Research Explorer

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Researcher

Lena Decuyper

Awards & Distinctions

25 Results

2020

Expedient synthesis of lupulones and their derivatization to 2,8-7H-dihydrochromen-7-ones

Lena DecuyperGurkirat KaurCharlotte VersyckEline BlondeelYves DepetterKristof Van HeckeMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

Synthesis and penicillin‐binding protein inhibitory assessment of dipeptidic 4‐phenyl‐β‐lactams from α‐amino acid‐derived imines

Lena DecuyperMarko JukičIzidor SosičAna Maria AmorosoOlivier VerlaineBernard JorisStanislav GobecMatthias D'hooghe

A1 Journal Article in CHEMISTRY-AN ASIAN JOURNAL

2019

Design, synthesis and evaluation of monocyclic β-lactams as inhibitors of penicillin-binding proteins of resistant bacteria

Lena DecuyperMatthias D'hooghe

Hit expansion of alfa-unsaturated 3-amino-1-carboxymethyl-beta-lactams as bacterial PBP inhibitors

α‐Unsaturated 3‐Amino‐1‐carboxymethyl‐β‐lactams as bacterial PBP inhibitors : synthesis and biochemical assessment

Lena DecuyperKatarina MagdalenicMarie VerstraeteMarko JukičIzidor SosičEric SauvageAna Maria AmorosoOlivier VerlaineBernard JorisStanislav Gobec et al.

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

2018

Antibacterial and β-lactamase inhibitory activity of monocyclic β-lactams

Lena DecuyperMarko JukičIzidor SosičAleš ŽulaMatthias D'hoogheStanislav Gobec

A1 Journal Article in MEDICINAL RESEARCH REVIEWS

Chemoenzymatic approach toward the synthesis of 3‑O‑(alfa/beta)-glucosylated 3‑hydroxy-beta-lactams

Lena DecuyperMaarten Debruyne

Chemoenzymatic approach toward the synthesis of 3-O-(α/β)-glucosylated 3-hydroxy-β-lactams

Lena DecuyperJorick FranceusShari DhaeneMaarten DebruyneKevin VandoorneNicola PiensGriet DewitteTom DesmetMatthias D'hooghe

A1 Journal Article in ACS OMEGA

Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase

Jorick FranceusLena DecuyperMatthias D'hoogheTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

In silico design and enantioselective synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as inhibitors of penicillin-binding proteins of resistant bacteria

In silico design and enantioselective synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-β-lactams as inhibitors of penicillin-binding proteins of resistant bacteria

Lena DecuyperSari DeketelaereLore VanparysMarko JukičIzidor SosičEric SauvageAna Maria AmorosoOlivier VerlaineBernard JorisStanislav Gobec et al.

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Targeting bacterial drug resistance : design, synthesis and evaluation of monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of Penicillin-binding proteins

2017

Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of PBPs of resistant bacteria

Sari DeketelaereLena DecuyperLore VanparysMarko JukičIzidor SosičEric SauvagePaulette CharlierBernard JorisStanislav GobecMatthias D'hooghe

Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of penicillin binding proteins of resistant bacteria

Sari DeketelaereLena DecuyperLore VanparysMarko JukičIzidor SosičEric SauvageAna Maria AmorosoOlivier VerlainePaulette CharlierBernard Joris et al.

Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of penicillin-binding proteins of resistant bacteria

Lena DecuyperSari DeketelaereLore VanparysMarko JukicIzidor SosicEric SauvagePaulette CharlierBernard JorisStanislav GobecMatthias D'hooghe

2016

A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

A1 Journal Article in RSC ADVANCES

Integrating biocatalytical processes into organic synthesis: nitrilase-mediated conversion of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones as a sustainable entry to functionalized γ-lactams and β-lactams

Nicola PiensLena DecuyperSaskia Vander MeerenJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

Synthesis and chemical/enzymatic hydrolysis of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensSaskia Vander MeerenJens MinckeJeroen BomonBert De SchrijverKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

Synthesis and cytotoxic evaluation of novel indenoisoquinoline-propan-2-ol hybrids

Tham Pham ThiLena DecuyperTan Luc QuangChinh Pham TheTuyet Anh Dang ThiHa Thanh NguyenThuy Giang Le NhatTra Nguyen ThanhPhuong Hoang ThiMatthias D'hooghe et al.

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of novel trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks

Hang Dao ThiLena DecuyperKaren MolletSara KennisNorbert De KimpeTuyen Nguyen VanMatthias D'hooghe

Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks

Hang Dao ThiLena DecuyperKaren MolletSara KenisNorbert De KimpeTuyen Van NguyenMatthias D'hooghe

A1 Journal Article in SYNLETT

2015

Synthesis and cytotoxic evaluation of novel dihydrobenzo[h]cinnoline-5,6-diones

Tuyet Anh Dang ThiLena DecuyperHoang Thi PhuongDoan Vu NgocHa Thanh NguyenTra Thanh NguyenThanh Do HuyHung Huy NguyenMatthias D'hoogheTuyen Van Nguyen

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Karen MolletLena DecuyperSaskia Vander MeerenNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

2014

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Lena DecuyperKaren MolletSaskia Vander MeerenNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks

Hang Dao ThiLena DecuyperKaren MolletSara KennisNorbert De KimpeTuyen Nguyen VanMatthias D'hooghe