Research Explorer

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Researcher

Laurens Raes

Awards & Distinctions

12 Results

2022

Light triggered nanoscale biolistics for efficient intracellular delivery of functional macromolecules in mammalian cells

Juan FraireElnaz Shaabani SichaniMaryam SharifiaghdamMatthias RombautCharlotte HinnekensDawei HuaJana RamonLaurens RaesEduardo Bolea FernandezToon Brans et al.

A1 Journal Article in NATURE COMMUNICATIONS

2021

Engineering and crystal structure of a monomeric FLT3 ligand variant

Erwin PannecouckeLaurens RaesSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS

Intracellular delivery of mRNA and proteins by VNB photoporation for cancer immunotherapy

Laurens RaesKevin BraeckmansKoen Raemdonck

Non-viral transfection technologies for next-generation therapeutic T cell engineering

Laurens RaesStefaan De SmedtKoen RaemdonckKevin Braeckmans

A1 Journal Article in BIOTECHNOLOGY ADVANCES

Photoporation with biodegradable polydopamine nanosensitizers enables safe and efficient delivery of mRNA in human T cells

Aranit HarizajMike WelsLaurens RaesStephan StremerschGlenn GoetgelukToon BransBart VandekerckhoveFélix SauvageStefaan De SmedtIne Lentacker et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Photothermal nanofibres enable safe engineering of therapeutic cells

Ranhua XiongDawei HuaJelter Van HoeckDominika BerdeckaLaurens LégerStijn De MunterJuan FraireLaurens RaesAranit HarizajFélix Sauvage et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

2020

Fluorescence-based quantification of messenger RNA and plasmid DNA decay kinetics in extracellular biological fluids and cell extracts

Heyang ZhangKoen RomboutsLaurens RaesRanhua XiongStefaan De SmedtKevin BraeckmansKatrien Remaut

A1 Journal Article in ADVANCED BIOSYSTEMS

Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation

Laurens RaesStephan StremerschJuan FraireToon BransGlenn GoetgelukStijn De MunterLien Van HoeckeRein VerbekeJelter Van HoeckRanhua Xiong et al.

A1 Journal Article in NANO-MICRO LETTERS

Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis

Juan FraireGaëlle HouthaeveJing LiuLaurens RaesLotte VermeulenStephan StremerschToon BransGerardo Garcia-Diaz BarrigaSarah De KeulenaerFilip Van Nieuwerburgh et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2019

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells

Lien Van HoeckeLaurens RaesStephan StremerschToon BransJuan FraireRia RoelandtWim DeclercqPeter VandenabeeleKoen RaemdonckKevin Braeckmans et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gold nanoparticle-mediated photoporation enables delivery of macromolecules over a wide range of molecular weights in human CD4+ T cells

Laurens RaesClarissa Van HeckeJulie MichielsStephan StremerschJuan FraireToon BransRanhua XiongStefaan De SmedtLinos VandekerckhoveKoen Raemdonck et al.

A1 Journal Article in CRYSTALS

2018

Photothermally triggered endosomal escape and its influence on transfection efficiency of gold-functionalized JetPEI/pDNA nanoparticles

Lotte VermeulenJuan FraireLaurens RaesEllen De MeesterSarah De KeulenaerFilip Van NieuwerburghStefaan De SmedtKatrien RemautKevin Braeckmans

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES