Research Explorer

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Researcher

Koen Venken

Awards & Distinctions

70 Results

2024

Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells

Tan-Yun ChengT PraveenaSrinath GovindarajanCatarina F AlmeidaDaniel G PellicciWellington C ArkinsIldiko Van RhijnKoen VenkenDirk ElewautDale I Godfrey et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tregs protect against invariant NKT cell-mediated autoimmune colitis and hepatitis

Koen VenkenTine DecruyTim SparwasserDirk Elewaut

A1 Journal Article in IMMUNOLOGY

2023

Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis

Koen VenkenMatthias JarlborgTine DecruyCéline MortierCarolien VliegheElisabeth GilisAnn-Sophie De CraemerJulie CoudenysIsabelle CambréDevan Fleury et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Gut inflammation in axial spondyloarthritis patients is characterized by a marked type 17 skewed mucosal innate‐like T cell signature

Céline MortierKatrien QuintelierAnn-Sophie De CraemerThomas RensonLiselotte DerooEmilie DumasEveline VerheugenJulie CoudenysTine DecruyZuzanna Łukasik et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Innate-like T cells and type 17 immune responses in the gut-joint axis in Spondyloarthritis

Céline MortierDirk ElewautKoen VenkenTom Van de Wiele

ROR gamma t inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating gamma delta-T cells

Céline MortierEric GraceyJulie CoudenysTeddy ManuelloTine DecruyMargaux MaelegheerFlore StappersElisabeth GilisDjoere GaublommeLuc Van Hoorebeke et al.

A1 Journal Article in RHEUMATOLOGY

2022

In vitro triple coculture with gut microbiota from spondyloarthritis patients is characterized by inter-individual differences in inflammatory responses

Annelore BeteramsMarta Calatayud ArroyoKim De PaepeAnn-Sophie De CraemerDirk ElewautKoen VenkenTom Van de Wiele

A1 Journal Article in SCIENTIFIC REPORTS

2021

Crossing the boundaries : IL-23 and its role in linking inflammation of the skin, gut and joints

Zuzanna ŁukasikEric GraceyKoen VenkenChristopher RitchlinDirk Elewaut

A1 Journal Article in RHEUMATOLOGY

2020

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids

Srinath GovindarajanEveline VerheugenKoen VenkenDjoere GaublommeMargaux MaelegheerEva ClootsFien GysensBruno De GeestTan‐Yun ChengD Branch Moody et al.

A1 Journal Article in EMBO REPORTS

Intestinal microbiota, HLA-B27, and spondyloarthritis dangerous liaisons

Emilie DumasKoen VenkenJames T. RosenbaumDirk Elewaut

A1 Journal Article in RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

MAIT cells come to the rescue in cancer immunotherapy?

Zuzanna ŁukasikDirk ElewautKoen Venken

A1 Journal Article in CANCERS

The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD

Elise De SmetHannelore Van EeckhoutteFrancisco Avila CobosEvy BlommeFien VerhammeSharen ProvoostSTIJN VERLEDENKoen VenkenTania MaesGuy Joos et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

2019

4''-O-Alkylated α-galactosylceramide analogues as iNKT-cell antigens : synthetic, biological, and structural studies

Jonas JanssensAruna BitraJing WangTine DecruyKoen VenkenJohan Van der EyckenDirk ElewautDirk ZajoncSerge Van Calenbergh

A1 Journal Article in CHEMMEDCHEM

Deletion of mucosa-associated lymphoid tissue lymphoma translocation protein 1 in mouse T cells protects against development of autoimmune arthritis but leads to spontaneous osteoporosis

Elisabeth GilisDjoere GaublommeJens StaalKoen VenkenMaarten DhaenensStijn LambrechtJulie CoudenysTine DecruyNadia SchryversYasmine Driege et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Koen VenkenPeggy JacquesCéline MortierMark E. LabadiaTine DecruyJulie CoudenysKathleen HoytAnita L. WayneRobert HughesMichael Turner et al.

A1 Journal Article in NATURE COMMUNICATIONS

Running promotes chronicity of arthritis by local modulation of complement activators and impairing T regulatory feedback loops

Isabelle CambréDjoere GaublommeNadia SchryversStijn LambrechtRik LoriesKoen VenkenDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2018

4"-O-alkylated α-galactosylceramide analogues as iNKT cell antigens : synthetic, biological and structural studies

Jonas JanssensJing WangAruna BitraTine DecruyKoen VenkenJohan Van der EyckenDirk ElewautDirk ZajoncSerge Van Calenbergh

A novel LPS-responsive beige-like anchor protein (LRBA) mutation presents with normal cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and overactive TH17 immunity

Marieke De BruyneDelfien BogaertKoen VenkenLien Van den BosscheCarolien BonroyLisa RoelsSimon TavernierEls van de VijverAnn DriessenMarielle van Gijn et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Meng ZhaoMattias ND SvenssonKoen VenkenAshu ChawlaShu LiangIsaac EngelPiotr MydelJeremy DayDirk ElewautNunzio Bottini et al.

A1 Journal Article in NATURE COMMUNICATIONS

Checkpoint inhibition in the treatment of multiple myeloma : a way to boost innate-like T cell anti-tumor function?

Koen VenkenMérédis FavreauDjoere GaublommeEline MenuKarin VanderkerkenDirk Elewaut

A1 Journal Article in MOLECULAR IMMUNOLOGY

It takes 'guts' to cause joint inflammation : role of innate-like T cells

Céline MortierSrinath GovindarajanKoen VenkenDirk Elewaut

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The role of the microbiome in gut and joint inflammation in psoriatic arthritis and spondyloarthritis

Elisabeth GilisCéline MortierKoen VenkenKarlijn DebusschereLars VereeckeDirk Elewaut

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

2017

Both mucosal-associated invariant and natural killer T-cell deficiency in multiple myeloma can be countered by PD-1 inhibition

Mérédis FavreauKoen VenkenSylvia FaictKen MaesKim De VeirmanElke De BruyneXavier LeleuLouis BoonDirk ElewautKarin Vanderkerken et al.

A1 Journal Article in HAEMATOLOGICA

Efficient divergent synthesis of new immunostimulant 4″-modified α-galactosylceramide analogues

Jonas JanssensTine DecruyKoen VenkenToshiyuki SekiSimon KrolsJohan Van der EyckenMoriya TsujiDirk ElewautSerge Van Calenbergh

A1 Journal Article in ACS MEDICINAL CHEMISTRY LETTERS

Immune therapy in multiple myeloma : can iNKT cells be targeted?

Mérédis FavreauEline MenuKarin VanderkerkenDirk ElewautKoen Venken

Leptin receptor antagonism of iNKT cell function : a novel strategy to combat multiple myeloma

Mérédis FavreauE MenuDjoere GaublommeK VanderkerkenS FaictK MaesE De BruyneSrinath GovindarajanMichael DrennanSerge Van Calenbergh et al.

A1 Journal Article in LEUKEMIA

Synthesis of C6′′-modified α-C-GalCer analogues as mouse and human iNKT cell agonists

Joren GuillaumeToshiyuki SekiTine DecruyKoen VenkenDirk ElewautMoriya TsujiSerge Van Calenbergh

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

2016

Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma?

Mérédis FavreauKarin VanderkerkenDirk ElewautKoen VenkenEline Menu

A1 Journal Article in ONCOTARGET

2015

IL-23 Responsive innate-like T cells in spondyloarthritis: the less frequent they are, the more vital they appear

Koen VenkenDirk Elewaut

A1 Journal Article in CURRENT RHEUMATOLOGY REPORTS

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level

Lennart ZabeauCathy J JensenSylvie SeeuwsKoen VenkenAnnick VerheeDominiek CatteeuwGeert van LooHui ChenKen WalderJacob Hollis et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

New immune cells in spondyloarthritis: key players or innocent bystanders?

Koen VenkenDirk Elewaut

A1 Journal Article in BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

2014

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

Koen VenkenSylvie SeeuwsLennart ZabeauPeggy JacquesTine DecruyJulie CoudenysEveline VerheugenFien WindelsDominiek CatteeuwMichael Drennan et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

An in silico approach for modelling T-helper polarizing iNKT cell agonists

Anton De SpiegeleerEvelien WynendaeleMatthias VandekerckhoveSofie StalmansMaxime BoucartNele Van Den NoortgateKoen VenkenSerge Van CalenberghSandrine AspeslaghDirk Elewaut

A1 Journal Article in PLOS ONE

Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-α production by interaction with its soluble E-cadherin ligand in chronically inflamed joints

Lode MelisLiesbet Van PraetHanspeter PircherKoen VenkenDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2013

A computational high-throughput screening approach of iNKT-agonists: a novel tool to find optimized iNKT cell ligands

Anton De SpiegeleerEvelien WynendaeleSofie StalmansNele Van Den NoortgateMatthias VandekerckhoveSerge Van CalenberghSandrine AspeslaghKoen VenkenDirk Elewaut

Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells

Koen VenkenTine DecruySandrine AspeslaghSerge Van CalenberghBart LambrechtDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Enhanced TCR footprint by a novel glycolipid increases NKT-dependent tumor protection

Sandrine AspeslaghMarek NemčovičNora PauwelsKoen VenkenJing WangSerge Van CalenberghDirk M ZajoncDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2012

Elevated soluble E-cadherin levels in chronically inflamed joints favour TNF production by KLRG1 expressing T cells

Lode MelisKoen VenkenLiesbet Van PraetDirk Elewaut

Elevated soluble E-cadherin levels in chronically inflamed joints favour TNF production by KLRG1 expressing T cells

Lode MelisKoen VenkenLiesbet Van PraetDirk Elewaut

Natural killer T cells in adipose tissue prevent insulin resistance

Henk S SchipperMaryam RakhshandehrooStan FJ van de GraafKoen VenkenArjen KoppenRinke StienstraSerge PropJenny MeerdingNicole HamersGurdyal Besra et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Soluble contributors to systemic inflammation and local peripheral synovitis in chronic arthritides

Lode MelisDirk ElewautKoen Venken

Synovial fluid derived iNKT cells in chronic arthritides show an increased PROGRAMMED DEATH-1 expression and anergic phenotype

Koen VenkenLode MelisPeggy JacquesLiesbet Van PraetFilip Van den BoschDirk Elewaut

2011

Galactose modified iNKT cell agonists stabilised by a novel structural modification of CD1D lead to marked TH1 polarisation in vivo

Sandrine AspeslaghYaLi LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardiTine DecruyKatrien Van BenedenKoen VenkenMichael Drennan et al.

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

Sandrine AspeslaghYali LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardTine DecruyKatrien Van BenedenKoen VenkenMichael Drennan et al.

A1 Journal Article in EMBO JOURNAL

Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia

Pieter HindryckxLindsey DevisscherDebby LaukensKoen VenkenHarald PeetersMartine De Vos

A1 Journal Article in LABORATORY INVESTIGATION

Mechanisms regulating TNF-driven gut and joint inflammation

Dirk ElewautPeggy JacquesLode MelisKoen Venken

A1 Journal Article in Advances in Experimental Medicine and Biology

2010

Disturbed regulatory T cell homeostasis in multiple sclerosis

Koen VenkenNiels HellingsRoland LiblauPiet Stinissen

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Haplotype 4 of the multiple sclerosis-associated interleukin-7 receptor alpha gene influences the frequency of recent thymic emigrants

B BrouxNiels HellingsKoen VenkenJean-Luc RummensKaren HensenB Van WijmeerschPiet Stinissen

A1 Journal Article in GENES AND IMMUNITY

Invariant natural killer T cells are natural regulators of murine spondylarthritis

Peggy JacquesKoen VenkenKatrien Van BenedenHamida HammadSylvie SeeuwsMichael DrennanDieter DeforceAugust VerbruggenMaria ApostolakiGeorge Kollias et al.

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Involvement of T-cell receptor-beta alterations in the development of otosclerosis linked to OTSC2

I SchrauwenKoen VenkenK VanderstraetenM ThysJJ HendrickxE FransenLut Van LaerPJ GovaertsM VerstrekenI Schatteman et al.

A1 Journal Article in GENES AND IMMUNITY

Memory CD4+CD127high T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens

Koen VenkenNiels HellingsKaren HensenJean-Luc RummensPiet Stinissen

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid

Sandrine AspeslaghYali LiTine DecruyKatrien Van BenedenMichael DrennanKoen VenkenMatthias TrappeniersSerge Van CalenberghDirk ZajoncDirk Elewaut

Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid

Sandrine AspeslaghYali LiTine DecruyKatrien Van BenedenKoen VenkenMatthias TrappeniersSerge Van CalenberghDirk ZajoncDirk Elewaut

Suppression of human natural killer T cell function by CD4(+)CD25(+)FOXP3(+) regulatory T cells

Koen VenkenTine DecruyKim DeswarteSandrine AspeslaghSerge Van CalenberghBart LambrechtDirk Elewaut

2009

A single nucleotide polymorphism within the interleukin-7 receptor alpha promoter influences recent thymic emigrants in multiple sclerosis

Bieke BrouxNiels HellingsKoen VenkenBart Van WijmeerschPiet Stinissen

2008

Compromised CD4+ CD25high regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

Koen VenkenNiels HellingsMarielle ThewissenVeerle SomersKaren HensenJean-Luc RummensRobert MedaerRaymond HuppertsPiet Stinissen

A1 Journal Article in IMMUNOLOGY

Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression

Koen VenkenNiels HellingsTom BroekmansKaren HensenJean-Luc RummensPiet Stinissen

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Natural naive regulatory T cell development and function are disturbed in multiple sclerosis patients

Koen VenkenNiels HellingsTom BroekmansKaren HensenJean-Luc RummensPiet Stinissen

Natural naive regulatory T cell development and function are disturbed in multiple sclerosis patients

Koen VenkenNiels HellingsKaren HensenJean-Luc RummensPiet Stinissen

2007

A CFSE based assay for measuring CD4+CD25+ regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses

Koen VenkenMarielle ThewissenNiels HellingsVeerle SomersKaren HensenJean-Luc RummensPiet Stinissen

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Analyses of immunosenescent markers in patients with autoimmune disease

Marielle ThewissenVeerle SomersKoen VenkenLoes LinsenPieter Van PaassenPiet GeusensJan DamoiseauxPiet Stinissen

A1 Journal Article in CLINICAL IMMUNOLOGY

CD4+CD28null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation

Marielle ThewissenVeerle SomersNiels HeltingsPiet StinissenKoen Venken

Compromised CD4+CD25Hi regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3 positive cells and a reduced FOXP3 expression at the single-cell level

Koen VenkenNiels HellingsMarielle ThewissenVeerle SomersKaren HensenJean-Luc RummensRobert MedaerRaymond HuppertsPiet Stinissen

Reduced number of blood circulating foxp3+CD25highCD4+regulatory T cells and a decreased foxp3 expression at the single-cell level in patients with relapsing-remitting multiple sclerosis

Koen VenkenNiels HellingsVeerle SomersPieter MeuwissenMarielle ThewissenKaren HensenJean-Luc RummensPiet Stinissen

2006

Effects of IFN-beta, leptin and sinivastatin on LIF secretion by T lymphocytes of MS patients and healthy controls

Joris VanderlochtJerome HendriksKoen VenkenPiet StinissenNiels Hellings

Effects of IFN-β, leptin and simvastatin on LIF secretion by T lymphocytes of MS patients and healthy controls

Joris VanderlochtJerome JA HendriksKoen VenkenPiet StinissenNiels Hellings

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression

Koen VenkenNiels HellingsKaren HensenJean-Luc RummensRobert MedaerMarie B D'hoogheBénédicte DuboisJef RausPiet Stinissen

A1 Journal Article in JOURNAL OF NEUROSCIENCE RESEARCH

Secondary progressive in contrast to relapsing: remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T cell function and FOXP3 expression

Koen VenkenNiels HellingsKaren HensenJean-Luc RummensRobert MedaerMarie B D'hoogheBénédicte DuboisJef RausPiet Stinissen

The role of CD4(+)CD28(null) T cells in autoimmune diseases

Marielle ThewissenVeerle SomersKoen VenkenPiet Stinissen

2004

Impaired suppressive capacity and reduced FOXP3 expression of CD4+CD25+ regulatory T cells isolated from multiple sclerosis patients

Koen VenkenNiels HellingsJ SchuermansJ RausPiet Stinissen