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Researcher
Koen Venken
Profile
Projects
Publications
Activities
Awards & Distinctions
66
Results
2023
Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis
Koen Venken
Matthias Jarlborg
Tine Decruy
Céline Mortier
Carolien Vlieghe
Elisabeth Gilis
Ann-Sophie De Craemer
Julie Coudenys
Isabelle Cambré
Devan Fleury
et al.
A1
Journal Article
in
ANNALS OF THE RHEUMATIC DISEASES
2023
ROR gamma t inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating gamma delta-T cells
Céline Mortier
Robert Eric Gracey
Julie Coudenys
Teddy Manuello
Tine Decruy
Margaux Maelegheer
Flore Stappers
Elisabeth Gilis
Djoere Gaublomme
Luc Van Hoorebeke
et al.
A1
Journal Article
in
RHEUMATOLOGY
2023
2022
In vitro triple coculture with gut microbiota from spondyloarthritis patients is characterized by inter-individual differences in inflammatory responses
Annelore Beterams
Marta Calatayud Arroyo
Kim De Paepe
Ann-Sophie De Craemer
Dirk Elewaut
Koen Venken
Tom Van de Wiele
A1
Journal Article
in
SCIENTIFIC REPORTS
2022
2021
Crossing the boundaries : IL-23 and its role in linking inflammation of the skin, gut and joints
Zuzanna Łukasik
Robert Eric Gracey
Koen Venken
Christopher Ritchlin
Dirk Elewaut
A1
Journal Article
in
RHEUMATOLOGY
2021
2020
ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids
Srinath Govindarajan
Eveline Verheugen
Koen Venken
Djoere Gaublomme
Margaux Maelegheer
Eva Cloots
Fien Gysens
Bruno De Geest
Tan‐Yun Cheng
D Branch Moody
et al.
A1
Journal Article
in
EMBO REPORTS
2020
Intestinal microbiota, HLA-B27, and spondyloarthritis dangerous liaisons
Emilie Dumas
Koen Venken
James T. Rosenbaum
Dirk Elewaut
A1
Journal Article
in
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
2020
MAIT cells come to the rescue in cancer immunotherapy?
Zuzanna Łukasik
Dirk Elewaut
Koen Venken
A1
Journal Article
in
CANCERS
2020
The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD
Elise De Smet
Hannelore Van Eeckhoutte
Francisco Avila Cobos
Evy Blomme
Fien Verhamme
Sharen Provoost
STIJN VERLEDEN
Koen Venken
Tania Maes
Guy Joos
et al.
A1
Journal Article
in
MUCOSAL IMMUNOLOGY
2020
2019
4''-O-Alkylated α-galactosylceramide analogues as iNKT-cell antigens : synthetic, biological, and structural studies
Jonas Janssens
Aruna Bitra
Jing Wang
Tine Decruy
Koen Venken
Johan Van der Eycken
Dirk Elewaut
Dirk Zajonc
Serge Van Calenbergh
A1
Journal Article
in
CHEMMEDCHEM
2019
Deletion of mucosa-associated lymphoid tissue lymphoma translocation protein 1 in mouse T cells protects against development of autoimmune arthritis but leads to spontaneous osteoporosis
Elisabeth Gilis
Djoere Gaublomme
Jens Staal
Koen Venken
Maarten Dhaenens
Stijn Lambrecht
Julie Coudenys
Tine Decruy
Nadia Schryvers
Yasmine Driege
et al.
A1
Journal Article
in
ARTHRITIS & RHEUMATOLOGY
2019
RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients
Koen Venken
Peggy Jacques
Céline Mortier
Mark E. Labadia
Tine Decruy
Julie Coudenys
Kathleen Hoyt
Anita L. Wayne
Robert Hughes
Michael Turner
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2019
Running promotes chronicity of arthritis by local modulation of complement activators and impairing T regulatory feedback loops
Isabelle Cambré
Djoere Gaublomme
Nadia Schryvers
Stijn Lambrecht
Rik Lories
Koen Venken
Dirk Elewaut
A1
Journal Article
in
ANNALS OF THE RHEUMATIC DISEASES
2019
2018
4"-O-alkylated α-galactosylceramide analogues as iNKT cell antigens : synthetic, biological and structural studies
Jonas Janssens
Jing Wang
Aruna Bitra
Tine Decruy
Koen Venken
Johan Van der Eycken
Dirk Elewaut
Dirk Zajonc
Serge Van Calenbergh
C3
Conference
2018
A novel LPS-responsive beige-like anchor protein (LRBA) mutation presents with normal cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and overactive TH17 immunity
Marieke De Bruyne
Delfien Bogaert
Koen Venken
Lien Van den Bossche
Carolien Bonroy
Lisa Roels
Simon Tavernier
Els van de Vijver
Ann Driessen
Marielle van Gijn
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2018
Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70
Meng Zhao
Mattias ND Svensson
Koen Venken
Ashu Chawla
Shu Liang
Isaac Engel
Piotr Mydel
Jeremy Day
Dirk Elewaut
Nunzio Bottini
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2018
Checkpoint inhibition in the treatment of multiple myeloma : a way to boost innate-like T cell anti-tumor function?
Koen Venken
Mérédis Favreau
Djoere Gaublomme
Eline Menu
Karin Vanderkerken
Dirk Elewaut
A1
Journal Article
in
MOLECULAR IMMUNOLOGY
2018
It takes 'guts' to cause joint inflammation : role of innate-like T cells
Céline Mortier
Srinath Govindarajan
Koen Venken
Dirk Elewaut
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2018
The role of the microbiome in gut and joint inflammation in psoriatic arthritis and spondyloarthritis
Elisabeth Gilis
Céline Mortier
Koen Venken
Karlijn Debusschere
Lars Vereecke
Dirk Elewaut
A1
Journal Article
in
JOURNAL OF RHEUMATOLOGY
2018
2017
Both mucosal-associated invariant and natural killer T-cell deficiency in multiple myeloma can be countered by PD-1 inhibition
Mérédis Favreau
Koen Venken
Sylvia Faict
Ken Maes
Kim De Veirman
Elke De Bruyne
Xavier Leleu
Louis Boon
Dirk Elewaut
Karin Vanderkerken
et al.
A1
Journal Article
in
HAEMATOLOGICA
2017
Efficient divergent synthesis of new immunostimulant 4″-modified α-galactosylceramide analogues
Jonas Janssens
Tine Decruy
Koen Venken
Toshiyuki Seki
Simon Krols
Johan Van der Eycken
Moriya Tsuji
Dirk Elewaut
Serge Van Calenbergh
A1
Journal Article
in
ACS MEDICINAL CHEMISTRY LETTERS
2017
Immune therapy in multiple myeloma : can iNKT cells be targeted?
Mérédis Favreau
Eline Menu
Karin Vanderkerken
Dirk Elewaut
Koen Venken
Dissertation
2017
Leptin receptor antagonism of iNKT cell function : a novel strategy to combat multiple myeloma
Mérédis Favreau
E Menu
Djoere Gaublomme
K Vanderkerken
S Faict
K Maes
E De Bruyne
Srinath Govindarajan
Michael Drennan
Serge Van Calenbergh
et al.
A1
Journal Article
in
LEUKEMIA
2017
Synthesis of C6′′-modified α-C-GalCer analogues as mouse and human iNKT cell agonists
Joren Guillaume
Toshiyuki Seki
Tine Decruy
Koen Venken
Dirk Elewaut
Moriya Tsuji
Serge Van Calenbergh
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2017
2016
Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma?
Mérédis Favreau
Karin Vanderkerken
Dirk Elewaut
Koen Venken
Eline Menu
A1
Journal Article
in
ONCOTARGET
2016
2015
IL-23 Responsive innate-like T cells in spondyloarthritis: the less frequent they are, the more vital they appear
Koen Venken
Dirk Elewaut
A1
Journal Article
in
CURRENT RHEUMATOLOGY REPORTS
2015
Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level
Lennart Zabeau
Cathy J Jensen
Sylvie Seeuws
Koen Venken
Annick Verhee
Dominiek Catteeuw
Geert van Loo
Hui Chen
Ken Walder
Jacob Hollis
et al.
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2015
New immune cells in spondyloarthritis: key players or innocent bystanders?
Koen Venken
Dirk Elewaut
A1
Journal Article
in
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
2015
2014
A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis
Koen Venken
Sylvie Seeuws
Lennart Zabeau
Peggy Jacques
Tine Decruy
Julie Coudenys
Eveline Verheugen
Fien Windels
Dominiek Catteeuw
Michael Drennan
et al.
A1
Journal Article
in
JOURNAL OF HEPATOLOGY
2014
An in silico approach for modelling T-helper polarizing iNKT cell agonists
Anton De Spiegeleer
Evelien Wynendaele
Matthias Vandekerckhove
Sofie Stalmans
Maxime Boucart
Nele Van Den Noortgate
Koen Venken
Serge Van Calenbergh
Sandrine Aspeslagh
Dirk Elewaut
A1
Journal Article
in
PLOS ONE
2014
Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-α production by interaction with its soluble E-cadherin ligand in chronically inflamed joints
Lode Melis
Liesbet Van Praet
Hanspeter Pircher
Koen Venken
Dirk Elewaut
A1
Journal Article
in
ANNALS OF THE RHEUMATIC DISEASES
2014
2013
A computational high-throughput screening approach of iNKT-agonists: a novel tool to find optimized iNKT cell ligands
Anton De Spiegeleer
Evelien Wynendaele
Sofie Stalmans
Nele Van Den Noortgate
Matthias Vandekerckhove
Serge Van Calenbergh
Sandrine Aspeslagh
Koen Venken
Dirk Elewaut
C3
Conference
2013
Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells
Koen Venken
Tine Decruy
Sandrine Aspeslagh
Serge Van Calenbergh
Bart Lambrecht
Dirk Elewaut
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2013
Enhanced TCR footprint by a novel glycolipid increases NKT-dependent tumor protection
Sandrine Aspeslagh
Marek Nemčovič
Nora Pauwels
Koen Venken
Jing Wang
Serge Van Calenbergh
Dirk M Zajonc
Dirk Elewaut
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2013
2012
Elevated soluble E-cadherin levels in chronically inflamed joints favour TNF production by KLRG1 expressing T cells
Lode Melis
Koen Venken
Liesbet Van Praet
Dirk Elewaut
C3
Conference
2012
Elevated soluble E-cadherin levels in chronically inflamed joints favour TNF production by KLRG1 expressing T cells
Lode Melis
Koen Venken
Liesbet Van Praet
Dirk Elewaut
C3
Conference
2012
Natural killer T cells in adipose tissue prevent insulin resistance
Henk S Schipper
Maryam Rakhshandehroo
Stan FJ van de Graaf
Koen Venken
Arjen Koppen
Rinke Stienstra
Serge Prop
Jenny Meerding
Nicole Hamers
Gurdyal Besra
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2012
Soluble contributors to systemic inflammation and local peripheral synovitis in chronic arthritides
Lode Melis
Dirk Elewaut
Koen Venken
Dissertation
2012
Synovial fluid derived iNKT cells in chronic arthritides show an increased PROGRAMMED DEATH-1 expression and anergic phenotype
Koen Venken
Lode Melis
Peggy Jacques
Liesbet Van Praet
Filip Van den Bosch
Dirk Elewaut
C3
Conference
2012
2011
Galactose modified iNKT cell agonists stabilised by a novel structural modification of CD1D lead to marked TH1 polarisation in vivo
Sandrine Aspeslagh
YaLi Li
Esther Dawen Yu
Nora Pauwels
Matthias Trappeniers
Enrico Girardi
Tine Decruy
Katrien Van Beneden
Koen Venken
Michael Drennan
et al.
C3
Conference
2011
Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis
Sandrine Aspeslagh
Yali Li
Esther Dawen Yu
Nora Pauwels
Matthias Trappeniers
Enrico Girard
Tine Decruy
Katrien Van Beneden
Koen Venken
Michael Drennan
et al.
A1
Journal Article
in
EMBO JOURNAL
2011
Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia
Pieter Hindryckx
Lindsey Devisscher
Debby Laukens
Koen Venken
Harald Peeters
Martine De Vos
A1
Journal Article
in
LABORATORY INVESTIGATION
2011
Mechanisms regulating TNF-driven gut and joint inflammation
Dirk Elewaut
Peggy Jacques
Lode Melis
Koen Venken
A1
Journal Article
in
Advances in Experimental Medicine and Biology
2011
2010
Disturbed regulatory T cell homeostasis in multiple sclerosis
Koen Venken
Niels Hellings
Roland Liblau
Piet Stinissen
A1
Journal Article
in
TRENDS IN MOLECULAR MEDICINE
2010
Haplotype 4 of the multiple sclerosis-associated interleukin-7 receptor alpha gene influences the frequency of recent thymic emigrants
B Broux
Niels Hellings
Koen Venken
Jean-Luc Rummens
Karen Hensen
B Van Wijmeersch
Piet Stinissen
A1
Journal Article
in
GENES AND IMMUNITY
2010
Invariant natural killer T cells are natural regulators of murine spondylarthritis
Peggy Jacques
Koen Venken
Katrien Van Beneden
Hamida Hammad
Sylvie Seeuws
Michael Drennan
Dieter Deforce
August Verbruggen
Maria Apostolaki
George Kollias
et al.
A1
Journal Article
in
ARTHRITIS AND RHEUMATISM
2010
Involvement of T-cell receptor-beta alterations in the development of otosclerosis linked to OTSC2
I Schrauwen
Koen Venken
K Vanderstraeten
M Thys
JJ Hendrickx
E Fransen
Lut Van Laer
PJ Govaerts
M Verstreken
I Schatteman
et al.
A1
Journal Article
in
GENES AND IMMUNITY
2010
Memory CD4+CD127high T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens
Koen Venken
Niels Hellings
Karen Hensen
Jean-Luc Rummens
Piet Stinissen
A1
Journal Article
in
JOURNAL OF NEUROIMMUNOLOGY
2010
Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid
Sandrine Aspeslagh
Yali Li
Tine Decruy
Katrien Van Beneden
Koen Venken
Matthias Trappeniers
Serge Van Calenbergh
Dirk Zajonc
Dirk Elewaut
C3
Conference
2010
Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid
Sandrine Aspeslagh
Yali Li
Tine Decruy
Katrien Van Beneden
Michael Drennan
Koen Venken
Matthias Trappeniers
Serge Van Calenbergh
Dirk Zajonc
Dirk Elewaut
C3
Conference
2010
Suppression of human natural killer T cell function by CD4(+)CD25(+)FOXP3(+) regulatory T cells
Koen Venken
Tine Decruy
Kim Deswarte
Sandrine Aspeslagh
Serge Van Calenbergh
Bart Lambrecht
Dirk Elewaut
C3
Conference
2010
2009
A single nucleotide polymorphism within the interleukin-7 receptor alpha promoter influences recent thymic emigrants in multiple sclerosis
Bieke Broux
Niels Hellings
Koen Venken
Bart Van Wijmeersch
Piet Stinissen
C3
Conference
2009
2008
Compromised CD4+ CD25high regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level
Koen Venken
Niels Hellings
Marielle Thewissen
Veerle Somers
Karen Hensen
Jean-Luc Rummens
Robert Medaer
Raymond Hupperts
Piet Stinissen
A1
Journal Article
in
IMMUNOLOGY
2008
Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression
Koen Venken
Niels Hellings
Tom Broekmans
Karen Hensen
Jean-Luc Rummens
Piet Stinissen
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2008
Natural naive regulatory T cell development and function are disturbed in multiple sclerosis patients
Koen Venken
Niels Hellings
Karen Hensen
Jean-Luc Rummens
Piet Stinissen
C3
Conference
2008
Natural naive regulatory T cell development and function are disturbed in multiple sclerosis patients
Koen Venken
Niels Hellings
Tom Broekmans
Karen Hensen
Jean-Luc Rummens
Piet Stinissen
C3
Conference
2008
2007
A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses
Koen Venken
Marielle Thewissen
Niels Hellings
Veerle Somers
Karen Hensen
Jean-Luc Rummens
Piet Stinissen
A1
Journal Article
in
JOURNAL OF IMMUNOLOGICAL METHODS
2007
Analyses of immunosenescent markers in patients with autoimmune disease
Marielle Thewissen
Veerle Somers
Koen Venken
Loes Linsen
Pieter Van Paassen
Piet Geusens
Jan Damoiseaux
Piet Stinissen
A1
Journal Article
in
CLINICAL IMMUNOLOGY
2007
CD4+CD28null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation
Marielle Thewissen
Veerle Somers
Niels Heltings
Piet Stinissen
Koen Venken
C3
Conference
2007
Compromised CD4+CD25Hi regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3 positive cells and a reduced FOXP3 expression at the single-cell level
Koen Venken
Niels Hellings
Marielle Thewissen
Veerle Somers
Karen Hensen
Jean-Luc Rummens
Robert Medaer
Raymond Hupperts
Piet Stinissen
C3
Conference
2007
Reduced number of blood circulating foxp3+CD25highCD4+regulatory T cells and a decreased foxp3 expression at the single-cell level in patients with relapsing-remitting multiple sclerosis
Koen Venken
Niels Hellings
Veerle Somers
Pieter Meuwissen
Marielle Thewissen
Karen Hensen
Jean-Luc Rummens
Piet Stinissen
C3
Conference
2007
2006
Effects of IFN-beta, leptin and sinivastatin on LIF secretion by T lymphocytes of MS patients and healthy controls
Joris Vanderlocht
Jerome Hendriks
Koen Venken
Piet Stinissen
Niels Hellings
C3
Conference
2006
Effects of IFN-β, leptin and simvastatin on LIF secretion by T lymphocytes of MS patients and healthy controls
Joris Vanderlocht
Jerome JA Hendriks
Koen Venken
Piet Stinissen
Niels Hellings
A1
Journal Article
in
JOURNAL OF NEUROIMMUNOLOGY
2006
Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression
Koen Venken
Niels Hellings
Karen Hensen
Jean-Luc Rummens
Robert Medaer
Marie B D'hooghe
Bénédicte Dubois
Jef Raus
Piet Stinissen
A1
Journal Article
in
JOURNAL OF NEUROSCIENCE RESEARCH
2006
Secondary progressive in contrast to relapsing: remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T cell function and FOXP3 expression
Koen Venken
Niels Hellings
Karen Hensen
Jean-Luc Rummens
Robert Medaer
Marie B D'hooghe
Bénédicte Dubois
Jef Raus
Piet Stinissen
C3
Conference
2006
The role of CD4(+)CD28(null) T cells in autoimmune diseases
Marielle Thewissen
Veerle Somers
Koen Venken
Piet Stinissen
C3
Conference
2006
2004
Impaired suppressive capacity and reduced FOXP3 expression of CD4+CD25+ regulatory T cells isolated from multiple sclerosis patients
Koen Venken
Niels Hellings
J Schuermans
J Raus
Piet Stinissen
C3
Conference
2004