Research Explorer

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Researcher

Kenny Roose

Awards & Distinctions

46 Results

2024

Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline : caution is warranted

Delphine Diana AcarWojciech WitkowskiMagdalena WejdaRuifang WeiTim DesmetBert SchepensSieglinde De CaeKoen SedeynHannah EeckhautDaria Fijalkowska et al.

A1 Journal Article in EBIOMEDICINE

2023

Improving therapeutic proteins by N-glycosylation engineering and conjugation

Berre Van MoerNico CallewaertKenny Roose

2021

An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models

Bert SchepensLoes van SchieWim NerinckxKenny RooseWander Van BreedamDaria FijalkowskaSimon DevosWannes WeytsSieglinde De CaeSandrine Vanmarcke et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

In vivo therapy with M2e-specific IgG selects for an influenza A virus mutant with delayed matrix protein 2 expression

Silvie Van den HoeckeMarlies BallegeerBram VranckenLei DengEmma JobKenny RooseBert SchepensLien Van HoeckePhilippe LemeyXavier Saelens

A1 Journal Article in MBIO

2020

Reverse engineering synthetic antiviral amyloids

Emiel MichielsKenny RooseRodrigo GallardoLadan KhodaparastLaleh KhodaparastRob van der KantMaxime SiemonsBert HoubenMeine RamakersHannah Wilkinson et al.

A1 Journal Article in NATURE COMMUNICATIONS

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Robbert BoudewijnsHendrik Jan ThibautSuzanne J. F. KapteinRong LiValentijn VergoteLaura SeldeslachtsJohan Van WeyenberghCarolien De KeyzerLindsey BervoetsSapna Sharma et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies

Daniel WrappDorien De VliegerKizzmekia S. CorbettGretel M. TorresNianshuang WangWander Van BreedamKenny RooseLoes van SchieMarkus HoffmannStefan Poehlmann et al.

A1 Journal Article in CELL

Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies (vol 181, pg 1004, 2020)

Daniel WrappDorien De VliegerKizzmekia S. CorbettGretel M. TorresNianshuang WangWander Van BreedamKenny RooseLoes van SchieMarkus HoffmannStefan Pohlmann et al.

The opposing effect of type I IFN on the T cell response by non-modified mRNA-lipoplex vaccines Is determined by the route of administration

Lien Van HoeckeKenny RooseMarlies BallegeerZifu ZhongNiek SandersStefaan De KokerXavier SaelensSandra Van Lint

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice

Lien Van HoeckeRein VerbekeDorien De VliegerHeleen DewitteKenny RooseSharon Van NevelOlga KryskoClaus BachertBert SchepensIne Lentacker et al.

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

mRNA-based therapeutics to induce immunity against cancer and infectious diseases

Lien Van HoeckeXavier SaelensSandra Van LintKenny Roose

2019

Mx1 in hematopoietic cells protects against Thogoto virus infection

Jan SpitaelsLien Van HoeckeKenny RooseGeorg KochsXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

2018

Antibodies directed toward neuraminidase N1 control disease in a mouse model of influenza

Emma JobMichael SchotsaertLorena IbanezAnouk SmetTine YsenbaertKenny RooseM. DaiC. A. M. de HaanH. KleanthousT. U. Vogel et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Determining the contribution of Mx1 in the antiviral immune cell compartement

Jan SpitaelsXavier SaelensKenny Roose

Removal of the N-glycosylation sequon at position N116 located in p27 of the respiratory syncytial virus fusion protein elicits enhanced antibody responses after DNA immunization

Annelies LeemansMarlies BoerenWinke Van der GuchtIsabel PintelonKenny RooseBert SchepensXavier SaelensDalan BaileyWim MartinetGuy Caljon et al.

A1 Journal Article in VIRUSES-BASEL

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

Lien Van HoeckeSandra Van LintKenny RooseAlexander Van ParysPeter VandenabeeleJohan GrootenJan TavernierStefaan De KokerXavier Saelens

A1 Journal Article in NATURE COMMUNICATIONS

2017

Arginine-rich peptide-based mRNA nanocomplexes efficiently instigate cytotoxic T cell immunity dependent on the amphipathic organization of the peptide

Vimal Kumar UdhayakumarAns De BeuckelaerJoanne McCaffreyCian M McCruddenJonathan L KirschmanDaryll VanoverLien Van HoeckeKenny RooseKim DeswarteBruno De Geest et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Bispecific T cell engaging antibody constructs targeting a universally conserved part of the viral M2 ectodomain cure and prevent influenza A virus infection

Jochen PendzialekKenny RooseAnouk SmetBert SchepensPeter KuferTobias RaumPatrick A BaeuerleMarkus MuenzXavier SaelensWalter Fiers

A1 Journal Article in ANTIVIRAL RESEARCH

Bronchoalveolar lavage of murine lungs to analyze inflammatory cell infiltration

Lien Van HoeckeEmma JobXavier SaelensKenny Roose

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Hierarchical and redundant roles of activating FcγRs in protection against influenza disease by M2e-specific IgG1 and IgG2a antibodies

Silvie Van den HoeckeKatrin EhrhardtAnnasaheb KolpeKarim El BakkouriLei DengHendrik GrootaertSteve SchoonoogheAnouk SmetMostafa BentahirKenny Roose et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Stefaan De KokerLien Van HoeckeAns De BeuckelaerKenny RooseKim DeswarteMonique WillartPieter BogaertThomas NaessensBruno De GeestXavier Saelens et al.

A1 Journal Article in SCIENTIFIC REPORTS

Oral delivery of Escherichia coli persistently infected with M2e-displaying bacteriophages partially protects against influenza A virus

Lei DengKenny RooseEmma JobRiet De RyckeEvelien Van HammeAmanda GonçalvesEef ParthoensLaetitia CiccheleroNiek SandersWalter Fiers et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2016

A20 deficiency in lung epithelial cells protects against influenza A virus infection

Jonathan MaelfaitKenny RooseLars VereeckeConor Mc GuireMozes SzeMartijn SchuijsMonique WillartLorena IbanezHamida HammadBart Lambrecht et al.

A1 Journal Article in PLOS PATHOGENS

Increased protein degradation improves influenza virus nucleoprotein-specific CD8⁺ T cell activation in vitro but not in C57BL/6 mice

Arwen F AltenburgCarolien E van de SandtStella E van TrierumHeidi LM De GruyterPeter RWA van RunRon AM FouchierKenny RooseXavier SaelensAsisa VolzGerd Sutter et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Inﬂuenza and memory T cells : how to awake the force

Jan SpitaelsKenny RooseXavier Saelens

A1 Journal Article in VACCINES

Type I interferons interfere with the capacity of mRNA lipoplex vaccines to elicit cytolytic T cell responses

Ans De BeuckelaerCharlotte PollardSandra Van LintKenny RooseLien Van HoeckeTom NaessensVimal Kumar UdhayakumarMuriel SmetNiek SandersStefan Lienenklaus et al.

A1 Journal Article in MOLECULAR THERAPY

2015

A GFP expressing influenza A virus to report in vivo tropism and protection by a matrix protein 2 ectodomain-specific monoclonal antibody

Sarah De BaetsJudith VerhelstSilvie Van den HoeckeAnouk SmetMichael SchotsaertEmma JobKenny RooseBert SchepensWalter FiersXavier Saelens

A1 Journal Article in PLOS ONE

Influenza vaccines to control influenza-associated bacterial infection: where do we stand?

Ioanna ChristopoulouKenny RooseLorena IbanezXavier Saelens

A1 Journal Article in EXPERT REVIEW OF VACCINES

Protection against influenza A virus challenge with M2e-displaying filamentous Escherichia coli phages

Lei DengLorena IbanezVERONIQUE VAN DEN BOSSCHEKenny RooseSameh A YoussefAlain de BruinWalter FiersXavier Saelens

A1 Journal Article in PLOS ONE

Sequence-dependent internalization of aggregating peptides

José R CouceiroRodrigo GallardoFrederik De SmetGreet De BaetsPieter BaatsenWim AnnaertKenny RooseXavier SaelensJoost SchymkowitzFrederic Rousseau

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody

Ki Joon ChoBert SchepensJong Hyeon SeokSella KimKenny RooseJi-Hye LeeRodrigo GallardoEvelien Van HammeJoost SchymkowitzFrederic Rousseau et al.

A1 Journal Article in JOURNAL OF VIROLOGY

2014

Presenting heterologous epitopes with hepatitis B core-based virus-like particles

Sarah De BaetsKenny RooseBert SchepensXavier Saelens

Bookchapter in Virus-like particles in vaccine development

Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein

Bert SchepensKoen SedeynLiesbeth Vande GinsteSarah De BaetsMichael SchotsaertKenny RooseLieselot HouspieMarc Van RanstBarbara GilbertNico van Rooijen et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge

Miguel Lopez CardosoLorena IbanezSilvie Van den HoeckeSarah De BaetsAnouk SmetKenny RooseBert SchepensFrancis DescampsWalter FiersSerge Muyldermans et al.

A1 Journal Article in JOURNAL OF VIROLOGY

2013

Hepatitis B core-based virus-like particles to present heterologous epitopes

Kenny RooseSarah De BaetsBert SchepensXavier Saelens

A1 Journal Article in EXPERT REVIEW OF VACCINES

M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A

Lorena IbanezKenny RooseMarina De FiletteMichael SchotsaertJessica De SloovereStefan RoelsCharlotte PollardBert SchepensJohan GrootenWalter Fiers et al.

A1 Journal Article in PLOS ONE

Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice

Sarah De BaetsBert SchepensKoen SedeynMichael SchotsaertKenny RoosePieter BogaertWalter FiersXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

2012

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection

Jonathan MaelfaitKenny RoosePieter BogaertMozes SzeXavier SaelensManolis PasparakisIsabelle CarpentierGeert van LooRudi Beyaert

A1 Journal Article in PLOS PATHOGENS

Cutting edge approaches towards novel and cross-protective influenza vaccines

Kenny RooseMichael SchotsaertKarim El BakkouriBert SchepensWalter FiersXavier Saelens

Bookchapter in Development of novel vaccines : skills, knowledge and translational technologies

Design and validation of novel cross-reactive influenza B vaccines

Kenny RooseXavier Saelens

2011

Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective

Marina De FiletteTine YsenbaertKenny RooseMichael SchotsaertStefan RoelsEls GoossensBert SchepensWalter FiersXavier Saelens

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

2009

M2e-based universal influenza A vaccine

Walter FiersMarina De FiletteKarim El BakkouriBert SchepensKenny RooseMichael SchotsaertA BirkettXavier Saelens

A1 Journal Article in VACCINE

PANDEMIC PREPAREDNESS: TOWARD A UNIVERSAL INFLUENZA VACCINE

Kenny RooseWalter FiersXavier Saelens

A1 Journal Article in DRUG NEWS & PERSPECTIVES

2008

An influenza A vaccine based on tetrameric ectodomain of matrix protein 2

Marina De FiletteWouter MartensKenny RooseTom DerooFrederik VervalleMostafa BentahirJoël VandekerckhoveWalter FiersXavier Saelens

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccine development by recombinant DNA technology. Part I: DNA Vaccines

Amin BredanKenny RooseMichael SchotsaertXavier Saelens

Bookchapter in The Oea Review of Medicine

Vaccine development by recombinant DNA technology. Part II: Virus-like Particles

Amin BredanKenny RooseMichael SchotsaertXavier Saelens

Bookchapter in The Oea Review of Medicine