Research Explorer

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Researcher

Lena Böhme

Publications & Research Data

Awards & Distinctions

16 Results

2026

In vivo modeling of human γS T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 VS2 T cell development

Celine LaAurelie DetavernierMaria PapadopoulouGuillem Sanchez SanchezVincent MartensSeverine ThomasMuriel NguyenValerie AcoltyMaxime MelchiorDesiree Venturoli et al.

A1 Journal Article in CELL REPORTS

2025

From cortex to medulla : navigating the thymic landscape of T cell education

Lena BoehmeNadav YayonSarah A. TeichmannTom Taghon

Editorial material

Thymic pioneers : charting the origin, identity, and fate of human thymus seeding progenitors

Kai Ling LiangLena BoehmeSilke PaepensMaryam HassanTom Taghon

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2024

A spatial human thymus cell atlas mapped to a continuous tissue axis

Nadav YayonVeronika R. KedlianLena BoehmeChenqu SuoBrianna T. WachterRebecca T. BeuschelOren AmsalemKrzysztof PolanskiSimon KoplevElizabeth Tuck et al.

A1 Journal Article in NATURE

HES6 knockdown in human hematopoietic precursor cells reduces their in vivo engraftment potential and their capacity to differentiate into erythroid cells, B cells, T cells and plasmacytoid dendritic cells

Tamara De VosNicole OatmanLena BoehmeTom PuttemanImke VelgheYana Van DroogenbroeckStijn De MunterMichaela CesnekovaFilip Van NieuwerburghBart Vandekerckhove et al.

A1 Journal Article in HAEMATOLOGICA

KLRG1 cell depletion as a novel therapeutic strategy in patients with mature T-cell lymphoma subtypes

Bimarzhan AssatovaRobert WillimChristopher TrevisaniGarrett HaskettKhyati Maulik KariyaKusha ChopraSung Rye ParkMichael Yevgeniy TolstorukovSean M. McCabeJessica Duffy et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

ThymoSpheres culture : a model to study human polyclonal unconventional T cells

Lore BillietHanne JansenMelissa PilleLena BoehmeGuillem Sanchez SanchezLaurenz De CockGlenn GoetgelukEva PascalStijn De MunterLucas Deseins et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

2023

A spatial human thymus cell atlas mapped to a continuous tissue axis

Nadav YayonVeronika R. KedlianLena BöhmeChenqu SuoBrianna WachterRebecca T. BeuschelOren AmsalemKrzysztof PolanskiSimon KoplevElizabeth Tuck et al.

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

Kai Ling LiangJuliette RoelsMarieke LavaertTom PuttemanLena BoehmeLaurentijn TillemanImke VelgheValentina PegorettiInge Van de WalleStephanie Sontag et al.

A1 Journal Article in NATURE IMMUNOLOGY

2022

Defective STAT5 activation and aberrant expression of BCL6 in naive CD4 T cells enhances follicular Th cell–like differentiation in patients with granulomatosis with polyangiitis

Sangmi KimLena BöhmeLouise NelAlina CasianShirish SangleEstefania Nova-LampertiVlad SeitanJo SpencerPaul LavenderDavid P. D’Cruz et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Development of gamma delta T cells in the thymus : a human perspective

Lena BöhmeJuliette RoelsTom Taghon

A1 Journal Article in SEMINARS IN IMMUNOLOGY

Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development

Juliette RoelsJolien Van HulleMarieke LavaertAnna KuchmiySteven StrubbeTom PuttemanBart VandekerckhoveGeorges LeclercqFilip Van NieuwerburghLena Boehme et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2021

A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma

Oscar MaiquesBruce FanshaweEva Crosas-MolistIrene Rodriguez-HernandezAlessia VolpeGaia CantelliLena BöhmeJose L. OrgazFaraz K. MardakhehVictoria Sanz-Moreno et al.

A1 Journal Article in BRITISH JOURNAL OF CANCER

2020

Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function

Brooke C. WilsonLena BöhmeAmbra AnnibaliAlan HodgkinsonThomas S. CarrollRebecca J. OakeyVlad C. Seitan

A1 Journal Article in NATURE COMMUNICATIONS

Myosin II reactivation and cytoskeletal remodeling as a hallmark and a vulnerability in melanoma therapy resistance

Jose L. OrgazEva Crosas-MolistAmine SadokAnna Perdrix-RosellOscar MaiquesIrene Rodriguez-HernandezJo MongerSilvia MeleMirella GeorgouliVictoria Bridgeman et al.

A1 Journal Article in CANCER CELL

2019

Nuclear genetic regulation of the human mitochondrial transcriptome

Aminah T AliLena BöhmeGuillermo CarbajosaVlad C SeitanKerrin S SmallAlan Hodgkinson

A1 Journal Article in ELIFE