Research Explorer

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Researcher

Leen Timbermont

Awards & Distinctions

69 Results

2016

Non-toxic perfringolysin O and α-toxin derivatives as potential vaccine candidates against bovine necrohaemorrhagic enteritis

Stefanie VerherstraetenEvy GoossensBonnie ValgaerenBart PardonLeen TimbermontFreddy HaesebrouckRichard DucatellePiet DeprezFilip Van Immerseel

A1 Journal Article in VETERINARY JOURNAL

The C-terminal domain of Clostridium perfringens alpha toxin as a vaccine candidate against bovine necrohemorrhagic enteritis

Evy GoossensStefanie VerherstraetenBonnie ValgaerenBart PardonLeen TimbermontStijn SchauvliegeDiego RodrigoFreddy HaesebrouckRichard DucatellePiet Deprez et al.

A1 Journal Article in VETERINARY RESEARCH

Toxin-neutralizing antibodies protect against Clostridium perfringens-induced necrosis in an intestinal loop model for bovine necrohemorrhagic enteritis

Evy GoossensStefanie VerherstraetenBonnie ValgaerenBart PardonLeen TimbermontStijn SchauvliegeDiego RodrigoFreddy HaesebrouckRichard DucatellePiet Deprez et al.

A1 Journal Article in BMC VETERINARY RESEARCH

2015

Haemorrhagic enteritis in newborn calves associated with Clostridium perfringens and colostrum delivery

Bonnie ValgaerenBart PardonStefanie VerherstraetenEvy GoossensLeen TimbermontFreddy HaesebrouckRichard DucatelleFilip Van ImmerseelPiet Deprez

A2 Journal Article in JMM CASE REPORTS

Perfringolysin O : the underrated Clostridium perfringens toxin?

Stefanie VerherstraetenEvy GoossensBonnie ValgaerenBart PardonLeen TimbermontFreddy HaesebrouckRichard DucatellePiet DeprezKristin R WadeRodney Tweten et al.

A1 Journal Article in TOXINS

Toxin-neutralizing antibodies protect against Clostridium perfringens challenge in an intestinal loop model for bovine enterotoxaemia

Evy GoossensStefanie VerherstraetenBonnie ValgaerenBart PardonLeen TimbermontStijn SchauvliegeFreddy HaesebrouckRichard DucatellePiet DeprezFilip Van Immerseel

Veal calves produce less antibodies against C. perfringens alpha toxin compared to beef calves

Bonnie ValgaerenBart PardonEvy GoossensStefanie VerherstraetenSophie RoelandtLeen TimbermontNicky Van Der VekensSabrina StuyvaertLinde GilleLaura Van Driessche et al.

A1 Journal Article in TOXINS

2014

Absence of an active shift from maternal to active immunity against Clostridium perfringens alpha toxin in veal calves compared to conventional beef calves

Bonnie ValgaerenBart PardonStefanie VerherstraetenEvy GoossensLeen TimbermontRichard DucatelleFilip Van ImmerseelPiet Deprez

Clostridium perfringens strains from bovine enterotoxemia cases are not superior in in vitro production of alpha toxin, perfringolysin O and proteolytic enzymes

Evy GoossensStefanie VerherstraetenLeen TimbermontBonnie ValgaerenBart PardonFreddy HaesebrouckRichard DucatellePiet DeprezFilip Van Immerseel

A1 Journal Article in BMC VETERINARY RESEARCH

Perfrin, a novel bacteriocin associated with netB positive Clostridium perfringens strains from broilers with necrotic eneteritis

Leen TimbermontLina De SmetFilip Van NieuwerburghValeria R PareiraGonzalez Van DriesscheFreddy HaesebrouckRichard DucatelleJohn PrescottDieter DeforceBart Devreese et al.

A1 Journal Article in VETERINARY RESEARCH

Progress and problems in vaccination against necrotic enteritis in broiler chickens

Dorien MotLeen TimbermontFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

A1 Journal Article in AVIAN PATHOLOGY

The mycotoxin deoxynivalenol predisposes for the development of Clostridium perfringens-induced necrotic enteritis in broiler chickens

Gunther AntonissenFilip Van ImmerseelFrank PasmansRichard DucatelleFreddy HaesebrouckLeen TimbermontMarc VerlindenGeert JanssensVenessa EeckhautMia Eeckhout et al.

A1 Journal Article in PLOS ONE

2013

Alpha toxin and perfringolysin act synergistically to induce hemorrhagic enteritis in veal calves

Stefanie VerherstraetenEvy GoossensBonnie ValgaerenBart PardonLeen TimbermontStijn SchauvliegeFreddy HaesebrouckRichard DucatellePiet DeprezFilip Van Immerseel

Chronic exposure to the mycotoxin deoxynivalenol affects the intestinal barrier function in broilers

Gunther AntonissenFilip Van ImmerseelFrank PasmansRichard DucatelleFreddy HaesebrouckAnn OsselaereLeen TimbermontMarc VerlindenMia EeckhoutEvelyne Delezie et al.

Day-of-hatch vaccination is not protective against necrotic enteritis in broiler chickens

Dorien MotLeen TimbermontEvelyne DelezieFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

A1 Journal Article in AVIAN PATHOLOGY

Deoxynivalenol predisposes for necrotic enteritis by affecting the intestinal barrier in broilers

Gunther AntonissenFilip Van ImmerseelFrank PasmansRichard DucatelleFreddy HaesebrouckLeen TimbermontMarc VerlindenGeert JanssensMia EeckhoutSarah De Saeger et al.

Effects of Fusarium mycotoxins on the pathogenesis of necrotic enteritis in broilers

Gunther AntonissenSiska CroubelsFrank PasmansRichard DucatelleFreddy HaesebrouckLeen TimbermontMarc VerlindenGeert JanssensMia EeckhoutSarah De Saeger et al.

Influence of mycotoxin contamination on intestinal protein availability for clostridial proliferation

Gunther AntonissenSiska CroubelsFrank PasmansRichard DucatelleFreddy HaesebrouckLeen TimbermontMarc VerlindenGeert JanssensSabine HessenbergerAn Martel et al.

Intestinal clostridial counts have no diagnostic value in the diagnosis of enterotoxaemia in veal calves

Bonnie ValgaerenBart PardonStefanie VerherstraetenEvy GoossensLeen TimbermontFreddy HaesebrouckRichard DucatellePiet DeprezFilip Van Immerseel

A1 Journal Article in VETERINARY RECORD

Lesion development in a new intestinal loop model indicates the involvement of a shared Clostridium perfringens virulence factor in haemorrhagic enteritis in calves

Bonnie ValgaerenBart PardonEvy GoossensStefanie VerherstraetenStijn SchauvliegeLeen TimbermontRichard DucatellePiet DeprezFilip Van Immerseel

A1 Journal Article in JOURNAL OF COMPARATIVE PATHOLOGY

Prevalence and bacterial colonization of fundic ulcerations in veal calves

Bonnie ValgaerenBart PardonBram FlahouStefanie VerherstraetenEvy GoossensLeen TimbermontFreddy HaesebrouckRichard DucatelleFilip Van ImmerseelPiet Deprez

A1 Journal Article in VETERINARY RECORD

Recombinant Clostridium perfringens α toxin as a potential vaccine against bovine enterotoxemia

Evy GoossensStefanie VerherstraetenBonnie ValgaerenBart PardonLeen TimbermontFreddy HaesebrouckRichard TitballRichard DucatellePiet DeprezFilip Van Immerseel

The impact of mycotoxin co-occurence on necrotic enteritis in broilers

Gunther AntonissenFilip Van ImmerseelFrank PasmansRichard DucatelleFreddy HaesebrouckLeen TimbermontMarc VerlindenMia EeckhoutSarah De SaegerEvelyne Delezie et al.

The synergistic necrohemorrhagic action of Clostridium perfringens perfringolysin and alpha toxin in the bovine intestine and against bovine endothelial cells

Stefanie VerherstraetenEvy GoossensBonnie ValgaerenBart PardonLeen TimbermontKaren VermeulenStijn SchauvliegeFreddy HaesebrouckRichard DucatellePiet Deprez et al.

A1 Journal Article in VETERINARY RESEARCH

2012

C. perfringens isolates from different origin induce typical hemorrhagic enteritis-like lesions in an in vivo jejunal loop assay in calves

Bonnie ValgaerenBart PardonEvy GoossensStefanie VerherstraetenStijn SchauvliegeLeen TimbermontRichard DucatelleFilip Van ImmerseelPiet Deprez

Deoxynivalenol predisposes for the development of necrotic enteritis in broilers

Gunther AntonissenFilip Van ImmerseelFrank PasmansRichard DucatelleFreddy HaesebrouckLeen TimbermontMarc VerlindenJeroen DewulfMia EeckhoutSarah De Saeger et al.

Efficacy of active and formalin inactivated supernatant derived vaccines against necrotic enteritis

Dorien MotLeen TimbermontFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

Lesion development in a new intestinal loop model indicates the involvement of a shared Clostridium perfringence virulence factor in hemorrhagic enteritis in calves

Bonnie ValgaerenBart PardonStefanie VerherstraetenEvy GoossensStijn SchauvliegeLeen TimbermontRichard DucatelleFilip Van ImmerseelPiet Deprez

Pathogenesis of Clostridium perfringens infections: the case of poultry

Leen TimbermontKoen ChiersHorst PosthausFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

Pathogenesis of Clostridium perfringens type C enteritis: the porcine case

Horst PosthausVanessa SchumacherAn MartelFrank PasmansLeen TimbermontRichard DucatelleFilip Van Immerseel

Perfrin, a novel bacteriocin from a necrotic enteritis associated Clostridium perfringens strain

Leen TimbermontSofie GeeraertsLina De SmetFilip Van NieuwerburghValeria R ParreiraGonzalez Van DriesscheFreddy HaesebrouckRichard DucatelleJohn PrescottDieter Deforce et al.

Practical pitfalls in vaccination against necrotic enteritis in broilers

Dorien MotLeen TimbermontFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

Purification and characterization of Perfrin, a novel bacteriocin from a virulent Clostridium perfringens strain

Leen TimbermontLina De SmetAnouk LanckrietFilip Van NieuwerburghValeria R ParreiraGonzalez Van DriesscheFreddy HaesebrouckRichard DucatelleJohn PrescottDieter Deforce et al.

The mycotoxin deoxynivalenol predisposes for the development of necrotic enteritis in broilers

Gunther AntonissenSiska CroubelsFrank PasmansRichard DucatelleFreddy HaesebrouckLeen TimbermontMarc VerlindenJeroen DewulfMia EeckhoutSarah De Saeger et al.

The mycotoxin deoxynivalenol predisposes for the development of necrotic enteritis in broilers

Gunther AntonissenFilip Van ImmerseelFrank PasmansRichard DucatelleFreddy HaesebrouckLeen TimbermontMarc VerlindenJeroen DewulfMia EeckhoutSarah De Saeger et al.

2011

Clostridium perfringens strains of various origin can cause hemorrhagic enteritis in a calf intestinal loop model

Bonnie ValgaerenEvy GoossensStefanie VerherstraetenBart PardonLeen TimbermontStijn SchauvliegheRichard DucatelleFilip Van ImmerseelPiet Deprez

Effect of supplementation of a combination of Sacchoromyces cereviseae and butyric acid on Clostridium perfringens faecal counts and weight gain in white veal calves

Bonnie ValgaerenBart PardonRandy BooneEvy GoossensLeen TimbermontStefanie VerherstraetenFilip Van ImmerseelPiet Deprez

Necrotic enteritis in broilers: an updated review on the pathogenesis

Leen TimbermontFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

A1 Journal Article in AVIAN PATHOLOGY

Prevalence of Clostridium perfringens in fundic ulcerations from Holstein Friesian and Belgian Blue white veal calves

Bonnie ValgaerenBart PardonEvy GoossensLeen TimbermontStefanie VerherstraetenFilip Van ImmerseelPiet Deprez

The use of an intestinal loop model in semi-ruminating and ruminating calves under complete anaesthesia: an in vivo model with intact neural and vascular systems

Bonnie ValgaerenStijn SchauvliegeBart PardonEvy GoossensStefanie VerherstraetenLeen TimbermontRichard DucatelleFilip Van ImmerseelPiet Deprez

2010

Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils

Leen TimbermontAnouk LanckrietJeroen DewulfNathalie NolletKoen SchwarzerFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

A1 Journal Article in AVIAN PATHOLOGY

Isolation of a clonal population of Clostridium perfringens type A from a Belgian Blue calf with abomasal ulceration

Filip Van ImmerseelBart PardonSofie MaesMarc HeyndrickxLeen TimbermontFilip BoyenFreddy HaesebrouckRichard DucatellePiet Deprez

A1 Journal Article in JOURNAL OF COMPARATIVE PATHOLOGY

Necrotic enteritis, an emerging disease in broilers, is associated with specific Clostridium perfringens strains

Leen TimbermontRichard DucatelleAnouk LanckrietFreddy HaesebrouckFilip Van Immerseel

The effect of commonly used anticoccidials and antibiotics in a subclinical necrotic enteritis model

Anouk LanckrietLeen TimbermontMaarten De GussemMaja MarienDieter VancraeynestFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

A1 Journal Article in AVIAN PATHOLOGY

Variable protection after vaccination of broiler chickens against necrotic enteritis using supernatants of different Clostridium perfringens strains

Anouk LanckrietLeen TimbermontVenessa EeckhautFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

A1 Journal Article in VACCINE

2009

Antimicrobial resistance in Clostridium perfringens isolates from broilers in Belgium

Ahmadreza GholamiandehkordiVenessa EeckhautAnouk LanckrietLeen TimbermontLotte BjerrumRichard DucatelleFreddy HaesebrouckFilip Van Immerseel

A1 Journal Article in VETERINARY RESEARCH COMMUNICATIONS

Clostridium perfringens and abomasal ulcers in calves: is the bacterium causative?

Filip Van ImmerseelBart PardonSofie MaesMark HeyndrickxLeen TimbermontFilip BoyenFreddy HaesebrouckRichard DucatellePiet Deprez

Generation of single-copy transposon insertions in Clostridium perfringens by electroporation of phage mu DNA transposition complexes

Anouk LanckrietLeen TimbermontLotta J HapponenMaria I PajunenFrank PasmansFreddy HaesebrouckRichard DucatelleHarri SavilahtiFilip Van Immerseel

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Intra-species growth-inhibition by Clostridium perfringens is a possible virulence trait in necrotic enteritis in broilers

Leen TimbermontAnouk LanckrietFrank PasmansFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

A1 Journal Article in VETERINARY MICROBIOLOGY

Origin of Clostridium perfringens isolates determines the ability to induce necrotic enteritis in broilers

Leen TimbermontAnouk LanckrietAhmadreeza GholamiandehkordiFrank PasmansAn MartelFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

A1 Journal Article in COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Purification and partial characterization of a novel antimicrobial peptide from Clostridium perfringens strain 56

Filip Van ImmerseelLeen TimbermontLina De SmetAnouk LanckrietGonzalez Van DriesscheFreddy HaesebrouckBart DevreeseRichard Ducatelle

Virulence mechanisms of Clostridium perfringens in broiler necrotic enteritis

Leen TimbermontFilip Van ImmerseelRichard Ducatelle

2008

Control of Clostridium perfringens induced necrotic enteritis in broilers by butyric acid, medium chain fatty acids and essential oils

Leen TimbermontAnouk LanckrietNatalie NolletKoen SchwarzerFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

Evaluation of the efficacy of a unique Lactobacillus-based product in a necrotic enteritis model in broilers

Leen TimbermontAnouk LanckrietAhmadreza GholamiandehkordiM MARIEND VANCRAEYNESTM DE GUSSEMFrank PasmansRichard DucatelleFreddy HaesebrouckFilip Van Immerseel

Generation of single-copy transposon insertions in Clostridium perfringens by electroporation of phage Mu DNA transposition complexes

Anouk LanckrietLeen TimbermontLJ HapponenM PajunenFrank PasmansFreddy HaesebrouckRichard DucatelleS SavilahtiFilip Van Immerseel

Intra-species growth-inhibition is an additional virulence trait of Clostridium perfringens in broiler necrotic enteritis

Leen TimbermontAnouk LanckrietFrank PasmansFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

Origin of Clostridium perfringens isolates determines the ability to induce necrotic enteritis in broilers

Leen TimbermontAnouk LanckrietAhmadreza GholamiandehkordiFrank PasmansAn MartelFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

2007

A semi-quantitative scoring system for gut lesions in a subclinical necrotic enteritis model

Leen TimbermontAhmadreza GholamiandehkordiAnouk LanckrietFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

Quantification of gut lesions in a subclinical necrotic enteritis model

Ahmadreza GholamiandehkordiLeen TimbermontAnouk LanckrietWim Van Den BroeckK PEDERSENJeroen DewulfFrank PasmansFreddy HaesebrouckRichard DucatelleFilip Van Immerseel

A1 Journal Article in AVIAN PATHOLOGY

2006

Clostridium perfringens bij pluimvee: ubiquitaire kiem, normale darmbewoner of pathogeen?

Filip Van ImmerseelLeen TimbermontAnouk LanckrietAhmadreza GholamiandehkordiFrank PasmansFreddy HaesebrouckRichard Ducatelle

A2 Journal Article in VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT

Developments and pitfalls of feed acidification in controlling gut pathogens in poultry, with emphasis on Salmonella

Filip Van ImmerseelInne GantoisLotte BohezLeen TimbermontFilip BoyenI HAUTEFORTJ HINTONFrank PasmansFreddy HaesebrouckRichard Ducatelle

Bookchapter in Avian Gut Function in Health and Disease

Lesions associated with Clostridium perfringens infection in a chicken intestinal loop model

Richard DucatelleLeen TimbermontAnouk LanckrietAhmadreza GholamiandehkordiFreddy HaesebrouckFilip Van Immerseel

Oral immunisation of laying hens with the live vaccine strains of TAD Salmonella vac (R) E and TAD Salmonella vac (R) T reduces internal egg contamination with Salmonella Enteritidis

Inne GantoisRichard DucatelleLeen TimbermontFilip BoyenLotte BohezFreddy HaesebrouckFrank PasmansFilip Van Immerseel

A1 Journal Article in VACCINE

Pathogenese en bestrijding van Salmonella bij leghennen en vleeskippen

Filip Van ImmerseelLeen TimbermontE VAN COILLIEN BOTTELDOORNW MESSENSJ DE BUCKL HERMANFreddy HaesebrouckMarc HeyndrickxRichard Ducatelle

The use of organic acids to combat Salmonella in poultry: a mechanistic explanation of the efficacy

Filip Van ImmerseelJB RUSSELLMD FLYTHEInne GantoisLeen TimbermontFrank PasmansFreddy HaesebrouckRichard Ducatelle

A1 Journal Article in AVIAN PATHOLOGY

2005

Developments and pitfalls of feed acidification to control gut pathogens in poultry, with emphasis on Salmonella

Filip Van ImmerseelInne GantoisLeen TimbermontI HAUTEFORTJ HINTONFrank PasmansFreddy HaesebrouckRichard Ducatelle

Salmonella in pluimveevlees en eieren: een gevaar voor de consument die om efficiënte bestrijdingsprogramma’s vraagt

Filip Van ImmerseelJeroen De BuckLeen TimbermontInne GantoisLotte BohezFilip BoyenFrank PasmansSophie BertrandJ COLLARDC SAEGERMAN et al.

A2 Journal Article in VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT

Supplementation of coated butyric acid in the feed reduces colonization and shedding of Salmonella in poultry

Filip Van ImmerseelFilip BoyenInne GantoisLeen TimbermontLotte BohezFrank PasmansFreddy HaesebrouckRichard Ducatelle

A1 Journal Article in POULTRY SCIENCE

2004

Clinical isolates of Clostridium perfringens in poultry are not superior alpha toxin producers in vitro

A GHOLAMIANDEHKORDILeen TimbermontAnouk LanckrietFreddy HaesebrouckRichard DucatelleFilip Van Immerseel