Research Explorer

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Researcher

Leen Van de Sande

Awards & Distinctions

25 Results

2024

Preclinical activity of two paclitaxel nanoparticle formulations after intraperitoneal administration in ovarian cancer murine xenografts

Jesse DemuytereCharlotte CarlierLeen Van de SandeAnne HoorensKaat De ClercqSilvia GiordanoLavinia MorosiCristina MatteoMassimo ZucchettiEnrico Davoli et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF NANOMEDICINE

2022

Phase I study of intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for unresectable peritoneal metastases

Wim CeelenLouis SandraLeen Van de SandeM GraversenMB MortensenAn VermeulenElke GasthuysDries ReyndersSarah CosynsAnne Hoorens et al.

A1 Journal Article in EBIOMEDICINE

2021

Intraperitoneal aerosolized nanoparticle albumin based paclitaxel (NAB-PTX) for irresectable peritoneal metastases : a first in human phase I study

Wim CeelenLouis SandraLeen Van de SandeMartin GraversenAn VermeulenDries ReyndersSarah CosynsAnne HoorensWouter Willaert

The feasibility of pressurised intraperitoneal aerosolised virotherapy (PIPAV) to administer oncolytic adenoviruses

Sophia J. TateLeen Van de SandeWim CeelenJared TorkingtonAlan L. Parker

A1 Journal Article in PHARMACEUTICS

2020

Albumin-based cancer therapeutics for intraperitoneal drug delivery : a review

Leen Van de SandeSarah CosynsWouter WillaertWim Ceelen

A1 Journal Article in DRUG DELIVERY

Effects of electrostatic precipitation on IP drug distribution and tissue penetration of nanoparticles

Mohammad Rahimi GorjiLeen Van de SandeCharlotte DebbautGhader GhorbaniaslWouter WillaertSarah CosynsWim Ceelen

Electrostatic intraperitoneal aerosol delivery of nanoparticles : proof of concept and preclinical validation

Leen Van de SandeMohammad Rahimi GorjiSilvia GiordanoEnrico DavoliCristina MatteoSonke DetlefsenKatharina D'HerdeHelena BraetMolood ShariatiKatrien Remaut et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Electrostatic precipitation is a valuable adjunct to pressurized intraperitoneal aerosol chemotherapy : an in vitro study

Leen Van de SandeMelanie CoetsierAzarie VictorSarah CosynsWouter WillaertMolood ShariatiHelena BraetKatrien RemautWim Ceelen

Intraperitoneal aerosolized drug delivery : technology, recent developments, and future outlook

Mohammad Rahimi GorjiLeen Van de SandeCharlotte DebbautGhader GhorbaniaslHelena BraetSarah CosynsKatrien RemautWouter WillaertWim Ceelen

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Pressurized intraperitoneal aerosol chemotherapy for the treatment of irresectable peritoneal metastasis

Leen Van de SandeWim CeelenWouter WillaertKatrien Remaut

Synergy between intraperitoneal aerosolization (PIPAC) and cancer nanomedicine : cisplatin-loaded polyarginine-hyaluronic acid nanocarriers efficiently eradicate peritoneal metastasis of advanced human ovarian cancer

Molood ShariatiGiovanna LolloKevin MathaBenedicte DescampsChristian VanhoveLeen Van de SandeWouter WillaertLieve BalcaenFrank VanhaeckeJean-Pierre Benoit et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

2019

Computational fluid dynamics model of pressurized intraperitoneal aerosol chemotherapy : gravity matters!

Mohammad Rahimi GorjiLeen Van de SandeCharlotte DebbautPatrick SegersWouter WillaertWim Ceelen

Computational model of pressurized intraperitoneal chemotherapy (PIPAC) for carcinomatosis treatment

Mohammad Rahimi GorjiCharlotte DebbautLeen Van de SandeWouter WillaertPatrick SegersWim Ceelen

Establishment of a rat ovarian peritoneal metastasis model to study pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Leen Van de SandeWouter WillaertSarah CosynsKaat De ClercqMolood ShariatiKatrien RemautWim Ceelen

A1 Journal Article in BMC CANCER

High pressure nebulization (PIPAC) versus injection for the intraperitoneal administration of mRNA complexes

Molood ShariatiHeyang ZhangLeen Van de SandeBenedicte DescampsChristian VanhoveWouter WillaertWim CeelenStefaan De SmedtKatrien Remaut

A1 Journal Article in PHARMACEUTICAL RESEARCH

Safety and preliminary efficacy of electrostatic precipitation during pressurized intraperitoneal aerosol chemotherapy (PIPAC) for unresectable carcinomatosis

Wouter WillaertLeen Van de SandeElke Van DaeleDirk Van de PutteYves Van NieuwenhovePiet PattynWim Ceelen

A1 Journal Article in EJSO

2018

EPIPAC for unresectabele peritoneal carcinomatosis : experience of 125 procedures

Wouter WillaertLeen Van de SandeElke Van DaeleDirk Van de PutteLucas E MatthyssensKatrien Van RenterghemYves Van NieuwenhovePiet PattynWim Ceelen

Electrostatic pressurizd intraperitoneal aerosol chemotherapy for unresectable peritoneal carcinomatosis : experience of 125 procedures

Wouter WillaertLeen Van de SandeWim Ceelen

Electrostatic pressurized intraperitoneal aerosol chemotherapy (EPIPAC) for unresectable peritoneal carcinomatosis : experience of 98 procedures

Wouter WillaertLeen Van de SandePiet PattynWim Ceelen

Intraperitoneal aerosolization of albumin-stabilized paclitaxel nanoparticles (Abraxane™) for peritoneal carcinomatosis : a phase I first-in-human study

Leen Van de SandeMartin GraversenMartin HubnerMarc PocardMarc ReymondMarco VairaSarah CosynsWouter WillaertWim Ceelen

A2 Journal Article in PLEURA AND PERITONEUM

Phase 1 study about nab-paclitaxel

Wouter WillaertLeen Van de SandeWim Ceelen

2017

Establishment of a rat model for pressurized intraperitoneal aerosol chemotherapy

Leen Van de SandeWouter WillaertSarah CosynsWim Ceelen

Pressurized IntraPeritoneal Aerosol Chemotherapy for unresectable peritoneal carcinomatosis : experience of 63 procedures

Wouter WillaertLeen Van de SandeSarah CosynsElke Van DaeleDirk Van de PutteLucas E MatthyssensKatrien Van RenterghemYves Van NieuwenhovePiet PattynWim Ceelen

Pressurized intraperitoneal aerosol chemotherapy, a new surgical technique for the treatment of unresectable peritoneal carcinomatosis

Wouter WillaertSarah CosynsLeen Van de SandePiet PattynWim Ceelen

2016

Pressurized intraperitoneal aerosol chemotherapy (PIPAC), a new surgical technique for the treatment of unresectable peritoneal carcinomatosis

Sarah CosynsLeen Van de SandeWim CeelenWouter Willaert