Research Explorer

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Researcher

Koen Sedeyn

Awards & Distinctions

15 Results

2023

Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins

Livija TušarJure LobodaFrancis ImpensPiotr SosnowskiEmmy Van QuickelbergheRobert VidmarHans DemolKoen SedeynXavier SaelensMatej Vizovišek et al.

A1 Journal Article in COMMUNICATIONS BIOLOGY

Unraveling the host-RSV interplay by proteomic approaches

Tessa Van RoyenXavier SaelensKoen Sedeyn

2022

An unexpected encounter : respiratory syncytial virus nonstructural protein 1 interacts with mediator subunit MED25

Tessa Van RoyenKoen SedeynGeorgios MoschonasWendy ToussaintM VuylstekeDelphi Van HaverFrancis ImpensSven EyckermanIrma LemmensJan Tavernier et al.

A1 Journal Article in JOURNAL OF VIROLOGY

How RSV proteins join forces to overcome the host innate immune response

Tessa Van RoyenIebe RosseyKoen SedeynBert SchepensXavier Saelens

A1 Journal Article in VIRUSES

2021

A vulnerable, membrane-proximal site in human respiratory syncytial virus F revealed by a prefusion-specific single-domain antibody

Iebe RosseyChing-Lin HsiehKoen SedeynMarlies BallegeerBert SchepensJason S. McLellanXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models

Bert SchepensLoes van SchieWim NerinckxKenny RooseWander Van BreedamDaria FijalkowskaSimon DevosWannes WeytsSieglinde De CaeSandrine Vanmarcke et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

Protective efficacy of recombinant influenza hemagglutinin ectodomain fusions

Nidhi MittalNayanika SenguptaSameer Kumar MalladiPoorvi ReddyMadhuraj BhatRaju S. RajmaniKoen SedeynXavier SaelensSomnath DuttaRaghavan Varadarajan

A1 Journal Article in VIRUSES-BASEL

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity

Fabien Henri TheryLia MartinaCaroline AsselmanHeidi RepoY ZhangKoen SedeynGeorgios MoschonasC BredowQW TeoJ Zhang et al.

A1 Journal Article in NATURE COMMUNICATIONS

2019

New antibody-based prevention and treatment options for influenza

Koen SedeynXavier Saelens

A1 Journal Article in ANTIVIRAL RESEARCH

Respiratory syncytial virus nonstructural proteins 1 and 2 : exceptional disrupters of innate immune responses

Koen SedeynBert SchepensXavier Saelens

A1 Journal Article in PLOS PATHOGENS

2018

Host-RSV interactions : a siRNA and proteomics approach

Koen SedeynXavier SaelensBert Schepens

2017

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

Iebe RosseyMorgan SA GilmanStephanie C KabecheKoen SedeynDaniel WrappMasaru KanekiyoMan ChenVicente MasJan SpitaelsJosé A Melero et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

CD8⁺ T cell immunity against human respiratory syncytial virus

Iebe RosseyKoen SedeynSarah De BaetsBert SchepensXavier Saelens

A1 Journal Article in VACCINE

Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein

Bert SchepensKoen SedeynLiesbeth Vande GinsteSarah De BaetsMichael SchotsaertKenny RooseLieselot HouspieMarc Van RanstBarbara GilbertNico van Rooijen et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2013

Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice

Sarah De BaetsBert SchepensKoen SedeynMichael SchotsaertKenny RoosePieter BogaertWalther FiersXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY