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Researcher
Laurens Léger
Profile
Projects
Publications
Activities
Awards & Distinctions
19
Results
2024
Combinatorial effects of surface plasma-treating and aligning PCL/chitosan nanofibers on the behavior of stem cell-derived cardiomyocytes for cardiac tissue engineering
Laurens Léger
Sheida Aliakbarshirazi
Pegah Zahedifar
Jeffrey Aalders
Pascal Van Der Voort
Nathalie De Geyter
Rino Morent
Jolanda van Hengel
Rouba Ghobeira
A1
Journal Article
in
APPLIED SURFACE SCIENCE
2024
Generation of a human induced pluripotent stem cell line UGENTi002-A from an arrhythmogenic cardiomyopathy patient carrying the c.817C>T DSP heterozygous variant and isogenic control using CRISPR/Cas9 editing
Laurens Léger
Jeffrey Aalders
Nina Heymans
Kiara Van Acker-Verberckt
Léa De Bleeckere
Paul Coucke
Björn Menten
Barbara Bauce
Libero Vitiello
Alessandra Rampazzo
et al.
A1
Journal Article
in
STEM CELL RESEARCH
2024
Improving cardiac differentiation of human pluripotent stem cells by targeting ferroptosis
Jeffrey Aalders
Laurens Léger
Behrouz Hassannia
Vera Goossens
Tom Vanden Berghe
Jolanda van Hengel
A1
Journal Article
in
REGENERATIVE THERAPY
2024
Photoporation-mediated spatial intracellular delivery of stem cell-derived cardiomyocytes
Laurens Léger
Chloë De Clercq
Jeffrey Aalders
Kiara Van Acker-Verberckt
Kevin Braeckmans
Jolanda van Hengel
A2
Journal Article
in
METHODSX
2024
Three-dimensional co-culturing of stem cell-derived cardiomyocytes and cardiac fibroblasts reveals a role for both cell types in Marfan-related cardiomyopathy
Jeffrey Aalders
Laurens Léger
Louis Van der Meeren
Sanjay Sinha
Andre Skirtach
Julie De Backer
Jolanda van Hengel
A1
Journal Article
in
MATRIX BIOLOGY
2024
2023
Generation of human induced pluripotent stem cell line UGENTi001-A from a patient with Marfan syndrome carrying a heterozygous c.7754 T > C variant in FBN1 and the isogenic control UGENT001-A-1 using CRISPR/Cas9 editing
Jeffrey Aalders
Laurens Léger
Anthony Demolder
Laura Muiño Mosquera
Paul Coucke
Björn Menten
Julie De Backer
Jolanda van Hengel
A1
Journal Article
in
STEM CELL RESEARCH
2023
2022
Dielectric barrier discharge-treated aligned electrospun chitosan/polycaprolactone nanofibers for cardiac tissue engineering
Laurens Léger
Sheida Aliakbarshirazi
Pegah Zahedifar
Nathalie De Geyter
Jeffrey Aalders
Rino Morent
Jolanda van Hengel
Rouba Ghobeira
C3
Conference
2022
In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells
Jeffrey Aalders
Laurens Léger
Louis Van der Meeren
Patrick Sips
Laura Muiño Mosquera
Andre Skirtach
Sanjay Sinha
Julie De Backer
Jolanda van Hengel
C3
Conference
2022
In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells
Jeffrey Aalders
Laurens Léger
Louis Van der Meeren
Patrick Sips
Laura Muiño Mosquera
Andre Skirtach
Sanjay Sinha
Julie De Backer
Jolanda van Hengel
C3
Conference
2022
2021
Effects of fibrillin mutations on the behaviour of heart muscle cells in Marfan syndrome
Jeffrey Aalders
Laurens Léger
Louis Van der Meeren
Natasja Van den Vreken
Andre Skirtach
Sanjay Sinha
Julie De Backer
Jolanda van Hengel
C3
Conference
2021
In vitro modelling of Marfan related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells
Jeffrey Aalders
Laurens Léger
Louis Van der Meeren
Natasja Van den Vreken
Andre Skirtach
Sanjay Sinha
Julie De Backer
Jolanda van Hengel
C3
Conference
2021
Liquid marbles : a cost-effective platform to generate cardiospheres from co-cultured cardiomyocytes and cardiac fibroblast for disease modelling
Jeffrey Aalders
Laurens Léger
Sergio Ledda
Jolanda van Hengel
C3
Conference
2021
Photothermal nanofibres enable safe engineering of therapeutic cells
Ranhua Xiong
Dawei Hua
Jelter Van Hoeck
Dominika Berdecka
Laurens Léger
Stijn De Munter
Juan Fraire
Laurens Raes
Aranit Harizaj
Félix Sauvage
et al.
A1
Journal Article
in
NATURE NANOTECHNOLOGY
2021
Use of transparent liquid marble : microbioreactor to culture cardiospheres
Jeffrey Aalders
Laurens Léger
Davide Piras
Jolanda van Hengel
Sergio Ledda
Bookchapter
in
Next generation culture platforms for reliable in vitro models
2021
2020
Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome
Jeffrey Aalders
Laurens Léger
Louis Van der Meeren
Natasja Van den Vreken
Andre Skirtach
Sanjay Sinha
Julie De Backer
Jolanda van Hengel
A1
Journal Article
in
SCIENTIFIC REPORTS
2020
Liquid marble technology to create cost-effective 3D cardiospheres as a platform for in vitro drug testing and disease modelling
Jeffrey Aalders
Laurens Léger
Tim Tuerlings
Sergio Ledda
Jolanda van Hengel
A2
Journal Article
in
METHODSX
2020
2019
In vitro characterization of stem cell derived Marfan syndrome cardiomyocytes
Jeffrey Aalders
Laurens Léger
Natasja Van den Vreken
Sanjay Sinha
Julie De Backer
Jolanda van Hengel
C3
Conference
2019
In vitro modelling of Marfan syndrome using stem cell derived cardiomyocytes
Jeffrey Aalders
Laurens Léger
Natasja Van den Vreken
Julie De Backer
Jolanda van Hengel
C3
Conference
2019
Modelling Marfan syndrome in vitro using human stem cell derived cardiomyocytes and fibroblasts
Jeffrey Aalders
Laurens Léger
Natasja Van den Vreken
Julie De Backer
Jolanda van Hengel
C3
Conference
2019