Research Explorer

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Researcher

Laurens Léger

12 Results

2023

Generation of human induced pluripotent stem cell line UGENTi001-A from a patient with Marfan syndrome carrying a heterozygous c.7754 T > C variant in FBN1 and the isogenic control UGENT001-A-1 using CRISPR/Cas9 editing

Jeffrey AaldersLaurens LégerAnthony DemolderLaura Muiño MosqueraPaul CouckeBjörn MentenJulie De BackerJolanda van Hengel

A1 Journal Article in STEM CELL RESEARCH

2022

In vitro modelling of Marfan-related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells

Jeffrey AaldersLaurens LégerLouis Van der MeerenPatrick SipsLaura Muiño MosqueraAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

2021

Effects of fibrillin mutations on the behaviour of heart muscle cells in Marfan syndrome

Jeffrey AaldersLaurens LégerLouis Van der MeerenNatasja Van den VrekenAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

In vitro modelling of Marfan related cardiomyopathy points to abnormalities in mechanobiology of the heart muscle cells

Jeffrey AaldersLaurens LégerLouis Van der MeerenNatasja Van den VrekenAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

Liquid marbles : a cost-effective platform to generate cardiospheres from co-cultured cardiomyocytes and cardiac fibroblast for disease modelling

Jeffrey AaldersLaurens LégerSergio LeddaJolanda van Hengel

Photothermal nanofibres enable safe engineering of therapeutic cells

Ranhua XiongDawei HuaJelter Van HoeckDominika BerdeckaLaurens LégerStijn De MunterJuan FraireLaurens RaesAranit HarizajFélix Sauvage et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

Use of transparent liquid marble : microbioreactor to culture cardiospheres

Jeffrey AaldersLaurens LégerDavide PirasJolanda van HengelSergio Ledda

Bookchapter in Next generation culture platforms for reliable in vitro models

2020

Effects of fibrillin mutations on the behavior of heart muscle cells in Marfan syndrome

Jeffrey AaldersLaurens LégerLouis Van der MeerenNatasja Van den VrekenAndre SkirtachSanjay SinhaJulie De BackerJolanda van Hengel

A1 Journal Article in SCIENTIFIC REPORTS

Liquid marble technology to create cost-effective 3D cardiospheres as a platform for in vitro drug testing and disease modelling

Jeffrey AaldersLaurens LégerTim TuerlingsSergio LeddaJolanda van Hengel

A2 Journal Article in METHODSX

2019

In vitro characterization of stem cell derived Marfan syndrome cardiomyocytes

Jeffrey AaldersLaurens LégerNatasja Van den VrekenSanjay SinhaJulie De BackerJolanda van Hengel

In vitro modelling of Marfan syndrome using stem cell derived cardiomyocytes

Jeffrey AaldersLaurens LégerNatasja Van den VrekenJulie De BackerJolanda van Hengel

Modelling Marfan syndrome in vitro using human stem cell derived cardiomyocytes and fibroblasts

Jeffrey AaldersLaurens LégerNatasja Van den VrekenJulie De BackerJolanda van Hengel