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Researcher
Kenny Roose
Profile
Projects
Publications
Activities
Awards & Distinctions
45
Results
2023
Improving therapeutic proteins by N-glycosylation engineering and conjugation
Berre Van Moer
Nico Callewaert
Kenny Roose
Dissertation
2023
2021
An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models
Bert Schepens
Loes van Schie
Wim Nerinckx
Kenny Roose
Wander Van Breedam
Daria Fijalkowska
Simon Devos
Wannes Weyts
Sieglinde De Cae
Sandrine Vanmarcke
et al.
A1
Journal Article
in
SCIENCE TRANSLATIONAL MEDICINE
2021
In vivo therapy with M2e-specific IgG selects for an influenza A virus mutant with delayed matrix protein 2 expression
Silvie Van den Hoecke
Marlies Ballegeer
Bram Vrancken
Lei Deng
Emma Job
Kenny Roose
Bert Schepens
Lien Van Hoecke
Philippe Lemey
Xavier Saelens
A1
Journal Article
in
MBIO
2021
2020
Reverse engineering synthetic antiviral amyloids
Emiel Michiels
Kenny Roose
Rodrigo Gallardo
Ladan Khodaparast
Laleh Khodaparast
Rob van der Kant
Maxime Siemons
Bert Houben
Meine Ramakers
Hannah Wilkinson
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2020
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
Robbert Boudewijns
Hendrik Jan Thibaut
Suzanne J. F. Kaptein
Rong Li
Valentijn Vergote
Laura Seldeslachts
Johan Van Weyenbergh
Carolien De Keyzer
Lindsey Bervoets
Sapna Sharma
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2020
Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies
Daniel Wrapp
Dorien De Vlieger
Kizzmekia S. Corbett
Gretel M. Torres
Nianshuang Wang
Wander Van Breedam
Kenny Roose
Loes van Schie
Markus Hoffmann
Stefan Poehlmann
et al.
A1
Journal Article
in
CELL
2020
Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies (vol 181, pg 1004, 2020)
Daniel Wrapp
Dorien De Vlieger
Kizzmekia S. Corbett
Gretel M. Torres
Nianshuang Wang
Wander Van Breedam
Kenny Roose
Loes van Schie
Markus Hoffmann
Stefan Pohlmann
et al.
Correction
2020
The opposing effect of type I IFN on the T cell response by non-modified mRNA-lipoplex vaccines Is determined by the route of administration
Lien Van Hoecke
Kenny Roose
Marlies Ballegeer
Zifu Zhong
Niek Sanders
Stefaan De Koker
Xavier Saelens
Sandra Van Lint
A1
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2020
mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice
Lien Van Hoecke
Rein Verbeke
Dorien De Vlieger
Heleen Dewitte
Kenny Roose
Sharon Van Nevel
Olga Krysko
Claus Bachert
Bert Schepens
Ine Lentacker
et al.
A1
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2020
mRNA-based therapeutics to induce immunity against cancer and infectious diseases
Lien Van Hoecke
Xavier Saelens
Sandra Van Lint
Kenny Roose
Dissertation
2020
2019
Mx1 in hematopoietic cells protects against Thogoto virus infection
Jan Spitaels
Lien Van Hoecke
Kenny Roose
Georg Kochs
Xavier Saelens
A1
Journal Article
in
JOURNAL OF VIROLOGY
2019
2018
Antibodies directed toward neuraminidase N1 control disease in a mouse model of influenza
Emma Job
Michael Schotsaert
Lorena Ibanez
Anouk Smet
Tine Ysenbaert
Kenny Roose
M. Dai
C. A. M. de Haan
H. Kleanthous
T. U. Vogel
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2018
Determining the contribution of Mx1 in the antiviral immune cell compartement
Jan Spitaels
Xavier Saelens
Kenny Roose
Dissertation
2018
Removal of the N-glycosylation sequon at position N116 located in p27 of the respiratory syncytial virus fusion protein elicits enhanced antibody responses after DNA immunization
Annelies Leemans
Marlies Boeren
Winke Van der Gucht
Isabel Pintelon
Kenny Roose
Bert Schepens
Xavier Saelens
Dalan Bailey
Wim Martinet
Guy Caljon
et al.
A1
Journal Article
in
VIRUSES-BASEL
2018
Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes
Lien Van Hoecke
Sandra Van Lint
Kenny Roose
Alexander Van Parys
Peter Vandenabeele
Johan Grooten
Jan Tavernier
Stefaan De Koker
Xavier Saelens
A1
Journal Article
in
NATURE COMMUNICATIONS
2018
2017
Arginine-rich peptide-based mRNA nanocomplexes efficiently instigate cytotoxic T cell immunity dependent on the amphipathic organization of the peptide
Vimal Kumar Udhayakumar
Ans De Beuckelaer
Joanne McCaffrey
Cian M McCrudden
Jonathan L Kirschman
Daryll Vanover
Lien Van Hoecke
Kenny Roose
Kim Deswarte
Bruno De Geest
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2017
Bispecific T cell engaging antibody constructs targeting a universally conserved part of the viral M2 ectodomain cure and prevent influenza A virus infection
Jochen Pendzialek
Kenny Roose
Anouk Smet
Bert Schepens
Peter Kufer
Tobias Raum
Patrick A Baeuerle
Markus Muenz
Xavier Saelens
Walther Fiers
A1
Journal Article
in
ANTIVIRAL RESEARCH
2017
Bronchoalveolar lavage of murine lungs to analyze inflammatory cell infiltration
Lien Van Hoecke
Emma Job
Xavier Saelens
Kenny Roose
A1
Journal Article
in
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
2017
Hierarchical and redundant roles of activating FcγRs in protection against influenza disease by M2e-specific IgG1 and IgG2a antibodies
Silvie Van den Hoecke
Katrin Ehrhardt
Annasaheb Kolpe
Karim El Bakkouri
Lei Deng
Hendrik Grootaert
Steve Schoonooghe
Anouk Smet
Mostafa Bentahir
Kenny Roose
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2017
Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12
Stefaan De Koker
Lien Van Hoecke
Ans De Beuckelaer
Kenny Roose
Kim Deswarte
Monique Willart
Pieter Bogaert
Thomas Naessens
Bruno De Geest
Xavier Saelens
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2017
Oral delivery of Escherichia coli persistently infected with M2e-displaying bacteriophages partially protects against influenza A virus
Lei Deng
Kenny Roose
Emma Job
Riet De Rycke
Evelien Van Hamme
Amanda Gonçalves
Eef Parthoens
Laetitia Cicchelero
Niek Sanders
Walther Fiers
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2017
2016
A20 deficiency in lung epithelial cells protects against influenza A virus infection
Jonathan Maelfait
Kenny Roose
Lars Vereecke
Conor Mc Guire
Mozes Sze
Martijn Schuijs
Monique Willart
Lorena Ibanez
Hamida Hammad
Bart Lambrecht
et al.
A1
Journal Article
in
PLOS PATHOGENS
2016
Increased protein degradation improves influenza virus nucleoprotein-specific CD8⁺ T cell activation in vitro but not in C57BL/6 mice
Arwen F Altenburg
Carolien E van de Sandt
Stella E van Trierum
Heidi LM De Gruyter
Peter RWA van Run
Ron AM Fouchier
Kenny Roose
Xavier Saelens
Asisa Volz
Gerd Sutter
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2016
Influenza and memory T cells : how to awake the force
Jan Spitaels
Kenny Roose
Xavier Saelens
A1
Journal Article
in
VACCINES
2016
Type I interferons interfere with the capacity of mRNA lipoplex vaccines to elicit cytolytic T cell responses
Ans De Beuckelaer
Charlotte Pollard
Sandra Van Lint
Kenny Roose
Lien Van Hoecke
Tom Naessens
Vimal Kumar Udhayakumar
Muriel Smet
Niek Sanders
Stefan Lienenklaus
et al.
A1
Journal Article
in
MOLECULAR THERAPY
2016
2015
A GFP expressing influenza A virus to report in vivo tropism and protection by a matrix protein 2 ectodomain-specific monoclonal antibody
Sarah De Baets
Judith Verhelst
Silvie Van den Hoecke
Anouk Smet
Michael Schotsaert
Emma Job
Kenny Roose
Bert Schepens
Walther Fiers
Xavier Saelens
A1
Journal Article
in
PLOS ONE
2015
Influenza vaccines to control influenza-associated bacterial infection: where do we stand?
Ioanna Christopoulou
Kenny Roose
Lorena Ibanez
Xavier Saelens
A1
Journal Article
in
EXPERT REVIEW OF VACCINES
2015
Protection against influenza A virus challenge with M2e-displaying filamentous Escherichia coli phages
Lei Deng
Lorena Ibanez
Veronique Van den Bossche
Kenny Roose
Sameh A Youssef
Alain de Bruin
Walther Fiers
Xavier Saelens
A1
Journal Article
in
PLOS ONE
2015
Sequence-dependent internalization of aggregating peptides
José R Couceiro
Rodrigo Gallardo
Frederik De Smet
Greet De Baets
Pieter Baatsen
Wim Annaert
Kenny Roose
Xavier Saelens
Joost Schymkowitz
Frederic Rousseau
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2015
Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody
Ki Joon Cho
Bert Schepens
Jong Hyeon Seok
Sella Kim
Kenny Roose
Ji-Hye Lee
Rodrigo Gallardo
Evelien Van Hamme
Joost Schymkowitz
Frederic Rousseau
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2015
2014
Presenting heterologous epitopes with hepatitis B core-based virus-like particles
Sarah De Baets
Kenny Roose
Bert Schepens
Xavier Saelens
Bookchapter
in
Virus-like particles in vaccine development
2014
Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein
Bert Schepens
Koen Sedeyn
Liesbeth Vande Ginste
Sarah De Baets
Michael Schotsaert
Kenny Roose
Lieselot Houspie
Marc Van Ranst
Barbara Gilbert
Nico van Rooijen
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2014
Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge
Miguel Lopez Cardoso
Lorena Ibanez
Silvie Van den Hoecke
Sarah De Baets
Anouk Smet
Kenny Roose
Bert Schepens
Francis Descamps
Walther Fiers
Serge Muyldermans
et al.
A1
Journal Article
in
JOURNAL OF VIROLOGY
2014
2013
Hepatitis B core-based virus-like particles to present heterologous epitopes
Kenny Roose
Sarah De Baets
Bert Schepens
Xavier Saelens
A1
Journal Article
in
EXPERT REVIEW OF VACCINES
2013
M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A
Lorena Ibanez
Kenny Roose
Marina De Filette
Michael Schotsaert
Jessica De Sloovere
Stefan Roels
Charlotte Pollard
Bert Schepens
Johan Grooten
Walther Fiers
et al.
A1
Journal Article
in
PLOS ONE
2013
Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice
Sarah De Baets
Bert Schepens
Koen Sedeyn
Michael Schotsaert
Kenny Roose
Pieter Bogaert
Walther Fiers
Xavier Saelens
A1
Journal Article
in
JOURNAL OF VIROLOGY
2013
2012
A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection
Jonathan Maelfait
Kenny Roose
Pieter Bogaert
Mozes Sze
Xavier Saelens
Manolis Pasparakis
Isabelle Carpentier
Geert van Loo
Rudi Beyaert
A1
Journal Article
in
PLOS PATHOGENS
2012
Cutting edge approaches towards novel and cross-protective influenza vaccines
Kenny Roose
Michael Schotsaert
Karim El Bakkouri
Bert Schepens
Walther Fiers
Xavier Saelens
Bookchapter
in
Development of novel vaccines : skills, knowledge and translational technologies
2012
Design and validation of novel cross-reactive influenza B vaccines
Kenny Roose
Xavier Saelens
Dissertation
2012
2011
Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective
Marina De Filette
Tine Ysenbaert
Kenny Roose
Michael Schotsaert
Stefan Roels
Els Goossens
Bert Schepens
Walther Fiers
Xavier Saelens
A1
Journal Article
in
JOURNAL OF GENERAL VIROLOGY
2011
2009
M2e-based universal influenza A vaccine
Walther Fiers
Marina De Filette
Karim El Bakkouri
Bert Schepens
Kenny Roose
Michael Schotsaert
A Birkett
Xavier Saelens
A1
Journal Article
in
VACCINE
2009
PANDEMIC PREPAREDNESS: TOWARD A UNIVERSAL INFLUENZA VACCINE
Kenny Roose
Walther Fiers
Xavier Saelens
A1
Journal Article
in
DRUG NEWS & PERSPECTIVES
2009
2008
An influenza A vaccine based on tetrameric ectodomain of matrix protein 2
Marina De Filette
Wouter Martens
Kenny Roose
Tom Deroo
Frederik Vervalle
Mostafa Bentahir
Joël Vandekerckhove
Walther Fiers
Xavier Saelens
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2008
Vaccine development by recombinant DNA technology. Part I: DNA Vaccines
Amin Bredan
Kenny Roose
Michael Schotsaert
Xavier Saelens
Bookchapter
in
The Oea Review of Medicine
2008
Vaccine development by recombinant DNA technology. Part II: Virus-like Particles
Amin Bredan
Kenny Roose
Michael Schotsaert
Xavier Saelens
Bookchapter
in
The Oea Review of Medicine
2008