Research Explorer

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Researcher

Lien Dejager

41 Results

2019

Overexpression of Gilz protects mice against lethal septic peritonitis

Marlies BallegeerJolien VandewalleMelanie EggermontGert Van IsterdaelLien DejagerLiesbet De BusJohan DecruyenaereRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in SHOCK

2017

Airway epithelial cells are crucial targets of glucocorticoids in a mouse model of allergic asthma

Carina KlassenAnna KarabinskayaLien DejagerSabine VettorazziJustine Van MoorleghemFred LuehderSebastiaan H MeijsingJan P TuckermannHanibal BohnenbergerClaude LibertHolger M Reichardt

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Dual-specificity phosphatase 3 deletion protects female, but not male, mice from endotoxemia-induced and polymicrobial-induced septic shock

Maud M VandereykenPratibha SinghCaroline P WathieuSophie JacquesTinatin ZurashvilliLien DejagerMathieu AmandLucia MusumeciManeesh SinghMichel P MoutschenClaude LibertSouad Rahmouni

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Glucocorticoid receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

Ioanna PettaNadia BougarneJolien VandewalleLien DejagerSofie VandevyverMarlies BallegeerSofie DesmetJonathan ThommisLode De CauwerSam LievensClaude LibertJan TavernierKarolien De Bosscher

A1 Journal Article in SCIENTIFIC REPORTS

2016

The interactome of the glucocorticoid receptor and its influence on the actions of glucocorticoids in combatting inflammatory and infectious diseases

Ioanna PettaLien DejagerMarlies BallegeerSam LievensJan TavernierKarolien De BosscherClaude Libert

A2 Journal Article in MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

2015

An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17

Lynda GrineLien DejagerClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

DUSP3 genetic deletion confers M2-like macrophage-dependent tolerance to septic shock

Pratibha SinghLien DejagerMathieu AmandEmilie TheatreMaud VandereykenTinatin ZurashviliManeesh SinghMatthias MackSteven TimmermansLucia MusumeciEmmanuel DejardinTomas MustelinJo A Van GinderachterMichel MoutschenCecile OuryClaude LibertSouad Rahmouni

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Determining differentially expressed miRNAs and validating miRNA-target relationships using the SPRET/Ei mouse strain

Steven TimmermansFilip Van HauwermeirenLeen PuimègeLien DejagerElien Van WonterghemValerie VanhoorenPieter MestdaghClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in MAMMALIAN GENOME

Dual inhibition of TNFR1 and IFNAR1 in imiquimod-induced psoriasiform skin inflammation in mice

Lynda GrineLien DejagerClaude LibertRoosmarijn Vandenbroucke

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1

Leen PuimègeFilip Van HauwermeirenSophie SteelandSara Van RyckeghemJolien VandewalleSofie LodensLien DejagerSofie VandevyverJan StaelensSteven TimmermansRoosmarijn VandenbrouckeClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1

Sabine VettorazziConstantin BodeLien DejagerLucien FrappartEkaterina ShelestCarina KlaßenAlpaslan TasdoganHolger M ReichardtClaude LibertMarion SchneiderFalk WeihN Henriette UhlenhautJean-Pierre DavidMarkus GrälerAnna KleimanJan P Tuckermann

A1 Journal Article in NATURE COMMUNICATIONS

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

Lien DejagerKaren DendonckerMelanie EggermontJolien SouffriauFilip Van HauwermeirenMonique WillartElien Van WonterghemThomas NaessensMarlies BallegeerSofie VandevyverHamida HammadBart LambrechtKarolien De BosscherJohan GrootenClaude Libert

A1 Journal Article in MUCOSAL IMMUNOLOGY

The glucocorticoid receptor in inflammatory processes : transrepression is not enough

Sabine HübnerLien DejagerClaude LibertJan P Tuckermann

A1 Journal Article in BIOLOGICAL CHEMISTRY

2014

An acute phase protein ready to go therapeutic for sepsis

Sofie VandevyverLien DejagerRoosmarijn VandenbrouckeClaude Libert

Editorial material

Cofactor profiling of the glucocorticoid receptor from a cellular environment

Sofie DesmetLien DejagerDorien ClarisseJonathan ThommisDiana MelchersNiek BastiaensenRob RuijtenbeekIlse BeckClaude LibertRenée HoutmanOnno C MeijerKarolien De Bosscher

Bookchapter in Steroid receptors : methods and protocols

Comprehensive overview of the structure and regulation of the glucocorticoid receptor

Sofie VandevyverLien DejagerClaude Libert

A1 Journal Article in ENDOCRINE REVIEWS

Dominance of the strongest: inflammatory cytokines versus glucocorticoids

Lien DejagerSofie VandevyverIoanna PettaClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

How steroids steer T cells

Claude LibertLien Dejager

A1 Journal Article in CELL REPORTS

Pharmacological inhibition of type I interferon signaling protects mice against lethal sepsis

Lien DejagerSofie VandevyverMarlies BallegeerElien Van WonterghemLing-Ling AnJeffrey RiggsRoland KolbeckClaude Libert

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1

Karolien De BosscherIlse BeckLien DejagerNadia BougarneAnthoula GaigneauxSebastien ChateauvieuxDariusz RatmanMarc BrackeJan TavernierWim Vanden BergheClaude LibertMarc DiederichGuy Haegeman

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2013

Direct effect of dsRNA mimetics on cancer cells induces endogenous IFN-beta production capable of improving dendritic cell function

Gerardo GattiNicolás Gonzalo NuñezDavid Andrés NoceraLien DejagerClaude LibertConstancio GiraudoMariana Maccioni

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering

Dariusz RatmanWim Vanden BergheLien DejagerClaude LibertJan TavernierIlse BeckKarolien De Bosscher

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome

Iris PinheiroLien DejagerIoanna PettaSofie VandevyverLeen PuimègeTina MahieuMarlies BallegeerFilip Van HauwermeirenCarlo RiccardiMarnik VuylstekeClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

New insights into the anti-inflammatory mechanisms of glucocorticoids : an emerging role for glucocorticoid-receptor-mediated transactivation

Sofie VandevyverLien DejagerJan TuckermannClaude Libert

A1 Journal Article in ENDOCRINOLOGY

2012

Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation

Sofie VandevyverLien DejagerTom Van BogaertAnna KleymanYusen LiuJan TuckermannClaude Libert

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

IFNβ produced by TLR4-activated tumor cells is involved in improving the antitumoral immune response

Nicolás Gonzalo NúñezVirginia AndreaniMaría Inés CrespoDavid Andrés NoceraMaría Laura BreserGabriel MorónLien DejagerClaude LibertVirginia RiveroMariana Maccioni

A1 Journal Article in CANCER RESEARCH

On the trail of the glucocorticoid receptor: into the nucleus and back

Sofie VandevyverLien DejagerClaude Libert

A1 Journal Article in TRAFFIC

2011

Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?

Lien DejagerIris PinheiroEline DejonckheereClaude Libert

A1 Journal Article in TRENDS IN MICROBIOLOGY

Strategies to inhibit the toxicity of systemic TNF treatment

Filip Van HauwermeirenLeen PuimègeSofie VandevyverTom Van BogaertIneke VanlaereLiesbeth HuysLien DejagerClaude Libert

A1 Journal Article in Advances in Experimental Medicine and Biology

The first MMP in sepsis

Roosmarijn VandenbrouckeLien DejagerClaude Libert

Editorial material

Tumor necrosis factor Inhibits glucocorticoid receptor function in mice a strong signal toward lethal shock

Tom Van BogaertSofie VandevyverLien DejagerFilip Van HauwermeirenIris PinheiroIoanna PettaDavid EngblomAnna KleymanGuenther SchutzJan TuckermannClaude Libert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

X-chromosome-located microRNAs in immunity: might they explain male/female differences?: the X chromosome-genomic context may affect X-located miRNAs and downstream signaling, thereby contributing to the enhanced immune response of females

Iris PinheiroLien DejagerClaude Libert

A1 Journal Article in BIOESSAYS

2010

Increased glucocorticoid receptor expression and activity mediate the LPS resistance of SPRET/EI mice

Lien DejagerIris PinheiroLeen PuimègeYe-Dong FanLies GremeauxHugo VankelecomClaude Libert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular and genetic analysis of the resistance of the mouse strain SPRET/Ei to endotoxemia and Gram-negative sepsis

Lien DejagerClaude Libert

Role for neutrophils in host immune responses and genetic factors that modulate resistance to Salmonella enterica serovar Typhimurium in the inbred mouse strain SPRET/Ei

Lien DejagerIris PinheiroPieter BogaertLiesbeth HuysClaude Libert

A1 Journal Article in INFECTION AND IMMUNITY

The X chromosome in immune functions: when a chromosome makes the difference

Claude LibertLien DejagerIris Pinheiro

A1 Journal Article in NATURE REVIEWS IMMUNOLOGY

2009

In vitro and in vivo protein-bound tyrosine nitration characterized by diagonal chromatography

Bart GhesquièreNiklaas ColaertKenny HelsensLien DejagerCaroline VanhauteKatleen VerleysenKoen KasEvy TimmermanMarc GoethalsClaude LibertJoël VandekerckhoveKris Gevaert

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Thirty years of Mus spretus: a promising future

Lien DejagerClaude LibertXavier Montagutelli

A1 Journal Article in TRENDS IN GENETICS

Type I interferon drives tumor necrosis factor-induced lethal shock

Liesbeth HuysFilip Van HauwermeirenLien DejagerEline DejonckheereStefan LienenklausSiegfried WeissGeorges LeclercqClaude Libert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2008

Tumor necrosis factor alpha mediates the lethal hepatotoxic effects of poly(I: C) in D-galactosamine-sensitized mice

Lien DejagerClaude Libert

A1 Journal Article in CYTOKINE

2007

Protection of zinc against tumor necrosis factor-induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy

Wim Van MolleMaarten Van RoyTom Van BogaertLien DejagerPhilippe Van LintIneke VanlaereK SEKIKAWAG KOLLIASClaude Libert

A1 Journal Article in CANCER RESEARCH