Research Explorer

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Researcher

Lars Emil Larsen

Awards & Distinctions

44 Results

2025

Chemogenetic modulation of the rat locus coeruleus alters hippocampal noradrenaline release and modulates perforant path-evoked responses

Sielke CaesteckerEmma LescrauwaetKristl VonckMathieu SprengersEvelien CarrettePaul BoonLars Emil LarsenRobrecht Raedt

A1 Journal Article in FRONTIERS IN NEUROSCIENCE

Photopharmacological activation of adenosine A1 receptor signaling suppresses seizures in a mouse model for temporal lobe epilepsy

Jeroen SpanogheEvelien WynendaeleMarijke VergaelenMaren De ColvenaerTina MarimanKristl VonckEvelien CarretteWytse WadmanErine CraeyLars Emil Larsen et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2024

Chemogenetic activation of the locus coeruleus increases hippocampal noradrenaline levels leading to modulation of hippocampal excitability

Sielke CaesteckerLars Emil LarsenPaul BoonKristl VonckRobrecht Raedt

Increased dentate gyrus excitability in the intrahippocampal kainic acid mouse model for temporal lobe epilepsy

Marijke VergaelenSimona ManzellaKristl VonckErine CraeyJeroen SpanogheMathieu SprengersEvelien CarretteWytse Jan WadmanJean DelbekePaul Boon et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2023

Chemogenetic activation of the locus coeruleus increases noradrenaline levels and modulates hippocampal excitability

Sielke CaesteckerRobrecht RaedtPaul BoonKristl VonckLars Emil Larsen

Chemogenetic activation of the locus coeruleus increases noradrenaline levels in the hippocampus and modulates its hippocampal excitability

Sielke CaesteckerRobrecht RaedtPaul BoonKristl VonckLars Emil Larsen

Focal adenosine A1 receptor activation through photopharmacology as a potential treatment for drug-resistant epilepsy

Jeroen SpanogheLars Emil LarsenErine CraeySimona ManzellaKristl VonckSerge Van CalenberghPaul BoonR. Raedt

Hippocampal seizures differentially modulate locus coeruleus activity and result in consistent time-locked release of noradrenaline in rat hippocampus

Lars Emil LarsenSielke CaesteckerLatoya StevensPieter van MierloEvelien CarrettePaul BoonKristl VonckRobrecht Raedt

A1 Journal Article in NEUROBIOLOGY OF DISEASE

In vivo inhibition of epileptiform afterdischarges in rat hippocampus by light-activated chloride channel, stGtACR2

Anirudh AcharyaLars Emil LarsenJean DelbekeWytse WadmanKristl VonckAlfred MeursPaul BoonRobrecht Raedt

A1 Journal Article in CNS NEUROSCIENCE & THERAPEUTICS

2022

Chemogenetic seizure control with clozapine and the novel ligand JHU37160 outperforms the effects of Levetiracetam in the intrahippocampal kainic acid mouse model

Jana DeslooverePaul BoonLars Emil LarsenMarie-Gabrielle GoossensJean DelbekeEvelien CarretteWytse WadmanKristl VonckRobrecht Raedt

A1 Journal Article in NEUROTHERAPEUTICS

Chemogenetic seizure control with clozapine and the novel ligand JHU37160 outperforms the effects of levetiracetam in the intrahippocampal kainic acid mouse model

Jana DeslooverePaul BoonLars Emil LarsenMarie-Gabrielle GoossensJean DelbekeEvelien CarretteWytse WadmanKristl VonckRobrecht Raedt

A1 Journal Article in NEUROTHERAPEUTICS

Ex vivo feedback control of neurotransmission using a photocaged adenosine A1 receptor agonist

Erine CraeyFabian HulpiaJeroen SpanogheSimona ManzellaLars Emil LarsenMathieu SprengersDimitri De BundelIlse SmoldersEvelien CarretteJean Delbeke et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hippocampal seizures strongly modulate the activity of locus coeruleus neurons

Sielke CaesteckerRobrecht RaedtPaul BoonKristl VonckLars Emil Larsen

Laryngeal muscle-evoked potential recording as an indicator of vagal nerve fiber activation

Charlotte BouckaertRobrecht RaedtLars Emil LarsenRiem El TahryStefanie GadeyneEvelien CarretteSilke ProesmansFrank DewaeleJean DelbekeVeerle De Herdt et al.

A1 Journal Article in NEUROMODULATION

Pilot study : vagus nerve stimulation reduces microglia around a demyelinating lesion in a lysolecithin-induced demyelination model

Helen BachmannS VandenabeeleLars Emil LarsenEvelien CarretteWytse WadmanJean DelbekeKristl VonckPaul BoonRobrecht RaedtGuy Laureys

2021

Attenuation of hippocampal evoked potentials in vivo by activation of GtACR2, an optogenetic chloride channel

Anirudh AcharyaLars Emil LarsenWouter Van LysebettensWytse WadmanJean DelbekeKristl VonckAlfred MeursPaul BoonRobrecht Raedt

A1 Journal Article in FRONTIERS IN NEUROSCIENCE

Feedback control of CA1 excitability in hippocampal slices with a photoactive adenosine A1 receptor agonist

Erine CraeyJeroen SpanogheSerge Van CalenberghLars Emil LarsenEvelien CarretteJean DelbekeKristl VonckPaul BoonWytse WadmanRobrecht Raedt

In vivo blue light illumination for optogenetic inhibition : effect on local temperature and excitability of the rat hippocampus

Anirudh AcharyaBram VandekerckhoveLars Emil LarsenJean DelbekeWytse WadmanKristl VonckEvelien CarretteAlfred MeursJan VanfleterenPaul Boon et al.

A1 Journal Article in JOURNAL OF NEURAL ENGINEERING

Level of hM4D(Gi) DREADD expression determines inhibitory and neurotoxic effects in the hippocampus

Marie-Gabrielle GoossensLars Emil LarsenMarijke VergaelenWytse WadmanChris Van den HauteWayra BrackxSilke ProesmansJana DesloovereEmma ChristiaenErine Craey et al.

A1 Journal Article in ENEURO

Long‐term chemogenetic suppression of seizures in a multifocal rat model of temporal lobe epilepsy

Marie-Gabrielle GoossensPaul BoonWytse WadmanChris Van den HauteVeerle BaekelandtAlain VerstraeteKristl VonckLars Emil LarsenMathieu SprengersEvelien Carrette et al.

A1 Journal Article in EPILEPSIA

Optical control of excitatory transmission in hippocampal slices with photoactive adenosine A1 receptor agonist

Erine CraeyFabian HulpiaSerge Van CalenberghLars Emil LarsenCharlotte MathysInge Van ColenJean DelbekeKristl VonckPaul BoonWytse Wadman et al.

Optical control of excitatory transmission in hippocampal slices with photoactive adenosine A1 receptor agonist

Erine CraeyFabian HulpiaSerge Van CalenberghLars Emil LarsenCharlotte MathysInge Van ColenJean DelbekeKristl VonckPaul BoonWytse Wadman et al.

Optimized parameters for transducing the locus coeruleus using canine adenovirus type 2 (CAV2) vector in rats for chemogenetic modulation research

Latoya StevensLars Emil LarsenWouter Van LysebettensEvelien CarrettePaul BoonRobrecht RaedtKristl Vonck

A1 Journal Article in FRONTIERS IN NEUROSCIENCE

The signaling pathways involved in the anticonvulsive effects of the adenosine A1 receptor

Jeroen SpanogheLars Emil LarsenErine CraeySimona ManzellaAnnelies Van DyckePaul BoonRobrecht Raedt

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2020

A feasibility study to investigate chemogenetic modulation of the locus coeruleus by means of single unit activity

Latoya StevensKristl VonckLars Emil LarsenWouter Van LysebettensCharlotte GermonpréVeerle BaekelandtChris Van den HauteEvelien CarretteWytse WadmanPaul Boon et al.

A1 Journal Article in FRONTIERS IN NEUROSCIENCE

Ambulatory electrocardiographic monitoring and ectopic beat detection in conscious mice

Felke SteijnsMáté István TóthAnthony DemolderLars Emil LarsenJana DesloovereMarjolijn RenardRobrecht RaedtPatrick SegersJulie De BackerPatrick Sips

A1 Journal Article in SENSORS

Deep brain stimulation reduces evoked potentials with a dual time course in freely moving rats : potential neurophysiological basis for intermittent as an alternative to continuous stimulation

Mathieu SprengersRobrecht RaedtLars Emil LarsenJean DelbekeWytse WadmanPaul BoonKristl Vonck

A1 Journal Article in EPILEPSIA

Dynamic functional connectivity and graph theory metrics in a rat model of temporal lobe epilepsy reveal a preference for brain states with a lower functional connectivity, segregation and integration

Emma ChristiaenMarie-Gabrielle GoossensBenedicte DescampsLars Emil LarsenPaul BoonRobrecht RaedtChristian Vanhove

A1 Journal Article in NEUROBIOLOGY OF DISEASE

Identification of vagus nerve stimulation parameters affecting rat hippocampal electrophysiology without temperature effects

Wouter Van LysebettensKristl VonckLars Emil LarsenLatoya StevensCharlotte BouckaertCharlotte GermonpréMathieu SprengersEvelien CarretteJean DelbekeWytse Wadman et al.

A1 Journal Article in BRAIN STIMULATION

Spontaneous right ventricular pseudoaneurysms and increased arrhythmogenicity in a mouse model of Marfan syndrome

Felke SteijnsMarjolijn RenardMarine VanhomwegenPetra VermassenJana DesloovereRobrecht RaedtLars Emil LarsenMáté István TóthJulie De BackerPatrick Sips

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2019

Alterations in the functional brain network in a rat model of epileptogenesis : a longitudinal resting state fMRI study

Emma ChristiaenMarie-Gabrielle GoossensRobrecht RaedtBenedicte DescampsLars Emil LarsenErine CraeyEvelien CarretteKristl VonckPaul BoonChristian Vanhove

A1 Journal Article in NEUROIMAGE

Hypothermia masks most of the effects of rapid cycling VNS on rat hippocampal electrophysiology

Wouter Van LysebettensKristl VonckLars Emil LarsenMathieu SprengersEvelien CarretteCharlotte BouckaertJean DelbekeWytse WadmanPaul BoonRobrecht Raedt

A1 Journal Article in INTERNATIONAL JOURNAL OF NEURAL SYSTEMS

Long-term chemogenetic suppression of spontaneous seizures in a mouse model for temporal lobe epilepsy.

Jana DeslooverePaul BoonLars Emil LarsenCaroline MerckxMarie-Gabrielle GoossensC Van den HauteV BaekelandtD De BundelEvelien CarretteJean Delbeke et al.

A1 Journal Article in EPILEPSIA

2018

Vagus nerve stimulation induced hypothermia drives most of the effects on hippocampal electrophysiology in rats

Wouter Van LysebettensKristl VonckLars Emil LarsenMathieu SprengersEvelien CarretteJean DelbekeWytse WadmanPaul BoonRobrecht Raedt

Vagus nerve stimulation induced hypothermia drives most of the effects on hippocampal electrophysiology in rats

Wouter Van LysebettensKristl VonckLars Emil LarsenMathieu SprengersEvelien CarretteJean DelbekeWytse WadmanPaul BoonRobrecht Raedt

2017

Clinical vagus nerve stimulation paradigms induce pronounced brain and body hypothermia in rats

Lars Emil LarsenWouter Van LysebettensCharlotte GermonpréSofie CarretteSofie DaelemansMathieu SprengersLisa ThyrionWytse Jan WadmanEvelien CarretteJean Delbeke et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF NEURAL SYSTEMS

2016

Disruption, but not overexpression of urate oxidase alters susceptibility to pentylenetetrazole- and pilocarpine-induced seizures in mice

Lisa ThyrionJeanelle PortelliRobrecht RaedtGriet GlorieuxLars Emil LarsenMathieu SprengersWouter Van LysebettensEvelien CarretteJean DelbekeKristl Vonck et al.

A1 Journal Article in EPILEPSIA

Investigation of neurophysiological mechanisms of vagus nerve stimulation

Lars Emil LarsenRobrecht RaedtKristl Vonck

Modulation of hippocampal activity by vagus nerve stimulation in freely moving rats

Lars Emil LarsenWytse WadmanPieter van MierloJean DelbekeAnnelies GrimonprezBregt Van NieuwenhuyseJeanelle PortelliPaul BoonKristl VonckRobrecht Raedt

A1 Journal Article in BRAIN STIMULATION

Vagus nerve stimulation applied with a rapid cycle has more profound influence on hippocampal electrophysiology than a standard cycle

Lars Emil LarsenWytse WadmanDaniele MarinazzoPieter van MierloJean DelbekeSofie DaelemansMathieu SprengersLisa ThyrionWouter Van LysebettensEvelien Carrette et al.

A1 Journal Article in NEUROTHERAPEUTICS

2015

A preclinical study of laryngeal motor-evoked potentials as a marker vagus nerve activation

Annelies GrimonprezRobrecht RaedtLeen De TaeyeLars Emil LarsenJean DelbekePaul BoonKristl Vonck

A1 Journal Article in INTERNATIONAL JOURNAL OF NEURAL SYSTEMS

The antidepressant-like effect of vagus nerve stimulation is mediated through the locus coeruleus

Annelies GrimonprezRobrecht RaedtJeanelle PortelliIne DauweLars Emil LarsenCharlotte BouckaertJean DelbekeEvelien CarretteAlfred MeursVeerle De Herdt et al.

A1 Journal Article in JOURNAL OF PSYCHIATRIC RESEARCH

Vagus nerve stimulation has antidepressant effects in the kainic acid model for temporal lobe epilepsy

Annelies GrimonprezRobrecht RaedtIne DauweLies MolletLars Emil LarsenAlfred MeursVeerle De HerdtWytse WadmanJean DelbekeKristl Vonck et al.

A1 Journal Article in BRAIN STIMULATION

2014

Vagus nerve stimulation decreases hippocampal and prefrontal EEG power in freely moving rats: a biomarker for effective stimulation?

Lars Emil LarsenPieter van MierloWytse WadmanJean DelbekeAnnelies GrimonprezLies MolletBregt Van NieuwenhuyseJeanelle PortelliPaul BoonKristl Vonck et al.