Research Explorer

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Researcher

Kenneth Verstraete

27 Results

2022

Design of protein-binding proteins from the target structure alone

Iva MarkovićKoen VerschuerenKenneth VerstraeteSavvas Savvides

A1 Journal Article in NATURE

The Charcot-Leyden crystal protein Galectin-10 is not a major determinant of human regulatory T-cell function

Helena Catharine AegerterKatrien StaesKenneth VerstraeteSavvas SavvidesBart Lambrecht

A1 Journal Article in ALLERGY

2021

A recombinant antibody fragment directed to the thymic stromal lymphopoietin receptor (CRLF2) efficiently targets pediatric Philadelphia chromosome-like acute lymphoblastic leukemia

Savvas SavvidesKenneth Verstraete

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase

Kenneth VerstraeteKoen VerschuerenAnn DansercoerSavvas Savvides

Editorial material

Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy

Helena Catharine AegerterUrsula SmoleInes HeyndrickxKenneth VerstraeteSavvas SavvidesHamida HammadBart Lambrecht

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

Minimal epitope for Mannitou IgM on paucimannose-carrying glycoproteins.

Ann DansercoerKenneth VerstraeteSavvas Savvides

A1 Journal Article in GLYCOBIOLOGY

2020

Charcot-Leyden crystals promote neutrophilic inflammation in patients with nasal polyposis

Elien GevaertTim DelemarreJoyceline De VolderNan ZhangGabriële HoltappelsNatalie De RuyckEmma PerssonInes HeyndrickxKenneth VerstraeteHelena Catharine AegerterHans NauwynckSavvas SavvidesBart LambrechtClaus Bachert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Single-chain soluble receptor fusion proteins as versatile cytokine inhibitors

Aurora Holgado MuñozHarald BraunKenneth VerstraeteDomien VannesteNico CallewaertSavvas SavvidesInna AfoninaRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Structure and assembly mechanism of the signaling complex mediated by human CSF-1 (vol 23, pg 1621, 2015)

Jan FélixSteven De MunckKenneth VerstraeteLeander MeurisNico CallewaertJonathan ElegheertSavvas Savvides

2019

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

Emma PerssonKenneth VerstraeteInes HeyndrickxElien GevaertHelena Catharine AegerterKim DeswarteKoen VerschuerenAnn DansercoerClaus BachertAmanda GonçalvesHanne Van GorpHamida HammadSavvas SavvidesBart Lambrecht

A1 Journal Article in SCIENCE

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle

Koen VerschuerenAnn DansercoerYehudi BlochJozef Van BeeumenSavvas SavvidesKenneth Verstraete

A1 Journal Article in NATURE

2018

Structure, mechanism and antagonism of the pro-inflammatory receptor complex mediated by interleukin-23

Yehudi BlochSavvas SavvidesKenneth Verstraete

2017

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Kenneth VerstraeteFrank PeelmanHarald BraunAnn DansercoerIsabel VandenbergheJan TavernierBart LambrechtHamida HammadRudi BeyaertSavvas Savvides

A1 Journal Article in NATURE COMMUNICATIONS

Virtual screening for inhibitors of the human TSLP:TSLPR interaction

Kenneth VerstraeteFrank PeelmanSavvas Savvides

A1 Journal Article in SCIENTIFIC REPORTS

2016

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Jan FélixSteven De MunckYehudi BlochAnn DansercoerBjorn VergauwenKenneth VerstraeteSavvas Savvides

A1 Journal Article in NATURE COMMUNICATIONS

2015

Structure and assembly mechanism of the signaling complex mediated by human CSF-1

Jan FélixSteven De MunckKenneth VerstraeteLeander MeurisNico CallewaertJonathan ElegheertSavvas Savvides

A1 Journal Article in STRUCTURE

2014

Structural basis of IL-23 antagonism by an Alphabody protein scaffold

Kenneth VerstraeteYehudi BlochYurong WenBart DevreeseSavvas Savvides

A1 Journal Article in NATURE COMMUNICATIONS

Structural basis of the proinflammatory signaling complex mediated by TSLP

Kenneth VerstraeteLoes van SchieLaurens VynckeYehudi BlochJan TavernierEwald PauwelsFrank PeelmanSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

2013

Structural and biochemical characterization of an atypical short-chain dehydrogenase/reductase reveals an unusual cofactor preference

Géraldine BuysschaertKenneth VerstraeteSavvas SavvidesBjorn Vergauwen

A1 Journal Article in FEBS JOURNAL

2012

Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1

Jonathan ElegheertNathalie BrackePhilippe PouliotKenneth VerstraeteAnaïs BekaertBart LambrechtBjorn VergauwenSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystallization of an atypical short-chain dehydrogenase from Vibrio vulnificus lacking the conserved catalytic tetrad

Géraldine BuysschaertKenneth VerstraeteSavvas SavvidesBjorn Vergauwen

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases

Kenneth VerstraeteSavvas Savvides

A1 Journal Article in NATURE REVIEWS CANCER

2011

Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles

Jonathan ElegheertNathalie BrackeKenneth VerstraeteKathleen Van CraenenbroeckBjorn VergauwenSavvas Savvides

A1 Journal Article in STRUCTURE

Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes

Kenneth VerstraeteBert RemmerieJonathan ElegheertBéatrice LintermansGuy HaegemanKathleen Van CraenenbroeckSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Structural insights into the extracellular assembly of the hematopoietic Flt3 ligand-receptor complex

Kenneth VerstraeteSavvas SavvidesJozef Van Beeumen

Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex

Kenneth VerstraeteJonathan ElegheertKathleen Van CraenenbroeckBjorn VergauwenSavvas Savvides

A1 Journal Article in BLOOD

2009

Efficient production of bioactive recombinant human Flt3 ligand in E. coli

Kenneth VerstraeteIsabel VandenbergheMaarten AertsSavvas Savvides

A1 Journal Article in PROTEIN JOURNAL