Research Explorer

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Researcher

Leen Van Simaey

Awards & Distinctions

29 Results

2024

Comparison of DeNovix, NanoDrop and Qubit for DNA quantification and impurity detection of bacterial DNA extracts

Nick VersmessenLeen Van SimaeyAbel Abera NegashMarjolein VandekerckhovePaco HulpiauMario VaneechouttePiet Cools

A1 Journal Article in PLOS ONE

Microbiological evaluation of ultraviolet C light-emitting diodes for disinfection of medical instruments

Hannah SiweAnnelies AerssensMieke V. FlourSilke TernestLeen Van SimaeyDuncan VerstraetenAlain KalmarIsabel Leroux-RoelsPhilip MeulemanPiet Cools

A1 Journal Article in HELIYON

2022

Optimization of propidium monoazide qPCR (viability-qPCR) to quantify the killing by the Gardnerella-specific endolysin PM-477, directly in vaginal samples from women with bacterial vaginosis

Agnieszka ŁątkaLeen Van SimaeyMarijke ReyndersPiet CoolsTess RogierBarbara LebbeLorenzo CorsiniChristine LandlingerMario Vaneechoutte

A1 Journal Article in ANTIBIOTICS-BASEL

Preclinical data on the Gardnerella-specific endolysin PM-477 indicate its potential to improve the treatment of bacterial vaginosis through enhanced biofilm removal and avoidance of resistance

Christine LandlingerVera OberbauerLenka Podpera TisakovaTimo SchwebsRocío BerdaguerLeen Van SimaeyMario VaneechoutteLorenzo Corsini

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2021

A case of phage therapy against pandrug-resistant Achromobacter xylosoxidans in a 12-year-old lung-transplanted cystic fibrosis patient

David LebeauxMaia MerabishviliEric CaudronDamien LannoyLeen Van SimaeyHans DuyvejonckRomain GuillemainCaroline ThumerelleIsabelle PodglajenFabrice Compain et al.

A1 Journal Article in VIRUSES-BASEL

Engineered phage endolysin eliminates Gardnerella biofilm without damaging beneficial bacteria in bacterial vaginosis ex vivo

C. LandlingerL. TisakovaV. OberbauerT. SchwebsA. MuhammadA. LatkaLeen Van SimaeyMario VaneechoutteA. GuschinG. Resch et al.

A1 Journal Article in PATHOGENS

2020

Comparison of procedures for RNA-extraction from peripheral blood mononuclear cells

Antonio Rodriguez SánchezHans DuyvejonckJonas Van BelleghemTessa GrypLeen Van SimaeyStefan VermeulenEls Van MechelenMario Vaneechoutte

A1 Journal Article in PLOS ONE

2019

Development of a qPCR platform for quantification of the five bacteriophages within bacteriophage cocktail 2 (BFC2)

Hans DuyvejonckMaia MerabishviliJean-Paul PirnayDaniel De VosGilbert VerbekenJonas Van BelleghemTessa GrypJulie De LeenheerKelly Van der BorghtLeen Van Simaey et al.

A1 Journal Article in SCIENTIFIC REPORTS

Emended description of Gardnerella vaginalis and description of Gardnerella leopoldii sp. nov., Gardnerella piotii sp. nov. and Gardnerella swidsinskii sp. nov., with delineation of 13 genomic species within the genus Gardnerella

Mario VaneechoutteAlexandr GuschinLeen Van SimaeyYannick GansemansFilip Van NieuwerburghPiet Cools

A1 Journal Article in INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

2018

Development and validation of an LC tandem MS assay for the quantification of β-lactam antibiotics in the sputum of cystic fibrosis patients

Katrien ForierVirginie Van HeckMieke CarlierEva Van BraeckelSabine Van daeleFrans De BaetsPetra SchelstraeteFilomeen HaerynckVeronique StoveLeen Van Simaey et al.

A1 Journal Article in JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Establishing the diagnosis of chronic colonization with Pseudomonas aeruginosa of cystic fibrosis patients : comparison of the European consensus criteria with genotyping of P. aeruginosa isolates

Leander JonckheerePetra SchelstraeteLeen Van SimaeyEva Van BraeckelJulie WillekensSabine Van daeleFrans De BaetsMario Vaneechoutte

A1 Journal Article in JOURNAL OF CYSTIC FIBROSIS

2017

Women with symptoms of a urinary tract infection but a negative urine culture : PCR-based quantification of Escherichia coli suggests infection in most cases

Stefan HeytensAn De SutterLiselotte CoorevitsPiet CoolsJerina BoelensLeen Van SimaeyThierry ChristiaensMario VaneechoutteGeert Claeys

A1 Journal Article in CLINICAL MICROBIOLOGY AND INFECTION

2016

Epidemic Achromobacter xylosoxidans strain among Belgian cystic fibrosis patients and review of literature

Piet CoolsErwin HoKatleen VranckxPetra SchelstraeteBettina WurthHilde FranckxGreet IevenLeen Van SimaeySabine Van daeleStijn Verhulst et al.

A1 Journal Article in BMC MICROBIOLOGY

Haemophilus influenzae biofilm formation in chronic otitis media with effusion

Helen Van HoeckeAnn-Sophie De PaepeEdward LambertJonas Van BelleghemPiet CoolsLeen Van SimaeyPieter DeschaghtMario VaneechoutteIngeborg Dhooge

A1 Journal Article in EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

2015

A single clone of Achromobacter xylosoxidans colonizes Belgian cystic fibrosis patients from different centres

Piet CoolsE HoPetra SchelstraeteB WürthH FranckxLeen Van SimaeySabine Van daeleS VerhulstFrans De BaetsMario Vaneechoutte

Pseudomonas aeruginosa genotyping: predicting transition to chronic colonization in cystic fibrosis patients

Leander JonckheereMario VaneechoutteFrans De BaetsSabine Van daeleFilomeen HaerynckLeen Van SimaeyPetra Schelstraete

2013

Is the improvement of CF patients, hospitalized for pulmonary exacerbation, correlated to a decrease in bacterial load?

Pieter DeschaghtPetra SchelstraeteLeen Van SimaeyMarleen VanderkerckenANN RAMANLinda MahieuSabine Van daeleFrans De BaetsMario Vaneechoutte

A1 Journal Article in PLOS ONE

2011

Granulomatous meningoencephalitis associated with Sporobolomyces roseus in a dog

Veronique SaeyAn VanhaesebrouckS MaesLeen Van SimaeyLuc Van HamPieter DeschaghtRichard Ducatelle

A1 Journal Article in VETERINARY PATHOLOGY

Rapid genotyping of Achromobacter xylosoxidans, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia isolates using melting curve analysis of RAPD-generated DNA-fragments (McRAPD)

Pieter DeschaghtLeen Van SimaeyEllen DecatEls Van MechelenSylvain BrisseMario Vaneechoutte

A1 Journal Article in RESEARCH IN MICROBIOLOGY

2010

Comparison of culture and qPCR for the detection of Pseudomonas aeruginosa in not chronically infected cystic fibrosis patients

Pieter DeschaghtPetra SchelstraeteGuido Lopes dos Santos SantiagoLeen Van SimaeyFilomeen HaerynckSabine Van daeleElke De WachterAnne MalfrootPatrick LebecqueChristiane Knoop et al.

A1 Journal Article in BMC MICROBIOLOGY

Genotype based evaluation of Pseudomonas aeruginosa eradication treatment success in cystic fibrosis patients

Petra SchelstraetePieter DeschaghtLeen Van SimaeySabine Van daeleFilomeen HaerynckMario VaneechoutteFrans De Baets

A1 Journal Article in JOURNAL OF CYSTIC FIBROSIS

2009

Comparison of the sensitivity of culture, PCR and quantitative real-time PCR for the detection of Pseudomonas aeruginosa in sputum of cystic fibrosis patients

Pieter DeschaghtThierry De BaereLeen Van SimaeySabine Van daeleFrans De BaetsDaniel De VosJean-Paul PirnayMario Vaneechoutte

A1 Journal Article in BMC MICROBIOLOGY

Genotype based evaluation of eradication treatment success for new Pseudomonas aeruginosa infections in cystic fibrosis patients

Petra SchelstraetePieter DeschaghtLeen Van SimaeySabine Van daeleFilomeen HaerynckMario VaneechoutteFrans De Baets

2005

Comparison between Gram stain and culture for the characterization of vaginal microflora: Definition of a distinct grade that resembles grade I microflora and revised categorization of grade I microflora

Rita VerhelstHans VerstraelenGeert ClaeysGerda VerschraegenLeen Van SimaeyCatharine Clara De GanckEllen De BackerMarleen TemmermanMario Vaneechoutte

A1 Journal Article in BMC MICROBIOLOGY

Shared genotypes of Achromobacter xylosoxidans strains isolated from patients at a cystic fibrosis rehabilitation center

Sabine Van daeleRita VerhelstGeert ClaeysGerda VerschraegenHilde FranckxLeen Van SimaeyCatharine Clara De GanckFrans De BaetsMario Vaneechoutte

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

2004

Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora points to a strong assocation between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis

Rita VerhelstHans VerstraelenGeert ClaeysGerda VerschraegenJoris DelangheLeen Van SimaeyCatharine Clara De GanckMarleen TemmermanMario Vaneechoutte

Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobiurn vaginae, Gardnerella vaginalis and bacterial vaginosis

Rita VerhelstHans VerstraelenGeert ClaeysGerda VerschraegenJoris DelangheLeen Van SimaeyCatharine Clara De GanckMarleen TemmermanMario Vaneechoutte

A1 Journal Article in BMC MICROBIOLOGY

2003

Comparison of five genotypic techniques for identification of optochin-resistant pneumococcus-like isolates

Rita VerhelstT KAIJALAINENThierry De BaereGerda VerschraegenGeert ClaeysLeen Van SimaeyCatharine Clara De GanckMario Vaneechoutte

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

2002

Evaluation of amplified rDNA restriction analysis (ARDRA) for the identification of cultured mycobacteria in a diagnostic laboratory

Thierry De BaereRicardo de MendoncaGeert ClaeysGerda VerschraegenWouter MijsRita VerhelstSylvianne RottiersLeen Van SimaeyCatharine Clara De GanckMario Vaneechoutte

A1 Journal Article in BMC MICROBIOLOGY