signal toward lethal shock
Tom Van Bogaert
Sofie Vandevyver
Lien Dejager
Filip Van Hauwermeiren
Iris Pinheiro
Ioanna Petta
David Engblom
Anna Kleyman
Guenther Schutz
Jan Tuckermann
et al.
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2011
X-chromosome-located microRNAs in immunity: might they explain male/female differences?: the X chromosome-genomic context may affect X-located miRNAs and downstream signaling, thereby contributing to the enhanced immune response of females
Iris Pinheiro
Lien Dejager
Claude Libert
A1
Journal Article
in
BIOESSAYS
2011
2010
Increased glucocorticoid receptor expression and activity mediate the LPS resistance of SPRET/EI mice
Lien Dejager
Iris Pinheiro
Leen Puimège
Yedong Fan
Lies Gremeaux
Hugo Vankelecom
Claude Libert
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2010
Molecular and genetic analysis of the resistance of the mouse strain SPRET/Ei to endotoxemia and Gram-negative sepsis
Lien Dejager
Claude Libert
Dissertation
2010
Role for neutrophils in host immune responses and genetic factors that modulate resistance to Salmonella enterica serovar Typhimurium in the inbred mouse strain SPRET/Ei
Lien Dejager
Iris Pinheiro
Pieter Bogaert
Liesbeth Huys
Claude Libert
A1
Journal Article
in
INFECTION AND IMMUNITY
2010
The X chromosome in immune functions: when a chromosome makes the difference
Claude Libert
Lien Dejager
Iris Pinheiro
A1
Journal Article
in
NATURE REVIEWS IMMUNOLOGY
2010
2009
In vitro and in vivo protein-bound tyrosine nitration characterized by diagonal chromatography
Bart Ghesquière
Niklaas Colaert
Kenny Helsens
Lien Dejager
Caroline Vanhaute
Katleen Verleysen
Koen Kas
Evy Timmerman
Marc Goethals
Claude Libert
et al.
A1
Journal Article
in
MOLECULAR & CELLULAR PROTEOMICS
2009
Thirty years of Mus spretus: a promising future
Lien Dejager
Claude Libert
Xavier Montagutelli
A1
Journal Article
in
TRENDS IN GENETICS
2009
Type I interferon drives tumor necrosis factor-induced lethal shock
Liesbeth Huys
Filip Van Hauwermeiren
Lien Dejager
Eline Dejonckheere
Stefan Lienenklaus
Siegfried Weiss
Georges Leclercq
Claude Libert
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2009
2008
Tumor necrosis factor alpha mediates the lethal hepatotoxic effects of poly(I: C) in D-galactosamine-sensitized mice
Lien Dejager
Claude Libert
A1
Journal Article
in
CYTOKINE
2008
2007
Protection of zinc against tumor necrosis factor-induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy
Wim Van Molle
Maarten Van Roy
Tom Van Bogaert
Lien Dejager
Philippe Van Lint
Ineke Vanlaere
K SEKIKAWA
G KOLLIAS
Claude Libert
A1
Journal Article
in
CANCER RESEARCH
2007