Research Explorer

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Researcher

Laurens Léger

Publications & Research Data

Awards & Distinctions

21 Results

2025

Phenotypic characterization of a hiPSC-derived cardiomyocyte model harbouring a pathogenic variant in desmoplakin associated with arrhythmogenic cardiomyopathy

Kiara Van Acker-VerbercktNina HeymansClaudia Vittoria OlmedaFrancesca BertomoroRebecca LuiseLaurens LégerLibero VitielloAlessandra RampazzoLeen PietersMartina Calore et al.

2024

Combinatorial effects of surface plasma-treating and aligning PCL/chitosan nanofibers on the behavior of stem cell-derived cardiomyocytes for cardiac tissue engineering

Laurens LégerSheida AliakbarshiraziPegah ZahedifarJeffrey AaldersPascal Van Der VoortNathalie De GeyterRino MorentJolanda van HengelRouba Ghobeira

A1 Journal Article in APPLIED SURFACE SCIENCE

Generation of a human induced pluripotent stem cell line UGENTi002-A from an arrhythmogenic cardiomyopathy patient carrying the c.817C>T DSP heterozygous variant and isogenic control using CRISPR/Cas9 editing

Laurens LégerJeffrey AaldersNina HeymansKiara Van Acker-VerbercktLéa De BleeckerePaul CouckeBjörn MentenBarbara BauceLibero VitielloAlessandra Rampazzo et al.

A1 Journal Article in STEM CELL RESEARCH

Improving cardiac differentiation of human pluripotent stem cells by targeting ferroptosis

Jeffrey AaldersLaurens LégerBehrouz HassanniaVera GoossensTom Vanden BergheJolanda van Hengel

A1 Journal Article in REGENERATIVE THERAPY

One cell type, infinite possibilities : utilizing human pluripotent stem cells for modeling arrhythmogenic cardiomyopathy and cardiac tissue engineering

Laurens LégerJolanda van HengelMartina Calore

Photoporation-mediated spatial intracellular delivery of stem cell-derived cardiomyocytes

Laurens LégerChloë De ClercqJeffrey AaldersKiara Van Acker-VerbercktKevin BraeckmansJolanda van Hengel

A2 Journal Article in METHODSX

Three-dimensional co-culturing of stem cell-derived cardiomyocytes and cardiac fibroblasts reveals a role for both cell types in Marfan-related cardiomyopathy

Jeffrey AaldersLaurens LégerLouis Van der MeerenSanjay SinhaAndre SkirtachJulie De BackerJolanda van Hengel

A1 Journal Article in MATRIX BIOLOGY

2023

Generation of human induced pluripotent stem cell line UGENTi001-A from a patient with Marfan syndrome carrying a heterozygous c.7754 T > C variant in FBN1 and the isogenic control UGENT001-A-1 using CRISPR/Cas9 editing

Jeffrey AaldersLaurens LégerAnthony DemolderLaura Muiño MosqueraPaul CouckeBjörn MentenJulie De BackerJolanda van Hengel

A1 Journal Article in STEM CELL RESEARCH

2022

Dielectric barrier discharge-treated aligned electrospun chitosan/polycaprolactone nanofibers for cardiac tissue engineering

Laurens LégerSheida AliakbarshiraziPegah ZahedifarNathalie De GeyterJeffrey AaldersRino MorentJolanda van HengelRouba Ghobeira

In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells

Jeffrey AaldersLaurens LégerLouis Van der MeerenPatrick SipsLaura Muiño MosqueraAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells

Jeffrey AaldersLaurens LégerLouis Van der MeerenPatrick SipsLaura Muiño MosqueraAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

2021

Effects of fibrillin mutations on the behaviour of heart muscle cells in Marfan syndrome

Jeffrey AaldersLaurens LégerLouis Van der MeerenNatasja Van den VrekenAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

In vitro modelling of Marfan related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells

Jeffrey AaldersLaurens LégerLouis Van der MeerenNatasja Van den VrekenAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

Liquid marbles : a cost-effective platform to generate cardiospheres from co-cultured cardiomyocytes and cardiac fibroblast for disease modelling

Jeffrey AaldersLaurens LégerSergio LeddaJolanda van Hengel

Photothermal nanofibres enable safe engineering of therapeutic cells

Ranhua XiongDawei HuaJelter Van HoeckDominika BerdeckaLaurens LégerStijn De MunterJuan FraireLaurens RaesAranit HarizajFélix Sauvage et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

Use of transparent liquid marble : microbioreactor to culture cardiospheres

Jeffrey AaldersLaurens LégerDavide PirasJolanda van HengelSergio Ledda

Bookchapter in Next generation culture platforms for reliable in vitro models

2020

Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome

Jeffrey AaldersLaurens LégerLouis Van der MeerenNatasja Van den VrekenAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

A1 Journal Article in SCIENTIFIC REPORTS

Liquid marble technology to create cost-effective 3D cardiospheres as a platform for in vitro drug testing and disease modelling

Jeffrey AaldersLaurens LégerTim TuerlingsSergio LeddaJolanda van Hengel

A2 Journal Article in METHODSX

2019

In vitro characterization of stem cell derived Marfan syndrome cardiomyocytes

Jeffrey AaldersLaurens LégerNatasja Van den VrekenSanjay SinhaJulie De BackerJolanda van Hengel

In vitro modelling of Marfan syndrome using stem cell derived cardiomyocytes

Jeffrey AaldersLaurens LégerNatasja Van den VrekenJulie De BackerJolanda van Hengel

Modelling Marfan syndrome in vitro using human stem cell derived cardiomyocytes and fibroblasts

Jeffrey AaldersLaurens LégerNatasja Van den VrekenJulie De BackerJolanda van Hengel