Research Explorer

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Researcher

Leen Seys

Publications & Research Data

Awards & Distinctions

22 Results

2026

Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages

Stijn VerwaerdeJean-François HastirSjoerd SchettersUrsula SmoleLeen SeysAntonio Pires da Silva BaptistaKieran EnglishMartijn SchuijsHelena Catharine AegerterKarel Van Damme et al.

A1 Journal Article in IMMUNITY

2025

Unravelling the cellular sources and intestinal location of IL-17A production during a Giardia infection

Charlotte Van CrombruggeBregt DecorteLeen SeysPeter Geldhof

Unravelling the cellular sources and location of IL-17A production during a Giardia infection

Charlotte Van CrombruggeBregt DecorteLeen SeysPeter Geldhof

A1 Journal Article in SCIENTIFIC REPORTS

2024

Role of glycosylation in the immunogenicity of the nematode specific activation-associated secreted proteins (ASPs) and its implication in vaccine efficacy

Laurens ZwanenburgPeter GeldhofLeen Seys

2023

Plant-based production of a protective vaccine antigen against the bovine parasitic nematode Ostertagia ostertagi

Laurens ZwanenburgJimmy BorlooBregt DecorteMyrna J. M. BunteSanaz MokhtariSonia SernaNiels-C. ReichardtLeen SeysAngela van DiepenArjen Schots et al.

A1 Journal Article in SCIENTIFIC REPORTS

Unraveling the cellular sources of IL-17A during a Giardia infection

Charlotte Van CrombruggeLeen SeysBregt DecortePeter Geldhof

2022

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Levi HosteLisa RoelsLeslie NaesensVictor BosteelsStijn VanheeSam DupontCedric BosteelsRobin BrowaeysNiels VandammeKevin Verstaen et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2021

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

Richard de ReuverEvelien DierickBartosz WiernickiKatrien StaesLeen SeysEllen De MeesterTuur MuyldermansAlexander BotzkiBart LambrechtFilip Van Nieuwerburgh et al.

A1 Journal Article in CELL REPORTS

Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID) : a factorial, randomised, controlled trial

Jozefien DeclercqKarel Van DammeElisabeth De LeeuwBastiaan MaesCedric BosteelsSimon TavernierStefanie De BuyserRoos ColmanMaya HitesGil Verschelden et al.

A1 Journal Article in LANCET RESPIRATORY MEDICINE

2018

Association of innate defense proteins BPIFA1 and BPIFB1 with disease severity in COPD

Elise De SmetLeen SeysFien VerhammeBart M VanaudenaerdeGuy BrusselleColin D BingleKen Bracke

A1 Journal Article in INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

DPP4, the Middle East respiratory syndrome coronavirus receptor, is upregulated in lungs of smokers and chronic obstructive pulmonary disease patients

Leen SeysW WidagdoFien VerhammeAlex KleinjanWim JanssensGuy JoosKen BrackeBart L HaagmansGuy Brusselle

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

2017

Dysregulation of type 2 innate lymphoid cells and TH2 cells impairs pollutant-induced allergic airway responses

Katrien De GroveSharen ProvoostRudi W HendriksAndrew NJ McKenzieLeen SeysSmitha KumarTania MaesGuy BrusselleGuy Joos

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure

Fien VerhammeLeen SeysElise De SmetSharen ProvoostW JanssensDirk ElewautGuy JoosGuy BrusselleKen Bracke

A1 Journal Article in MUCOSAL IMMUNOLOGY

Epidemiology and impact of chronic bronchitis in chronic obstructive pulmonary disease

Lies LahousseLeen SeysGuy JoosOscar H FrancoBruno H StrickerGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

MicroRNA profiling reveals a role for microRNA-218-5p in the pathogenesis of chronic obstructive pulmonary disease

Griet ConickxPieter MestdaghFrancisco Avila CobosFien VerhammeTania MaesBart M VanaudenaerdeLeen SeysLies LahousseRichard Y KimAlan C Hsu et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The role of dicer in alveolar macrophages and dendritic cells in smoke-induced inflammation

Elise De SmetPieter MestdaghS ProvoostLeen SeysGuy JoosKarim VermaelenGuy BrusselleKen Bracke

2016

B cells in chronic obstructive pulmonary disease : moving to center stage

Francesca PolverinoLeen SeysKen BrackeCaroline A Owen

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Epidemiology of chronic bronchitis in chronic obstructive pulmonary disease (COPD)

Leen SeysLies LahousseGuy JoosA HofmanB StrickerGuy Brusselle

Mucosal immunity in COPD : from mucociliary dysfunction to lymphoid follicles

Leen SeysGuy BrusselleKen Bracke

2015

Airway surface dehydration aggravates cigarette smoke-induced hallmarks of COPD in mice

Leen SeysFien VerhammeLisa DupontElke DesauterJulia DuerrAyca Seyhan AgircanGriet ConickxGuy JoosGuy BrusselleMarcus A Mall et al.

A1 Journal Article in PLOS ONE

Role of B cell-activating factor in chronic obstructive pulmonary disease

Leen SeysFien VerhammeAnja SchinwaldHamida HammadDanen Mootoosamy CunoosamyClaudie Bantsimba-MalandaAlan SabirshEileen McCallLiz FlavellRonald Herbst et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

2013

Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary disease

Ken BrackeFien VerhammeLeen SeysClaudie Bantsimba-MalandaDanen Mootoosamy CunoosamyRonald HerbstHamida HammadBart LambrechtGuy JoosGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE