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Researcher
Leen Van Simaey
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
31
Results
2026
Systematic engineering of lysins yields serum resistant and in vivo active compounds towards drug-resistant Acinetobacter baumannii
Guy Hermans
Dennis Grimon
Jens Van Liefferinge
Leen Van Simaey
Martijn Verhelst
Gilles Vandermarliere
Maria João de Carvalho Maurício da Fonseca
Kristof Van Emelen
Yves Briers
C3
Conference
2026
2025
From design to function : an automation-enabled pipeline for the development of precision lysin therapeutics
Dennis Grimon
Jens Van Liefferinge
Leen Van Simaey
Martijn Verhelst
Gilles Vandermarliere
Maria João de Carvalho Maurício da Fonseca
Bjorn Criel
Kristof Van Emelen
Guy Hermans
Yves Briers
C3
Conference
2025
2024
Comparison of DeNovix, NanoDrop and Qubit for DNA quantification and impurity detection of bacterial DNA extracts
Nick Versmessen
Leen Van Simaey
Abel Abera Negash
Marjolein Vandekerckhove
Paco Hulpiau
Mario Vaneechoutte
Piet Cools
A1
Journal Article
in
PLOS ONE
2024
Microbiological evaluation of ultraviolet C light-emitting diodes for disinfection of medical instruments
Hannah Siwe
Annelies Aerssens
Mieke V. Flour
Silke Ternest
Leen Van Simaey
Duncan Verstraeten
Alain Kalmar
Isabel Leroux-Roels
Philip Meuleman
Piet Cools
A1
Journal Article
in
HELIYON
2024
2022
Optimization of propidium monoazide qPCR (viability-qPCR) to quantify the killing by the Gardnerella-specific endolysin PM-477, directly in vaginal samples from women with bacterial vaginosis
Agnieszka Łątka
Leen Van Simaey
Marijke Reynders
Piet Cools
Tess Rogier
Barbara Lebbe
Lorenzo Corsini
Christine Landlinger
Mario Vaneechoutte
A1
Journal Article
in
ANTIBIOTICS-BASEL
2022
Preclinical data on the Gardnerella-specific endolysin PM-477 indicate its potential to improve the treatment of bacterial vaginosis through enhanced biofilm removal and avoidance of resistance
Christine Landlinger
Vera Oberbauer
Lenka Podpera Tisakova
Timo Schwebs
Rocío Berdaguer
Leen Van Simaey
Mario Vaneechoutte
Lorenzo Corsini
A1
Journal Article
in
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2022
2021
A case of phage therapy against pandrug-resistant Achromobacter xylosoxidans in a 12-year-old lung-transplanted cystic fibrosis patient
David Lebeaux
Maia Merabishvili
Eric Caudron
Damien Lannoy
Leen Van Simaey
Hans Duyvejonck
Romain Guillemain
Caroline Thumerelle
Isabelle Podglajen
Fabrice Compain
et al.
A1
Journal Article
in
VIRUSES-BASEL
2021
Engineered phage endolysin eliminates Gardnerella biofilm without damaging beneficial bacteria in bacterial vaginosis ex vivo
C. Landlinger
L. Tisakova
V. Oberbauer
T. Schwebs
A. Muhammad
A. Latka
Leen Van Simaey
Mario Vaneechoutte
A. Guschin
G. Resch
et al.
A1
Journal Article
in
PATHOGENS
2021
2020
Comparison of procedures for RNA-extraction from peripheral blood mononuclear cells
Antonio Rodriguez Sánchez
Hans Duyvejonck
Jonas Van Belleghem
Tessa Gryp
Leen Van Simaey
Stefan Vermeulen
Els Van Mechelen
Mario Vaneechoutte
A1
Journal Article
in
PLOS ONE
2020
2019
Development of a qPCR platform for quantification of the five bacteriophages within bacteriophage cocktail 2 (BFC2)
Hans Duyvejonck
Maia Merabishvili
Jean-Paul Pirnay
Daniel De Vos
Gilbert Verbeken
Jonas Van Belleghem
Tessa Gryp
Julie De Leenheer
Kelly Van der Borght
Leen Van Simaey
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
Emended description of Gardnerella vaginalis and description of Gardnerella leopoldii sp. nov., Gardnerella piotii sp. nov. and Gardnerella swidsinskii sp. nov., with delineation of 13 genomic species within the genus Gardnerella
Mario Vaneechoutte
Alexandr Guschin
Leen Van Simaey
Yannick Gansemans
Filip Van Nieuwerburgh
Piet Cools
A1
Journal Article
in
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
2019
2018
Development and validation of an LC tandem MS assay for the quantification of β-lactam antibiotics in the sputum of cystic fibrosis patients
Katrien Forier
Virginie Van Heck
Mieke Carlier
Eva Van Braeckel
Sabine Van daele
Frans De Baets
Petra Schelstraete
Filomeen Haerynck
Veronique Stove
Leen Van Simaey
et al.
A1
Journal Article
in
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
2018
Establishing the diagnosis of chronic colonization with Pseudomonas aeruginosa of cystic fibrosis patients : comparison of the European consensus criteria with genotyping of P. aeruginosa isolates
Leander Jonckheere
Petra Schelstraete
Leen Van Simaey
Eva Van Braeckel
Julie Willekens
Sabine Van daele
Frans De Baets
Mario Vaneechoutte
A1
Journal Article
in
JOURNAL OF CYSTIC FIBROSIS
2018
2017
Women with symptoms of a urinary tract infection but a negative urine culture : PCR-based quantification of Escherichia coli suggests infection in most cases
Stefan Heytens
An De Sutter
Liselotte Coorevits
Piet Cools
Jerina Boelens
Leen Van Simaey
Thierry Christiaens
Mario Vaneechoutte
Geert Claeys
A1
Journal Article
in
CLINICAL MICROBIOLOGY AND INFECTION
2017
2016
Epidemic Achromobacter xylosoxidans strain among Belgian cystic fibrosis patients and review of literature
Piet Cools
Erwin Ho
Katleen Vranckx
Petra Schelstraete
Bettina Wurth
Hilde Franckx
Greet Ieven
Leen Van Simaey
Sabine Van daele
Stijn Verhulst
et al.
A1
Journal Article
in
BMC MICROBIOLOGY
2016
Haemophilus influenzae biofilm formation in chronic otitis media with effusion
Helen Van Hoecke
Ann-Sophie De Paepe
Edward Lambert
Jonas Van Belleghem
Piet Cools
Leen Van Simaey
Pieter Deschaght
Mario Vaneechoutte
Ingeborg Dhooge
A1
Journal Article
in
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
2016
2015
A single clone of Achromobacter xylosoxidans colonizes Belgian cystic fibrosis patients from different centres
Piet Cools
E Ho
Petra Schelstraete
B Würth
H Franckx
Leen Van Simaey
Sabine Van daele
S Verhulst
Frans De Baets
Mario Vaneechoutte
C3
Conference
2015
Pseudomonas aeruginosa genotyping: predicting transition to chronic colonization in cystic fibrosis patients
Leander Jonckheere
Mario Vaneechoutte
Frans De Baets
Sabine Van daele
Filomeen Haerynck
Leen Van Simaey
Petra Schelstraete
C3
Conference
2015
2013
Is the improvement of CF patients, hospitalized for pulmonary exacerbation, correlated to a decrease in bacterial load?
Pieter Deschaght
Petra Schelstraete
Leen Van Simaey
Marleen Vanderkercken
ANN RAMAN
Linda Mahieu
Sabine Van daele
Frans De Baets
Mario Vaneechoutte
A1
Journal Article
in
PLOS ONE
2013
2011
Granulomatous meningoencephalitis associated with Sporobolomyces roseus in a dog
Veronique Saey
An Vanhaesebrouck
S Maes
Leen Van Simaey
Luc Van Ham
Pieter Deschaght
Richard Ducatelle
A1
Journal Article
in
VETERINARY PATHOLOGY
2011
Rapid genotyping of Achromobacter xylosoxidans, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia isolates using melting curve analysis of RAPD-generated DNA-fragments (McRAPD)
Pieter Deschaght
Leen Van Simaey
Ellen Decat
Els Van Mechelen
Sylvain Brisse
Mario Vaneechoutte
A1
Journal Article
in
RESEARCH IN MICROBIOLOGY
2011
2010
Comparison of culture and qPCR for the detection of Pseudomonas aeruginosa in not chronically infected cystic fibrosis patients
Pieter Deschaght
Petra Schelstraete
Guido Lopes dos Santos Santiago
Leen Van Simaey
Filomeen Haerynck
Sabine Van daele
Elke De Wachter
Anne Malfroot
Patrick Lebecque
Christiane Knoop
et al.
A1
Journal Article
in
BMC MICROBIOLOGY
2010
Genotype based evaluation of Pseudomonas aeruginosa eradication treatment success in cystic fibrosis patients
Petra Schelstraete
Pieter Deschaght
Leen Van Simaey
Sabine Van daele
Filomeen Haerynck
Mario Vaneechoutte
Frans De Baets
A1
Journal Article
in
JOURNAL OF CYSTIC FIBROSIS
2010
2009
Comparison of the sensitivity of culture, PCR and quantitative real-time PCR for the detection of Pseudomonas aeruginosa in sputum of cystic fibrosis patients
Pieter Deschaght
Thierry De Baere
Leen Van Simaey
Sabine Van daele
Frans De Baets
Daniel De Vos
Jean-Paul Pirnay
Mario Vaneechoutte
A1
Journal Article
in
BMC MICROBIOLOGY
2009
Genotype based evaluation of eradication treatment success for new Pseudomonas aeruginosa infections in cystic fibrosis patients
Petra Schelstraete
Pieter Deschaght
Leen Van Simaey
Sabine Van daele
Filomeen Haerynck
Mario Vaneechoutte
Frans De Baets
C3
Conference
2009
2005
Comparison between Gram stain and culture for the characterization of vaginal microflora: Definition of a distinct grade that resembles grade I microflora and revised categorization of grade I microflora
Rita Verhelst
Hans Verstraelen
Geert Claeys
Gerda Verschraegen
Leen Van Simaey
Catharine Clara De Ganck
Ellen De Backer
Marleen Temmerman
Mario Vaneechoutte
A1
Journal Article
in
BMC MICROBIOLOGY
2005
Shared genotypes of Achromobacter xylosoxidans strains isolated from patients at a cystic fibrosis rehabilitation center
Sabine Van daele
Rita Verhelst
Geert Claeys
Gerda Verschraegen
Hilde Franckx
Leen Van Simaey
Catharine Clara De Ganck
Frans De Baets
Mario Vaneechoutte
A1
Journal Article
in
JOURNAL OF CLINICAL MICROBIOLOGY
2005
2004
Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora points to a strong assocation between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis
Rita Verhelst
Hans Verstraelen
Geert Claeys
Gerda Verschraegen
Joris Delanghe
Leen Van Simaey
Catharine Clara De Ganck
Marleen Temmerman
Mario Vaneechoutte
C1
Conference
2004
Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobiurn vaginae, Gardnerella vaginalis and bacterial vaginosis
Rita Verhelst
Hans Verstraelen
Geert Claeys
Gerda Verschraegen
Joris Delanghe
Leen Van Simaey
Catharine Clara De Ganck
Marleen Temmerman
Mario Vaneechoutte
A1
Journal Article
in
BMC MICROBIOLOGY
2004
2003
Comparison of five genotypic techniques for identification of optochin-resistant pneumococcus-like isolates
Rita Verhelst
T KAIJALAINEN
Thierry De Baere
Gerda Verschraegen
Geert Claeys
Leen Van Simaey
Catharine Clara De Ganck
Mario Vaneechoutte
A1
Journal Article
in
JOURNAL OF CLINICAL MICROBIOLOGY
2003
2002
Evaluation of amplified rDNA restriction analysis (ARDRA) for the identification of cultured mycobacteria in a diagnostic laboratory
Thierry De Baere
Ricardo de Mendonca
Geert Claeys
Gerda Verschraegen
Wouter Mijs
Rita Verhelst
Sylvianne Rottiers
Leen Van Simaey
Catharine Clara De Ganck
Mario Vaneechoutte
A1
Journal Article
in
BMC MICROBIOLOGY
2002