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Researcher
Lena Böhme
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
15
Results
2025
From cortex to medulla : navigating the thymic landscape of T cell education
Lena Boehme
Nadav Yayon
Sarah A. Teichmann
Tom Taghon
Editorial material
2025
Thymic pioneers : charting the origin, identity, and fate of human thymus seeding progenitors
Kai Ling Liang
Lena Boehme
Silke Paepens
Maryam Hassan
Tom Taghon
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2025
2024
A spatial human thymus cell atlas mapped to a continuous tissue axis
Nadav Yayon
Veronika R. Kedlian
Lena Boehme
Chenqu Suo
Brianna T. Wachter
Rebecca T. Beuschel
Oren Amsalem
Krzysztof Polanski
Simon Koplev
Elizabeth Tuck
et al.
A1
Journal Article
in
NATURE
2024
HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells
Tamara De Vos
Nicole Oatman
Lena Boehme
Tom Putteman
Imke Velghe
Yana Van Droogenbroeck
Stijn De Munter
Michaela Cesnekova
Filip Van Nieuwerburgh
Bart Vandekerckhove
et al.
A1
Journal Article
in
HAEMATOLOGICA
2024
KLRG1 cell depletion as a novel therapeutic strategy in patients with mature T-cell lymphoma subtypes
Bimarzhan Assatova
Robert Willim
Christopher Trevisani
Garrett Haskett
Khyati Maulik Kariya
Kusha Chopra
Sung Rye Park
Michael Yevgeniy Tolstorukov
Sean M. McCabe
Jessica Duffy
et al.
A1
Journal Article
in
CLINICAL CANCER RESEARCH
2024
ThymoSpheres culture : a model to study human polyclonal unconventional T cells
Lore Billiet
Hanne Jansen
Melissa Pille
Lena Boehme
Guillem Sanchez Sanchez
Laurenz De Cock
Glenn Goetgeluk
Eva Pascal
Stijn De Munter
Lucas Deseins
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
2024
2023
A spatial human thymus cell atlas mapped to a continuous tissue axis
Nadav Yayon
Veronika R. Kedlian
Lena Böhme
Chenqu Suo
Brianna Wachter
Rebecca T. Beuschel
Oren Amsalem
Krzysztof Polanski
Simon Koplev
Elizabeth Tuck
et al.
Preprint
2023
Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF
Kai Ling Liang
Juliette Roels
Marieke Lavaert
Tom Putteman
Lena Boehme
Laurentijn Tilleman
Imke Velghe
Valentina Pegoretti
Inge Van de Walle
Stephanie Sontag
et al.
A1
Journal Article
in
NATURE IMMUNOLOGY
2023
2022
Defective STAT5 activation and aberrant expression of BCL6 in naive CD4 T cells enhances follicular Th cell–like differentiation in patients with granulomatosis with polyangiitis
Sangmi Kim
Lena Böhme
Louise Nel
Alina Casian
Shirish Sangle
Estefania Nova-Lamperti
Vlad Seitan
Jo Spencer
Paul Lavender
David P. D’Cruz
et al.
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2022
Development of gamma delta T cells in the thymus : a human perspective
Lena Böhme
Juliette Roels
Tom Taghon
A1
Journal Article
in
SEMINARS IN IMMUNOLOGY
2022
Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development
Juliette Roels
Jolien Van Hulle
Marieke Lavaert
Anna Kuchmiy
Steven Strubbe
Tom Putteman
Bart Vandekerckhove
Georges Leclercq
Filip Van Nieuwerburgh
Lena Boehme
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2022
2021
A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma
Oscar Maiques
Bruce Fanshawe
Eva Crosas-Molist
Irene Rodriguez-Hernandez
Alessia Volpe
Gaia Cantelli
Lena Böhme
Jose L. Orgaz
Faraz K. Mardakheh
Victoria Sanz-Moreno
et al.
A1
Journal Article
in
BRITISH JOURNAL OF CANCER
2021
2020
Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
Brooke C. Wilson
Lena Böhme
Ambra Annibali
Alan Hodgkinson
Thomas S. Carroll
Rebecca J. Oakey
Vlad C. Seitan
A1
Journal Article
in
NATURE COMMUNICATIONS
2020
Myosin II reactivation and cytoskeletal remodeling as a hallmark and a vulnerability in melanoma therapy resistance
Jose L. Orgaz
Eva Crosas-Molist
Amine Sadok
Anna Perdrix-Rosell
Oscar Maiques
Irene Rodriguez-Hernandez
Jo Monger
Silvia Mele
Mirella Georgouli
Victoria Bridgeman
et al.
A1
Journal Article
in
CANCER CELL
2020
2019
Nuclear genetic regulation of the human mitochondrial transcriptome
Aminah T Ali
Lena Böhme
Guillermo Carbajosa
Vlad C Seitan
Kerrin S Small
Alan Hodgkinson
A1
Journal Article
in
ELIFE
2019