Research Explorer

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Researcher

Laurens Lambrechts

Publications & Research Data

Awards & Distinctions

32 Results

2025

Blood and tissue HIV-1 reservoirs display plasticity and lack of compartmentalization in virally suppressed people

Marion PardonsLaurens LambrechtsYtse NoppeLiesbet TermoteSofie De BraekeleerJerel VegaEllen Van GulckSarah GerloLinos Vandekerckhove

A1 Journal Article in NATURE COMMUNICATIONS

Evolution of the HIV-1 integration site landscape and inducible reservoir in early-treated people.

Tine StruyveMarion PardonsJozefien De ClercqLiesbet TermoteLaurens LambrechtsYtse NoppeMathias LichterfeldSofie RutsaertLinos Vandekerckhove

U Journal Article in PLoS pathogens

Integrative assessment of total and intact HIV-1 reservoir by a 5-region multiplexed rainbow DNA digital PCR assay

Mareva DelporteLaurens LambrechtsEvy BlommeWillem van SnippenbergSofie RutsaertMaxime VerschooreEvelien De SmetYtse NoppeNele De LangheMarie-Angélique De Scheerder et al.

A1 Journal Article in CLINICAL CHEMISTRY

2024

Development of a novel assay to characterize the HIV-1 reservoir using long-read sequencing

Laurens LambrechtsLinos VandekerckhoveWim Van Criekinge

HIV-PULSE as a new platform to unveil HIV-1 reservoir composition : intactness, drug resistance, tropism and immune therapy predictions

Sofie De BraekeleerLiesbet TermoteSofie RutsaertLaurens LambrechtsWilhelm A. VosAlbert L. GroenendijkLouise E. van EekerenMarc BlaauwJanneke StalenhoefAnnelies Verbon et al.

Longitudinal analysis in early treated individuals reveals alteration in the HIV-1 integration site landscape and composition of the inducible reservoir

Tine StruyveMarion PardonsJozefien De ClercqLiesbet TermoteLaurens LambrechtsYtse NoppeM. LichterfeldSofie RutsaertLinos Vandekerckhove

2023

HIV-PULSE : a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization

Laurens LambrechtsNoah BonineRita VerstraetenMarion PardonsYtse NoppeSofie RutsaertFilip Van NieuwerburghWim Van CriekingeBasiel ColeLinos Vandekerckhove

A1 Journal Article in NUCLEIC ACIDS RESEARCH

HIV-PULSE : a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization

Laurens LambrechtsNoah BonineRita VerstraetenMarion PardonsYtse NoppeSofie RutsaertFilip Van NieuwerburghWim Van CriekingeBasiel ColeLinos Vandekerckhove

In-depth assessment of the HIV-1 viral reservoir in early treated individuals

Tine StruyveMarion PardonsLiesbet TermoteJozefien De ClercqLaurens LambrechtsJerel VegaDaniel BodenMathias LichterfeldSofie RutsaertLinos Vandekerckhove

Linking inducible HIV-1 reservoir to rebound after treatment interruption

Laurens LambrechtsYtse NoppeMarion PardonsBasiel ColeSofie RutsaertStéphane De WitGuido VanhamEric FlorenceLinos Vandekerckhove

Optimization of a long-read sequencing assay for near full-length HIV-1 proviral genome characterization

Sofie De BraekeleerLaurens LambrechtsSofie RutsaertLinos Vandekerckhove

Optimization of a long-read sequencing assay for near full-length HIV-1 proviral genome characterization to enhance read accuracy

Sofie De BraekeleerLaurens LambrechtsSofie RutsaertLinos Vandekerckhove

Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir

Marion PardonsBasiel ColeLaurens LambrechtsWillem van SnippenbergSofie RutsaertYtse NoppeNele De LangheAnnemieke DhondtJerel VegaFilmon Eyassu et al.

A1 Journal Article in NATURE COMMUNICATIONS

The Rainbow 5-plex digital PCR assay improves quantification of the viral reservoir resulting in a better understanding of the HIV-1 proviral landscape

Mareva DelporteLaurens LambrechtsMarion PardonsSofie De BraekeleerEvy BlommeSofie RutsaertWim TrypsteenLinos Vandekerckhove

Unraveling ongoing inflammation after early ART by in-depth analysis of lymph nodes

Jozefien De ClercqKathleen Busman-SahayLaurens LambrechtsSofie RutsaertSol Taylor-BrillStephen BondocMarie-Angélique De ScheerderJacob EstesSarah GerloLinos Vandekerckhove

2022

Characterization of the HIV-1 viral reservoir in subtype B early treated individuals

Tine StruyveMarion PardonsLiesbet TermoteJozefien De ClercqLaurens LambrechtsJerel VegaDaniel BodenMathias LichterfeldSofie RutsaertLinos Vandekerckhove

Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruption

Basiel ColeLaurens LambrechtsZoe BoyerYtse NoppeMarie-Angélique De ScheerderJohn-Sebastian EdenBram VranckenTimothy E. SchlubSherry McLaughlinLisa M. Frenkel et al.

A1 Journal Article in CELL REPORTS

Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

Laurens LambrechtsRita VerstraetenNoah BonineYtse NoppeSofie RutsaertMarion PardonsBasiel ColeLinos Vandekerckhove

Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

Laurens LambrechtsRita VerstraetenNoah BonineYtse NoppeSofie RutsaertMarion PardonsBasiel ColeLinos Vandekerckhove

Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

Laurens LambrechtsRita VerstraetenNoah BonineYtse NoppeMarion PardonsBasiel ColeLinos Vandekerckhove

Two years of genomic surveillance in Belgium during the SARS-CoV-2 pandemic to attain country-wide coverage and monitor the introduction and spread of emerging variants

Lize CuypersSimon DellicourSamuel L. HongBarney I. PotterBruno VerhasseltNick VereeckeLaurens LambrechtsKeith DurkinVincent BoursSofieke Klamer et al.

A1 Journal Article in VIRUSES-BASEL

Unraveling persistent inflammation after very early ART through in-depth analysis of lymph nodes

Jozefien De ClercqKathleen Busman-SahayLaurens LambrechtsSofie RutsaertStephen BondocSol Taylor-BrillMarie-Angélique De ScheerderJacob EstesSarah GerloLinos Vandekerckhove

2021

In-depth characterization of HIV-1 reservoirs reveals links to viral rebound during treatment interruption

Basiel ColeLaurens LambrechtsZoe BoyerYtse NoppeMarie-Angélique De ScheerderJohn-Sebastian EdenBram VranckenTimothy SchlubSherry McLaughlinLisa M. Frenkel et al.

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

Basiel ColeLaurens LambrechtsPierre GantnerYtse NoppeNoah BonineWojciech WitkowskiLennie ChenSarah PalmerJames I. MullinsNicolas Chomont et al.

A1 Journal Article in NATURE COMMUNICATIONS

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of residual viremia and rebound viruses

Basiel ColeLaurens LambrechtsPierre GantnerYtse NoppeNoah BonineLennie ChenSarah PalmerJames MullinsNicolas ChomontMarion Pardons et al.

Organ-specific genome diversity of replication-competent SARS-CoV-2

Jolien Van CleemputWillem van SnippenbergLaurens LambrechtsAmélie DendoovenValentino D'OnofrioLiesbeth CouckWim TrypsteenJan VanrusseltSebastiaan TheunsNick Vereecke et al.

A1 Journal Article in NATURE COMMUNICATIONS

PCIP-seq : simultaneous sequencing of integrated viral genomes and their insertion sites with long reads

Maria ArtesiVincent HahautBasiel ColeLaurens LambrechtsFereshteh AshrafiAmbroise MarçaisOlivier HerminePhilip GriebelNatasa ArsicFrank van der Meer et al.

A1 Journal Article in GENOME BIOLOGY

2020

Combined assays shed new light on HIV-1 proviral sequence and linked integration site

Basiel ColeLaurens LambrechtsMaria ArtesiVincent HahautWojciech WitkowskiYtse NoppeAnnemieke DhondtKeith DurkinAnne Van den BroekeLinos Vandekerckhove

Emerging PCR-based techniques to study HIV-1 reservoir persistence

Laurens LambrechtsBasiel ColeSofie RutsaertWim TrypsteenLinos Vandekerckhove

A1 Journal Article in VIRUSES-BASEL

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

Erik AlmEeva K BrobergThomas ConnorEmma B HodcroftAndrey B KomissarovSebastian Maurer-StrohAngeliki MelidouRichard A NeherÁine O’TooleDmitriy Pereyaslov et al.

A1 Journal Article in EUROSURVEILLANCE

The elusive source of HIV-1 rebound after treatment interruption

Laurens LambrechtsBasiel ColeMarie-Angélique De ScheerderZoe BoyerYtse NoppeKatie FisherJohn-Sebastian EdenWim Van CriekingeLisa FrenkelSarah Palmer et al.

2019

The potential of long-read sequencing by MinION in the setting of a diverse genetic background of HIV-1

Laurens Lambrechts