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Researcher
Lennart Zabeau
Profile
Projects
Publications
Activities
Awards & Distinctions
35
Results
2024
High efficacy of huCD20-targeted AcTaferon in humanized patient derived xenograft models of aggressive B cell lymphoma
Willem Daneels
Alexander Van Parys
Leander Huyghe
Elke Rogge
Steffi De Rouck
Ruben Christiaen
Lennart Zabeau
Sylvie Taveirne
Jo Van Dorpe
Niko Kley
et al.
A1
Journal Article
in
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
2024
2020
Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies
Leander Huyghe
Alexander Van Parys
Anje Cauwels
Sandra Van Lint
Stijn De Munter
Jennyfer Bultinck
Lennart Zabeau
Jeroen Hostens
An Goethals
Nele Vanderroost
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2020
2017
Leptin receptor antagonism of iNKT cell function : a novel strategy to combat multiple myeloma
Mérédis Favreau
E Menu
Djoere Gaublomme
K Vanderkerken
S Faict
K Maes
E De Bruyne
Srinath Govindarajan
Michael Drennan
Serge Van Calenbergh
et al.
A1
Journal Article
in
LEUKEMIA
2017
The leptin receptor complex : heavier than expected?
Joris Wauman
Lennart Zabeau
Jan Tavernier
A1
Journal Article
in
FRONTIERS IN ENDOCRINOLOGY
2017
2016
Hyperleptinemia is associated with impaired pulmonary host defense
Niki DJ Ubags
Renee D Stapleton
Juanita H.J. Vernooy
Elianne Burg
Jenna Bement
Catherine M Hayes
Sebastian Ventrone
Lennart Zabeau
Jan Tavernier
Matthew E Poynter
et al.
A1
Journal Article
in
JCI INSIGHT
2016
2015
An abnormally glycosylated isoform of erythropoietin in hemangioblastoma is associated with polycythemia
Sigurd E Delanghe
Jan Dierick
Thomas Maenhout
Lennart Zabeau
Jan Tavernier
Kathleen Claes
Joris Bleyen
Joris Delanghe
A1
Journal Article
in
CLINICA CHIMICA ACTA
2015
Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level
Lennart Zabeau
Cathy J Jensen
Sylvie Seeuws
Koen Venken
Annick Verhee
Dominiek Catteeuw
Geert van Loo
Hui Chen
Ken Walder
Jacob Hollis
et al.
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2015
Leptin: from structural insights to the design of antagonists
Lennart Zabeau
Frank Peelman
Jan Tavernier
A1
Journal Article
in
LIFE SCIENCES
2015
2014
20 Years of leptin: insights into signaling assemblies of the leptin receptor
Frank Peelman
Lennart Zabeau
Kedar Moharana
Savvas Savvides
Jan Tavernier
A1
Journal Article
in
JOURNAL OF ENDOCRINOLOGY
2014
A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis
Koen Venken
Sylvie Seeuws
Lennart Zabeau
Peggy Jacques
Tine Decruy
Julie Coudenys
Eveline Verheugen
Fien Windels
Dominiek Catteeuw
Michael Drennan
et al.
A1
Journal Article
in
JOURNAL OF HEPATOLOGY
2014
Antagonizing leptin: current status and future directions
Lennart Zabeau
Frank Peelman
Jan Tavernier
A1
Journal Article
in
BIOLOGICAL CHEMISTRY
2014
Inhibition of the connexin 43 elevation may be involved in the neuroprotective activity of leptin against brain ischemic injury
Zi-Hui Deng
Jie Liao
Jin-Ying Zhang
Chen Liang
Cui-Hong Song
Ming Han
Lu-Huan Wang
Hui Xue
Kai Zhang
Lennart Zabeau
et al.
A1
Journal Article
in
CELLULAR AND MOLECULAR NEUROBIOLOGY
2014
Kinetics of leptin binding to the Q223R leptin receptor
Hans Verkerke
Caitlin Naylor
Lennart Zabeau
Jan Tavernier
William A, Jr Petri
Chelsea Marie
A1
Journal Article
in
PLOS ONE
2014
Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins
Kedar Moharana
Lennart Zabeau
Frank Peelman
Philippe Ringler
Henning Stahlberg
Jan Tavernier
Savvas Savvides
A1
Journal Article
in
STRUCTURE
2014
The anti-tumor activity of a neutralizing nanobody targeting leptin receptor in a mouse model of melanoma
Travis McMurphy
Run Xiao
Daniel Magee
Andrew Slater
Lennart Zabeau
Jan Tavernier
Lei Cao
A1
Journal Article
in
PLOS ONE
2014
The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury
Niki D Ubags
Juanita H Vernooy
Elianne Burg
Catherine Hayes
Jenna Bement
Estee Dilli
Lennart Zabeau
Edward Abraham
Katie R Poch
Jerry A Nick
et al.
A1
Journal Article
in
CRITICAL CARE MEDICINE
2014
2013
Leptin attenuates lipopolysaccharide-induced apoptosis of thymocytes partially via down-regulation of cPLA2 and p38 MAPK activation
Chen Liang
Jie Liao
Zihui Deng
Cuihong Song
Jinying Zhang
Lennart Zabeau
Jan Tavernier
Kai Zhang
Hui Xue
Guangtao Yan
A1
Journal Article
in
INTERNATIONAL IMMUNOPHARMACOLOGY
2013
2012
Biologically active, magnICON®-expressed EPO-Fc from stably transformed Nicotiana benthamiana plants presenting tetra-antennary N-glycan structures
Bieke Nagels
Els Van Damme
Nico Callewaert
Lennart Zabeau
Jan Tavernier
Joris Delanghe
Annemie Boets
Alexandra Castilho
Koen Weterings
A1
Journal Article
in
JOURNAL OF BIOTECHNOLOGY
2012
Selection of non-competitive leptin antagonists using a random nanobody-based approach
Lennart Zabeau
Annick Verhee
Dominiek Catteeuw
Liesbeth Faes
Sylvie Seeuws
Tine Decruy
Dirk Elewaut
Frank Peelman
Jan Tavernier
A1
Journal Article
in
BIOCHEMICAL JOURNAL
2012
2011
Chylomicron formation and glucagon-like peptide 1 receptor are involved in activation of the nutritional anti-inflammatory pathway
Tim Lubbers
Jacco J de Haan
M'hamed Hadfoune
Lennart Zabeau
Jan Tavernier
Yiren Zhang
David Grundy
Jan Willem M Greve
Wim A Buurman
A1
Journal Article
in
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
2011
2010
Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice
JHJ Vernooy
Ken Bracke
NEA Drummen
NSA Pauwels
Lennart Zabeau
RJ van Suylen
Jan Tavernier
Guy Joos
EFM Wouters
Guy Brusselle
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2010
2007
Leptin induces inflammation-related genes in RINm5F insulinoma cells
P HEKERMAN
J ZEIDLER
S KORFMACHER
S BAMBERG-LEMPER
H KNOBELSPIES
Lennart Zabeau
Jan Tavernier
W BECKER
A1
Journal Article
in
BMC MOLECULAR BIOLOGY
2007
2006
A complex interaction pattern of CIS and SOCS2 with the leptin receptor
Delphine Lavens
Tony Montoye
Julie Piessevaux
Lennart Zabeau
Joël Vandekerckhove
Kris Gevaert
W BECKER
Sven Eyckerman
Jan Tavernier
A1
Journal Article
in
JOURNAL OF CELL SCIENCE
2006
Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin center dot leptin receptor complex
Frank Peelman
Hannes Iserentant
Anne-Sophie De Smet
Joël Vandekerckhove
Lennart Zabeau
Jan Tavernier
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2006
Techniques: New pharmacological perspectives for the leptin receptor
Frank Peelman
C COUTURIER
J DAM
Lennart Zabeau
Jan Tavernier
R JOCKERS
A1
Journal Article
in
TRENDS IN PHARMACOLOGICAL SCIENCES
2006
2005
Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains
Lennart Zabeau
D DEFEAU
H ISERENTANT
Joël Vandekerckhove
Frank Peelman
Jan Tavernier
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2005
Leptin, immune responses and autoimmune disease. Perspectives on the use of leptin antagonists
Frank Peelman
Hannes Iserentant
Sven Eyckerman
Lennart Zabeau
Jan Tavernier
A1
Journal Article
in
CURRENT PHARMACEUTICAL DESIGN
2005
Mapping of the interface between leptin and the leptin receptor CRH2 domain
H ISERENTANT
Frank Peelman
D DEFEAU
Joël Vandekerckhove
Lennart Zabeau
Jan Tavernier
A1
Journal Article
in
JOURNAL OF CELL SCIENCE
2005
2004
Functional analysis of leptin receptor activation using a Janus kinase/signal transducer and activator of transcription complementation assay
Lennart Zabeau
Delphine Defeau
José Van Der Heyden
Hannes Iserentant
Joël Vandekerckhove
Jan Tavernier
A1
Journal Article
in
MOLECULAR ENDOCRINOLOGY
2004
Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases
Frank Peelman
Wim Waelput
Hannes Iserentant
Delphine Lavens
Sven Eyckerman
Lennart Zabeau
Jan Tavernier
A1
Journal Article
in
PROGRESS IN LIPID RESEARCH
2004
Mapping of the leptin binding sites and design of a leptin antagonist
Frank Peelman
Katrien Van Beneden
Lennart Zabeau
Hannes Iserentant
Peter Ulrichts
Delphine Defeau
Annick Verhee
Dominiek Catteeuw
Dirk Elewaut
Jan Tavernier
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2004
2003
Heteromeric MAPPIT: a novel strategy to study modification-dependent protein-protein interactions in mammalian cells
Irma Lemmens
Sven Eyckerman
Lennart Zabeau
Dominiek Catteeuw
Els Vertenten
K VERSCHUEREN
D HUYLEBROECK
Joël Vandekerckhove
Jan Tavernier
A1
Journal Article
in
NUCLEIC ACIDS RESEARCH
2003
Interleukin 5, eosinophilic diseases and therapeutic intervention
Lennart Zabeau
Philippe Gevaert
Claus Bachert
Jan Tavernier
A4
Journal Article
in
INFLAMMATION & ALLERGY : DRUG TARGETS
2003
The ins and outs of leptin receptor activation
Lennart Zabeau
Delphine Lavens
Frank Peelman
Sven Eyckerman
Joël Vandekerckhove
Jan Tavernier
A1
Journal Article
in
FEBS LETTERS
2003
2001
Neutralizing monoclonal antibodies can potentiate IL-5 signaling.
Lennart Zabeau
J VAN DER HEYDEN
Daniël Broekaert
A VERHEE
Joël Vandekerckhove
SJ WU
I CHAIKEN
P HEINRICH
I BEHRMANN
Jan Tavernier
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
2001