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Researcher
Leen Puimège
Profile
Projects
Publications
Activities
Awards & Distinctions
17
Results
2015
Determining differentially expressed miRNAs and validating miRNA-target relationships using the SPRET/Ei mouse strain
Steven Timmermans
Filip Van Hauwermeiren
Leen Puimège
Lien Dejager
Elien Van Wonterghem
Valerie Vanhooren
Pieter Mestdagh
Claude Libert
Roosmarijn Vandenbroucke
A1
Journal Article
in
MAMMALIAN GENOME
2015
Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1
Sophie Steeland
Leen Puimège
Roosmarijn Vandenbroucke
Filip Van Hauwermeiren
Jurgen Haustraete
Nick Devoogdt
Paco Hulpiau
Geert Leroux-Roels
Debby Laukens
Philip Meuleman
et al.
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2015
Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1
Leen Puimège
Filip Van Hauwermeiren
Sophie Steeland
Sara Van Ryckeghem
Jolien Vandewalle
Sofie Lodens
Lien Dejager
Sofie Vandevyver
Jan Staelens
Steven Timmermans
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2015
2014
Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models
Filip Van Hauwermeiren
Roosmarijn Vandenbroucke
Lynda Grine
Leen Puimège
Elien Van Wonterghem
Hong Zhang
Claude Libert
A1
Journal Article
in
INTERNATIONAL JOURNAL OF CANCER
2014
Regulation and dysregulation of tumor necrosis factor receptor-1
Leen Puimège
Claude Libert
Filip Van Hauwermeiren
A1
Journal Article
in
CYTOKINE & GROWTH FACTOR REVIEWS
2014
2013
A molecular genetic analysis of TNFR1 regulation in SPRET/Ei and generation of new TNFR1 inhibitory tools
Leen Puimège
Claude Libert
Dissertation
2013
LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome
Iris Pinheiro
Lien Dejager
Ioanna Petta
Sofie Vandevyver
Leen Puimège
Tina Mahieu
Marlies Ballegeer
Filip Van Hauwermeiren
Carlo Riccardi
Marnik Vuylsteke
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2013
Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium
Filip Van Hauwermeiren
Marietta Armaka
Niki Karagianni
Ksanthi Kranidioti
Roosmarijn Vandenbroucke
Sonja Loges
Maarten Van Royen
Jan Staelens
Leen Puimège
Ajay Palagani
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2013
2012
Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases
Roosmarijn Vandenbroucke
Eline Dejonckheere
Philippe Van Lint
Delphine Demeestere
Elien Van Wonterghem
Ineke Vanlaere
Leen Puimège
Filip Van Hauwermeiren
Riet De Rycke
Conor Mc Guire
et al.
A1
Journal Article
in
JOURNAL OF NEUROSCIENCE
2012
2011
Strategies to inhibit the toxicity of systemic TNF treatment
Filip Van Hauwermeiren
Leen Puimège
Sofie Vandevyver
Tom Van Bogaert
Ineke Vanlaere
Liesbeth Huys
Lien Dejager
Claude Libert
A1
Journal Article
in
Advances in Experimental Medicine and Biology
2011
2010
Increased glucocorticoid receptor expression and activity mediate the LPS resistance of SPRET/EI mice
Lien Dejager
Iris Pinheiro
Leen Puimège
Ye-Dong Fan
Lies Gremeaux
Hugo Vankelecom
Claude Libert
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2010
2009
Increased rat serum corticosterone suggests immunomodulation by stimulation of the vagal nerve
Veerle De Herdt
Leen Puimège
Jan De Waele
Robrecht Raedt
Tine Wyckhuys
RIEM EL TAHRY
Claude Libert
Wytse Wadman
Paul Boon
Kristl Vonck
A1
Journal Article
in
JOURNAL OF NEUROIMMUNOLOGY
2009
2007
Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock
Ben Wielockx
Jan Staelens
Leen Puimège
Ineke Vanlaere
Maarten Van Roy
Philippe Van Lint
Frans Van Roy
Claude Libert
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2007
2005
Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis
Philippe Van Lint
Ben Wielockx
Leen Puimège
Agnès Noël
Carlos López-Otin
Claude Libert
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2005
2004
Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids
Tino Hochepied
Luc Schoonjans
Jan Staelens
Veerle Kreemers
Sophie Danloy
Leen Puimège
Désiré Collen
Frans Van Roy
Claude Libert
A1
Journal Article
in
STEM CELLS
2004
Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders
Jan Staelens
Leen Puimège
Tina Mahieu
Gwenda Pynaert
Tino Hochepied
Annelies Vandenabeele
Johan Grooten
Dimitris Kontoyiannis
Frans Van Roy
George Kollias
et al.
A1
Journal Article
in
MAMMALIAN GENOME
2004
2002
Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy
Jan Staelens
Ben Wielockx
Leen Puimège
Frans Van Roy
Jean-Louis Guénet
Claude Libert
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2002