Manage settings
MENU
About this site
In het Nederlands
Home
Researchers
Projects
Organisations
Outputs & Impact
Infrastructure
Contact
Research Explorer
Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.
Researcher
Koen Sedeyn
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
18
Results
2025
Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base
Sieglinde De Cae
Inge Van Molle
Loes van Schie
Sophie R. Shoemaker
Julie Deckers
Nincy Debeuf
Sahine Lameire
Wim Nerinckx
Kenny Roose
Daria Fijalkowska
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2025
2024
Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline : caution is warranted
Delphine Diana Acar
Wojciech Witkowski
Magdalena Wejda
Ruifang Wei
Tim Desmet
Bert Schepens
Sieglinde De Cae
Koen Sedeyn
Hannah Eeckhaut
Daria Fijalkowska
et al.
A1
Journal Article
in
EBIOMEDICINE
2024
Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa
Jozefien Declercq
Sarah Gerlo
Sharon Van Nevel
Natalie De Ruyck
Gabriële Holtappels
Liesbeth Delesie
Els Tobback
Inés Lammens
Nikita Gerebtsov
Koen Sedeyn
et al.
A1
Journal Article
in
SCIENCE TRANSLATIONAL MEDICINE
2024
2023
Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins
Livija Tušar
Jure Loboda
Francis Impens
Piotr Sosnowski
Emmy Van Quickelberghe
Robert Vidmar
Hans Demol
Koen Sedeyn
Xavier Saelens
Matej Vizovišek
et al.
A1
Journal Article
in
COMMUNICATIONS BIOLOGY
2023
Unraveling the host-RSV interplay by proteomic approaches
Tessa Van Royen
Xavier Saelens
Koen Sedeyn
Dissertation
2023
2022
An unexpected encounter : respiratory syncytial virus nonstructural protein 1 interacts with mediator subunit MED25
Tessa Van Royen
Koen Sedeyn
Georgios Moschonas
Wendy Toussaint
M Vuylsteke
Delphi Van Haver
Francis Impens
Sven Eyckerman
Irma Lemmens
Jan Tavernier
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2022
How RSV proteins join forces to overcome the host innate immune response
Tessa Van Royen
Iebe Rossey
Koen Sedeyn
Bert Schepens
Xavier Saelens
A1
Journal Article
in
VIRUSES
2022
2021
A vulnerable, membrane-proximal site in human respiratory syncytial virus F revealed by a prefusion-specific single-domain antibody
Iebe Rossey
Ching-Lin Hsieh
Koen Sedeyn
Marlies Ballegeer
Bert Schepens
Jason S. McLellan
Xavier Saelens
A1
Journal Article
in
JOURNAL OF VIROLOGY
2021
An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models
Bert Schepens
Loes van Schie
Wim Nerinckx
Kenny Roose
Wander Van Breedam
Daria Fijalkowska
Simon Devos
Wannes Weyts
Sieglinde De Cae
Sandrine Vanmarcke
et al.
A1
Journal Article
in
SCIENCE TRANSLATIONAL MEDICINE
2021
Protective efficacy of recombinant influenza hemagglutinin ectodomain fusions
Nidhi Mittal
Nayanika Sengupta
Sameer Kumar Malladi
Poorvi Reddy
Madhuraj Bhat
Raju S. Rajmani
Koen Sedeyn
Xavier Saelens
Somnath Dutta
Raghavan Varadarajan
A1
Journal Article
in
VIRUSES-BASEL
2021
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity
Fabien Henri Thery
Lia Martina
Caroline Asselman
Heidi Repo
Y Zhang
Koen Sedeyn
Georgios Moschonas
C Bredow
QW Teo
J Zhang
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2021
2019
New antibody-based prevention and treatment options for influenza
Koen Sedeyn
Xavier Saelens
A1
Journal Article
in
ANTIVIRAL RESEARCH
2019
Respiratory syncytial virus nonstructural proteins 1 and 2 : exceptional disrupters of innate immune responses
Koen Sedeyn
Bert Schepens
Xavier Saelens
A1
Journal Article
in
PLOS PATHOGENS
2019
2018
Host-RSV interactions : a siRNA and proteomics approach
Koen Sedeyn
Xavier Saelens
Bert Schepens
Dissertation
2018
2017
Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
Iebe Rossey
Morgan SA Gilman
Stephanie C Kabeche
Koen Sedeyn
Daniel Wrapp
Masaru Kanekiyo
Man Chen
Vicente Mas
Jan Spitaels
José A Melero
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2017
2014
CD8⁺ T cell immunity against human respiratory syncytial virus
Iebe Rossey
Koen Sedeyn
Sarah De Baets
Bert Schepens
Xavier Saelens
A1
Journal Article
in
VACCINE
2014
Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein
Bert Schepens
Koen Sedeyn
Liesbeth Vande Ginste
Sarah De Baets
Michael Schotsaert
Kenny Roose
Lieselot Houspie
Marc Van Ranst
Barbara Gilbert
Nico van Rooijen
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2014
2013
Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice
Sarah De Baets
Bert Schepens
Koen Sedeyn
Michael Schotsaert
Kenny Roose
Pieter Bogaert
Walter Fiers
Xavier Saelens
A1
Journal Article
in
JOURNAL OF VIROLOGY
2013