Research Explorer

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Researcher

Lars Vereecke

Publications & Research Data

Awards & Distinctions

73 Results

2026

Good grief : how metabolites from dying cells help and harm

Laura BoeckaertsKodi RavichandranLars Vereecke

Modulating efferocytosis in the intestinal epithelial cells during colorectal cancer

Laura BoeckaertsTania Love AaesEvi ScheirlinckxSze Men ChoiYunus IncikAmanda GonçalvesTino HochepiedLars VereeckeKodi Ravichandran

A1 Journal Article in FRONTIERS IN ONCOLOGY

TNFAIP3/A20 dysfunction drives innate and sterile hyperinflammation

Karel Van DammePieter HertensDorine SichienKatrien Van Der BorghtJustine Van MoorleghemSofie De PrijckAlex KLarenbeekEls LouagieInés LammensStijn Vanhee et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2025

A guide to germ-free and gnotobiotic mouse technology to study health and disease

Maude JansLars Vereecke

A1 Journal Article in FEBS JOURNAL

Depleting IL1R2+ tumor-infiltrating regulatory T cells with an ADCC-prone nanobody construct boosts the efficacy of anti-PD-1 immunotherapy

Sana M. ArnoukDaliya KanchevaHelena Van DammeGuillaume E. CourtoyRomina Mora BarthelmessJolien Van CraenenbroeckEls LebeggeYvon ElkrimNaela AssafYves Heremans et al.

A1 Journal Article in CANCER RESEARCH

Metabolomics-based evaluation of murine models of cow’s milk allergy

Ellen De PaepeVera PlekhovaEline De LanghePablo VangeenderhuysenLars VereeckeMyriam Van WinckelTom Van de WieleLynn Vanhaecke

Microbial contributions to gut and joint disease

Alexandra ThiranLars VereeckeDirk Elewaut

Neonatal microbiota colonization primes maturation of goblet cell-mediated protection in the pre-weaning colon

Asa JohanssonMahadevan Venkita SubramaniBahtiyar YilmazElisabeth E. L. NystromElena LayuntaLiisa ArikeFelix SommerPhilip RosenstielLars VereeckeLouise Manneras-Holm et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

New thoughts on the gut-immune axis of arthritis

Alexandra ThiranLars Vereecke

A1 Journal Article in TRENDS IN IMMUNOLOGY

Physiological drivers of pks+ E. coli in colorectal cancer

Maude JansLars Vereecke

A1 Journal Article in TRENDS IN MICROBIOLOGY

Study of host-microbe interactions in colorectal cancer

Maude JansLars VereeckeGeert van Loo

The gut-brain axis in Alzheimer's disease is shaped by commensal gut microbiota derived extracellular vesicles

Junhua XieLien Van HoeckeElien Van WonterghemGriet Van ImschootVanessa AndriesLars VereeckeRoosmarijn Vandenbroucke

A1 Journal Article in GUT MICROBES

VSIG4-expressing macrophages contribute to antiparasitic and antimetastatic responses in the peritoneal cavity

Els LebeggeDaliya KanchevaJolien Van CraenenbroeckSam ErnstPauline M. R. BardetAarushi A. CaroMate KissNeema Ahishakiye JumapiliRomina Mora BarthelmessMaida Zivalj et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

2024

Beyond inflammation : GDF15's influence on bone remodeling in arthritis

Renée Van der CruyssenDirk ElewautLars Vereecke

Colibactin-driven colon cancer requires adhesin-mediated epithelial binding

Maude JansMagdalena KolataGillian BlanckeAline D'HondtClaudia GrafMaarten CiersMozes SzeAlexandra ThiranIoanna PettaVanessa Andries et al.

A1 Journal Article in NATURE

Heart failure-induced microbial dysbiosis contributes to colonic tumour formation in mice

Sanne de WitLotte GeerlingsCanxia ShiJust DronkersElisabeth M. SchoutenGillian BlanckeVanessa AndriesTess YntemaWouter C. MeijersDebby P. Y. Koonen et al.

A1 Journal Article in CARDIOVASCULAR RESEARCH

Integrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE-mediated pediatric cow's milk allergy

Ellen De PaepeVera PlekhovaPablo VangeenderhuysenNele BaeckDominique BullensTania ClaeysMarilyn De GraeveKristien KamoenAnneleen NotebaertTom Van de Wiele et al.

A1 Journal Article in ALLERGY

Metabolite-based inter-kingdom communication controls intestinal tissue recovery following chemotherapeutic injury

Christopher AndersonLaura BoeckaertsPriscilla ChinJavier BurgoaWei XieAmanda GonçalvesGillian BlanckeSam BensonSebastian RogattiMariska S. Simpson et al.

A1 Journal Article in CELL HOST & MICROBE

Myeloid A20 is critical for alternative macrophage polarization and type-2 immune-mediated helminth resistance

Ioanna PettaMarie ThorpMaarten CiersGillian BlanckeLouis BoonTim MeeseFilip Van NieuwerburghAndy WullaertRichard GrencisDirk Elewaut et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2023

Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1

Alexandra L. DegraeveVincent HaufroidAxelle LoriotLaurent GattoVanessa AndriesLars VereeckeLaure ElensLaure B. Bindels

A1 Journal Article in MICROBIOME

Gut microbiota regulates blood-cerebrospinal fluid barrier function and Aβ pathology

Junhua XieArnout BruggemanClint De NolfCharysse VandendriesscheGriet Van ImschootElien Van WonterghemLars VereeckeRoosmarijn Vandenbroucke

A1 Journal Article in EMBO JOURNAL

Hepatic glutamine synthetase controls N-5-methylglutamine in homeostasis and cancer

Victor H. VillarMaria Francesca AllegaRuhi DeshmukhTobias AckermannMark A. NakasoneJohan Vande VoordeThomas M. DrakeJanina OetjenAlgernon BloomColin Nixon et al.

A1 Journal Article in NATURE CHEMICAL BIOLOGY

Integrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE-mediated pediatric cow’s milk allergy

Ellen De PaepeVera PlekhovaPablo VangeenderhuysenLars VereeckeMyriam Van WinckelMarilyn De GraeveTom Van de WieleEric CoxLynn Vanhaecke

Integrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE-mediated pediatric cow’s milk allergy

Ellen De PaepeVera PlekhovaLars VereeckeMyriam Van WinckelMarilyn De GraeveTom Van de WieleEric CoxLynn Vanhaecke

OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

Lien VerboomChristopher AndersonMaude JansIoanna PettaGillian BlanckeArne MartensMozes SzeTino HochepiedKodi RavichandranLars Vereecke et al.

A1 Journal Article in CELL DEATH & DISEASE

Sterile triggers drive joint inflammation in TNF‐ and IL-1β‐dependent mouse arthritis models

Alexandra ThiranIoanna PettaGillian BlanckeMarie ThorpGuillaume PlanckaertMaude JansVanessa AndriesKorneel BarbryElisabeth GilisJulie Coudenys et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

The autoinflammation-associated NLRC4<SUP>V341A</SUP> mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice

Elien EeckhoutTomoko AsaokaHanne Van GorpDieter DemonCharlotte Girard-Guyonvarc'hVanessa AndriesLars VereeckeCem GabayMohamed LamkanfiGeert van Loo et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Richard de ReuverSimon VerdonckEvelien DierickJosephine NemegeerEline HessmannSadeem AhmadMaude JansGillian BlanckeFilip Van NieuwerburghAlexander Botzki et al.

A1 Journal Article in NATURE

Metabolome alterations in a mouse model support microbiome-metabolite interactions in a cohort of children with cow's milk allergy

Ellen De PaepeVera PlekhovaLars VereeckeMyriam Van WinckelMarilyn De GraeveEric CoxLynn Vanhaecke

Metabolome alterations in a mouse model support microbiome-metabolite interactions in a cohort of children with cow's milk allergy

Ellen De PaepeVera PlekhovaLars VereeckeMyriam Van WinckelMarilyn De GraeveTom Van de WieleEric CoxLynn Vanhaecke

Metabolome alterations in a mouse model support microbiome-metabolite interactions in a cohort of children with cow's milk allergy

Ellen De PaepeVera PlekhovaLars VereeckeMyriam Van WinckelMarilyn De GraeveTom Van de WieleEric CoxLynn Vanhaecke

Metabolome alterations in a mouse model support microbiome-metabolite interactions in a cohort of children with cow’s milk allergy

Ellen De PaepeVera PlekhovaLars VereeckeMyriam Van WinckelMarilyn De GraeveTom Van de WieleEric CoxLynn Vanhaecke

Novel lipidomic biomarker panel towards improving of diagnostic accuracy in pediatric cow's milk allergy

Vera PlekhovaEllen De PaepeLars VereeckeMyriam Van WinckelEric CoxLynn Vanhaecke

Rothia mucilaginosa is an anti-inflammatory bacterium in the respiratory tract of patients with chronic lung disease

Charlotte RigautsJuliana AizawaSteven TaylorGeraint B. RogersMatthias GovaertsPaul CosLisa OstynSarah SimsEva VandeplasscheMozes Sze et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

The bacterial quorum sensing peptide iAM373 is a novel inducer of sarcopenia

Anton De SpiegeleerEvelien WynendaeleAmélie DescampsNathan DebunneBart BraeckmanMarjan De MeyJulie CoudenysLiesbeth CrombezFrederick VerbekeYorick Janssens et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL MEDICINE

The quorum sensing peptide EntF* promotes colorectal cancer metastasis in mice : a new factor in the host-microbiome interaction

Evelien WynendaeleNathan DebunneYorick JanssensAnton De SpiegeleerFrederick VerbekeLiesa TackSophie Van WeldenEvy GoossensDaniel KnappeRalf Hoffmann et al.

A1 Journal Article in BMC BIOLOGY

Towards a mouse model for studying food allergies from a metabolomics perspective : the case of pediatric cow’s milk allergy

Ellen De PaepeVera PlekhovaLars VereeckeMyriam Van WinckelMarilyn De GraeveEric CoxLynn Vanhaecke

2021

Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

Marion PicardSatoru YonekuraKarolina SlowickaIoanna PettaConrad RauberBertrand RoutyCorentin RichardValerio IebbaMaryam Tidjani AlouSonia Becharef et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Microbes exploit death-induced nutrient release by gut epithelial cells

Christopher AndersonChristopher B. MedinaBrady J. BarronLaura KarvelyteTania Love AaesIrina LambertzJustin S. A. PerryParul MehrotraAmanda GonçalvesKelly Lemeire et al.

A1 Journal Article in NATURE

Therapeutic depletion of CCR8(+) tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

Helena Van DammeBruno DombrechtMate KissHeleen RooseElizabeth AllenEva Van OvermeireDaliya KanchevaLiesbet MartensAleksandar MurgaskiPauline Madeleine Rachel Bardet et al.

A1 Journal Article in JOURNAL FOR IMMUNOTHERAPY OF CANCER

2020

Publisher correction : Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

Revisiting the gut-joint axis : links between gut inflammation and spondyloarthritis

Eric GraceyLars VereeckeDermot McGovernMareike FröhlingGeorg SchettSilvio DaneseMartine De VosFilip Van den BoschDirk Elewaut

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

Targeting neutrophils in asthma : a therapeutic opportunity?

Joyceline De VolderLars VereeckeGuy JoosTania Maes

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

A1 Journal Article in NATURE CANCER

2019

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

Hannah Van HoveLiesbet MartensIsabelle ScheyltjensKaren De VlaminckAna Rita Pombo AntunesSofie De PrijckNiels VandammeSebastiaan De SchepperGert Van IsterdaelCharlotte Scott et al.

A1 Journal Article in NATURE NEUROSCIENCE

Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis

Karolina SlowickaInmaculada Serramito-GómezEmilio Boada-RomeroArne MartensMozes SzeIoanna PettaHanna-Kaisa VikkulaRiet De RyckeEef ParthoensSaskia Lippens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Risks and benefits of corticosteroids in arthritic diseases in the clinic

Ioanna PettaIsabelle PeeneDirk ElewautLars VereeckeKarolien De Bosscher

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

The anti-inflammatory protein TNFAIP3/A20 binds the WD40 domain of ATG16L1 to control the autophagic response, NFKB/NF-κB activation and intestinal homeostasis

Inmaculada Serramito-GomezEmilio Boada-RomeroKarolina SlowickaLars VereeckeGeert van LooFelipe X Pimentel-Muinos

Editorial material

2018

Study of intestinal homeostasis and pathology through mouse gene targeting

Karolina SlowickaGeert van LooLars Vereecke

The role of the microbiome in gut and joint inflammation in psoriatic arthritis and spondyloarthritis

Elisabeth GilisCéline MortierKoen VenkenKarlijn DebusschereLars VereeckeDirk Elewaut

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

Tumour necrosis factor : out of my heart!

Lars VereeckeDirk Elewaut

Editorial material

2017

Ruminococcus on the horizon in arthritic disease

Lars VereeckeDirk Elewaut

Editorial material

2016

A20 deficiency in lung epithelial cells protects against influenza A virus infection

Jonathan MaelfaitKenny RooseLars VereeckeConor Mc GuireMozes SzeMartijn SchuijsMonique WillartLorena IbanezHamida HammadBart Lambrecht et al.

A1 Journal Article in PLOS PATHOGENS

A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death

Leen CatrysseMorvarid Farhang GhahremaniLars VereeckeSA YoussefConor Mc GuireMozes SzeA WeberM HeikenwalderA de BruinRudi Beyaert et al.

A1 Journal Article in CELL DEATH & DISEASE

Cellular functions of optineurin in health and disease

Karolina SlowickaLars VereeckeGeert van Loo

A1 Journal Article in TRENDS IN IMMUNOLOGY

M-CSF and GM-CSF receptor signaling differentially regulate monocyte maturation and macrophage polarization in the tumor microenvironment

Eva Van OvermeireBenoît StijlemansFelix HeymannJiri KeirsseYannick MoriasYvon ElkrimLea BrysChloé AbelsQods LahmarCan Ergen et al.

A1 Journal Article in CANCER RESEARCH

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

Karolina SlowickaLars VereeckeConor Mc GuireMozes SzeJonathan MaelfaitAnnasaheb KolpeXavier SaelensRudi BeyaertGeert van Loo

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

The prosurvival IKK-related kinase IKKε integrates LPS and IL17A signaling cascades to promote Wnt-dependent tumor development in the intestine

Serkan Ismail GöktunaKateryna ShostakTieu-Lan ChauLukas C HeukampBenoit HennuyHong-Quan DuongAurélie LadangPierre CloseIva KlevernicFabrice Olivier et al.

A1 Journal Article in CANCER RESEARCH

2015

Structural and adhesive properties of the long polar fimbriae protein LpfD from adherent-invasive Escherichia coli

Fanny CoppensJegan IyyathuraiSegolène RuerAntonella FioravantiJoemar TagannaLars VereeckeHenri De GreveHan Remaut

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

2014

A20 controls intestinal homeostasis through cell-specific activities

Lars VereeckeSara Vieira-SilvaThomas BillietJohan H van EsConor Mc GuireKarolina SlowickaMozes SzeMaaike van den BornGert De HertoghHans Clevers et al.

A1 Journal Article in NATURE COMMUNICATIONS

A20 in inflammation and autoimmunity

Leen CatrysseLars VereeckeRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN IMMUNOLOGY

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Nozomi TakahashiLars VereeckeMathieu BertrandLinde DuprezScott B BergerTatyana DivertAmanda GonçalvesMozes SzeBarbara GilbertStephanie Kourula et al.

A1 Journal Article in NATURE

2012

Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes

Jan Van den BosscheWouter H LamersEleonorre S KoehlerJan MC GeunsLeena AlhonenAnne UimariSini Pirnes-KarhuEva Van OvermeireYannick MoriasLea Brys et al.

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

2011

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

Mourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc GuireLars Vereecke et al.

A1 Journal Article in NATURE GENETICS

A20 (TNFAIP3) deficiency in myeloid cells triggers rheumatoid arthritis

Dirk ElewautMourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc Guire et al.

Controlling inflammation and cell death at the intestinal epithelial interface and beyond: lessons from conditional A20 knockout mice

Lars VereeckeRudi BeyaertGeert van Loo

Enterocyte death and intestinal barrier maintenance in homeostasis and disease

Lars VereeckeRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimrnune disease

Lars VereeckeRudi BeyaertGeert van Loo

A1 Journal Article in BIOCHEMICAL SOCIETY TRANSACTIONS

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

Saskia LippensS LefebvreBarbara GilbertMozes SzeMichael DevosKelly VerhelstLars VereeckeConor Mc GuireChris GuerinPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2010

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis

Lars VereeckeMozes SzeConor Mc GuireBrecht RogiersYuanyuan ChuMarc Schmidt-SupprianManolis PasparakisRudi BeyaertGeert van Loo

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2009

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

Lars VereeckeRudi BeyaertGeert van Loo

A1 Journal Article in TRENDS IN IMMUNOLOGY

2008

Prolonged exposure to IL-1 beta and IFN gamma induces necrosis of L929 tumor cells via a p38MAPK/NF-kappa B/NO-dependent mechanism

Elisabeth VercammenJens StaalAeke Van Den BroekeMira HaegmanLars VereeckePeter SchotteRudi Beyaert

A1 Journal Article in ONCOGENE

2007

Identification and evaluation of protein-protein interactions involved in NF-kB signaling using MAPPIT technology

Lars VereeckeSam LievensJan TavernierGeert van LooMozes SzeRudi Beyaert