Research Explorer

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Researcher

Kenneth Verstraete

23 Results

2021

Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy

Helena Catharine AegerterUrsula SmoleInes HeyndrickxKenneth VerstraeteSavvas SavvidesHamida HammadBart Lambrecht

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins.

Stefania RobakiewiczClarisse BridotSonia SernaAna GimenoBegoña EcheverriaSandra DelgadoJérôme de RuyckShubham SemwalDiego CharroAnn DansercoerKenneth VerstraeteMikel AzkargortaKim van NoortRuud WilbersSavvas SavvidesNicola G. A. AbresciaAna ArdaNiels C. ReichardtJesús Jiménez-BarberoJulie Bouckaert

A1 Journal Article in GLYCOBIOLOGY

2020

Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis

Elien GevaertTim DelemarreJoyceline De VolderNan ZhangGabriële HoltappelsNatalie De RuyckEmma PerssonInes HeyndrickxKenneth VerstraeteHelena Catharine AegerterHans NauwynckSavvas SavvidesBart LambrechtClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Single-chain soluble receptor fusion proteins as versatile cytokine inhibitors

Aurora Holgado MunozHarald BraunKenneth VerstraeteDomien VannesteNico CallewaertSavvas SavvidesInna AfoninaRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Structure and assembly mechanism of the signaling complex mediated by human CSF-1 (vol 23, pg 1621, 2015)

Jan FélixSteven De MunckKenneth VerstraeteLeander MeurisNico CallewaertJonathan ElegheertSavvas Savvides

2019

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

Emma PerssonKenneth VerstraeteInes HeyndrickxElien GevaertHelena Catharine AegerterJean-Michel PercierKim DeswarteKoen VerschuerenAnn DansercoerDelphine GrasPascal ChanezClaus BachertAmanda GonçalvesHanne Van GorpHans De HaardChristophe BlanchetotMichael SaundersHamida HammadSavvas SavvidesBart Lambrecht

A1 Journal Article in SCIENCE

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle

Koen VerschuerenClement BlanchetJan FelixAnn DansercoerDirk De VosYehudi BlochJozef Van BeeumenDmitri SvergunIrina GutscheSavvas SavvidesKenneth Verstraete

A1 Journal Article in NATURE

2018

Structure, mechanism and antagonism of the pro-inflammatory receptor complex mediated by interleukin-23

Yehudi BlochSavvas SavvidesKenneth Verstraete

2017

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Kenneth VerstraeteFrank PeelmanHarald BraunJuan LopezDries Van RompaeyAnn DansercoerIsabel VandenbergheKris PauwelsJan TavernierBart LambrechtHamida HammadHans De WinterRudi BeyaertGuy LippensSavvas Savvides

A1 Journal Article in NATURE COMMUNICATIONS

Virtual screening for inhibitors of the human TSLP:TSLPR interaction

Dries Van RompaeyKenneth VerstraeteFrank PeelmanSavvas SavvidesKoen AugustynsPieter Van Der VekenHans De Winter

A1 Journal Article in SCIENTIFIC REPORTS

2016

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Jan FélixEaazhisai KandiahSteven De MunckYehudi BlochGydo CP van ZundertKris PauwelsAnn DansercoerKatka NovanskaRandy J ReadAlexandre MJJ BonvinBjorn VergauwenKenneth VerstraeteIrina GutscheSavvas Savvides

A1 Journal Article in NATURE COMMUNICATIONS

2015

Structure and assembly mechanism of the signaling complex mediated by human CSF-1

Jan FélixSteven De MunckKenneth VerstraeteLeander MeurisNico CallewaertJonathan ElegheertSavvas Savvides

A1 Journal Article in STRUCTURE

2014

Structural basis of IL-23 antagonism by an Alphabody protein scaffold

Johan DesmetKenneth VerstraeteYehudi BlochEric LorentYurong WenBart DevreeseKaren VandenbrouckeStefan LoverixThore HettmannSabrina DerooKlaartje SomersPaula HenderikxIgnace LastersSavvas Savvides

A1 Journal Article in NATURE COMMUNICATIONS

Structural basis of the proinflammatory signaling complex mediated by TSLP

Kenneth VerstraeteLoes van SchieLaurens VynckeYehudi BlochJan TavernierEwald PauwelsFrank PeelmanSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

2013

Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference

Géraldine BuysschaertKenneth VerstraeteSavvas SavvidesBjorn Vergauwen

A1 Journal Article in FEBS JOURNAL

2012

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1

Jonathan ElegheertNathalie BrackePhilippe PouliotIrina GutscheAlexander V ShkumatovNicolas TarbouriechKenneth VerstraeteAnaïs BekaertWim P BurmeisterDmitri I SvergunBart LambrechtBjorn VergauwenSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystallization of an atypical short-chain dehydrogenase from Vibrio vulnificus lacking the conserved catalytic tetrad

Géraldine BuysschaertKenneth VerstraeteSavvas SavvidesBjorn Vergauwen

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases

Kenneth VerstraeteSavvas Savvides

A1 Journal Article in NATURE REVIEWS CANCER

2011

Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles

Jonathan ElegheertAmbroise DesfossesAlexander V ShkumatovXiongwu WuNathalie BrackeKenneth VerstraeteKathleen Van CraenenbroeckBernard R BrooksDmitri I SvergunBjorn VergauwenIrina GutscheSavvas Savvides

A1 Journal Article in STRUCTURE

Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes

Kenneth VerstraeteBert RemmerieJonathan ElegheertBéatrice LintermansGuy HaegemanPeter VanhoenackerKathleen Van CraenenbroeckSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Structural insights into the extracellular assembly of the hematopoietic Flt3 ligand-receptor complex

Kenneth VerstraeteSavvas SavvidesJozef Van Beeumen

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex

Kenneth VerstraeteGonzalez VandriesscheMariska JanuarJonathan ElegheertAlexander V ShkumatovAmbroise DesfossesKathleen Van CraenenbroeckDmitri I SvergunIrina GutscheBjorn VergauwenSavvas Savvides

A1 Journal Article in BLOOD

2009

Efficient production of bioactive recombinant human Flt3 ligand in E. coli

Kenneth VerstraeteSina KochSevgi ErtugrulIsabel VandenbergheMaarten AertsGonzalez VandriesscheChristian ThiedeSavvas Savvides

A1 Journal Article in PROTEIN JOURNAL