Research Explorer

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Researcher

Kristel Van Steen

Awards & Distinctions

154 Results

2019

Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data

Alberto RomagnoniSimon JégouKristel Van SteenGilles WainribJean-Pierre Hugotthe International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)Harald PeetersDebby Laukens

A1 Journal Article in SCIENTIFIC REPORTS

2018

Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease

Elena S GusarevaJean-Claude TwizereKristel SleegersPierre DourlenJose F AbisambraShelby MeierRyan CloydBlaine WeissBart DermautKyrylo Bessonov et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

2017

Specific members of the predominant gut microbiota predict pouchitis following colectomy and IPAA in UC

Kathleen MachielsJoão SabinoLeen VandermostenMarie JoossensIngrid ArijsMagali de BruynVenessa EeckhautGert Van AsscheMarc FerranteJan Verhaegen et al.

A1 Journal Article in GUT

2016

Genome-wide copy number variation scan identifies complement component C4 as novel susceptibility gene for Crohn's disease

Isabelle CleynenPeter KoningsCaroline RobberechtDebby LaukensLeila AmininejadEmilie ThéâtreKathleen MachielsIngrid ArijsPaul RutgeertsEdouard Louis et al.

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

2015

High-density mapping of the MHC identifies a shared role for HLA-DRB1⋆01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

Philippe GoyetteGabrielle BoucherDermot MallonEva EllinghaustLuke JostinsHaiLiang HuangStephan RipkeElena S GusarevaVito AnneseStephen L Hauser et al.

A1 Journal Article in NATURE GENETICS

2014

A comparison of multivariate genome-wide association methods

Tessel E GaleslootKristel Van SteenLambertus ALM KiemeneyLuc L JanssSita H Vermeulen

A1 Journal Article in PLOS ONE

Active PAI-1 as marker for venous thromboembolism : case-control study using a comprehensive panel of PAI-1 and TAFI assays

Lize BollenMarijke PeetermansMiet PeetersKristel Van SteenMarc F HoylaertsPaul J DeclerckPeter VerhammeAnn Gils

A1 Journal Article in THROMBOSIS RESEARCH

Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood

Olga E SavenijeJestinah M Mahachie JohnRaquel GranellMarjan KerkhofF Nicole DijkJohan C de JongsteHenriette A SmitBert BrunekreefDirkje S PostmaKristel Van Steen et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Behind the (impedance) baseline in children

S SalvatoreA SalvatoniKristel Van SteenD UmmarinoB HauserY Vandenplas

A1 Journal Article in DISEASES OF THE ESOPHAGUS

Discovering main genetic interactions with LABNet LAsso-Based Network Inference

Francesco GadaletaKristel Van Steen

A1 Journal Article in PLOS ONE

Disease severity after 3 years of treating newly diagnosed pediatric Crohn's disease patients (The Belcro cohort)

Elisabeth De GreefJestinah Mahachie JohnIlse HoffmanFrançoise SmetsStephanie Van BiervlietPatrick BontemsIsabelle PaquotPhilip AllietKristel Van SteenGigi Veereman

Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease

I CleynenE VazeilleM ArtiedaHW VerspagetM SzczypiorskaMA BringerPL LakatosF SeiboldK ParnellRK Weersma et al.

A1 Journal Article in GUT

Genome-wide association interaction analysis for Alzheimer's disease

Elena S GusarevaMinerva M CarrasquilloCeline BellenguezElise CuyversSamuel ColonNeill R Graff-RadfordRonald C PetersenDennis W DicksonJestinah M Mahachie JohnKyrylo Bessonov et al.

A1 Journal Article in NEUROBIOLOGY OF AGING

Neutrophil gelatinase B-associated lipocalin and matrix metalloproteinase-9 complex as a surrogate serum marker of mucosal healing in ulcerative colitis

M de BruynI ArijsWJ WollantsK MachielsKristel Van SteenG Van AsscheM FerranteP RutgeertsS VermeireG Opdenakker

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

Practical aspects of genome-wide association interaction analysis

Elena S GusarevaKristel Van Steen

A1 Journal Article in HUMAN GENETICS

Predominant gut microbiota predict pouchitis following colectomy and IPAA in ulcerative colitis

Kathleen MachielsMarie JoossensIngrid ArijsIsabelle TerrassonVera BalletMarc FerranteJan VerhaegenKristel Van SteenAnthony de Buck van OverstraetenAlbert M Wolthuis et al.

Risk of malignancies in patients with inflammatory bowel disease treated with thiopurines or anti-TNF alpha antibodies

F BeigelA SteinbornF SchnitzlerC TillackS BreiteneicherJM JohnKristel Van SteenRP LaubenderB GokeJ Seiderer et al.

A1 Journal Article in PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

The Belgian Registry of Pediatric Crohn's disease (BELCRO) : growth status after 3 year follow up

E De GreefJ MahanchieI HoffmanF SmetsStephanie Van BiervlietP BontemsP AllietI PaquotKristel Van SteenG Veereman-Wauters

2013

A novel integrated framework for rare variant analysis

R FouladiK BessonovF Van LishoutJ MooreKristel Van Steen

A robustness study of parametric and non-parametric tests in model-based multifactor dimensionality reduction for epistasis detection

JMM JohnF Van LishoutES GusarevaKristel Van Steen

A1 Journal Article in BIODATA MINING

An efficient algorithm to perform multiple testing in epistasis screening

F Van LishoutJMM JohnES GusarevaV UrreaI CleynenE TheatreB CharloteauxML CalleL WehenkelKristel Van Steen

A1 Journal Article in BMC BIOINFORMATICS

EU Pancreas : an integrated European platform for pancreas cancer research : from basic science to clinical and public health interventions for a rare disease

R MilneC La VecchiaKristel Van SteenS HahnM BuchholzE CostelloI EspositoJD HoheiselB LangeN Lopez-Bigas et al.

A1 Journal Article in PUBLIC HEALTH GENOMICS

Esophageal impedance baseline is age dependent

S SalvatoreA SalvatoniM Van BerkelKristel Van SteenD UnmarinoA GhanmaB HauserY Vandenplas

A1 Journal Article in JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Familial aggregation in the response to anti-TNF in inflammatory bowel disease patients

T BillietI CleynenV BalletM FerranteKristel Van SteenPJ RutgeertsS Vermeire

Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress

E HoefkensK NysJM JohnKristel Van SteenI ArijsJ Van der GotenG Van AsscheP AgostinisP RutgeertsS Vermeire et al.

A1 Journal Article in AUTOPHAGY

Genetic variations in toll-like receptor pathway and lung function decline in Cystic Fibrosis patients

Filomeen HaerynckJM Mahachie JohnKristel Van SteenPetra SchelstraeteSabine Van daeleBart LoeysMira Van ThielenI De CanckLieve NuytinckFrans De Baets

A1 Journal Article in HUMAN IMMUNOLOGY

Haplotype information combined with iterative pruning PCA (ipPCA) to improve population clustering

K ChaichoompuR FouladiP WangkumhangA WilanthoW ChareanchimA SakuntabhaiS TongsimaKristel Van Steen

Integration analysis of 'OMICS' data using penalized regression methods : an application to bladder cancer

S PinedaN MalatsKristel Van Steen

Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease

Z WeiW WangJ BradfieldJ LiC CardinaleE FrackeltonC KimF MentchKristel Van SteenPM Visscher et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Molecular reclassification of Crohn's disease : a cautionary note on population stratification

Baerbel MausCamille JungJestinah M. Mahachie JohnJean-Pierre HugotEmmanuelle GeninKristel Van Steen

A1 Journal Article in PLOS ONE

Neutrophil gelatinase B-associated lipocalin-matrix metalloproteinase-9 (NGAL-MMP-9) complex as a surrogate serum marker for mucosal healing in ulcerative colitis

M de BruynI ArijsWJ WollantsK MachielsKristel Van SteenM FerrantePJ RutgeertsS VermeireG Opdenakker

Profile of pediatric Crohn's disease in Belgium

E De GreefJM Mahachie JohnI HoffmanF SmetsStephanie Van BiervlietM ScaillonB HauserI PaquotP AllietW Arts et al.

A2 Journal Article in JOURNAL OF CROHNS & COLITIS

Therapeutic strategy and patient outcome during the first 2 years of pediatric Crohn’s disease

Gigi VeeremanJestinah Mahachie JohnElisabeth De GreefFrançoise SmetsStephanie Van BiervlietKristel Van Steen

Unique gene expression and MR T-2 relaxometry patterns define chronic murine dextran sodium sulphate colitis as a model for connective tissue changes in human Crohn's disease

Christine BreynaertTom DresselaersClementine PerrierIngrid ArijsJonathan CremerLeentje Van LommelKristel Van SteenMarc FerranteFrans SchuitSeverine Vermeire et al.

A1 Journal Article in PLOS ONE

2012

A robustness study to investigate the performance of parametric and non-parametric tests used in model-based multifactor dimensionality reduction epistasis detection

JMM JohnE GusarevaF Van LishoutKristel Van Steen

An Ensemble pipeline to enable detection of epistasis in genomic data

BJ GradyT CattaertKristel Van SteenMD Ritchie

Challenges and opportunities in genome-wide environmental interaction (GWEI) studies

H AschardS LutzB MausEJ DuellTE FingerlinN ChatterjeeP KraftKristel Van Steen

A1 Journal Article in HUMAN GENETICS

Clustering of Crohn's disease patients : identification of sub-phenotypes and population stratification

B MausE GeninJMM JohnKristel Van Steen

Comparison of different methods for detecting gene-gene interactions in case-control data

T CattaertJAR GarciaE GusarevaKristel Van Steen

Does pet ownership in infancy lead to asthma or allergy at school age? : pooled analysis of individual participant data from 11 European birth cohorts

Karin C Lodrup CarlsenStephanie RollKai-Hakon CarlsenPetter MowinckelAlet H WijgaBert BrunekreefMaties TorrentGraham RobertsS Hasan ArshadInger Kull et al.

A1 Journal Article in PLOS ONE

Effects of domperidone on QTc interval in infants

MC VieiraNI MiyagueKristel Van SteenS SalvatoreY Vandenplas

A1 Journal Article in ACTA PAEDIATRICA

Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis

L MarquezC ShenI CleynenG De HertoghKristel Van SteenK MachielsC PerrierV BalletS OrganeM Ferrante et al.

A1 Journal Article in GUT

Factors determining therapeutic strategy at diagnosis and evolution of disease severity in a cohort of Belgian pediatric Crohn's disease patients (BELCRO)

Elisabeth De GreefJestinah M Mahachie JohnIlse HoffmanFrançoise SmetsStephanie Van BiervlietBruno HauserIsabelle PaquotPhilippe L AllietWim ArtsOlivier Dewit et al.

Genetic variations in toll-like receptor pathway and lung function decline in cystic fibrosis patients

Filomeen HaerynckKristel Van SteenJM JohnPetra SchelstraeteSabine Van daeleBart LoeysM Van ThielenI De CanckFrans De Baets

Genome-wide epistasis screening for Crohn's disease

ES GusarevaKristel Van Steen

Heterogeneous nuclear RNPs as targets of autoantibodies in systemic rheumatic diseases

K Op de BeeckL MaesK Van den BerghR DeruaE WaelkensKristel Van SteenP VermeerschR WesthovensK De VlamP Verschueren et al.

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Integration of biological data in the context of GWAI studies

Kristel Van SteenF Van LishoutE Gusareva

Lower-order effects adjustment in quantitative traits model-based multifactor dimensionality reduction

Jestinah M Mahachie JohnTpù CattaertFrançois Van LishoutElena S GusarevaKristel Van Steen

A1 Journal Article in PLOS ONE

Polymorphisms in the lectin pathway genes as a possible cause of early chronic Pseudomonas aeruginosa colonization in cystic fibrosis patients

Filomeen HaerynckKristel Van SteenT CattaertBart LoeysSabine Van daelePetra SchelstraeteKathleen ClaesM Van ThielenI De CanckJM Mahachie John et al.

A1 Journal Article in HUMAN IMMUNOLOGY

Prognostic value of serologic and histologic markers on clinical relapse in ulcerative colitis patients with mucosal healing

T BessissowB LemmensM FerranteR BisschopsKristel Van SteenK GeboesG Van AsscheS VermeireP RutgeertsG De Hertogh

A1 Journal Article in AMERICAN JOURNAL OF GASTROENTEROLOGY

Repeated cycles of DSS inducing a chronically relapsing inflammation : a novel model to study fibrosis using in vivo MRI T2 relaxometry

CM BreynaertT DresselaersJ CremerKristel Van SteenC PerrierS VermeirePJ RutgeertsJL CeuppensU HimmelreichG Van Assche

Safety and cost of infliximab for the treatment of Belgian pediatric patients with Crohn’s disease

E De GreefI HoffmanG D’HaensStephanie Van BiervlietF SmetsM ScaillonO DewitHarald PeetersI PaquotP Alliet et al.

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

Sequential T2 relaxometry as a non-invasive assessment of transmural inflammation in a murine model of chronically relapsing colitis

CM BreynaertT DresselaersJ CremerKristel Van SteenC PerrierS VermeirePJ RutgeertsJL CeuppensU HimmelreichG Van Assche

Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma

Claus BachertKristel Van SteenNan ZhangGabriële HoltappelsTom CattaertBärbel MausRoland BuhlChristian TaubeStephanie KornMarek Kowalski et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Travelling the world of gene-gene interactions

Kristel Van Steen

A1 Journal Article in BRIEFINGS IN BIOINFORMATICS

2011

A report of the First Biennial Meeting on Capita Selecta in Complex Disease Analysis (CSCDA2010), Leuven, Belgium, August 25-27, 2010

Kristel Van SteenK Sleegers

A1 Journal Article in ANNALS OF HUMAN GENETICS

Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease

L HenckaertsI CleynenM BrinarJM JohnKristel Van SteenP RutgeertsS Vermeire

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

High-throughput method for comparative analysis of denaturing gradient gel electrophoresis profiles from human fecal samples reveals significant increases in two bifidobacterial species after inulin-type prebiotic intake

Marie JoossensGeert HuysKristel Van SteenMargo CnockaertSeverine VermeirePaul RutgeertsKristin VerbekePeter VandammeVicky De Preter

A1 Journal Article in FEMS MICROBIOLOGY ECOLOGY

Identification of a novel autoantigen in inflammatory bowel disease by protein microarray

N VermeulenKO de BeeckS VermeireKristel Van SteenG MichielsV BalletP RutgeertsX Bossuyt

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

Investigating Hardy-Weinberg equilibrium in case-control or cohort studies or meta-analysis

A ZieglerKristel Van SteenS Wellek

A1 Journal Article in BREAST CANCER RESEARCH AND TREATMENT

Levels of C-reactive protein are associated with response to infliximab therapy in patients with Crohn's disease

M JurgensJMM JohnI CleynenF SchnitzlerH FidderW Van MoerkerckeV BalletM NomanI HoffmanG Van Assche et al.

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis

Philippe GevaertNicholas Van BruaeneTom CattaertKristel Van SteenThibaut Van ZeleFrederic AckeNatalie De RuyckKatrien BlommeAnna SousaRichard Marshall et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Model-based multifactor dimensionality reduction for detecting epistasis in case-control data in the presence of noise

T CattaertML CalleSM DudekJMM JohnF Van LishoutV UrreaMD RitchieKristel Van Steen

A1 Journal Article in ANNALS OF HUMAN GENETICS

Model-based multifactor dimensionality reduction to detect epistasis for quantitative traits in the presence of error-free and noisy data

Jestinah M Mahachie JohnFrançois Van LishoutKristel Van Steen

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

Mucosal gene expression of cell adhesion molecules, chemokines, and chemokine receptors in patients with inflammatory bowel disease before and after infliximab treatment

I ArijsG De HertoghK MachielsKristel Van SteenK LemaireA SchraenenL Van LommelR QuintensG Van AsscheS Vermeire et al.

A1 Journal Article in AMERICAN JOURNAL OF GASTROENTEROLOGY

Mucosal gene expression profiling differentiates early from late ileal Crohn's disease

I ArijsL Van LommelG De HertoghK MachielsK LemaireKristel Van SteenGA Van AsscheS VermeireFC SchuitPJ Rutgeens

Outcome of pregnancy in women with inflammatory bowel disease treated with antitumor necrosis factor therapy

F SchnitzlerH FidderM FerranteV BalletM NomanG Van AsscheB SpitzI HoffmanKristel Van SteenS Vermeire et al.

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

Perspectives on genome-wide multi-stage family-based association studies

Kristel Van Steen

A1 Journal Article in STATISTICS IN MEDICINE

Rate of malignancies and infections in a large single center cohort of IBD patients treated with thiopurines and anti-TNF-antibodies

T OchsenkuhnA SteinbomF BeigelS BreiteneicherKristel Van SteenF SchnitzlerB GokeM WeidingerS BrandL Seiderer

Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a Northern Swedish population

Lotte N MoensPeter De RijkJoke ReumersMaarten JA Van den BosscheWim GlasseeSonia De ZutterAn-Sofie LenaertsAnnelie NordinLars-Goran NilssonIgnacio Medina Castello et al.

A1 Journal Article in PLOS ONE

The protease genes Cyld and USP40 are associated with Crohn's disease : results from a European consortium

I CleynenM ArtiedaM SzczypiorskaHW VerspagetPL LakatosF SeiboldT AhmadRK WeersmaS MullerA Tordai et al.

Tolerability of shortened infliximab infusion times in patients with inflammatory bowel diseases : a single-center cohort study

C BreynaertM FerranteH FidderKristel Van SteenM NomanV BalletS VermeireP RutgeertsG Van Assche

A1 Journal Article in AMERICAN JOURNAL OF GASTROENTEROLOGY

2010

A detailed view on model-based multifactor dimensionality reduction for detecting gene-gene interactions in case-control data in the absence and presence of noise

Kristel Van SteenT CattaertML CalleSM DudekJMM JohnF Van LishoutV UrreaMD Ritchie

A screening methodology based on Random Forests to improve the detection of gene-gene interactions

Lizzy De LobelPierre GeurtsGuy BaeleFrancesc Castro-GinerManolis KogevinasKristel Van Steen

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

A two-stage approach to test for gene-gene interactions in family data based on within-family and between-family information

Lizzy De LobelKristel Van Steen

Alternative risk cell definitions based on ranking improve performance of model-based multifactor dimensionality reduction for epistasis detection

T CattaertJMM JohnF Van LishoutKristel Van Steen

Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk

JMM JohnH BaurechtE RodriguezA NaumannS WagenpfeilN KloppM MempelN NovakT BieberHE Wichmann et al.

A1 Journal Article in ALLERGY

Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk

H BaurechtJM JohnE RodriguezA NaumannS WagenpfeilN KloppM MempelN NovakT BieberH Wichmann et al.

FAM-MDR : a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals

Tom CattaertVictor UrreaAdam C NajLizzy De LobelVanessa De WitMao FuJestinah M Mahachie JohnHaiQing ShenM Luz CalleMarylyn D Ritchie et al.

A1 Journal Article in PLOS ONE

Familial aggregation and antimicrobial response dose-dependently affect the risk for Crohn's disease

Marie JoossensKristel Van SteenJulien BrancheBoualem SendidPaul RutgeertsFrancis VasseurDaniel PoulainFranck BrolyJean-Frederic ColombelSeverine Vermeire et al.

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma

Robyn T CohenBenjamin A RabyKristel Van SteenAnne L FuhlbriggeJuan C CeledonBernard A RosnerRobert C StrunkRobert S ZeigerScott T Weiss

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Model-based multifactor dimensionality reduction to detect epistasis for quantitative traits in the presence of error-free and noisy data

JM JohnF Van LishoutKristel Van Steen

Molecular reclassification of Crohn's disease by cluster analysis of genetic variants

Isabemme CleynenJestinah M Mahachie JohnLiesbet HenckaertsWouter Van MoerkerckePaul RutgeertsKristel Van SteenSeverine Vermeire

A1 Journal Article in PLOS ONE

Predictive value of epithelial gene expression profiles for response to infliximab in Crohn's disease

I ArijsR QuintensL Van LommelKristel Van SteenG De HertoghK LemaireA SchraenenC PerrierG Van AsscheS Vermeire et al.

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma

Claus BachertNan ZhangGabriële HoltappelsLizzy De LobelPaul Van CauwenbergeShiXi LiuPing LinJean BousquetKristel Van Steen

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

mbmdr : an R package for exploring gene-gene interactions associated with binary or quantitative traits

ML CalleV UrreaN MalatsKristel Van Steen

A1 Journal Article in BIOINFORMATICS

2009

A family-based association test to detect gene-gene interactions in the presence of linkage

Lizzy De LobelHans De MeyerLutgarde ThijsTatiana KouznetsovaJan StaessenKristel Van Steen

GENESTAT : an information portal for design and analysis of genetic association studies

Samuli RipattiTim BeckerHeike BickebollerAnnica DominicusChristine FischerKeith HumphreysGudrun JonasdottirYves MoreauMarita OlssonAlexander Ploner et al.

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

Genetic risk profiling and prediction of disease course in Crohn's disease patients

Liesbet HenckaertsKristel Van SteenIsabel VerstrekenIsabelle CleynenAndre FrankeStefan SchreiberPaul RutgeertsSeverine Vermeire

A1 Journal Article in CLINICAL GASTROENTEROLOGY AND HEPATOLOGY

Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma

Benjamin A RabyKristel Van SteenJessica Lasky-SuKelan TantisiraFeige KaplanScott T Weiss

A1 Journal Article in RESPIRATORY RESEARCH

Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease : results from a single-centre cohort

F SchnitzlerH FidderM FerranteM NomanI ArijsG Van AsscheI HoffmanKristel Van SteenS VermeireP Rutgeerts

A1 Journal Article in GUT

Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment

Ingrid ArijsGert De HertoghKatleen LemaireRoel QuintensLeentje Van LommelKristel Van SteenPeter LeemansIsabelle CleynenGert Van AsscheSeverine Vermeire et al.

A1 Journal Article in PLOS ONE

Mucosal gene signatures to predict response to infliximab in patients with ulcerative colitis

I ArijsK LiG ToedterR QuintensL Van LommelKristel Van SteenP LeemansG De HertoghK LemaireM Ferrante et al.

A1 Journal Article in GUT

Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohn's disease

F SchnitzlerH FidderM FerranteM NomanI ArijsG Van AsscheI HoffmanKristel Van SteenS VermeireP Rutgeerts

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit

L HenckaertsKR NielsenR SteffensenKristel Van SteenC MathieuA GiuliettiPJ WoutersI MilantsI VanhorebeekL Langouche et al.

A1 Journal Article in CRITICAL CARE MEDICINE

Polymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men

Griet VanbillemontVeerle BogaertDirk De BacquerBruno LapauwStefan GoemaereKaatje ToyeKristel Van SteenYouri TaesJean Kaufman

A1 Journal Article in CLINICAL ENDOCRINOLOGY

Predictive value of C-reactive protein level changes on the long term outcome of infliximab in Crohn's disease

M JurgensF SchnitzlerKristel Van SteenJ MahachieV BalletM NomanI HoffmanGA Van AsschePJ RutgeertsS Venneire

Small effect of the androgen receptor gene GGN repeat polymorphism on serum testosterone levels in healthy men

Veerle BogaertGriet VanbillemontYouri TaesDirk De BacquerEllen DeschepperKristel Van SteenJean Kaufman

A1 Journal Article in EUROPEAN JOURNAL OF ENDOCRINOLOGY

TECK and MADCAM-1 mucosal expression in active IBD : the effect of infliximab therapy

I ArijsR QuintensL Van LommelKristel Van SteenG De HertoghGA Van AsscheS VermeireK GeboesFC SchuitPJ Rutgeerts

The impact of infliximab therapy on colonic mucosal expression of barrier genes in patients with inflammatory bowel disease

I ArijsR QuintensL Van LommelKristel Van SteenG De HertoghGA Van AsscheS VermeireK GeboesFC SchuitPJ Rutgeerts

2008

A family-based association test for quantitative traits to detect gene-gene interactions

Lizzy De LobelHans De MeyerL ThijsT KouznetsovaJ StaessenKristel Van Steen

Genetic markers and the risk of complicated disease behaviour in Crohn's disease patients

L HenckaertsI CleynenMarie JoossensKristel Van SteenK ClaesP RutgeertsS Vermeire

Heritability of blood concentrations of sex-steroids in relation to body composition in young adult male siblings

Veerle BogaertYouri TaesPeter KoningsKristel Van SteenDirk De BacquerStefan GoemaereHans-Georg ZmierczakPatricia CrabbeJean Kaufman

A1 Journal Article in CLINICAL ENDOCRINOLOGY

Long-term outcome after infliximab for refractory ulcerative colitis

Marc FerranteSéverine VermeireHerma FidderFabian SchnitzlerMaja NomanGert Van AsscheGert De HertoghIlse HoffmanAndre D'HooreKristel Van Steen et al.

A1 Journal Article in JOURNAL OF CROHNS & COLITIS

Microarray study of mucosal antimicrobial peptides in patients with inflammatory bowel disease before and after first infliximab treatment

I ArijsL Van LommelKristel Van SteenG De HertoghR QuintensK LemaireMarie JoossensFC SchuitK GeboesGA Van Assche et al.

Mucosal gene signatures to predict response to infliximab in patients with inflammatory bowel disease

I ArijsL Van LommelKristel Van SteenG De HertoghM FerranteMarie JoossensK GeboesGA Van AsscheS VermeireFC Schuit et al.

Stability of gut microbiota over time in Crohn’s disease patients compared to healthy relatives

Marie JoossensVicky De PreterKristel Van SteenNathalie VermeulenGeert HuysKristin VerbekePeter VandammePaul RutgeertsSeverine Vermeire

TNFA-3086 > A in two international population-based cohorts and risk of asthma

F Castro-GinerM KogevinasM MachlerR de CidKristel Van SteenM ImbodenC SchindlerW BergerJR GonzalezKA Franklin et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

2007

Approaches to handling incomplete data in family-based association testing

Kristel Van SteenN. M. LairdP. MarkelG. Molenberghs

A1 Journal Article in ANNALS OF HUMAN GENETICS

Faecal bacterial DGGE profiles of Crohn's disease patients are different from those of their healthy first degree relatives and matched healthy controls

Marie JOOSSENSTom VanhoutteVicky De PreterKristel Van SteenLiesbet HenckaertsIngrid ArijsGeert HuysKristin VerbekePeter VandammePaul Rutgeerts et al.

Gene expression profiling to predict the response of infliximab in patients with UC

I ArijsL Van LommelKristel Van SteenG De HertoghF SchuitK GeboesG Van AsscheS VermeirePJ Rutgeerts

Genetic markers and the risk of complicated disease behaviour in Crohn's disease patients

L HenckaertsI VerstrekenKristel Van SteenR VlietinckP RutgeertsS Vermeire

Mixed IBD families : a distinct entity within IBD

M PierikKristel Van SteenMarie JoossensPJ RutgeertsS Vermeire

New serological markers in inflammatory bowel disease are associated with complicated disease behaviour

M FerranteL HenckaertsMarie JoossensM PierikS JoossensN DotanGL NormanRT AltstockKristel Van SteenP Rutgeerts et al.

A1 Journal Article in GUT

Pet ownership in eight European birth cohorts : results of a GA(2)LEN initiative

S RollT KeilE EllerC Bindslev-JensenU KraemerC ChenA von BergH SmitA WijgaKL Carlsen et al.

2006

Does a patient's self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer?

F EfficaceA BottomleyC CoensKristel Van SteenT ConroyP SchoffskiH SchmollE Van CutsemCH Kohne

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

Eotaxin polymorphisms and serum total IgE levels in children with asthma

BA RabyKristel Van SteenR LazarusJC CeledonEK SilvermanST Weiss

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T-bet polymorphisms are associated with asthma and airway hyperresponsiveness

BA RabyES HwangKristel Van SteenK TantisiraS PengA LitonjuaR LazarusC GiallourakisJD RiouxD Sparrow et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Toll-like receptor-1,-2, and-6 polymorphisms influence disease extension in inflammatory bowel diseases

M PierikS JoossensKristel Van SteenN Van SchuerbeekR VlietinckP RutgeertsS Vermeire

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

2005

An equivalence test for comparing DNA sequences

Kristel Van SteenBA RabyG MolenberghsH ThijsM De WitM Peeters

A1 Journal Article in PHARMACEUTICAL STATISTICS

Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q

MB McQueenB DevlinSV FaraoneVL NimgaonkarP SklarJW SmollerRA JamraM AlbusSA BacanuM Baron et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Comparison of linkage and association strategies for quantitative traits using the COGA dataset

MB McQueenA MurphyP KraftJ SuR LazarusNM LairdC LangeKristel Van Steen

A1 Journal Article in BMC GENETICS

Crohn's disease and month of birth

M Van RanstMarie JoossensS JoossensKristel Van SteenM PierikS VermeireP Rutgeerts

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

Genomic screening and replication using the same data set in family-based association testing

Kristel Van SteenMB McQueenA HerbertB RabyH LyonDL DeMeoA MurphyJ SuS DattaC Rosenow et al.

A1 Journal Article in NATURE GENETICS

Genomic screening in family based association testing and the multiple testing problem

Kristel Van SteenMB McQueenA HerbertC RosenowEK SilvermanNM LairdST WeissC Lange

Genomic screening in family-based association testing

A MurphyMB McGueenJ SuP KraftR LazarusNM LairdC LangeKristel Van Steen

A1 Journal Article in BMC GENETICS

Paternal history of asthma and airway responsiveness in children with asthma

BA RabyKristel Van SteenJC CeledonAA LitonjuaC LangeST Weiss

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Permutation based methods for comparing quality of life between observed treatments

Beatrijs MoerkerkeEls GoetghebeurKristel Van SteenSimon Van BelleVeronique Cocquyt

A1 Journal Article in STATISTICS IN MEDICINE

Predicting survival using health related quality of life scores in glioblastoma cancers : findings from an international phase III randomised controlled trial

A BottomleyM TaphoornC CoensD OsobaKristel Van SteenF EfficaceM van Den BentB BaumertW MasonR Stupp

The value of patient-reported symptoms as prognostic factors for survival in advanced colorectal cancer

F EfficaceA BottomleyC CoensKristel Van SteenT ConroyP SchoffskiHJ SchmollE van CutsemCH Kohne

2004

Deficient host-bacteria interactions in inflammatory bowel disease? : the toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis

D FranchimontS VermeireH El HousniM PierikKristel Van SteenT GustotE QuertinmontM AbramowiczA Van GossumJ Deviere et al.

A1 Journal Article in GUT

Genome wide scan in a Flemish inflammatory bowel disease population : support for the IBD4 locus, population heterogeneity, and epistasis

S VermeireP RutgeertsKristel Van SteenS JoossensG ClaessensM PierikMarc PeetersR Vlietinck

A1 Journal Article in GUT

Health-related quality of life parameters as prognostic factors in a nonmetastatic breast cancer population : an international multicenter study

F EfficaceP TherasseMJ PiccartC CoensKristel Van SteenM Welnicka-JaskiewiczT CuferJ DyczkaM LichinitserL Shepherd et al.

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

Interassay and interobserver variability in the detection of anti-neutrophil cytoplasmic antibodies in patients with ulcerative colitis

S JoossensM DapernoZ ShumsKristel Van SteenJA GoekenC TrapaniGL NormanG GodefridisG ClaessensA Pera et al.

A1 Journal Article in CLINICAL CHEMISTRY

Introducing the multivariate dale model in population-based genetic association studies

Kristel Van SteenN TahriG Molenberghs

A1 Journal Article in BIOMETRICAL JOURNAL

Pancreatic autoantibodies in inflammatory bowel disease

S JoossensS VermeireKristel Van SteenG GodefridisG ClaessensM PierikR HietinckR AertsP RutgeertsX Bossuyt

A1 Journal Article in INFLAMMATORY BOWEL DISEASES

Predicting survival with health-related quality of life scores in locally advanced breast cancer : results from an international randomized controlled trial

F EfficaceP TherasseM PiccartC CoensKristel Van SteenM Welnicka-JaskiewiczT CuferM LichinitserL ShepherdA Bottomley

Transmission of CARD15 (NOD2) variants within families of patients with inflammatory bowel disease

N EstersM PierikKristel Van SteenS VermeireG ClaessensS JoossensR VlietinckP Rutgeerts

A1 Journal Article in AMERICAN JOURNAL OF GASTROENTEROLOGY

2003

Autoimmunity associated with anti-tumor necrosis factor alpha treatment in Crohn's disease : a prospective cohort study

S VermeireM NomanG Van AsscheF BaertKristel Van SteenN EstersS JoossensX BossuytP Rutgeerts

A1 Journal Article in GASTROENTEROLOGY

Guidelines for the use of epoetin : have quality-of-life benefits been proven?

A BottomleyR ThomasKristel Van SteenH FlechtnerA de Graeff

A1 Journal Article in JOURNAL OF CLINICAL ONCOLOGY

The value of serologic markers in indeterminate colitis : a prospective follow-up study : reply

S JoossensKristel Van SteenSV VermeireW ReinischJF ColombelP Rutgeerts

A1 Journal Article in GASTROENTEROLOGY

Transmission of CARD15 (NOD2) variants in families with Crohns disease

S VermeireN EstersM PierikG ClaessensS JoossensR VlietinckKristel Van SteenP Rutgeerts

2002

Erythropoietin improves quality of life : a response

A BottomleyR ThomasKristel Van SteenH FlechtnerB Djulbegovic

Editorial material

Human recombinant erythropoietin and quality of life : a wonder drug or something to wonder about?

A BottomleyR ThomasKristel Van SteenH FlechtnerB Djulbegovic

A1 Journal Article in LANCET ONCOLOGY

Multicollinearity in prognostic factor analyses using the EORTC QLQ-C30 : identification and impact on model selection

Kristel Van SteenD CurranJ KramerG MolenberghsA Van VreckemA BottomleyR Sylvester

A1 Journal Article in STATISTICS IN MEDICINE

2001

An equivalence test for comparing DNA sequences

H ThijsKristel Van SteenG MolenberghsM De WitM Peeters

Introduction of the multivariate Dale model in genetic association studies

Kristel Van SteenN TahriG Molenberghs

Sensitivity analysis of longitudinal binary quality of life data with drop-out : an example using the EORTC QLQ-C30

Kristel Van SteenD CurranG Molenberghs

A1 Journal Article in STATISTICS IN MEDICINE

1999

Characterizations by automorphism groups of some rank 3 buildings, II : a half strongly-transitive locally finite triangle building is a Bruhat-Tits building

Hendrik Van MaldeghemKristel Van Steen

A1 Journal Article in GEOMETRIAE DEDICATA

Characterizations by automorphism groups of some rank 3 buildings, III : Moufang-like conditions

Kristel Van Steen

A1 Journal Article in GEOMETRIAE DEDICATA

Characterizations by automorphism groups of some rank 3 buildings, IV : hyperbolic p-adic Moufang buildings of rank 3

Hendrik Van MaldeghemKristel Van Steen

A1 Journal Article in GEOMETRIAE DEDICATA

1998

Characterizations by automorphism groups of some rank 3 buildings, I : some properties of half strongly-transitive triangle buildings

Hendrik Van MaldeghemKristel Van Steen

A1 Journal Article in GEOMETRIAE DEDICATA

1997

Moufang affine buildings have Moufang spherical buildings at infinity

Hendrik Van MaldeghemKristel Van Steen

A1 Journal Article in GLASGOW MATHEMATICAL JOURNAL

1996

Non-spherical tits-buildings of rank 3

Kristel Van SteenH. Van Maldeghem