Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Researcher

Lennart Zabeau

Publications & Research Data

Awards & Distinctions

36 Results

2024

High efficacy of huCD20-targeted AcTaferon in humanized patient derived xenograft models of aggressive B cell lymphoma

Willem DaneelsAlexander Van ParysLeander HuygheElke RoggeSteffi De RouckRuben ChristiaenLennart ZabeauSylvie TaveirneJo Van DorpeNiko Kley et al.

A1 Journal Article in EXPERIMENTAL HEMATOLOGY & ONCOLOGY

2020

Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies

Leander HuygheAlexander Van ParysAnje CauwelsSandra Van LintStijn De MunterJennyfer BultinckLennart ZabeauJeroen HostensAn GoethalsNele Vanderroost et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

A novel leptin receptor antagonist uncouples leptin’s metabolic and immune functions

Lennart ZabeauJoris WaumanJulie DamSandra Van LintElianne BurgJennifer De GeestElke RoggeAnisia SilvaRalf JockersJan Tavernier

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2017

Leptin receptor antagonism of iNKT cell function : a novel strategy to combat multiple myeloma

Mérédis FavreauE MenuDjoere GaublommeK VanderkerkenS FaictK MaesE De BruyneSrinath GovindarajanMichael DrennanSerge Van Calenbergh et al.

A1 Journal Article in LEUKEMIA

The leptin receptor complex : heavier than expected?

Joris WaumanLennart ZabeauJan Tavernier

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

2016

Hyperleptinemia is associated with impaired pulmonary host defense

Niki DJ UbagsRenee D StapletonJuanita H.J. VernooyElianne BurgJenna BementCatherine M HayesSebastian VentroneLennart ZabeauJan TavernierMatthew E Poynter et al.

A1 Journal Article in JCI INSIGHT

2015

An abnormally glycosylated isoform of erythropoietin in hemangioblastoma is associated with polycythemia

Sigurd E DelangheJan DierickThomas MaenhoutLennart ZabeauJan TavernierKathleen ClaesJoris BleyenJoris Delanghe

A1 Journal Article in CLINICA CHIMICA ACTA

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level

Lennart ZabeauCathy J JensenSylvie SeeuwsKoen VenkenAnnick VerheeDominiek CatteeuwGeert van LooHui ChenKen WalderJacob Hollis et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Leptin: from structural insights to the design of antagonists

Lennart ZabeauFrank PeelmanJan Tavernier

A1 Journal Article in LIFE SCIENCES

2014

20 Years of leptin: insights into signaling assemblies of the leptin receptor

Frank PeelmanLennart ZabeauKedar MoharanaSavvas SavvidesJan Tavernier

A1 Journal Article in JOURNAL OF ENDOCRINOLOGY

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

Koen VenkenSylvie SeeuwsLennart ZabeauPeggy JacquesTine DecruyJulie CoudenysEveline VerheugenFien WindelsDominiek CatteeuwMichael Drennan et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

Antagonizing leptin: current status and future directions

Lennart ZabeauFrank PeelmanJan Tavernier

A1 Journal Article in BIOLOGICAL CHEMISTRY

Inhibition of the connexin 43 elevation may be involved in the neuroprotective activity of leptin against brain ischemic injury

Zi-Hui DengJie LiaoJin-Ying ZhangChen LiangCui-Hong SongMing HanLu-Huan WangHui XueKai ZhangLennart Zabeau et al.

A1 Journal Article in CELLULAR AND MOLECULAR NEUROBIOLOGY

Kinetics of leptin binding to the Q223R leptin receptor

Hans VerkerkeCaitlin NaylorLennart ZabeauJan TavernierWilliam A, Jr PetriChelsea Marie

A1 Journal Article in PLOS ONE

Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins

Kedar MoharanaLennart ZabeauFrank PeelmanPhilippe RinglerHenning StahlbergJan TavernierSavvas Savvides

A1 Journal Article in STRUCTURE

The anti-tumor activity of a neutralizing nanobody targeting leptin receptor in a mouse model of melanoma

Travis McMurphyRun XiaoDaniel MageeAndrew SlaterLennart ZabeauJan TavernierLei Cao

A1 Journal Article in PLOS ONE

The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury

Niki D UbagsJuanita H VernooyElianne BurgCatherine HayesJenna BementEstee DilliLennart ZabeauEdward AbrahamKatie R PochJerry A Nick et al.

A1 Journal Article in CRITICAL CARE MEDICINE

2013

Leptin attenuates lipopolysaccharide-induced apoptosis of thymocytes partially via down-regulation of cPLA2 and p38 MAPK activation

Chen LiangJie LiaoZihui DengCuihong SongJinying ZhangLennart ZabeauJan TavernierKai ZhangHui XueGuangtao Yan

A1 Journal Article in INTERNATIONAL IMMUNOPHARMACOLOGY

2012

Biologically active, magnICON®-expressed EPO-Fc from stably transformed Nicotiana benthamiana plants presenting tetra-antennary N-glycan structures

Bieke NagelsEls Van DammeNico CallewaertLennart ZabeauJan TavernierJoris DelangheAnnemie BoetsAlexandra CastilhoKoen Weterings

A1 Journal Article in JOURNAL OF BIOTECHNOLOGY

Selection of non-competitive leptin antagonists using a random nanobody-based approach

Lennart ZabeauAnnick VerheeDominiek CatteeuwLiesbeth FaesSylvie SeeuwsTine DecruyDirk ElewautFrank PeelmanJan Tavernier

A1 Journal Article in BIOCHEMICAL JOURNAL

2011

Chylomicron formation and glucagon-like peptide 1 receptor are involved in activation of the nutritional anti-inflammatory pathway

Tim LubbersJacco J de HaanM'hamed HadfouneLennart ZabeauJan TavernierYiren ZhangDavid GrundyJan Willem M GreveWim A Buurman

A1 Journal Article in JOURNAL OF NUTRITIONAL BIOCHEMISTRY

2010

Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice

JHJ VernooyKen BrackeNEA DrummenNSA PauwelsLennart ZabeauRJ van SuylenJan TavernierGuy JoosEFM WoutersGuy Brusselle

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2007

Leptin induces inflammation-related genes in RINm5F insulinoma cells

P HEKERMANJ ZEIDLERS KORFMACHERS BAMBERG-LEMPERH KNOBELSPIESLennart ZabeauJan TavernierW BECKER

A1 Journal Article in BMC MOLECULAR BIOLOGY

2006

A complex interaction pattern of CIS and SOCS2 with the leptin receptor

Delphine LavensTony MontoyeJulie PiessevauxLennart ZabeauJoël VandekerckhoveKris GevaertW BECKERSven EyckermanJan Tavernier

A1 Journal Article in JOURNAL OF CELL SCIENCE

Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin center dot leptin receptor complex

Frank PeelmanHannes IserentantAnne-Sophie De SmetJoël VandekerckhoveLennart ZabeauJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Techniques: New pharmacological perspectives for the leptin receptor

Frank PeelmanC COUTURIERJ DAMLennart ZabeauJan TavernierR JOCKERS

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

2005

Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains

Lennart ZabeauD DEFEAUH ISERENTANTJoël VandekerckhoveFrank PeelmanJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin, immune responses and autoimmune disease. Perspectives on the use of leptin antagonists

Frank PeelmanHannes IserentantSven EyckermanLennart ZabeauJan Tavernier

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Mapping of the interface between leptin and the leptin receptor CRH2 domain

H ISERENTANTFrank PeelmanD DEFEAUJoël VandekerckhoveLennart ZabeauJan Tavernier

A1 Journal Article in JOURNAL OF CELL SCIENCE

2004

Functional analysis of leptin receptor activation using a Janus kinase/signal transducer and activator of transcription complementation assay

Lennart ZabeauDelphine DefeauJosé Van Der HeydenHannes IserentantJoël VandekerckhoveJan Tavernier

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases

Frank PeelmanWim WaelputHannes IserentantDelphine LavensSven EyckermanLennart ZabeauJan Tavernier

A1 Journal Article in PROGRESS IN LIPID RESEARCH

Mapping of the leptin binding sites and design of a leptin antagonist

Frank PeelmanKatrien Van BenedenLennart ZabeauHannes IserentantPeter UlrichtsDelphine DefeauAnnick VerheeDominiek CatteeuwDirk ElewautJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2003

Heteromeric MAPPIT: a novel strategy to study modification-dependent protein-protein interactions in mammalian cells

Irma LemmensSven EyckermanLennart ZabeauDominiek CatteeuwEls VertentenK VERSCHUEREND HUYLEBROECKJoël VandekerckhoveJan Tavernier

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Interleukin 5, eosinophilic diseases and therapeutic intervention

Lennart ZabeauPhilippe GevaertClaus BachertJan Tavernier

A4 Journal Article in INFLAMMATION & ALLERGY : DRUG TARGETS

The ins and outs of leptin receptor activation

Lennart ZabeauDelphine LavensFrank PeelmanSven EyckermanJoël VandekerckhoveJan Tavernier

A1 Journal Article in FEBS LETTERS

2001

Neutralizing monoclonal antibodies can potentiate IL-5 signaling.

Lennart ZabeauJ VAN DER HEYDENDaniël BroekaertA VERHEEJoël VandekerckhoveSJ WUI CHAIKENP HEINRICHI BEHRMANNJan Tavernier

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY