Research Explorer

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Researcher

Kim Deswarte

42 Results

2021

Lipid-polyglutamate nanoparticle vaccine platform

Dorien Van LysebettenAlessio MalfantiKim DeswarteKaloian KoynovBianka GolbaTingting YeZifu ZhongSabah KasmiAlexander LamootYong ChenSimon Van HerckBart LambrechtNiek SandersStefan LienenklausSunil A. DavidMaría J. VicentStefaan De KokerBruno De Geest

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Squaric ester-based, pH-degradable nanogels : modular nanocarriers for safe, systemic administration of toll-like receptor 7/8 agonistic immune modulators

Anne HuppertsbergLeonard KapsZifu ZhongSascha SchmittJudith StickdornKim DeswarteFrancis CombesChristian CzyschJana De VriezeSabah KasmiNiklas ChoteschovskyAdrian KlefenzCarolina Medina-MontanoPia WinterwerberChaojian ChenMatthias BrosStefan LienenklausNiek SandersKaloian KoynovDetlef SchuppanBart LambrechtSunil A. DavidBruno De GeestLutz Nuhn

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sterilizing immunity against SARS‐CoV‐2 infection in mice by a single‐shot and lipid amphiphile imidazoquinoline TLR7/8 agonist‐adjuvanted recombinant spike protein vaccine**

Sonia JangraJana De VriezeAngela ChoiRaveen RathnasingheGabriel LaghlaliAnnemiek UvynSimon Van HerckLutz NuhnKim DeswarteZifu ZhongNiek SandersStefan LienenklausSunil A. DavidShirin StrohmeierFatima AmanatFlorian KrammerHamida HammadBart LambrechtLynda CoughlanAdolfo García‐SastreBruno De GeestMichael Schotsaert

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2020

Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles

Bi WangSimon Van HerckYong ChenXiangyang BaiZifu ZhongKim DeswarteBart LambrechtNiek SandersStefan LienenklausHans W. ScheerenSunil A. DavidFabian KiesslingTwan LammersBruno De GeestYang Shi

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sterilizing immunity against SARS-CoV-2 infection in mice by a single-shot and modified imidazoquinoline TLR7/8 agonist-adjuvanted recombinant spike protein vaccine

Sonia JangraJana De VriezeAngela ChoiRaveen RathnasingheGabriel LaghlaliAnnemiek UvynSimon Van HerckLutz NuhnKim DeswarteZifu ZhongNiek SandersStefan LienenklausSunil DavidShirin StrohmeierFatima AmanatFlorian KrammerHamida HammadBart LambrechtLynda CoughlanAdolfo García-SastreBruno De GeestMichael Schotsaert

TAO-kinase 3 governs the terminal differentiation of conventional dendritic cells

Matthias VanderkerkenBastiaan MaesLana VandersarrenWendy ToussaintKim DeswarteManon VanheerswynghelsPhilippe PouliotLiesbet MartensSofie Van GassenConnie M. ArthurMargaret E. KirklingBoris ReizisDaniel ConradSean StowellHamida HammadBart Lambrecht

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2019

A synthetic, transiently thermoresponsive homopolymer with UCST behaviour within a physiologically relevant window

Zhiyue ZhangHui LiSabah KasmiSimon Van HerckKim DeswarteBart LambrechtRichard HoogenboomLutz NuhnBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells

Annemiek UvynRuben De CoenOlivier De WeverKim DeswarteBart LambrechtBruno De Geest

A1 Journal Article in CHEMICAL COMMUNICATIONS

IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation

Aurora Holgado MunozHarald BraunElien Van NuffelSammy DetryMartijn SchuijsKim DeswarteKarl VergoteMira HaegmanGriet BaudeletJurgen HaustraeteHamida HammadBart LambrechtSavvas SavvidesInna AfoninaRudi Beyaert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists

Jana De VriezeBenoit LouageKim DeswarteZifu ZhongRuben De CoenSimon Van HerckLutz NuhnCamilla Kaas FrichAlexander N ZelikinStefan LienenklausNiek SandersBart LambrechtSunil A DavidBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prophylactic allergen immunotherapy with Der p 2 prevents murine asthma by regulating lung GM-CSF

Eline HaspeslaghManon VanheerswynghelsKim DeswarteJustine Van MoorleghemAlain JacquetBart LambrechtHamida Hammad

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

Emma PerssonKenneth VerstraeteInes HeyndrickxElien GevaertHelena Catharine AegerterJean-Michel PercierKim DeswarteKoen VerschuerenAnn DansercoerDelphine GrasPascal ChanezClaus BachertAmanda GonçalvesHanne Van GorpHans De HaardChristophe BlanchetotMichael SaundersHamida HammadSavvas SavvidesBart Lambrecht

A1 Journal Article in SCIENCE

Single-cell RNA sequencing of the T helper cell response to house dust mites defines a distinct gene expression signature in airway Th2 cells

Christopher Andrew TibbittJulian Mario StarkLiesbet MartensJunjie MaJeff Eron MoldKim DeswarteGanna OliynykXiaogang FengBart LambrechtPieter De BleserSusanne NylenHamida HammadMarie Arsenian HenrikssonYvan SaeysJonathan Marie Coquet

A1 Journal Article in IMMUNITY

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Nincy DebeufAssem ZhakupovaRegula SteinerSofie Van GassenKim DeswarteFarzaneh FayazpourJustine Van MoorleghemKarl VergoteBenjamin PavieKelly LemeireHamida HammadThorsten HornemannSophie JanssensBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van MoorleghemSofie De PrijckNozomi TakahashiPeter VandenabeeleLouis BoonGeert van LooEric VivierBart LambrechtSophie Janssens

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2018

A bispecific antibody strategy to target multiple type 2 cytokines in asthma

Marie GodarKim DeswarteKarl VergoteMichael SaundersHans de HaardHamida HammadChristophe BlanchetotBart Lambrecht

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dendritic cell targeting mRNA lipopolyplexes combine strong antitumor T-cell immunity with improved inflammatory safety

Kevin Van der JeughtStefaan De KokerLukasz BialkowskiCarlo HeirmanPatrick Tjok JoeFederico PercheSarah MaenhoutSanne BeversKatrijn BroosKim DeswarteVirginie MalardHamida HammadPatrick BarilThierry BenvegnuPaul-Alain JaffresSander AA KooijmansRaymond SchiffelersStefan LienenklausPatrick MidouxChantal PichonKarine BreckpotKris Thielemans

A1 Journal Article in ACS NANO

FRET monitoring of intracellular ketal hydrolysis in synthetic nanoparticles

Lutz NuhnSimon Van HerckAndreas BestKim DeswarteMaria KokkinopoulouIngo LieberwirthKaloian KoynovBart LambrechtBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hyaluronic acid conjugates of TLR7/8 agonists for targeted delivery to secondary lymphoid tissue

Euna YooAlex CD SalyerMichael JH BrushYupeng LiKathryn L TrautmanNikunj M ShuklaAns De BeuckelaerStefan LienenklausKim DeswarteBart LambrechtBruno De GeestSunil A David

A1 Journal Article in BIOCONJUGATE CHEMISTRY

Lymph-node-targeted immune activation by engineered block copolymer amphiphiles-TLR7/8 agonist conjugates

Simon Van HerckKim DeswarteLutz NuhnZifu ZhongJoão Portela CataniYupeng LiNiek SandersStefan LienenklausStefaan De KokerBart LambrechtSunil A DavidBruno De Geest

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses

Lutz NuhnStefaan De KokerSandra Van LintZifu ZhongJoão Portela CataniFrancis CombesKim DeswarteYupeng LiBart LambrechtStefan LienenklausNiek SandersSunil A DavidJan TavernierBruno De Geest

A1 Journal Article in ADVANCED MATERIALS

Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist

Lutz NuhnLien Van HoeckeKim DeswarteBert SchepensYupeng LiBart LambrechtStefaan De KokerSunil A DavidXavier SaelensBruno De Geest

A1 Journal Article in BIOMATERIALS

Role of NKp46⁺ natural killer cells in house dust mite-driven asthma

Eline HaspeslaghMary van HeldenKim DeswarteSofie De PrijckJustine Van MoorleghemLouis BoonHamida HammadEric VivierBart Lambrecht

A1 Journal Article in EMBO MOLECULAR MEDICINE

2017

Arginine-rich peptide-based mRNA nanocomplexes efficiently instigate cytotoxic T cell immunity dependent on the amphipathic organization of the peptide

Vimal Kumar UdhayakumarAns De BeuckelaerJoanne McCaffreyCian M McCruddenJonathan L KirschmanDaryll VanoverLien Van HoeckeKenny RooseKim DeswarteBruno De GeestStefan LienenklausPhilip J SantangeloJohan GrootenHelen O McCarthyStefaan De Koker

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Stefaan De KokerLien Van HoeckeAns De BeuckelaerKenny RooseKim DeswarteMonique WillartPieter BogaertThomas NaessensBruno De GeestXavier SaelensBart LambrechtJohan Grooten

A1 Journal Article in SCIENTIFIC REPORTS

The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome

Lotte PyfferoenElisabeth BrabantsCeline EveraertNancy De CabooterKelly HeynsKim DeswarteManon VanheerswynghelsSofie De PrijckGlenn WaegemansMelissa DullaersHamida HammadOlivier De WeverPieter MestdaghJo VandesompeleBart LambrechtKarim Vermaelen

A1 Journal Article in ONCOIMMUNOLOGY

Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10

Hamida HammadMatthias VanderkerkenPhilippe PouliotKim DeswarteWendy ToussaintKarl VergoteLana VandersarrenSophie JanssensIoanna RamouSavvas SavvidesJody HaighRudi HendriksManfred KopfKatleen CraessaertsBart de StrooperJohn F KearneyDaniel H ConradBart Lambrecht

A1 Journal Article in NATURE IMMUNOLOGY

2016

Early IL-1 signaling promotes iBALT induction after influenza virus infection

Katrijn NeytCorine H GeurtsvanKesselKim DeswarteHamida HammadBart Lambrecht

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation

Lutz NuhnNane VanparijsAns De BeuckelaerLien LybaertGlenn VerstraeteKim DeswarteStefan LienenklausNikunj M ShuklaAlex CD SalyerBart LambrechtJohan GrootenSunil A DavidStefaan De KokerBruno De Geest

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2015

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

Martijn SchuijsMonique WillartKarl VergoteDelphine GrasKim DeswarteMarkus J EgeFilipe Branco MadeiraRudi BeyaertGeert van LooFranz BracherErika von MutiusPascal ChanezBart LambrechtHamida Hammad

A1 Journal Article in SCIENCE

Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming

Melanie MatheuShivashankar OthyMilton L GreenbergTobias X DongMartijn SchuijsKim DeswarteHamida HammadBart LambrechtIan ParkerMichael D Cahalan

A1 Journal Article in NATURE COMMUNICATIONS

Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites

Jonathan CoquetMartijn SchuijsMark J SmythKim DeswarteRudi BeyaertHarald BraunLouis BoonGunilla B Karlsson HedestamSteven L NuttHamida HammadBart Lambrecht

A1 Journal Article in IMMUNITY

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven GoossensEnrico RadaelliOdile BlanchetKaat DurinckJoni Van der MeulenSofie PeirsTom TaghonCedric S TremblayMagdaline CostaMorvarid Farhang GhahremaniJelle De MedtsSona BartunkovaKatharina HaighClaire SchwabNatalie FarlaTim PietersFilip MatthijssensNadine Van RoyJ Adam BestKim DeswartePieter BogaertCatherine CarmichaelAdam RickardSanti SuryaniLauryn S BrackenRaed AlserihiKirsten Cante-BarretLieven HaenebalckeEmmanuelle ClappierPieter RondouKarolina SlowickaDanny HuylebroeckAnanda W GoldrathViktor JanzenMatthew P McCormackRichard B LockDavid J CurtisChristine HarrisonGeert BerxFranki SpelemanJules PP MeijerinkJean SoulierPieter Van VlierbergheJody Haigh

A1 Journal Article in NATURE COMMUNICATIONS

2014

Flow cytometric sexing of spider sperm reveals an equal sperm production ratio in a female-biased species

Bram VanthournoutKim DeswarteHamida HammadT BildeBart LambrechtFrederik Hendrickx

A1 Journal Article in BIOLOGY LETTERS

2013

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

Martin GuilliamsIsmé De KleerSandrine HenriSijranke PostLeen VanhoutteSofie De PrijckKim DeswarteBernard MalissenHamida HammadBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Conventional and monocyte-derived CD11b⁺ dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen

Maud PlantingaMartin GuilliamsManon VanheerswynghelsKim DeswarteFilipe Branco MadeiraWendy ToussaintLeen VanhoutteKatrijn NeytNigel KilleenBernard MalissenHamida HammadBart Lambrecht

A1 Journal Article in IMMUNITY

2012

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

Monique WillartKim DeswartePhilippe PouliotHarald BraunRudi BeyaertBart LambrechtHamida Hammad

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2011

Alternatively activated macrophages and impaired phagocytosis of S-aureus in chronic rhinosinusitis

Olga KryskoGabriële HoltappelsNan ZhangMalgorzata KubicaKim DeswarteLara DeryckeSofie ClaeysHamida HammadGuy BrussellePeter VandenabeeleDmitri KryskoClaus Bachert

A1 Journal Article in ALLERGY

2010

Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

Hamida HammadMaud PlantingaKim DeswartePhilippe PouliotMonique WillartMirjam KoolFemke MuskensBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Suppression of human natural killer T cell function by CD4(+)CD25(+)FOXP3(+) regulatory T cells

Koen VenkenTine DecruyKim DeswarteSANDRINE ASPESLAGHSerge Van CalenberghBart LambrechtDirk Elewaut

Vegf regulates embryonic erythroid development through Gata1 modulation

Benjamin DrogatJoanna KaluckaLaura GutierrezHamida HammadSteven GoossensMorvarid Farhang GhahremaniSona BartunkovaKatharina HaighKim DeswarteOmar NyabiMichaël NaessensNapoleone FerraraUursula KlingmullerBart LambrechtAndras NagySjaak PhilipsenJody Haigh

A1 Journal Article in BLOOD

2009

The lung vascular filter as a site of immune induction for T cell responses to large embolic antigen

Monique WillartHendrik Jan de HeerHamida HammadThomas SoulliéKim DeswarteBjörn E ClausenLouis BoonHenk C HoogstedenBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE