Research Explorer

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Researcher

Kenneth Verstraete

Publications & Research Data

Awards & Distinctions

34 Results

2026

Improved protein binder design using β-pairing targeted RFdiffusion

Isaac SappingtonMartin ToulDavid S. LeeStephanie A. RobinsonInna GoreshnikClara MccurdyTung Ching ChanNic BuchholzBuwei HuangDionne Vafeados et al.

U Journal Article in NATURE COMMUNICATIONS

2025

ACLY inhibition promotes tumour immunity and suppresses liver cancer

Jaya GautamJianhan WuJames S. V. LallyJamie D. McNicolRussta FayyaziElham AhmadiDaniela Carmen OniciuSpencer HeatonRoger S. NewtonSonia Rehal et al.

A1 Journal Article in NATURE

Small-angle X-ray scattering of engineered antigen-binding fragments : the case of glycosylated Fab from the Mannitou IgM antibody

Shubham SemwalMaria KaramolegkouStéphanie FlamentNessim RaouraouaKenneth VerstraeteAurélien ThureauFrank WienFabrice BraySavvas SavvidesJulie Bouckaert

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS

2024

Structural and functional studies of receptor complexes mediated by Interleukin-19 and Interleukin-26

Maria KaramolegkouSavvas SavvidesKenneth Verstraete

Ym1 protein crystals promote type 2 immunity

Ines HeyndrickxKim DeswarteKenneth VerstraeteKoen VerschuerenUrsula SmoleHelena Catharine AegerterAnn DansercoerHamida HammadSavvas SavvidesBart Lambrecht

A1 Journal Article in ELIFE

2023

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

Alexandra TsirigotakiAnn DansercoerKoen VerschuerenIva MarkovićChristoph PollmannMaximillian HaferJan FélixCatherine BirckWouter Van PutteDominiek Catteeuw et al.

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rare antagonistic leptin variants and severe, early-onset obesity

Jan-Bernd FunckeBarbara MoeppsJulian RoosJulia von SchnurbeinKenneth VerstraeteElke Fröhlich-ReitererKatja KohlsdorfAdriana NunziataStephanie BrandtAlexandra Tsirigotaki et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

2022

Design of protein-binding proteins from the target structure alone

Longxing CaoBrian CoventryInna GoreshnikBuwei HuangWilliam ShefflerJoon Sung ParkKevin M. JudeIva MarkovićRameshwar U. KadamKoen Verschueren et al.

A1 Journal Article in NATURE

The Charcot-Leyden crystal protein Galectin-10 is not a major determinant of human regulatory T-cell function

Rebeca Arroyo-HorneroHelena Catharine AegerterIbrahim HamadBeatriz Corte-RealKatrien StaesBas van Der WoningKenneth VerstraeteSavvas SavvidesBart LambrechtMarkus Kleinewietfeld

A1 Journal Article in ALLERGY

2021

A recombinant antibody fragment directed to the thymic stromal lymphopoietin receptor (CRLF2) efficiently targets pediatric Philadelphia chromosome-like acute lymphoblastic leukemia

Sara M. A. MohamedAndreas WohlmannPeter SchofieldKeith C. S. SiaHannah McCalmontSavvas SavvidesKenneth VerstraeteMaria KavallarisDaniel ChristKarl-Heinz Friedrich et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase

Kenneth VerstraeteKoen VerschuerenAnn DansercoerSavvas Savvides

Editorial material

Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy

Helena Catharine AegerterUrsula SmoleInes HeyndrickxKenneth VerstraeteSavvas SavvidesHamida HammadBart Lambrecht

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins.

Stefania RobakiewiczClarisse BridotSonia SernaAna GimenoBegoña EcheverriaSandra DelgadoJérôme de RuyckShubham SemwalDiego CharroAnn Dansercoer et al.

A1 Journal Article in GLYCOBIOLOGY

2020

Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis

Elien GevaertTim DelemarreJoyceline De VolderNan ZhangGabriële HoltappelsNatalie De RuyckEmma PerssonInes HeyndrickxKenneth VerstraeteHelena Catharine Aegerter et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Single-chain soluble receptor fusion proteins as versatile cytokine inhibitors

Aurora Holgado MuñozHarald BraunKenneth VerstraeteDomien VannesteNico CallewaertSavvas SavvidesInna AfoninaRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Structure and assembly mechanism of the signaling complex mediated by human CSF-1 (vol 23, pg 1621, 2015)

Jan FélixSteven De MunckKenneth VerstraeteLeander MeurisNico CallewaertJonathan ElegheertSavvas Savvides

2019

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

Emma PerssonKenneth VerstraeteInes HeyndrickxElien GevaertHelena Catharine AegerterJean-Michel PercierKim DeswarteKoen VerschuerenAnn DansercoerDelphine Gras et al.

A1 Journal Article in SCIENCE

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle

Koen VerschuerenClement BlanchetJan FelixAnn DansercoerDirk De VosYehudi BlochJozef Van BeeumenDmitri SvergunIrina GutscheSavvas Savvides et al.

A1 Journal Article in NATURE

2018

Structure, mechanism and antagonism of the pro-inflammatory receptor complex mediated by interleukin-23

Yehudi BlochSavvas SavvidesKenneth Verstraete

2017

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Kenneth VerstraeteFrank PeelmanHarald BraunJuan LopezDries Van RompaeyAnn DansercoerIsabel VandenbergheKris PauwelsJan TavernierBart Lambrecht et al.

A1 Journal Article in NATURE COMMUNICATIONS

Virtual screening for inhibitors of the human TSLP:TSLPR interaction

Dries Van RompaeyKenneth VerstraeteFrank PeelmanSavvas SavvidesKoen AugustynsPieter Van Der VekenHans De Winter

A1 Journal Article in SCIENTIFIC REPORTS

2016

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Jan FélixEaazhisai KandiahSteven De MunckYehudi BlochGydo CP van ZundertKris PauwelsAnn DansercoerKatka NovanskaRandy J ReadAlexandre MJJ Bonvin et al.

A1 Journal Article in NATURE COMMUNICATIONS

2015

Structure and assembly mechanism of the signaling complex mediated by human CSF-1

Jan FélixSteven De MunckKenneth VerstraeteLeander MeurisNico CallewaertJonathan ElegheertSavvas Savvides

A1 Journal Article in STRUCTURE

2014

Structural basis of IL-23 antagonism by an Alphabody protein scaffold

Johan DesmetKenneth VerstraeteYehudi BlochEric LorentYurong WenBart DevreeseKaren VandenbrouckeStefan LoverixThore HettmannSabrina Deroo et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural basis of the proinflammatory signaling complex mediated by TSLP

Kenneth VerstraeteLoes van SchieLaurens VynckeYehudi BlochJan TavernierEwald PauwelsFrank PeelmanSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

2013

Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference

Géraldine BuysschaertKenneth VerstraeteSavvas SavvidesBjorn Vergauwen

A1 Journal Article in FEBS JOURNAL

2012

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1

Jonathan ElegheertNathalie BrackePhilippe PouliotIrina GutscheAlexander V ShkumatovNicolas TarbouriechKenneth VerstraeteAnaïs BekaertWim P BurmeisterDmitri I Svergun et al.

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystallization of an atypical short-chain dehydrogenase from Vibrio vulnificus lacking the conserved catalytic tetrad

Géraldine BuysschaertKenneth VerstraeteSavvas SavvidesBjorn Vergauwen

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases

Kenneth VerstraeteSavvas Savvides

A1 Journal Article in NATURE REVIEWS CANCER

2011

Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles

Jonathan ElegheertAmbroise DesfossesAlexander V ShkumatovXiongwu WuNathalie BrackeKenneth VerstraeteKathleen Van CraenenbroeckBernard R BrooksDmitri I SvergunBjorn Vergauwen et al.

A1 Journal Article in STRUCTURE

Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes

Kenneth VerstraeteBert RemmerieJonathan ElegheertBéatrice LintermansGuy HaegemanPeter VanhoenackerKathleen Van CraenenbroeckSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Structural insights into the extracellular assembly of the hematopoietic Flt3 ligand-receptor complex

Kenneth VerstraeteSavvas SavvidesJozef Van Beeumen

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex

Kenneth VerstraeteGonzalez VandriesscheMariska JanuarJonathan ElegheertAlexander V ShkumatovAmbroise DesfossesKathleen Van CraenenbroeckDmitri I SvergunIrina GutscheBjorn Vergauwen et al.

A1 Journal Article in BLOOD

2009

Efficient production of bioactive recombinant human Flt3 ligand in E. coli

Kenneth VerstraeteSina KochSevgi ErtugrulIsabel VandenbergheMaarten AertsGonzalez VandriesscheChristian ThiedeSavvas Savvides

A1 Journal Article in PROTEIN JOURNAL