Research Explorer

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Researcher

Leslie Naesens

Awards & Distinctions

52 Results

2025

Cytokine multiplex in clinical practice : resolving FUO/IUO

Leslie NaesensLevi HosteBram MeertensKarlien ClaesVeronique DebackerSimon TavernierMarie-Angélique De ScheerderSteven CallensFilomeen Haerynck

From gut to gene : how colitis led to the diagnosis of a rare immunodeficiency

Leslie NaesensMarie-Angélique De ScheerderFilomeen HaerynckSteven Callens

Impact of reporting rapid susceptibility results in Gram negative bloodstream infections : a real world prospective study

Anne-Sophie MessiaenStien VandendriesscheEmilie De MuynckGregory StrubbeLiesbet De BusPetra SchelstraeteKristen DecommerSanne De SmetAlexander SoetensLeslie Naesens et al.

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Inborn Errors of Nucleic Acid Sensing and Type I Interferon Signaling Determine Viral Susceptibility in Humans

Leslie NaesensSteven CallensTessa KerreSimon J. TavernierFilomeen Haerynck

U Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Ureaplasma parvum septic arthritis in patient with LRBA deficiency treated with rituximab in the context of Hodgkin lymphoma

Katrien TimmermansLeslie NaesensStien VandendriesscheDiana Huis in 't Veld

2024

A novel heterozygous variant in AICDA impairs Ig class switching and somatic hypermutation in human B cells and is associated with autosomal dominant HIGM2 syndrome

Erika Della MinaKatherine J. L. JacksonAlexander J. I. CrawfordMegan L. FaulksKarrnan PathmanandavelNicolino AcquarolaMichael O’SullivanTessa KerreLeslie NaesensKarlien Claes et al.

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Implementation of machine learning-based multiplex cytokine analysis for resolving FUO/IUO (fever and inflammation of unknown origin) : a tertiary hospital experience

Leslie NaesensBram MeertensLevi HosteKarlien ClaesMarie-Angélique De ScheerderSteven CallensFilomeen HaerynckVeronique Debacker

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

Astrid MarchalElizabeth T. CirulliIva NeveuxEvangelos BellosRyan S. ThwaitesKelly M. Schiabor BarrettYu ZhangIvana Nemes-BokunMariya KalinovaAndrew Catchpole et al.

A2 Journal Article in HUMAN GENETICS AND GENOMICS ADVANCES

Longevity of the humoral and cellular responses after SARS-CoV-2 booster vaccinations in immunocompromised patients

Matthijs OyaertMarie-Angélique De ScheerderSophie Van HerrewegeGuy LaureysSofie Van AsscheMelissa CambronLeslie NaesensLevi HosteKarlien ClaesFilomeen Haerynck et al.

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Management challenges of extrapulmonary nontuberculous mycobacterial infection : a single-center case series and literature review

Maja KiselinovaLeslie NaesensDiana Huis in 't VeldJerina BoelensEva Van BraeckelYannick Vande WeygaerdeSteven Callens

A1 Journal Article in PATHOGENS

PTPN2 deficiency expands the monogenetic causes of dysregulated JAK/STAT signaling resulting in autoimmunity

Leslie NaesensBram MeertensLore PottieMarieke De BruyneCiel De VriendtTessa KerreSimon TavernierFilomeen Haerynck

SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency

Yi-Hao ChanVanja LundbergJérémie Le PenJiayi YuanDanyel LeeFrancesca PinciStefano VolpiKoji NakajimaVincent BondetSanna Åkesson et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Unveiling PTPN2 mutations in two families as a novel genetic driver fueling autoimmunity

Leslie NaesensBram MeertensMarieke De BruyneLore PottieCiel De VriendtTessa KerreSimon TavernierFilomeen Haerynck

2023

Exome sequencing and multigene panel testing in 1,411 patients with adult-onset neurologic disorders

Nika SchuermansHannah VerdinJody GhijselsMadeleine HellemansElke DebackereElke BogaertSofie SymoensLeslie NaesensElien LecomteDavid Crosiers et al.

A1 Journal Article in NEUROLOGY-GENETICS

Innate immune sensors balance infection surveillance and autoinflammation

Leslie NaesensFilomeen HaerynckTessa KerreSimon Tavernier

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Daniela MatuozzoEstelle TalouarnAstrid MarchalPeng ZhangJeremy ManryYoann SeeleuthnerYu ZhangAlexandre BolzeMatthieu ChaldebasBaptiste Milisavljevic et al.

A1 Journal Article in GENOME MEDICINE

The RNA polymerase III–RIG-I axis in antiviral immunity and inflammation

Leslie NaesensFilomeen HaerynckMichaela U. Gack

A1 Journal Article in TRENDS IN IMMUNOLOGY

2022

A unique phenotype of longitudinal extensive transverse myelitis in autoimmune lymphoproliferative syndrome

Cathérine DekeyserLeslie NaesensFritz OffnerCiel De VriendtAlexander SchauwvliegheTessa KerreGuy Laureys

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

Another brick in the wall against herpesviruses

Autoimmune loss of entero-endocrine cells is a hallmark apeced manifestation that results in severe malabsorption but can recover with immune suppressants

Levi HosteLeslie NaesensSara Van AkenBruno LapauwGuy T'SjoenCharlotte VerrokenNicolette MoesRuth De BruyneTessa KerreFilomeen Haerynck

Evaluation of humoral and cellular responses in SARS-CoV-2 mRNA vaccinated immunocompromised patients

Matthijs OyaertMarie-Angélique De ScheerderSophie Van HerrewegeGuy LaureysSofie Van AsscheMelissa CambronLeslie NaesensLevi HosteKarlien ClaesFilomeen Haerynck et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Functional validation and management of patients with CTLA4/LRBA deficiency

Levi HosteLisa RoelsLeslie Naesens

GTF3A deficiency in humans predisposes to herpes simplex encephalitis by abrogating transcription of the host-derived RIG-I ligand RNA5SP141

GTF3A deficiency predisposes to invasive HSV-1 encephalitis by abrogated transcription of a host RIG-I ligand

GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141

Leslie NaesensSantoshi MuppalaDhiraj AcharyaJosephine NemegeerDelfien BogaertJung-Hyun LeeKatrien StaesVeronique DebackerPieter De BleserMarieke De Bruyne et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

GTF3A deficiency expands the genetic susceptibility to HSV-1 encephalitis

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

Cedric BosteelsKarel Van DammeElisabeth De LeeuwJozefien DeclercqBastiaan MaesVictor BosteelsLevi HosteLeslie NaesensNincy DebeufJulie Deckers et al.

A1 Journal Article in CELL REPORTS MEDICINE

Mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF, and result in Aicardi-Goutières syndrome with severe end-organ involvement

Leslie NaesensJosephine NemegeerFilip RoelensLore VallaeysMarije MeuwissenKatrien JanssensPATRICK VERLOOBenson OgunjimiDimitri HemelsoetLevi Hoste et al.

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Shortcutting the diagnostic odyssey : the multidisciplinary program for undiagnosed rare diseases in adults (UD-PrOZA)

Nika SchuermansDimitri HemelsoetWim TerrynSanne SteyaertRudy Van CosterPaul CouckeWouter SteyaertBert CallewaertElke BogaertPATRICK VERLOO et al.

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Levi HosteLisa RoelsLeslie NaesensVictor BosteelsStijn VanheeSam DupontCedric BosteelsRobin BrowaeysNiels VandammeKevin Verstaen et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Viral RHIM proteins antagonise necroptosis by preventing ZBP1-induced RIPK1/RIPK3 amyloid formation in human cells

Josephine NemegeerLeslie NaesensSimon VerdonckEvelien DierickKatrien StaesPeter VandenabeeleJonathan Maelfait

2021

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Paul BastardAdrian GervaisTom Le VoyerJérémie RosainQuentin PhilippotJérémy ManryEleftherios MichailidisHans-Heinrich HoffmannShohei EtoMarina Garcia-Prat et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Clinical, genetic and immunological evaluation of the type I interferonopathy Aicardi-Goutieres syndrome caused by mutations in RNU7-1

Leslie NaesensJosephine NemegeerTessa KerreRudi BeyaertSimon TavernierJonathan MaelfaitFilomeen Haerynck

Diagnosis and immunosuppressive treatment of inflammatory cardiomyopathy : a case report

Leslie NaesensM. PenickaW. Heggermont

A1 Journal Article in ACTA CLINICA BELGICA

Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID) : a factorial, randomised, controlled trial

Jozefien DeclercqKarel Van DammeElisabeth De LeeuwBastiaan MaesCedric BosteelsSimon TavernierStefanie De BuyserRoos ColmanMaya HitesGil Verschelden et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

GTF3A mutations in a patient with herpes simplex encephalitis reveals a novel role in viral immunity by transcribing 5S rRNA pseudogenes serving as RIG-I ligands

Leslie NaesensSantoshi MuppalaJung-Hyun LeeJosephine NemegeerDhiraj AcharyaDelfien BogaertMichiel van GentJens StaalKatrien StaesVeronique Debacker et al.

Novel mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF and result in Aicardi-Goutières syndrome with severe end-organ involvement

Leslie NaesensJosephine NemegeerFilip RoelensLore VallaeysMarije MeuwissenKatrien JanssensPATRICK VERLOOBenson OgunjimiDimitri HemelsoetProgram for Undiagnosed Rare Diseases (UD-PrOZA) et al.

Plasma C3d levels as a diagnostic marker for complete complement factor I deficiency

Leslie NaesensJulie SmetSimon TavernierPetra SchelstraeteLevi HosteStijn LambrechtHelene VerhelstJutte van der Werff Ten BoschAlina FersterSophie Blumental et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

Takaki AsanoBertrand BoissonFanny OnodiDaniela MatuozzoMarcela Moncada-VelezMajistor Raj Luxman Maglorius RenkilarajPeng ZhangLaurent MeertensAlexandre BolzeMarie Materna et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

2020

Case report : convalescent plasma, a targeted therapy for patients with CVID and severe COVID-19

Karel Van DammeSimon TavernierNele Van RoyElisabeth De LeeuwJozefien DeclercqCedric BosteelsBastiaan MaesMarieke De BruyneDelfien BogaertVictor Bosteels et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

GATA2 deficiency and haematopoietic stem cell transplantation : challenges for the clinical practitioner

Delfien BogaertGenevieve LaureysLeslie NaesensDominiek MazureMarieke De BruyneAmy P. HsuMaria Bordon Cueto De BraemErik WoutersSimon TavernierBart Lambrecht et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian ZhangPaul BastardZhiyong LiuJérémie Le PenMarcela Moncada-VelezJie ChenMasato OgishiIra K. D. SabliStephanie HodeibCecilia Korol et al.

A1 Journal Article in SCIENCE

2019

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

Simon TavernierV AthanasopoulosPATRICK VERLOOG BehrensJens StaalDelfien BogaertLeslie NaesensMarieke De BruyneSofie Van GassenEef Parthoens et al.

A1 Journal Article in NATURE COMMUNICATIONS

GATA2 deficiency and hematopoietic stem cell transplantation : challenges for the clinical practitioner

Delfien BogaertLeslie NaesensGenevieve LaureysMaria Bordon Cueto De BraemErik WoutersSimon TavernierBart LambrechtFilomeen HaerynckTessa Kerre

Immune dysregulation with lymphoproliferation progressing to a rare T-cell non-hodgkin lymphoma

Leslie NaesensHilde DemuynckKristof CokelaereCiel De VriendtDelfien BogaertCarolien BonroyRik SchrijversFilomeen HaerynckTessa Kerre

Pitfalls in diagnosing complement factor I deficiencies : from clinical phenotype to laboratory diagnosis

Leslie NaesensJulie SmetSimon TavernierStijn LambrechtTessa KerreJohan Van de WalleLubka RoumeninaPatrick StordeurFilomeen Haerynck

Thyreostaticageïnduceerde agranulocytose : casus en literatuuroverzicht

Leslie NaesensPaul Van CrombruggeLiesbeth Van HuffelFrank Nobels

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2018

Mediastinal myeloid sarcoma with TP53 mutation preceding acute myeloid leukemia with a PICALM-MLLT10 fusion gene

Leslie NaesensHelena DevosFriedel NolletLucienne MichauxDominik Selleslag

A1 Journal Article in ACTA HAEMATOLOGICA

Opportunistische infecties bij een 91-jarige immuungecompromitteerde patiënte

Leslie NaesensHANS VAN DER MEERSCHRaf Van HoeyweghenMargareta Lambert

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2016

What kind of prostate cancers do we miss on multiparametric magnetic resonance imaging?

Pieter De VisschereLeslie NaesensLouis LibbrechtCharles Van PraetNicolaas LumenValérie FonteyneEVA PATTYNGeert Villeirs

A1 Journal Article in EUROPEAN RADIOLOGY

2015

What kind of high-grade prostate cancers do we miss on multiparametric magentic resonance imaging?

Pieter De VisschereLeslie NaesensLouis LibbrechtNicolaas LumenValérie FonteyneEVA PATTYNGeert Villeirs

2014

What kind of high-grade prostate cancers do we miss with multiparametric magnetic resonance imaging?

Pieter De VisschereLeslie NaesensLouis LibbrechtCharles Van PraetNicolaas LumenPiet OstValérie FonteyneKarel DecaesteckerEVA PATTYNGeert Villeirs