Research Explorer

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Researcher

Levi Hoste

Awards & Distinctions

89 Results

2024

Age-dependent signature of serum inflammatory cytokines IL-1Ra, IL-1β, IL-6, IL-18, TNF-α, CXCL9 and CXCL10 in healthy children

Maarten BuytaertRachida El KaddouriLevi HosteBram MeertensSimon TavernierVeronique DebackerKarlien ClaesJo DehoorneFilomeen Haerynck

Challenges in performing clinical trials in low incidence disease

Levi HosteSylvie Rottey

Data standardisation within pediatrics : BPCRN's analysis of trials identifying cross-cutting data points

Eva DegraeuweDaphné ChristiaensAnando SenSimon VanderschaegheLaura PersijnLevi HosteLieve NuytinckAvril PalmeriJohan Vande WalleAnn Raes et al.

Development of the BPCRN

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

Astrid MarchalElizabeth T. CirulliIva NeveuxEvangelos BellosRyan S. ThwaitesKelly M. Schiabor BarrettYu ZhangIvana Nemes-BokunMariya KalinovaAndrew Catchpole et al.

A2 Journal Article in HUMAN GENETICS AND GENOMICS ADVANCES

Long live the BPCRN : 2024 update on the (revived) BPCRN

Levi HosteAn SpiessensLaura PersijnEva DegraeuweAnn RaesJohan Vande WalleLieve Nuytinck

Longevity of the humoral and cellular responses after SARS-CoV-2 booster vaccinations in immunocompromised patients

Matthijs OyaertMarie-Angélique De ScheerderSophie Van HerrewegeGuy LaureysSofie Van AsscheMelissa CambronLeslie NaesensLevi HosteKarlien ClaesFilomeen Haerynck et al.

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Made in Belgium : exploring the immune horizon : systemic inflammatory diseases in the era of SARS-CoV-2 and beyond

Levi HosteFilomeen HaerynckJo DehoorneSimon Tavernier

A2 Journal Article in BELGIAN JOURNAL OF PAEDIATRICS

Mucocutaneous manifestations of Mycoplasma pneumoniae infection

Marte De MoorLevi HostePetra Schelstraete

My PhD in 300s : exploring the immune horizon : systemic inflammatory diseases in the era of SARS-CoV-2 and beyond

Nurturing upcoming investigators within pediatric pharmacology : European Mentorship Program development and launch within conect4children (c4c)

Eva DegraeuweLaura PersijnTessa van der GeestLevi HosteLieve NuytinckAnn RaesRicardo FernandesSaskia de WildtJohan Vande WalleMark Turner

Serum proteomics reveals hemophagocytic lymphohistiocytosis-like phenotype in a subset of patients with multisystem inflammatory syndrome in children

Adam J. TullingMarloes G. HolierhoekAnja M. Jansen-HoogendijkLevi HosteFilomeen HaerynckSimon TavernierRianne OostenbrinkCorinne M.P. BuysseMichiel A.G.E. BannierJolita Bekhof et al.

A1 Journal Article in CLINICAL IMMUNOLOGY

Successful treatment of ulcerative colitis with anakinra : a case report

Marie TruyensLevi HosteJeroen GeldofAnne HoorensFilomeen HaerynckDiana Huis in 't VeldTriana Lobatón Ortega

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

Systemic inflammatory diseases in the era of SARS-CoV-2 and beyond

The European Paediatric Clinical Trials Network conect4children (c4c) : 6-year progress report of paediatric trial facilitation within Belgium : update of the Belgian Paediatric Clinical Research Network (BPCRN)

Levi HosteEva DegraeuweLaura PersijnAn SpiessensMark TurnerLieve NuytinckAnnelies De MaréDaphné ChristiaensAnn RaesKarel Allegaert et al.

The hyperPed-COVID international registry : impact of age of onset, disease presentation and geographical distribution on the final outcome of MIS-C

Roberta CaorsiAlessandro ConsolaroCamilla SpezianiBetul SozeriKadir UluEnrique Faugier-FuentesHector Menchaca-AguayoSeza OzenSeher SenerShahana Akhter Rahman et al.

A1 Journal Article in JOURNAL OF AUTOIMMUNITY

The riddle of recurrent fever : a clinical approach to pediatric autoinflammatory diseases

Bram MeertensLevi HosteSimon TavernierFilomeen Haerynck

A1 Journal Article in FRONTIERS IN PEDIATRICS

c4c outreach : how to spread the word within academia

Levi HostePernille SkovbyAthimalaipet Ramanan

2023

A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Karel Van DammeLevi HosteJozefien DeclercqElisabeth De LeeuwBastiaan MaesLiesbet MartensRoos ColmanRobin BrowaeysCedric BosteelsStijn Verwaerde et al.

A complement atlas identifies interleukin-6-dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Karel Van DammeLevi HosteJozefien DeclercqElisabeth De LeeuwBastiaan MaesLiesbet MartensRoos ColmanRobin BrowaeysCedric BosteelsStijn Verwaerde et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

COVID-19 vaccination in patients with primary immunodeficiencies : an international survey on patient vaccine hesitancy and self-reported adverse events

Martine PergentFilomeen HaerynckLevi HosteAnn Gardulf

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Combined deficient response to polysaccharide-based and protein-based vaccines predicts a severe clinical phenotype

Maaike CockxFilomeen HaerynckLevi HosteRik SchrijversJutte Van der Werff ten BoschDoreen DillaertsDebby ThomasHeidi SchaballieGiorgia BucciolWiert Robberechts et al.

A1 Journal Article in CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Comparison of SARS-CoV-2 seroconversion in children with chronic diseases with healthy children and adults during the first waves of the COVID-19 pandemic

Levi HosteAgnieszka Prytula-EbelsJo DehoorneRuth De BruyneStephanie Van BiervlietKathleen De WaeleEvelyn MaesVictoria BordonArnaud VanlanderKarlien Claes et al.

A1 Journal Article in FRONTIERS IN PEDIATRICS

Cytokine signatures in hyperinflammatory diseases

Exploring the immune horizon : systemic inflammatory diseases in the era of SARS-CoV-2 and beyond

Levi HosteFilomeen HaerynckJo DehoorneSimon Tavernier

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children : a propensity-weighted cohort study

Samuel Channon-WellsOrtensia VitoAndrew J McArdleEleanor G SeabyPriyen ShahEkaterina PazukhinaClare WilsonClaire BroderickGiselle D'SouzaIlana Keren et al.

A1 Journal Article in LANCET RHEUMATOLOGY

Invited Lecture : MISC and abdominal pain

MultiNicheNet : a flexible framework for differential cell-cell communication analysis from multi-sample multi-condition single-cell transcriptomics data

Robin BrowaeysJeroen GilisChananchida Sang-aramPieter De BleserLevi HosteSimon TavernierDiether LambrechtsRuth SeurinckYvan Saeys

Paediatric subspecialties in Belgium : past, present, and future

Laurens Van CampLevi HosteEline VermeirenStéphane MoniotteAnna Bael

A2 Journal Article in BELGIAN JOURNAL OF PAEDIATRICS

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Daniela MatuozzoEstelle TalouarnAstrid MarchalPeng ZhangJeremy ManryYoann SeeleuthnerYu ZhangAlexandre BolzeMatthieu ChaldebasBaptiste Milisavljevic et al.

A1 Journal Article in GENOME MEDICINE

Single cell and TCR sequencing reveals pathophysiology of rare and severe hyperinflammation in children after SARS-CoV-2 infection

TIM3+TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

2022

Acute perimyocarditis in a case of multisystem inflammatory syndrome in adults

Jens Van PraetPascale De PaepeLevi HosteFilomeen Haerynck

Editorial material

Autoimmune loss of entero-endocrine cells is a hallmark apeced manifestation that results in severe malabsorption but can recover with immune suppressants

Levi HosteLeslie NaesensSara Van AkenBruno LapauwGuy T'SjoenCharlotte VerrokenNicolette MoesRuth De BruyneTessa KerreFilomeen Haerynck

Delayed presentations of severe combined immunodeficiency during the SARS‑CoV‑2 pandemic

Levi HosteGiorgia BucciolAnniek CorveleynStijn CornelisVictoria BordonAnnik de JaegerHeidi SchaballieEllen DeoletJo Van DorpeGregory Strubbe et al.

Evaluation of humoral and cellular responses in SARS-CoV-2 mRNA vaccinated immunocompromised patients

Matthijs OyaertMarie-Angélique De ScheerderSophie Van HerrewegeGuy LaureysSofie Van AsscheMelissa CambronLeslie NaesensLevi HosteKarlien ClaesFilomeen Haerynck et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Foliumzuurgevoelige aandoeningen

Functional validation and management of patients with CTLA4/LRBA deficiency

Levi HosteLisa RoelsLeslie Naesens

Klinische immunologie in een notendop

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

Cedric BosteelsKarel Van DammeElisabeth De LeeuwJozefien DeclercqBastiaan MaesVictor BosteelsLevi HosteLeslie NaesensNincy DebeufJulie Deckers et al.

A1 Journal Article in CELL REPORTS MEDICINE

Mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF, and result in Aicardi-Goutières syndrome with severe end-organ involvement

Leslie NaesensJosephine NemegeerFilip RoelensLore VallaeysMarije MeuwissenKatrien JanssensPATRICK VERLOOBenson OgunjimiDimitri HemelsoetLevi Hoste et al.

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Safety of COVID-19 vaccination in children with a history of MIS-C : an international survey

Levi HosteAntoni Soriano-ArandesEmilie Pauline BuddinghElizabeth WhittakerAlexandre BelotRolando Ulloa-GutierrezPeter OlbrichFilomeen Haerynck

Severe acute respiratory syndrome coronavirus 2 vaccination in children with a history of multisystem inflammatory syndrome in children : an international survey

Levi HosteAntoni Soriano-ArandesEmilie Pauline BuddinghElizabeth WhittakerAlexandre BelotRolando Ulloa-GutierrezPeter OlbrichFilomeen Haerynck

A1 Journal Article in JOURNAL OF PEDIATRICS

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Levi HosteLisa RoelsLeslie NaesensVictor BosteelsStijn VanheeSam DupontCedric BosteelsRobin BrowaeysNiels VandammeKevin Verstaen et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

When a SCID-like phenotype is not an inborn error of immunity

Whole blood tcr vβ21.3 staining as a diagnostic test for multisystem inflammatory syndrome in children : a proof-of-concept study

Levi HosteJef WillemsEvelyn DhontPetra SchelstraeteJo DehoorneKristof VandekerckhoveAlexandre BelotBrigitte Bader-MeunierChristophe MalcusSimon Tavernier et al.

2021

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Paul BastardAdrian GervaisTom Le VoyerJérémie RosainQuentin PhilippotJérémy ManryEleftherios MichailidisHans-Heinrich HoffmannShohei EtoMarina Garcia-Prat et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID) : a factorial, randomised, controlled trial

Jozefien DeclercqKarel Van DammeElisabeth De LeeuwBastiaan MaesCedric BosteelsSimon TavernierStefanie De BuyserRoos ColmanMaya HitesGil Verschelden et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Essentials in saline pharmacology for nasal or respiratory hygiene in times of COVID-19

Suzy HuijghebaertLevi HosteGuido Vanham

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Hyperactivated mononuclear phagocytes, type II interferon and cytotoxic T cells with restricted clonal repertoire underly SARS-CoV2 related multisystem inflammatory syndrome in children

IFNg mediates interactions of TIM-3 expressing TRBV11-2+ T cells, CD16+ NK cells and patrolling monocytes in MIS-C

Immunoglobulin g subclass and specific polysaccharide antibody deficiency : a clinical and immunological profile in a tertiary cohort

Levi HosteJudith ClausSimon SchelfhoutJarno De CraemerLaurens De KetelaereDelfien BogaertCarolien BonroyJan PhilippéJulie WillekensTessa Kerre et al.

Impact of COVID-19 on Belgian paediatric trainees

Levi HosteTine AllietThomas Gestels

Impact of COVID-19 pandemic on paediatric trainees in Belgium

Tine AllietThomas GestelsSiel DaelemansLevi Hoste

A2 Journal Article in INDONESIAN JOURNAL OF COMMUNITY AND OCCUPATIONAL MEDICINE

Introduction to multisystem inflammatory syndrome in children (MIS-C)

Multisystem inflammatory syndrome in children related to COVID-19 : a systematic review

Levi HosteRuben Van PaemelFilomeen Haerynck

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

Novel insights in the pathogenesis of MIS-C (multisystem inflammatory syndrome in children)

Novel mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF and result in Aicardi-Goutières syndrome with severe end-organ involvement

Leslie NaesensJosephine NemegeerFilip RoelensLore VallaeysMarije MeuwissenKatrien JanssensPATRICK VERLOOBenson OgunjimiDimitri HemelsoetProgram for Undiagnosed Rare Diseases (UD-PrOZA) et al.

Paediatrician in Training Discussion Panel 1 : the challenges of tele-paediatrics : a lockdown-inspired clinical grand round

Eline HermansBram MeertensDelfien BogaertLien DosscheLevi Hoste

Parental experience and emotional well-being in families with a child with a chronic disease during the COVID 19 pandemic

Eline Van HoeckeKarlien DhondtAnn RaesStephanie Van BiervlietBarbara De MoerlooseSara Van AkenFilomeen HaerynckLevi HosteHelene VerhelstBart Soenens et al.

Plasma C3d levels as a diagnostic marker for complete complement factor I deficiency

Leslie NaesensJulie SmetSimon TavernierPetra SchelstraeteLevi HosteStijn LambrechtHelene VerhelstJutte van der Werff Ten BoschAlina FersterSophie Blumental et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

SARS-CoV-2–related MIS-C : a key to the viral and genetic causes of Kawasaki disease?

Vanessa Sancho-ShimizuPetter BrodinAurélie CobatCatherine M. BiggsJulie ToubianaCarrie L. LucasSarah E. HenricksonAlexandre BelotElie HaddadKathie Beland et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

SeroCovid19 : prospective seroprevalence monitoring reveals substantially reduced SARS-CoV-2 infection rate among tertiary pediatric patients

Levi HosteAgnieszka Prytula-EbelsJo DehoorneRuth De BruyneStephanie Van BiervlietKATHLEEN DE WAELEPetra SchelstraeteEvelyn MaesMaria Bordon Cueto De BraemArnaud Vanlander et al.

Some trainees are more equal than others : the pediatric residency pay gap

Levi HosteSiel DaelemansAnn De GuchtenaereAn Bael

TIM3+ TRBV11-2 T cells and IFNg signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Treatment of multisystem inflammatory syndrome in children

A J McArdleO VitoH PatelE G SeabyP ShahC WilsonC BroderickR NijmanA H TremouletD Munblit et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

Takaki AsanoBertrand BoissonFanny OnodiDaniela MatuozzoMarcela Moncada-VelezMajistor Raj Luxman Maglorius RenkilarajPeng ZhangLaurent MeertensAlexandre BolzeMarie Materna et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

‘Nieuwe heren, nieuwe wetten’ : identificatie van een nieuw pediatrisch inflammatoir syndroom in het midden van de SARS-CoV-2-pandemie

Levi HosteSimon TavernierFilomeen Haerynck

A4 Journal Article in PERCENTIEL (NEDERLANDSE ED.)

2020

Case report : convalescent plasma, a targeted therapy for patients with CVID and severe COVID-19

Karel Van DammeSimon TavernierNele Van RoyElisabeth De LeeuwJozefien DeclercqCedric BosteelsBastiaan MaesMarieke De BruyneDelfien BogaertVictor Bosteels et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Cytokine profiling by multiplex immunoassay as a valuable tool for diagnosis and monitoring patients with autoinflammatory disorders

Levi HosteJo DehoornePeggy JacquesSteven CallensJeroen van der HilstVito SabatoBenson OgunjimiSimon TavernierFilomeen Haerynck

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian ZhangPaul BastardZhiyong LiuJérémie Le PenMarcela Moncada-VelezJie ChenMasato OgishiIra K. D. SabliStephanie HodeibCecilia Korol et al.

A1 Journal Article in SCIENCE

Multisystem inflammatory syndrome in children related to COVID-19 : a systematic review

Levi HosteRuben Van PaemelFilomeen Haerynck

Some trainees are more equal than others : the paediatric residency payment gap, as illustrated in a cross-sectional study in Flanders

Levi HosteSiel DaelemansLien DosscheAnn De GuchtenaereAn Bael

A2 Journal Article in BELGIAN JOURNAL OF PAEDIATRICS

2019

An unusual case of SpO2-PaO2 discrepancy in an intensive care neonate illustrating an important pitfall in routine pulse oxygen monitoring

Levi HosteKris De Coen

Immunoglobulin g subclass and specific polysaccharide antibody deficiency : a clinical and immunological profile in a tertiary cohort

Levi HosteJudith ClausSimon SchelfhoutJarno De CraemerLaurens De KetelaereDelfien BogaertCarolien BonroyJan PhilippéJulie WillekensTessa Kerre et al.

Ranitidine-induced thrombocytopenia in a neonate : a case report and review of literature

Levi HosteIsabel George

A2 Journal Article in JOURNAL OF PEDIATRIC PHARMACOLOGY AND THERAPEUTICS

2018

A CARD9 founder mutation disrupts NF-κB signaling by inhibiting BCL10 and MALT1 recruitment and signalosome formation

Marieke De BruyneLevi HosteDelfien BogaertLien Van den BosscheSimon TavernierEef ParthoensMélanie MigaudDeborah KonopnickiJean Cyr YombiBart Lambrecht et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The complex differential diagnosis underlying fungal infections : a clinical practice guideline regarding persistent, recurrent or invasive candidiasis

Levi HosteDelfien BogaertMarieke De BruyneMaria Bordon Cueto De BraemPetra SchelstraeteCarolien BonroySimon TavernierFilomeen Haerynck

When one rare disease hides another : Kartagener syndrome masking FMF

Levi HosteFrans De BaetsSabine Van daelePetra SchelstraeteMieke BoonMarieke De BruyneMelissa DullaersFrauke CoppietersFilomeen Haerynck

A1 Journal Article in CLINICAL PEDIATRICS

2017

A CARD9 Turkisch founder mutation disrupts NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneLevi HosteDelfien BogaertMélanie MigaudDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne PuelJean-Christophe Goffard et al.

A CARD9 founder mutation p.Arg70Trp in Belgian and French patients of Turkish origin with a spectrum of chronic mucocutaneous and invasive fungal infections

Marieke De BruyneDelfien BogaertLevi HosteMélanie MigaudJean-Christophe GoffardAnne PuelElfride De BaereFilomeen HaerynckMelissa Dullaers

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneDelfien BogaertLevi HosteMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneDelfien BogaertLevi HosteMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneLevi HosteDelfien BogaertMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

Ranitidine-induced thrombocytopenia in a neonate : a case report and review of literature

Levi HosteIsabel George

2016

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype

Julie ToubianaSatoshi OkadaJulia HillerMatias OleastroMacarena Lagos GomezJuan Carlos Aldave BecerraMarie Ouachée-ChardinFanny FouyssacKatta Mohan GirishaAmos Etzioni et al.

A1 Journal Article in BLOOD

Recurrent cutaneous abscesses as the presenting manifestation of STAT1 gain-of-function mutation

Levi HosteMarieke De BruyneDelfien BogaertElfride De BaereCarolien BonroyPetra SchelstraeteMelissa DullaersTom VercruysseFilomeen Haerynck

When two rare diseases coincide : Kartagener Syndrome and Familial Mediterranean Fever

Levi HosteFrans De BaetsSabine Van daelePetra SchelstraeteMieke BoonElfride De BaereFrauke CoppietersFilomeen Haerynck