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Researcher
Laura De Clerck
Profile
Projects
Publications
Activities
Awards & Distinctions
24
Results
2024
Effects of hypothermia and hypoxia on cytochrome P450‐mediated drug metabolism in neonatal Göttingen minipigs
Marina‐Stefania Stroe
Laura De Clerck
Maarten Dhaenens
Rachel Sian Dennis
Dieter Deforce
Sebastien Carpentier
Pieter Annaert
Karen Leys
Anne Smits
Karel Allegaert
et al.
A1
Journal Article
in
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
2024
2022
A large scale mass spectrometry-based histone screening for assessing epigenetic developmental toxicity
Sigrid Verhelst
Bart Van Puyvelde
Sander Willems
Simon Daled
Senne Cornelis
Laura Corveleyn
Ewoud Willems
Dieter Deforce
Laura De Clerck
Maarten Dhaenens
A1
Journal Article
in
SCIENTIFIC REPORTS
2022
Analyzing data independent acquisition mass spectrometry with noiseless ion-networks
Sander Willems
Simon Daled
Bart Van Puyvelde
Laura De Clerck
Sofie Vande Casteele
Filip Van Nieuwerburgh
Dieter Deforce
Maarten Dhaenens
Preprint
2022
2021
An experimental design to extract more information from MS-based histone studies
Laura De Clerck
Sander Willems
Simon Daled
Bart Van Puyvelde
Sigrid Verhelst
Laura Corveleyn
Dieter Deforce
Maarten Dhaenens
A1
Journal Article
in
MOLECULAR OMICS
2021
Cov-MS : a community-based template assay for mass-spectrometry-based protein detection in SARS-CoV-2 patients
Bart Van Puyvelde
Katleen Van Uytfanghe
Olivier Tytgat
Laurence Van Oudenhove
Ralf Gabriels
Robbin Bouwmeester
Simon Daled
Tim Van Den Bossche
Pathmanaban Ramasamy
Sigrid Verhelst
et al.
A2
Journal Article
in
JACS AU
2021
Hepatic cytochrome P450 abundance and activity in the developing and adult Gottingen Minipig : Pivotal data for PBPK modeling
Laura Buyssens
Laura De Clerck
Wim Schelstraete
Maarten Dhaenens
Dieter Deforce
Miriam Ayuso
Chris Van Ginneken
Steven Van Cruchten
A1
Journal Article
in
FRONTIERS IN PHARMACOLOGY
2021
Histone sample preparation for bottom-up mass spectrometry : a roadmap to informed decisions
Simon Daled
Sander Willems
Bart Van Puyvelde
Laura Corveleyn
Sigrid Verhelst
Laura De Clerck
Dieter Deforce
Maarten Dhaenens
A2
Journal Article
in
PROTEOMES
2021
Large scale toxicoepigenetics on histones : a mass spectrometry-based screening assay applied to developmental toxicity
Sigrid Verhelst
Bart Van Puyvelde
Sander Willems
Simon Daled
Senne Cornelis
Laura Corveleyn
Ewoud Willems
Dieter Deforce
Laura De Clerck
Maarten Dhaenens
Preprint
2021
2020
Comprehensive histone epigenetics : a mass spectrometry based screening assay to measure epigenetic toxicity
Sigrid Verhelst
Laura De Clerck
Sander Willems
Bart Van Puyvelde
Simon Daled
Dieter Deforce
Maarten Dhaenens
A2
Journal Article
in
METHODSX
2020
Removing the hidden data dependency of DIA with predicted spectral libraries
Bart Van Puyvelde
Sander Willems
Ralf Gabriels
Simon Daled
Laura De Clerck
Sofie Vande Casteele
An Staes
Francis Impens
Dieter Deforce
Lennart Martens
et al.
A1
Journal Article
in
PROTEOMICS
2020
2019
Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective
Wim Schelstraete
Laura De Clerck
Elisabeth Govaert
Joske Millecam
Mathias Devreese
Dieter Deforce
Jan Van Bocxlaer
Siska Croubels
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
Endometrial stromal cell proteome mapping in repeated implantation failure and recurrent pregnancy loss cases and fertile women
Lien Dhaenens
Sylvie Lierman
Laura De Clerck
Elisabeth Govaert
Dieter Deforce
Kelly Tilleman
Petra De Sutter
A1
Journal Article
in
REPRODUCTIVE BIOMEDICINE ONLINE
2019
Integrative proteomic profiling reveals PRC2-dependent epigenetic crosstalk maintains ground-state pluripotency
Guido van Mierlo
René AM Dirks
Laura De Clerck
Arie B Brinkman
Michelle Huth
Susan L Kloet
Nehmé Saksouk
Leonie I Kroeze
Sander Willems
Matthias Farlik
et al.
A1
Journal Article
in
CELL STEM CELL
2019
Tracking changes in the histone modification pattern by untargeted mass spectrometry : how naïve are human embryonic stem cells and data-dependent acquisition?
Laura De Clerck
Dieter Deforce
Maarten Dhaenens
Dissertation
2019
Untargeted histone profiling during naive conversion uncovers conserved modification markers between mouse and human
Laura De Clerck
Jasin Taelman
Mina Popovic
Sander Willems
Margot Van der Jeught
Björn Heindryckx
Petra De Sutter
Hendrik Marks
Dieter Deforce
Maarten Dhaenens
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
hSWATH : unlocking SWATH’s full potential for an untargeted histone perspective
Laura De Clerck
Sander Willems
Roberta Noberini
Camilla Restellini
Bart Van Puyvelde
Simon Daled
Tiziana Bonaldi
Dieter Deforce
Maarten Dhaenens
A1
Journal Article
in
JOURNAL OF PROTEOME RESEARCH
2019
2018
Maturation of hepatic cytochrome P450 enzymes in conventional pigs : fact or fiction?
Joske Millecam
Laura De Clerck
Elisabeth Govaert
Mathias Devreese
Elke Gasthuys
Wim Schelstraete
Dieter Deforce
Lies De Bock
Jan Van Bocxlaer
Stanislas Sys
et al.
C3
Conference
2018
Maturation of hepatic cytochrome P450 enzymes in conventional pigs : the added value of proteomics
Joske Millecam
Laura De Clerck
Elisabeth Govaert
Mathias Devreese
Elke Gasthuys
Wim Schelstraete
Dieter Deforce
Lies De Bock
Jan Van Bocxlaer
Stanislas Sys
et al.
C3
Conference
2018
Maturation of hepatic cytochrome P450 enzymes in conventional pigs as model for preclinical paediatric drug research
Joske Millecam
Laura De Clerck
Elisabeth Govaert
Mathias Devreese
Elke Gasthuys
Wim Schelstraete
Dieter Deforce
Lies De Bock
Jan Van Bocxlaer
Stanislas Sys
et al.
C3
Conference
2018
The ontogeny of cytochrome P450 enzyme activity and protein abundance in conventional pigs in support of preclinical pediatric drug research
Joske Millecam
Laura De Clerck
Elisabeth Govaert
Mathias Devreese
Elke Gasthuys
Wim Schelstraete
Dieter Deforce
Lies De Bock
Jan Van Bocxlaer
Stanislas Sys
et al.
A1
Journal Article
in
FRONTIERS IN PHARMACOLOGY
2018
2017
Flagging false positives following untargeted LCMS characterization of histone PTM combinations
Sander Willems
Maarten Dhaenens
Elisabeth Govaert
Laura De Clerck
Paulien Meert
Christophe Van Neste
Filip Van Nieuwerburgh
Dieter Deforce
A1
Journal Article
in
JOURNAL OF PROTEOME RESEARCH
2017
2016
Extracting histones for the specific purpose of label-free MS
Elisabeth Govaert
Katleen Van Steendam
Ellen Scheerlinck
Liesbeth Vossaert
Paulien Meert
Martina Stella
Sander Willems
Laura De Clerck
Maarten Dhaenens
Dieter Deforce
A1
Journal Article
in
PROTEOMICS
2016
Tackling aspecific side reactions during histone propionylation: the promise of reversing overpropionylation
Paulien Meert
Sebastiaan Dierickx
Elisabeth Govaert
Laura De Clerck
Sander Willems
Maarten Dhaenens
Dieter Deforce
A1
Journal Article
in
PROTEOMICS
2016
2015
Dissolution properties of co-amorphous drug-amino acid formulations in buffer and biorelevant media
A. T. Heikkinen
Laura De Clerck
K. Löbmann
H. Grohganz
T. Rades
R. Laitinen
A1
Journal Article
in
PHARMAZIE
2015